IL210063A0 - 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitors - Google Patents
3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitorsInfo
- Publication number
- IL210063A0 IL210063A0 IL210063A IL21006310A IL210063A0 IL 210063 A0 IL210063 A0 IL 210063A0 IL 210063 A IL210063 A IL 210063A IL 21006310 A IL21006310 A IL 21006310A IL 210063 A0 IL210063 A0 IL 210063A0
- Authority
- IL
- Israel
- Prior art keywords
- triazolo
- pyrimidin
- benzyl
- kinase inhibitors
- met kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008028905A DE102008028905A1 (en) | 2008-06-18 | 2008-06-18 | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
PCT/EP2009/003675 WO2009152920A1 (en) | 2008-06-18 | 2009-05-25 | 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
IL210063A0 true IL210063A0 (en) | 2011-02-28 |
IL210063A IL210063A (en) | 2015-06-30 |
Family
ID=40973097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL210063A IL210063A (en) | 2008-06-18 | 2010-12-16 | נגזרות 3–(3–פירימידין–2–איל–בנזיל)–4,2,1–טריאזולו[3,4 –b]פירידזין כמעכבי met קינאז |
Country Status (19)
Country | Link |
---|---|
US (1) | US8497266B2 (en) |
EP (1) | EP2285811B1 (en) |
JP (1) | JP5662311B2 (en) |
KR (1) | KR101661777B1 (en) |
CN (1) | CN102066378B (en) |
AR (1) | AR072860A1 (en) |
AU (1) | AU2009259764B2 (en) |
BR (1) | BRPI0915417B8 (en) |
CA (1) | CA2728194C (en) |
DE (1) | DE102008028905A1 (en) |
DK (1) | DK2285811T3 (en) |
EA (1) | EA019534B1 (en) |
ES (1) | ES2400117T3 (en) |
IL (1) | IL210063A (en) |
MX (1) | MX2010013649A (en) |
PL (1) | PL2285811T3 (en) |
PT (1) | PT2285811E (en) |
WO (1) | WO2009152920A1 (en) |
ZA (1) | ZA201100437B (en) |
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DE102007026341A1 (en) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (en) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | pyridazinone derivatives |
DE102007038957A1 (en) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-thioxo-pyridazine derivatives |
DE102007061963A1 (en) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | pyridazinone derivatives |
DE102008019907A1 (en) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | pyridazinone derivatives |
DE102008028905A1 (en) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
DE102008037790A1 (en) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclic triazole derivatives |
DE102008063667A1 (en) * | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - ° [1,2,4] triazolo [4,3-b] pyrimidine derivatives |
PT2361250E (en) | 2008-12-22 | 2013-11-11 | Merck Patent Gmbh | Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
DE102008062825A1 (en) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
JP6435323B2 (en) * | 2013-06-19 | 2018-12-05 | ガラパゴス・ナムローゼ・フェンノートシャップGalapagos N.V. | Novel compounds for the treatment of inflammatory disorders and pharmaceutical compositions thereof |
GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
ES2946551T3 (en) | 2017-10-17 | 2023-07-20 | Palau Pharma S L U | Synthesis of 4-aminopyrimidine compounds |
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KR19990082463A (en) | 1996-02-13 | 1999-11-25 | 돈 리사 로얄 | Quinazolin derivatives as vascular endothelial growth factor inhibitors |
WO1997032856A1 (en) | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
JPH10259176A (en) | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | New amide derivative having vascularization inhibiting action and its use |
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GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
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EP1572693A1 (en) | 2002-12-20 | 2005-09-14 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
MXPA06000091A (en) | 2003-07-02 | 2006-04-07 | Sugen Inc | Arylmethyl triazolo and imidazopyrazines as c-met inhibitors. |
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BRPI1013159A2 (en) | 2009-03-30 | 2015-09-15 | Sumitomo Chemical Co | USE OF PYRIDAZINONE COMPOUND FOR ARTHROPOD PEST CONTROL |
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2008
- 2008-06-18 DE DE102008028905A patent/DE102008028905A1/en not_active Withdrawn
-
2009
- 2009-05-25 PL PL09765500T patent/PL2285811T3/en unknown
- 2009-05-25 DK DK09765500.5T patent/DK2285811T3/en active
- 2009-05-25 WO PCT/EP2009/003675 patent/WO2009152920A1/en active Application Filing
- 2009-05-25 JP JP2011513897A patent/JP5662311B2/en active Active
- 2009-05-25 ES ES09765500T patent/ES2400117T3/en active Active
- 2009-05-25 AU AU2009259764A patent/AU2009259764B2/en active Active
- 2009-05-25 KR KR1020117001150A patent/KR101661777B1/en active IP Right Grant
- 2009-05-25 MX MX2010013649A patent/MX2010013649A/en active IP Right Grant
- 2009-05-25 US US12/999,873 patent/US8497266B2/en active Active
- 2009-05-25 CN CN200980122766.4A patent/CN102066378B/en active Active
- 2009-05-25 EA EA201100031A patent/EA019534B1/en not_active IP Right Cessation
- 2009-05-25 CA CA2728194A patent/CA2728194C/en active Active
- 2009-05-25 PT PT97655005T patent/PT2285811E/en unknown
- 2009-05-25 EP EP09765500A patent/EP2285811B1/en active Active
- 2009-05-25 BR BRPI0915417A patent/BRPI0915417B8/en not_active IP Right Cessation
- 2009-06-17 AR ARP090102184A patent/AR072860A1/en active IP Right Grant
-
2010
- 2010-12-16 IL IL210063A patent/IL210063A/en active IP Right Grant
-
2011
- 2011-01-17 ZA ZA2011/00437A patent/ZA201100437B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0915417A2 (en) | 2015-11-03 |
AU2009259764A1 (en) | 2009-12-23 |
IL210063A (en) | 2015-06-30 |
EA019534B1 (en) | 2014-04-30 |
BRPI0915417B1 (en) | 2020-02-11 |
AR072860A1 (en) | 2010-09-29 |
CN102066378B (en) | 2014-04-16 |
EP2285811B1 (en) | 2012-12-05 |
JP5662311B2 (en) | 2015-01-28 |
WO2009152920A1 (en) | 2009-12-23 |
EP2285811A1 (en) | 2011-02-23 |
DK2285811T3 (en) | 2013-03-11 |
EA201100031A1 (en) | 2011-08-30 |
CA2728194C (en) | 2016-11-29 |
US8497266B2 (en) | 2013-07-30 |
BRPI0915417B8 (en) | 2021-05-25 |
AU2009259764B2 (en) | 2013-09-26 |
ZA201100437B (en) | 2011-09-28 |
MX2010013649A (en) | 2010-12-21 |
JP2011524385A (en) | 2011-09-01 |
US20110092498A1 (en) | 2011-04-21 |
DE102008028905A1 (en) | 2009-12-24 |
PL2285811T3 (en) | 2013-04-30 |
KR20110031329A (en) | 2011-03-25 |
CN102066378A (en) | 2011-05-18 |
KR101661777B1 (en) | 2016-09-30 |
ES2400117T3 (en) | 2013-04-05 |
PT2285811E (en) | 2013-03-05 |
CA2728194A1 (en) | 2009-12-23 |
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