PL2258346T3 - Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV - Google Patents

Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV

Info

Publication number
PL2258346T3
PL2258346T3 PL10181268T PL10181268T PL2258346T3 PL 2258346 T3 PL2258346 T3 PL 2258346T3 PL 10181268 T PL10181268 T PL 10181268T PL 10181268 T PL10181268 T PL 10181268T PL 2258346 T3 PL2258346 T3 PL 2258346T3
Authority
PL
Poland
Prior art keywords
dosage form
hiv protease
pharmaceutical dosage
protease inhibitor
solid
Prior art date
Application number
PL10181268T
Other languages
English (en)
Polish (pl)
Inventor
Jörg Rosenberg
Ulrich Reinhold
Bernd Liepold
Gunther Berndl
Laman Alani
Soumojeet Ghosh
Jörg Breitenbach
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34217089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2258346(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PL2258346T3 publication Critical patent/PL2258346T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL10181268T 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV PL2258346T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/650,178 US20050048112A1 (en) 2003-08-28 2003-08-28 Solid pharmaceutical dosage form
EP10181268.3A EP2258346B1 (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form comprising an hiv protease inhibitor solid dispersion
EP04816820A EP1663183B9 (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form comprising ritonavir

Publications (1)

Publication Number Publication Date
PL2258346T3 true PL2258346T3 (pl) 2018-01-31

Family

ID=34217089

Family Applications (5)

Application Number Title Priority Date Filing Date
PL10181264T PL2258345T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV
PL10181250T PL2258344T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję rytonawiru i lopinawiru
PL10181268T PL2258346T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV
PL04816820T PL1663183T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca rytonawir
PL15169378T PL2942051T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL10181264T PL2258345T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV
PL10181250T PL2258344T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję rytonawiru i lopinawiru

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL04816820T PL1663183T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca rytonawir
PL15169378T PL2942051T3 (pl) 2003-08-28 2004-08-23 Stała farmaceutyczna postać dawkowania zawierająca stałą dyspersję inhibitora proteazy HIV

Country Status (31)

Country Link
US (1) US20050048112A1 (und)
EP (6) EP2942051B1 (und)
JP (6) JP4815348B2 (und)
KR (5) KR101457967B1 (und)
CN (5) CN101919858B (und)
AT (1) ATE516017T1 (und)
AU (3) AU2004283087C1 (und)
CA (2) CA2689639C (und)
CR (3) CR8256A (und)
CY (5) CY1111981T1 (und)
DK (5) DK1663183T3 (und)
EA (4) EA011924B1 (und)
EC (1) ECSP066397A (und)
ES (5) ES2666390T3 (und)
HK (4) HK1094766A1 (und)
HR (1) HRP20110555T1 (und)
HU (3) HUE035985T2 (und)
IL (3) IL173939A (und)
ME (2) MEP17608A (und)
MX (2) MX358033B (und)
NO (3) NO330282B1 (und)
NZ (2) NZ545499A (und)
PL (5) PL2258345T3 (und)
PT (5) PT2258345T (und)
RS (2) RS59969B1 (und)
SG (3) SG145690A1 (und)
SI (5) SI2258346T1 (und)
TW (1) TWI342221B (und)
UA (1) UA85564C2 (und)
WO (1) WO2005039551A2 (und)
ZA (3) ZA200801362B (und)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175205B1 (en) * 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
US8025899B2 (en) * 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
AU2012202831B2 (en) * 2005-02-23 2015-01-22 Abbvie Inc. A solid pharmaceutical dosage formulation
KR20070025070A (ko) * 2005-08-31 2007-03-08 주식회사 대웅제약 시부트라민 및 계면활성제를 함유하는 고체분산체 및 그의제조방법
AP2008004533A0 (en) * 2005-12-14 2008-08-31 Cipla Ltd Pharmaceutical combination
WO2007068615A2 (en) * 2005-12-14 2007-06-21 F. Hoffmann-La Roche Ag Hcv prodrug formulation
US20090136570A1 (en) * 2006-01-20 2009-05-28 Bhagwant Rege Taste-Masked Tablets and Granules
EP1832281A1 (en) * 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
EP1880715A1 (en) * 2006-07-19 2008-01-23 Abbott GmbH & Co. KG Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
PE20080422A1 (es) * 2006-08-10 2008-04-28 Cipla Ltd Composicion solida antirretroviral de administracion oral
CA2669938C (en) * 2006-11-15 2016-01-05 Abbott Laboratories Solid pharmaceutical dosage formulations
DK2487166T3 (en) 2007-02-23 2017-02-20 Gilead Sciences Inc Modulators of the pharmacokinetic properties of therapeutics
PA8809601A1 (es) * 2007-12-24 2009-07-23 Cipla Ltd Combinación anti-retroviral
TWI583405B (zh) * 2008-02-28 2017-05-21 艾伯維有限公司 錠劑及其製備
WO2009153654A1 (en) * 2008-06-17 2009-12-23 Aurobindo Pharma Limited Solid dosage forms of antiretrovirals
MY160340A (en) * 2008-10-07 2017-02-28 Astrazeneca Uk Ltd Pharmaceutical formulation 514
EP2391350A1 (en) 2008-12-18 2011-12-07 Ranbaxy Laboratories Limited Atazanavir formulations
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
TWI471321B (zh) 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Ｂｃｌ－２族群抑制劑之口服醫藥劑型
WO2011013110A1 (en) 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Unit dosage forms of hiv protease inhibitors
US20110034489A1 (en) 2009-07-31 2011-02-10 Ranbaxy Laboratories Limited Solid dosage forms of hiv protease inhibitors
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2683378A4 (en) * 2011-03-07 2014-09-03 Hetero Research Foundation AMORPHOUS FORM OF A MIXTURE OF LOPINAVIR AND RITONAVIR
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated
EP2744481A4 (en) * 2011-08-16 2015-07-01 Merck Sharp & Dohme USE OF INORGANIC MATRIX AND COMBINATIONS OF ORGANIC POLYMERS FOR THE PREPARATION OF STABLE AMORPHOUS DISPERSIONS
EP2564832A1 (en) 2011-08-29 2013-03-06 Hexal AG Solid dosage form of HIV protease inhibitors
KR101794032B1 (ko) * 2011-09-21 2017-11-07 (주)바이오시네틱스 나노입자 제조방법
WO2013131645A1 (en) 2012-03-07 2013-09-12 Ratiopharm Gmbh Dosage form comprising non-crystalline lopinavir and crystalline ritonavir
EP2822554B1 (en) 2012-03-07 2016-05-18 ratiopharm GmbH Dosage form comprising lopinavir and ritonavir
CN103655571B (zh) * 2012-09-11 2016-04-20 上海星泰医药科技有限公司 一种洛匹那韦和利托那韦复方高均匀度纳米共分散体及其制备方法
US9744240B2 (en) 2012-09-27 2017-08-29 Basf Se Storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin E-derivative and at least one hydrophilic polymer
CN104684545B (zh) 2012-09-27 2018-04-03 巴斯夫欧洲公司 包含至少一种水溶性维生素e衍生物和至少一种亲水聚合物的储存稳定的无粉尘均质颗粒状配制剂
CN104661652B (zh) 2012-09-27 2018-08-28 巴斯夫欧洲公司 包含至少一种水溶性维生素e衍生物和至少一种亲水聚合物的储存稳定的无粉尘均质颗粒状配制剂
US9789063B2 (en) 2012-09-27 2017-10-17 Basf Se Storage-stable dust-free homogeneous particulate formulation
RU2505286C1 (ru) 2012-12-29 2014-01-27 Открытое Акционерное Общество "Фармасинтез" Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения
RU2543322C1 (ru) * 2013-09-19 2015-02-27 Открытое Акционерное Общество "Фармасинтез" Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения
RU2619840C1 (ru) * 2016-09-21 2017-05-18 Общество с ограниченной ответственностью "Изварино Фарма" Фармацевтическая композиция для лечения ВИЧ-инфекции
RU2659693C1 (ru) * 2017-06-30 2018-07-03 Общество с ограниченной ответственностью "Изварино Фарма" Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции
US20190038754A1 (en) * 2017-08-07 2019-02-07 SE Tylose, USA, Inc. Pharmaceutical composition in solid extruded form
US20190269662A1 (en) * 2018-03-02 2019-09-05 The University Of Liverpool Solid compositions of actives, processes for preparing same and uses of such solid compositions
CN108186578A (zh) * 2018-03-27 2018-06-22 聊城大学 一种利托那韦固体分散体的制备方法
EP3569225A1 (en) 2018-05-18 2019-11-20 Pharmaceutical Oriented Services Ltd Solid dispersion containing ritonavir
TWI799599B (zh) * 2019-06-06 2023-04-21 華納國際生物科技股份有限公司 醫藥或保健品自乳化固體分散組成物
CN114146061B (zh) * 2020-09-07 2023-06-30 歌礼生物科技（杭州）有限公司 包含固体分散体的蛋白酶抑制剂增效组合物及其制备方法
CN113318076B (zh) * 2021-06-02 2022-09-23 聊城大学 一种兼具增溶及抑晶效果的利托那韦固体分散体及其制备方法
CN114557967B (zh) * 2022-03-17 2023-06-02 乐普制药科技有限公司 一种利托那韦固体分散体的制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
DE3830353A1 (de) 1988-09-07 1990-03-15 Basf Ag Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5542206A (en) 1994-10-11 1996-08-06 Lisch; Albert Lure and tackle stacking container
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US6232333B1 (en) * 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6027747A (en) * 1997-11-11 2000-02-22 Terracol; Didier Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions
DE19841244A1 (de) * 1998-09-09 2000-03-16 Knoll Ag Verfahren und Vorrichtung zum Herstellen von Tabletten
DE60039379D1 (de) 1999-02-10 2008-08-21 Pfizer Prod Inc Pharmazeutische feste Dispersionen
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
DE19913606A1 (de) 1999-03-25 2000-09-28 Basf Ag Pulverförmige Solubilisationshilfsstoffe für feste pharmazeutische Darreichungsformen
DE19913692A1 (de) 1999-03-25 2000-09-28 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
PL197671B1 (pl) 1999-06-04 2008-04-30 Abbott Lab Kompozycja farmaceutyczna zawierająca ritonavir
JP4815085B2 (ja) 1999-11-12 2011-11-16 アボット・ラボラトリーズ 固体分散体医薬製剤
EP1175205B1 (en) 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
MXPA03011922A (es) 2001-06-22 2004-03-26 Pfizer Prod Inc Composiciones farmaceuticas que contienen un dispersion solida de un farmaco ligeramente soluble en una matriz y plimero mejorador de solubilidad.
WO2003063833A1 (en) * 2002-02-01 2003-08-07 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
DE10213242A1 (de) * 2002-03-25 2003-10-16 Abbott Gmbh & Co Kg Testsystem zur Evaluierung der Kompatibilität biologisch aktiver Substanzen mit Copolymeren
DE10247037A1 (de) * 2002-10-09 2004-04-22 Abbott Gmbh & Co. Kg Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
CA2669938C (en) 2006-11-15 2016-01-05 Abbott Laboratories Solid pharmaceutical dosage formulations

Also Published As

Publication number Publication date
NZ545499A (en) 2009-11-27
CN102772380A (zh) 2012-11-14
NO20131743L (no) 2006-05-29
DK2942051T3 (en) 2018-05-07
CY1118505T1 (el) 2017-07-12
RS20060140A (en) 2008-09-29
SI1663183T1 (sl) 2011-09-30
TW200522979A (en) 2005-07-16
WO2005039551A3 (en) 2006-08-03
ZA200801361B (en) 2011-11-30
IL207260A (en) 2017-10-31
SI2942051T1 (en) 2018-06-29
CN102764244A (zh) 2012-11-07
EP2258344A2 (en) 2010-12-08
NO20061342L (no) 2006-05-29
HUE035985T2 (hu) 2018-06-28
JP2011236232A (ja) 2011-11-24
EA200600473A1 (ru) 2006-10-27
MX358033B (es) 2018-08-02
JP2013241460A (ja) 2013-12-05
PL2258344T3 (pl) 2013-04-30
AU2004283087A1 (en) 2005-05-06
EP1663183A2 (en) 2006-06-07
KR20110122771A (ko) 2011-11-10
KR101457967B1 (ko) 2014-11-07
EP2258345A3 (en) 2011-01-19
EP1663183B9 (en) 2012-06-13
EP2258344B1 (en) 2012-11-14
ES2367173T3 (es) 2011-10-31
JP2018035163A (ja) 2018-03-08
HUE031153T2 (en) 2017-07-28
HK1217298A1 (zh) 2017-01-06
EP1663183B1 (en) 2011-07-13
RS57663B1 (sr) 2018-11-30
IL173939A0 (en) 2006-07-05
JP2016094433A (ja) 2016-05-26
EA033224B1 (ru) 2019-09-30
IL173939A (en) 2017-03-30
ECSP066397A (es) 2006-08-30
TWI342221B (en) 2011-05-21
ME00130B (me) 2010-10-10
WO2005039551A2 (en) 2005-05-06
KR101281994B1 (ko) 2013-07-04
SG145690A1 (en) 2008-09-29
ATE516017T1 (de) 2011-07-15
PL2942051T3 (pl) 2018-07-31
CN101919858A (zh) 2010-12-22
AU2004283087B2 (en) 2007-09-20
RS20181262A1 (sr) 2019-02-28
KR101132602B1 (ko) 2012-04-06
KR20060121837A (ko) 2006-11-29
ES2666390T3 (es) 2018-05-04
MEP17608A (en) 2010-06-10
EP2258344A3 (en) 2011-01-19
JP2011126898A (ja) 2011-06-30
SI2258346T1 (sl) 2017-12-29
NO334418B1 (no) 2014-03-03
CY1120138T1 (el) 2018-12-12
US20050048112A1 (en) 2005-03-03
CA2689639C (en) 2014-06-10
ZA200601718B (en) 2009-11-25
IL254581A0 (en) 2017-11-30
CY1119651T1 (el) 2018-04-04
SG179401A1 (en) 2012-04-27
EP2258346B1 (en) 2017-09-27
EP2942051B1 (en) 2018-01-17
JP5903413B2 (ja) 2016-04-13
EP2942051A1 (en) 2015-11-11
CN101919858B (zh) 2013-10-30
SI2258344T1 (sl) 2013-03-29
NZ579622A (en) 2011-01-28
KR20120054666A (ko) 2012-05-30
AU2010238573B2 (en) 2012-12-13
AU2010238573A1 (en) 2010-11-18
EA011924B1 (ru) 2009-06-30
CN1901884A (zh) 2007-01-24
DK2258346T3 (da) 2017-11-13
SI2258345T1 (sl) 2017-01-31
CA2536638C (en) 2010-04-06
EP2258345A2 (en) 2010-12-08
EP3354261A1 (en) 2018-08-01
EP2258345B1 (en) 2016-09-21
CR8256A (es) 2008-01-11
ES2399810T3 (es) 2013-04-03
JP2007504142A (ja) 2007-03-01
NO20100367L (no) 2006-05-29
JP4815348B2 (ja) 2011-11-16
PL1663183T3 (pl) 2011-10-31
RS59969B1 (sr) 2020-03-31
DK1663183T3 (da) 2011-08-29
JP5498411B2 (ja) 2014-05-21
CN1901884B (zh) 2012-07-25
DK2258344T3 (da) 2013-01-02
CN105106104A (zh) 2015-12-02
HRP20110555T1 (hr) 2011-09-30
ES2608720T3 (es) 2017-04-12
EA020992B1 (ru) 2015-03-31
EA201890737A2 (ru) 2018-08-31
NO335326B1 (no) 2014-11-10
ZA200801362B (en) 2009-03-25
JP5395125B2 (ja) 2014-01-22
PT1663183E (pt) 2011-08-25
PT2942051T (pt) 2018-04-23
PL2258345T3 (pl) 2017-03-31
CA2689639A1 (en) 2005-05-06
KR20140046078A (ko) 2014-04-17
PT2258345T (pt) 2017-01-20
EA200900292A1 (ru) 2009-06-30
AU2007249115B2 (en) 2010-08-12
MXPA06002346A (es) 2006-05-19
HK1145969A1 (en) 2011-05-13
KR101563222B1 (ko) 2015-10-26
PT2258346T (pt) 2017-10-24
AU2007249115A1 (en) 2008-01-10
HUE038792T2 (hu) 2018-11-28
HK1257502A1 (zh) 2019-10-25
CA2536638A1 (en) 2005-05-06
DK2258345T3 (en) 2017-01-16
CN102772380B (zh) 2015-08-19
PT2258344E (pt) 2013-02-18
EA201301045A1 (ru) 2014-05-30
CY1111981T1 (el) 2015-11-04
KR20150044031A (ko) 2015-04-23
EA201890737A3 (ru) 2019-01-31
UA85564C2 (ru) 2009-02-10
HK1094766A1 (en) 2007-04-13
ES2653762T3 (es) 2018-02-08
NO330282B1 (no) 2011-03-21
EP2258346A3 (en) 2011-01-19
CR20120661A (es) 2013-03-13
AU2004283087C1 (en) 2008-04-24
CY1113596T1 (el) 2016-06-22
EP2258346A2 (en) 2010-12-08
CR20120662A (es) 2013-03-13
SG10201507902UA (en) 2015-10-29

Similar Documents

Publication Publication Date Title
HK1257502A1 (zh) 一種包含hiv蛋白酶抑制劑固體分散體的固體藥物劑型