CA2689639C - Solid pharmaceutical dosage form - Google Patents

Solid pharmaceutical dosage form Download PDF

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Publication number
CA2689639C
CA2689639C CA2689639A CA2689639A CA2689639C CA 2689639 C CA2689639 C CA 2689639C CA 2689639 A CA2689639 A CA 2689639A CA 2689639 A CA2689639 A CA 2689639A CA 2689639 C CA2689639 C CA 2689639C
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
weight
melt
dosage form
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2689639A
Other languages
English (en)
French (fr)
Other versions
CA2689639A1 (en
Inventor
Joerg Rosenberg
Ulrich Reinhold
Bernd Liepold
Gunther Berndl
Joerg Breitenbach
Laman Alani
Soumojeet Ghosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34217089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2689639(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CA2689639A1 publication Critical patent/CA2689639A1/en
Application granted granted Critical
Publication of CA2689639C publication Critical patent/CA2689639C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
CA2689639A 2003-08-28 2004-08-23 Solid pharmaceutical dosage form Expired - Fee Related CA2689639C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/650,178 2003-08-28
US10/650,178 US20050048112A1 (en) 2003-08-28 2003-08-28 Solid pharmaceutical dosage form
CA2536638A CA2536638C (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2536638A Division CA2536638C (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form

Publications (2)

Publication Number Publication Date
CA2689639A1 CA2689639A1 (en) 2005-05-06
CA2689639C true CA2689639C (en) 2014-06-10

Family

ID=34217089

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2689639A Expired - Fee Related CA2689639C (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form
CA2536638A Expired - Fee Related CA2536638C (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2536638A Expired - Fee Related CA2536638C (en) 2003-08-28 2004-08-23 Solid pharmaceutical dosage form

Country Status (31)

Country Link
US (1) US20050048112A1 (und)
EP (6) EP2258345B1 (und)
JP (6) JP4815348B2 (und)
KR (5) KR101563222B1 (und)
CN (5) CN102772380B (und)
AT (1) ATE516017T1 (und)
AU (3) AU2004283087C1 (und)
CA (2) CA2689639C (und)
CR (3) CR8256A (und)
CY (5) CY1111981T1 (und)
DK (5) DK2942051T3 (und)
EA (4) EA201890737A3 (und)
EC (1) ECSP066397A (und)
ES (5) ES2653762T3 (und)
HK (4) HK1094766A1 (und)
HR (1) HRP20110555T1 (und)
HU (3) HUE031153T2 (und)
IL (3) IL173939A (und)
ME (2) ME00130B (und)
MX (2) MX358033B (und)
NO (3) NO330282B1 (und)
NZ (2) NZ579622A (und)
PL (5) PL2258346T3 (und)
PT (5) PT2258345T (und)
RS (2) RS59969B1 (und)
SG (3) SG145690A1 (und)
SI (5) SI1663183T1 (und)
TW (1) TWI342221B (und)
UA (1) UA85564C2 (und)
WO (1) WO2005039551A2 (und)
ZA (3) ZA200801362B (und)

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KR101794032B1 (ko) * 2011-09-21 2017-11-07 (주)바이오시네틱스 나노입자 제조방법
EP2822553B1 (en) * 2012-03-07 2016-05-18 ratiopharm GmbH Dosage form comprising non-crystalline lopinavir and crystalline ritonavir
CA2866206A1 (en) 2012-03-07 2013-09-12 Ratiopharm Gmbh Dosage form comprising lopinavir and ritonavir
CN103655571B (zh) * 2012-09-11 2016-04-20 上海星泰医药科技有限公司 一种洛匹那韦和利托那韦复方高均匀度纳米共分散体及其制备方法
WO2014048783A1 (en) 2012-09-27 2014-04-03 Basf Se A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer
US9789063B2 (en) 2012-09-27 2017-10-17 Basf Se Storage-stable dust-free homogeneous particulate formulation
US9744240B2 (en) 2012-09-27 2017-08-29 Basf Se Storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin E-derivative and at least one hydrophilic polymer
CN104661652B (zh) 2012-09-27 2018-08-28 巴斯夫欧洲公司 包含至少一种水溶性维生素e衍生物和至少一种亲水聚合物的储存稳定的无粉尘均质颗粒状配制剂
RU2505286C1 (ru) * 2012-12-29 2014-01-27 Открытое Акционерное Общество "Фармасинтез" Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения
RU2543322C1 (ru) * 2013-09-19 2015-02-27 Открытое Акционерное Общество "Фармасинтез" Фармацевтическая композиция для лечения вич-инфекции, способ ее получения и способ лечения
RU2619840C1 (ru) * 2016-09-21 2017-05-18 Общество с ограниченной ответственностью "Изварино Фарма" Фармацевтическая композиция для лечения ВИЧ-инфекции
RU2659693C1 (ru) * 2017-06-30 2018-07-03 Общество с ограниченной ответственностью "Изварино Фарма" Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции
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Also Published As

Publication number Publication date
EP2942051A1 (en) 2015-11-11
KR20120054666A (ko) 2012-05-30
IL173939A (en) 2017-03-30
SG145690A1 (en) 2008-09-29
EP2258345A2 (en) 2010-12-08
JP2013241460A (ja) 2013-12-05
ATE516017T1 (de) 2011-07-15
NO330282B1 (no) 2011-03-21
KR20060121837A (ko) 2006-11-29
PT2942051T (pt) 2018-04-23
NO20131743L (no) 2006-05-29
EA011924B1 (ru) 2009-06-30
JP2011236232A (ja) 2011-11-24
JP2016094433A (ja) 2016-05-26
ME00130B (me) 2010-10-10
CN101919858A (zh) 2010-12-22
CA2689639A1 (en) 2005-05-06
SI2258345T1 (sl) 2017-01-31
IL207260A (en) 2017-10-31
JP2018035163A (ja) 2018-03-08
CN102772380A (zh) 2012-11-14
ES2653762T3 (es) 2018-02-08
AU2007249115A1 (en) 2008-01-10
ES2608720T3 (es) 2017-04-12
IL254581A0 (en) 2017-11-30
AU2004283087B2 (en) 2007-09-20
MXPA06002346A (es) 2006-05-19
ES2666390T3 (es) 2018-05-04
ZA200801362B (en) 2009-03-25
SI2942051T1 (en) 2018-06-29
EA201301045A1 (ru) 2014-05-30
PL1663183T3 (pl) 2011-10-31
KR101281994B1 (ko) 2013-07-04
EP2258345A3 (en) 2011-01-19
EA200900292A1 (ru) 2009-06-30
IL173939A0 (en) 2006-07-05
PT2258345T (pt) 2017-01-20
MX358033B (es) 2018-08-02
US20050048112A1 (en) 2005-03-03
EA201890737A3 (ru) 2019-01-31
EA020992B1 (ru) 2015-03-31
EP2258344A3 (en) 2011-01-19
JP4815348B2 (ja) 2011-11-16
NO20100367L (no) 2006-05-29
AU2007249115B2 (en) 2010-08-12
HK1145969A1 (en) 2011-05-13
PL2258346T3 (pl) 2018-01-31
CR20120661A (es) 2013-03-13
CY1120138T1 (el) 2018-12-12
CY1111981T1 (el) 2015-11-04
EP1663183B1 (en) 2011-07-13
WO2005039551A2 (en) 2005-05-06
ES2399810T3 (es) 2013-04-03
SG10201507902UA (en) 2015-10-29
AU2010238573A1 (en) 2010-11-18
ECSP066397A (es) 2006-08-30
EP2258344B1 (en) 2012-11-14
TWI342221B (en) 2011-05-21
ES2367173T3 (es) 2011-10-31
JP5498411B2 (ja) 2014-05-21
CY1113596T1 (el) 2016-06-22
SI2258344T1 (sl) 2013-03-29
DK2258344T3 (da) 2013-01-02
EP2258344A2 (en) 2010-12-08
DK1663183T3 (da) 2011-08-29
KR101457967B1 (ko) 2014-11-07
CY1118505T1 (el) 2017-07-12
EA200600473A1 (ru) 2006-10-27
SI2258346T1 (sl) 2017-12-29
CN101919858B (zh) 2013-10-30
CY1119651T1 (el) 2018-04-04
CA2536638A1 (en) 2005-05-06
HK1257502A1 (zh) 2019-10-25
EP3354261A1 (en) 2018-08-01
PL2258345T3 (pl) 2017-03-31
NZ579622A (en) 2011-01-28
HUE035985T2 (hu) 2018-06-28
KR20150044031A (ko) 2015-04-23
EP2258346B1 (en) 2017-09-27
EP2942051B1 (en) 2018-01-17
HUE038792T2 (hu) 2018-11-28
CN1901884A (zh) 2007-01-24
EA201890737A2 (ru) 2018-08-31
JP2007504142A (ja) 2007-03-01
AU2004283087C1 (en) 2008-04-24
ZA200601718B (en) 2009-11-25
SI1663183T1 (sl) 2011-09-30
TW200522979A (en) 2005-07-16
RS20181262A1 (sr) 2019-02-28
DK2258345T3 (en) 2017-01-16
HK1217298A1 (zh) 2017-01-06
EA033224B1 (ru) 2019-09-30
CA2536638C (en) 2010-04-06
PL2258344T3 (pl) 2013-04-30
KR101132602B1 (ko) 2012-04-06
UA85564C2 (ru) 2009-02-10
KR20110122771A (ko) 2011-11-10
DK2942051T3 (en) 2018-05-07
KR101563222B1 (ko) 2015-10-26
PT2258346T (pt) 2017-10-24
EP2258345B1 (en) 2016-09-21
HK1094766A1 (en) 2007-04-13
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