PL2152712T3 - Związki aminoheterocykliczne - Google Patents

Związki aminoheterocykliczne

Info

Publication number
PL2152712T3
PL2152712T3 PL08737600T PL08737600T PL2152712T3 PL 2152712 T3 PL2152712 T3 PL 2152712T3 PL 08737600 T PL08737600 T PL 08737600T PL 08737600 T PL08737600 T PL 08737600T PL 2152712 T3 PL2152712 T3 PL 2152712T3
Authority
PL
Poland
Prior art keywords
amino
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
PL08737600T
Other languages
English (en)
Inventor
Patrick Robert Verhoest
Caroline Proulx-Lafrance
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PL2152712T3 publication Critical patent/PL2152712T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
PL08737600T 2007-05-11 2008-05-05 Związki aminoheterocykliczne PL2152712T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91733307P 2007-05-11 2007-05-11
PCT/IB2008/001125 WO2008139293A1 (en) 2007-05-11 2008-05-05 Amino-heterocyclic compounds
EP08737600A EP2152712B1 (en) 2007-05-11 2008-05-05 Amino-heterocyclic compounds

Publications (1)

Publication Number Publication Date
PL2152712T3 true PL2152712T3 (pl) 2012-05-31

Family

ID=39672073

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08737600T PL2152712T3 (pl) 2007-05-11 2008-05-05 Związki aminoheterocykliczne

Country Status (44)

Country Link
US (1) US7964607B2 (pl)
EP (1) EP2152712B1 (pl)
JP (1) JP4579346B2 (pl)
KR (1) KR101222330B1 (pl)
CN (1) CN101687876B (pl)
AP (1) AP2524A (pl)
AR (1) AR066502A1 (pl)
AT (1) ATE540954T1 (pl)
AU (1) AU2008249750B2 (pl)
BR (1) BRPI0811280B8 (pl)
CA (1) CA2687035C (pl)
CL (1) CL2008001374A1 (pl)
CO (1) CO6241157A2 (pl)
CR (1) CR11095A (pl)
CU (1) CU23834B1 (pl)
CY (1) CY1112332T1 (pl)
DK (1) DK2152712T3 (pl)
DO (1) DOP2009000258A (pl)
EA (1) EA016510B1 (pl)
EC (1) ECSP099728A (pl)
ES (1) ES2377849T3 (pl)
GE (1) GEP20125405B (pl)
GT (1) GT200900294A (pl)
HK (1) HK1142595A1 (pl)
HR (1) HRP20120105T1 (pl)
IL (1) IL201977A (pl)
MA (1) MA31373B1 (pl)
ME (1) ME00954B (pl)
MX (1) MX2009011830A (pl)
MY (1) MY147330A (pl)
NI (1) NI200900204A (pl)
NZ (1) NZ580904A (pl)
PA (1) PA8779901A1 (pl)
PE (1) PE20090247A1 (pl)
PL (1) PL2152712T3 (pl)
PT (1) PT2152712E (pl)
RS (1) RS52166B (pl)
SI (1) SI2152712T1 (pl)
SV (1) SV2009003411A (pl)
TN (1) TN2009000471A1 (pl)
TW (1) TWI362262B (pl)
UA (1) UA94660C2 (pl)
WO (1) WO2008139293A1 (pl)
ZA (1) ZA200907776B (pl)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
JP5498392B2 (ja) 2007-11-30 2014-05-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 1,5−ジヒドロ−ピラゾロ[3,4−d]ピリミジン−4−オン誘導体及びcns障害の治療のためのpde9aモジュレーターとしてのそれらの使用
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
PE20110383A1 (es) 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
PT2540297E (pt) 2008-11-19 2015-08-26 Forum Pharmaceuticals Inc Tratamento de distúrbios cognitivos com (r)-7-cloro-n- (quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmaceuticamente aceitáveis desta
TWI404721B (zh) * 2009-01-26 2013-08-11 Pfizer 胺基-雜環化合物
UY32531A (es) 2009-03-31 2010-10-29 Boehringer Ingelheim Int Nuevos compuestos para el tratamiento de trastornos del snc
AU2010247835A1 (en) * 2009-05-11 2011-12-08 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
EP2485771A4 (en) * 2009-10-08 2014-11-12 Intra Cellular Therapies Inc PLATORS TARGETING PHOSPHODESTERASE 1 AND ASSOCIATED METHODS
SA111320455B1 (ar) 2010-05-17 2014-10-16 Envivo Pharmaceuticals Inc صورة بلورية من (R)-7- كلورو -N- (كينوكليدين -3- يل) بنزو[b] ثيوفين -2- كربوكساميد هيدروكلوريد أحادي الهيدرات
CN103052639B (zh) 2010-08-12 2016-02-17 贝林格尔.英格海姆国际有限公司 6-环烷基-1,5-二氢-吡唑并[3,4-d]嘧啶-4-酮衍生物及其作为PDE9A抑制剂的用途
WO2012033144A1 (ja) 2010-09-07 2012-03-15 アステラス製薬株式会社 ピラゾロキノリン化合物
AU2011305568B2 (en) 2010-09-20 2015-12-10 Ironwood Pharmaceuticals, Inc. Imidazotriazinone compounds
US20130040971A1 (en) * 2011-02-14 2013-02-14 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders
US8809345B2 (en) * 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
ME02394B (me) 2011-10-07 2016-09-20 Eisai R&D Man Co Ltd Pirazolohinolinski derivati kao inhibitori pde9
JP2015531401A (ja) 2011-10-10 2015-11-02 ハー・ルンドベック・アクチエゼルスカベット イミダゾピラジノン骨格を有するpde9i
SG11201403909RA (en) * 2012-01-26 2014-10-30 Lundbeck & Co As H Pde9 inhibitors with imidazo triazinone backbone
WO2013142269A1 (en) * 2012-03-19 2013-09-26 Envivo Pharmaceuticals, Inc. Imidazotriazinone compounds
EP3666272A1 (en) 2012-05-08 2020-06-17 Forum Pharmaceuticals Inc. Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit
EP3255049A1 (en) 2012-06-29 2017-12-13 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
WO2014024125A1 (en) 2012-08-08 2014-02-13 Celon Pharma S.A. Pyrazolo[4,3-d]pyrimidin-7(6h)-one derivatives as pde9 inhibitors
US9801882B2 (en) 2013-02-17 2017-10-31 Intra-Cellular Therapies, Inc. Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
ES2654094T3 (es) 2013-04-05 2018-02-12 Eisai R&D Management Co., Ltd. Compuestos piridinilpirazoloquinolina
CA2907971C (en) 2013-04-05 2020-12-29 Eisai R&D Management Co., Ltd. Salt of pyrazoloquinoline derivative, and crystal thereof
CN103626774B (zh) * 2013-11-20 2015-11-04 苏州明锐医药科技有限公司 伊鲁替尼的制备方法
US9695171B2 (en) 2013-12-17 2017-07-04 Pfizer Inc. 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
WO2016022893A1 (en) 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
ES2857567T3 (es) * 2014-09-17 2021-09-29 Intra Cellular Therapies Inc Derivados de 7,8-dihidro-[2h]-imidazo-[1,2-a]pirazolo[4,3-e]pirimidin-4(5h)-ona como inhibidores de fosfodiesterasa 1 (PDE1) para tratar enfermedades, trastornos o lesiones del sistema nervioso central (SNC)
TW201629064A (zh) 2014-10-10 2016-08-16 H 朗德貝克公司 作爲pde1抑制劑之三唑並吡酮
BR112017012007B1 (pt) 2014-12-06 2022-11-01 Intra-Cellular Therapies, Inc Compostos orgânicos inibitórios de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2
AU2015357498B2 (en) * 2014-12-06 2019-09-12 Intra-Cellular Therapies, Inc. Organic compounds
WO2016103097A1 (en) 2014-12-22 2016-06-30 Pfizer Inc. Antagonists of prostaglandin ep3 receptor
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
AU2016289856B2 (en) 2015-07-07 2020-11-26 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
EP3350178B1 (en) 2015-09-14 2021-10-20 Pfizer Inc. Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
JP6983161B2 (ja) 2015-09-15 2021-12-17 プラクシス・バイオリサーチ・エルエルシー フェンカンファミンのプロドラッグ
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11780848B2 (en) 2015-10-16 2023-10-10 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
SG10201913993QA (en) 2015-10-16 2020-03-30 Abbvie Inc PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
TWI729109B (zh) * 2016-04-12 2021-06-01 丹麥商H 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
WO2018009424A1 (en) 2016-07-06 2018-01-11 Imara, Inc. Pde9 inhibitors for treatment of peripheral diseases
EP3529250B1 (en) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
SG11201903061YA (en) 2016-10-28 2019-05-30 H Lundbeck As Combination treatments comprising administration of imidazopyrazinones
MX2019004763A (es) 2016-10-28 2019-07-01 H Lundbeck As Tratamientos de combinacion que comprenden imidazopirazinonas para el tratamiento de trastornos psiquiatricos y/o cognitivos.
US10981916B2 (en) 2016-12-28 2021-04-20 Dart Neuroscience, Llc Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
TWI791021B (zh) * 2017-05-26 2023-02-01 美商伊馬拉公司 製備和使用pde9抑制劑之方法
AU2018278422B2 (en) 2017-06-01 2022-03-17 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
WO2018221546A1 (en) 2017-06-01 2018-12-06 Eisai R&D Management Co., Ltd. Pharmaceutical composition comprising pde9 inhibitor
CA3060030A1 (en) 2017-06-01 2018-12-06 Eisai R&D Management Co., Ltd. Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil
US11147803B2 (en) 2017-06-01 2021-10-19 Eisai R&D Management Co., Ltd. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
CA3064938A1 (en) 2017-06-08 2018-12-13 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde9 inhibitors
AU2018373258B2 (en) 2017-11-27 2023-03-02 Dart Neuroscience, Llc Substituted furanopyrimidine compounds as PDE1 inhibitors
EP3746081A4 (en) 2018-01-31 2021-10-27 Intra-Cellular Therapies, Inc. INNOVATIVE USES
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
WO2020086481A1 (en) * 2018-10-21 2020-04-30 Intra-Cellular Therapies, Inc. Novel uses
KR20200068994A (ko) * 2018-12-06 2020-06-16 한국화학연구원 Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도
CN111471059B (zh) 2019-01-23 2022-12-02 药捷安康(南京)科技股份有限公司 Pde9抑制剂及其用途
US20230192707A1 (en) * 2021-12-16 2023-06-22 Pfizer Inc. Solid forms of pyrazolo[3,4-d]pyrimidine compounds
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020156277A1 (en) 2001-04-20 2002-10-24 Fick David B. Synthesis and methods of use of purine analogues and derivatives
US20040176361A1 (en) 2001-05-23 2004-09-09 Masakazu Fujio Fused heterocyclic compound and medicinal use thereof
HN2002000317A (es) * 2001-11-02 2003-05-21 Pfizer Inhibidores de pde9 para tratamiento de trastornos cardiovasculares
IL161155A0 (en) * 2001-11-02 2004-08-31 Pfizer Prod Inc Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
AU2003253915A1 (en) * 2002-07-12 2004-02-02 Massachusetts Institute Of Technology Reconfigurable microphotonics devices via deformable membrane platform
DE10238722A1 (de) * 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20030139427A1 (en) 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
US7051174B2 (en) * 2002-09-24 2006-05-23 International Business Machines Corporation Method, system, and program for restoring data in cache
AU2003301662A1 (en) 2002-10-21 2004-05-13 Bristol-Myers Squibb Company Quinazolinones and derivatives thereof as factor xa inhibitors
US7111287B2 (en) * 2003-01-10 2006-09-19 International Business Machines Corporation Global processor resource assignment in an assembler
ES2289377T3 (es) 2003-03-18 2008-02-01 The Jordanian Pharmaceutical Manufacturing Co. Ltd. Nuevas pirazolopirimidonas y su uso como inhibidores de pde.
US7687625B2 (en) 2003-03-25 2010-03-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
DE10320785A1 (de) * 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine

Also Published As

Publication number Publication date
CA2687035C (en) 2011-09-20
CL2008001374A1 (es) 2008-11-14
TN2009000471A1 (fr) 2011-03-31
DOP2009000258A (es) 2010-05-15
CU23834B1 (es) 2012-10-15
IL201977A0 (en) 2010-06-16
MA31373B1 (fr) 2010-05-03
RS52166B (en) 2012-08-31
TW200902015A (en) 2009-01-16
ME00954B (me) 2012-06-20
AU2008249750B2 (en) 2011-07-14
GT200900294A (es) 2011-08-29
EA200901373A1 (ru) 2010-06-30
SV2009003411A (es) 2010-05-21
PE20090247A1 (es) 2009-03-13
CN101687876A (zh) 2010-03-31
BRPI0811280B1 (pt) 2021-05-11
EP2152712A1 (en) 2010-02-17
ES2377849T3 (es) 2012-04-02
MX2009011830A (es) 2009-11-13
PT2152712E (pt) 2012-02-29
UA94660C2 (en) 2011-05-25
BRPI0811280B8 (pt) 2021-05-25
AP2009005048A0 (en) 2009-12-31
MY147330A (en) 2012-11-30
EA016510B1 (ru) 2012-05-30
EP2152712B1 (en) 2012-01-11
ATE540954T1 (de) 2012-01-15
CO6241157A2 (es) 2011-01-20
CR11095A (es) 2009-12-04
JP2010526863A (ja) 2010-08-05
DK2152712T3 (da) 2012-03-26
ZA200907776B (en) 2011-01-26
CU20090184A7 (es) 2011-07-11
NZ580904A (en) 2012-02-24
ECSP099728A (es) 2009-12-28
NI200900204A (es) 2010-03-11
CY1112332T1 (el) 2015-12-09
SI2152712T1 (sl) 2012-03-30
IL201977A (en) 2014-07-31
AU2008249750A1 (en) 2008-11-20
CN101687876B (zh) 2012-12-12
GEP20125405B (en) 2012-02-27
WO2008139293A1 (en) 2008-11-20
CA2687035A1 (en) 2008-11-20
BRPI0811280A2 (pt) 2015-01-20
PA8779901A1 (es) 2008-12-18
TWI362262B (en) 2012-04-21
AP2524A (en) 2012-12-04
HK1142595A1 (en) 2010-12-10
AR066502A1 (es) 2009-08-26
KR101222330B1 (ko) 2013-01-15
JP4579346B2 (ja) 2010-11-10
HRP20120105T1 (hr) 2012-02-29
KR20100007985A (ko) 2010-01-22
US20090030003A1 (en) 2009-01-29
US7964607B2 (en) 2011-06-21

Similar Documents

Publication Publication Date Title
AP2524A (en) Amino-heterocyclic compounds
GB0704407D0 (en) Compounds
GB0704394D0 (en) Compounds
GB0705672D0 (en) Compounds
GB0706173D0 (en) Compounds
GB0706188D0 (en) Compounds
GB0706165D0 (en) Compounds
GB0706168D0 (en) Compounds
GB0706167D0 (en) Compounds
GB0706187D0 (en) Compounds
GB0706174D0 (en) Compounds
GB0706189D0 (en) Compounds
GB0706170D0 (en) Compounds
GB0706164D0 (en) Compounds
GB0704939D0 (en) Compounds
GB0703756D0 (en) Compounds
GB0701985D0 (en) Compounds
GB0700286D0 (en) Compounds
GB0701969D0 (en) Compounds
GB0702891D0 (en) Compounds
GB0702960D0 (en) Compounds
GB0702961D0 (en) Compounds
GB0702976D0 (en) Compounds
GB0703067D0 (en) Compounds
GB0706176D0 (en) Compounds