SG11201403909RA - Pde9 inhibitors with imidazo triazinone backbone - Google Patents
Pde9 inhibitors with imidazo triazinone backboneInfo
- Publication number
- SG11201403909RA SG11201403909RA SG11201403909RA SG11201403909RA SG11201403909RA SG 11201403909R A SG11201403909R A SG 11201403909RA SG 11201403909R A SG11201403909R A SG 11201403909RA SG 11201403909R A SG11201403909R A SG 11201403909RA SG 11201403909R A SG11201403909R A SG 11201403909RA
- Authority
- SG
- Singapore
- Prior art keywords
- pde9 inhibitors
- backbone
- imidazo
- imidazo triazinone
- triazinone backbone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012070718 | 2012-01-26 | ||
| CN2012080208 | 2012-08-16 | ||
| PCT/EP2013/051451 WO2013110768A1 (en) | 2012-01-26 | 2013-01-25 | Pde9 inhibitors with imidazo triazinone backbone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201403909RA true SG11201403909RA (en) | 2014-10-30 |
Family
ID=47603775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403909RA SG11201403909RA (en) | 2012-01-26 | 2013-01-25 | Pde9 inhibitors with imidazo triazinone backbone |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9434733B2 (en) |
| EP (2) | EP3178820B1 (en) |
| CN (2) | CN104093720B (en) |
| AP (1) | AP2014007820A0 (en) |
| AU (2) | AU2013213603B2 (en) |
| BR (1) | BR112014018199A8 (en) |
| CO (1) | CO7020913A2 (en) |
| CR (1) | CR20140361A (en) |
| DO (1) | DOP2014000175A (en) |
| EC (1) | ECSP14015609A (en) |
| HK (1) | HK1199879A1 (en) |
| MX (1) | MX351582B (en) |
| PH (1) | PH12014501695A1 (en) |
| SG (1) | SG11201403909RA (en) |
| WO (1) | WO2013110768A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR083058A1 (en) | 2010-09-20 | 2013-01-30 | Envivo Pharmaceuticals Inc | IMIDAZOTRIAZINONA STRUCTURE COMPOUNDS |
| EP2624903B1 (en) | 2010-10-08 | 2018-05-16 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
| EP2906562B1 (en) | 2011-10-10 | 2016-10-05 | H. Lundbeck A/S | Pde9i with imidazo pyrazinone backbone |
| MX351582B (en) | 2012-01-26 | 2017-10-20 | H Lundbeck As | Pde9 inhibitors with imidazo triazinone backbone. |
| WO2013142269A1 (en) * | 2012-03-19 | 2013-09-26 | Envivo Pharmaceuticals, Inc. | Imidazotriazinone compounds |
| WO2016006975A2 (en) * | 2014-07-11 | 2016-01-14 | St Pharm Co., Ltd. | Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof |
| KR20160007347A (en) | 2014-07-11 | 2016-01-20 | 에스티팜 주식회사 | Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof |
| TW201629064A (en) | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | Triazolopyrainones as PDE1 inhibitors |
| JO3627B1 (en) | 2015-04-30 | 2020-08-27 | H Lundbeck As | Imidazopyrazinones as PDE1 inhibitors |
| WO2017000276A1 (en) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| EP3303339B1 (en) | 2015-07-07 | 2021-01-13 | H. Lundbeck A/S | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| CN105669680B (en) * | 2016-03-24 | 2018-02-23 | 南京药捷安康生物科技有限公司 | (1H) ketone derivatives class PDE9A inhibitor of pyrrolo- [2,1 f] [1,2,4] triazine 4 |
| TWI729109B (en) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-c]PYRIDIN-4-ONES AS PDE1 INHIBITORS |
| WO2018009424A1 (en) | 2016-07-06 | 2018-01-11 | Imara, Inc. | Pde9 inhibitors for treatment of peripheral diseases |
| US10633382B2 (en) | 2016-10-18 | 2020-04-28 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors |
| RS60716B1 (en) | 2016-10-28 | 2020-09-30 | H Lundbeck As | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
| SG11201903061YA (en) | 2016-10-28 | 2019-05-30 | H Lundbeck As | Combination treatments comprising administration of imidazopyrazinones |
| CN109963834B (en) * | 2016-11-18 | 2023-04-14 | 综合研究实验室瑞典股份公司 | Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| US10919898B2 (en) | 2017-02-23 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Medical use of compound III |
| PT3630772T (en) * | 2017-05-26 | 2024-02-05 | Cardurion Pharmaceuticals Inc | Methods of making and using pde9 inhibitors |
| CN110003213B (en) * | 2018-01-04 | 2021-10-08 | 南京农业大学 | Benzimidazole triazine ketone compound, preparation method and application |
| CN111587116A (en) | 2018-01-05 | 2020-08-25 | 迪克纳制药公司 | Decreasing beta-catenin and IDO expression to boost immunotherapy |
| CA3100988A1 (en) | 2018-05-25 | 2019-11-28 | Imara Inc. | Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one |
| TW202108585A (en) * | 2019-05-07 | 2021-03-01 | 美商伊馬拉公司 | Pde9 inhibitors for treating thalassemia |
| CN113072556B (en) * | 2021-03-30 | 2022-02-01 | 牡丹江医学院 | Medicine for treating glioma and preparation method thereof |
| WO2024107445A1 (en) * | 2022-11-15 | 2024-05-23 | Freedom Biosciences, Inc. | Enhancement of the efficacy of serotonergic psychedelic drugs in the treatment or prevention of certain neuropsychiatric disorders through inhibition of type-9 phosphodiesterases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024433A1 (en) | 1997-11-12 | 1999-05-20 | Bayer Aktiengesellschaft | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| CN1344268A (en) | 1999-01-20 | 2002-04-10 | 德雷斯顿药品工厂有限公司 | Use of imidazo [1,5-a]pyrido[3,2-e]-pyrazinones as medicaments |
| PL370599A1 (en) | 2001-11-02 | 2005-05-30 | Pfizer Products Inc. | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
| HN2002000317A (en) | 2001-11-02 | 2003-05-21 | Pfizer | PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS |
| GB2388111A (en) | 2002-05-01 | 2003-11-05 | Bayer Ag | Novel imidazotriazinone compounds |
| US6684626B1 (en) | 2002-07-30 | 2004-02-03 | General Electric Company | Aircraft gas turbine engine with control vanes for counter rotating low pressure turbines |
| US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
| WO2005041972A1 (en) | 2003-10-31 | 2005-05-12 | Pfizer Products Inc. | Phosphodiesterase 9 inhibition as treatment for obesity-related conditions |
| MY139689A (en) | 2004-07-20 | 2009-10-30 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| TW200815436A (en) | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| EP2103613B1 (en) | 2006-12-13 | 2016-02-17 | ASKA Pharmaceutical Co., Ltd. | Quinoxaline derivative |
| CN101687876B (en) * | 2007-05-11 | 2012-12-12 | 辉瑞有限公司 | Amino-heterocyclic compounds |
| DE102007032349A1 (en) | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo, pyrazolopyrazines and imidazotriazines and their use |
| EP2231646A1 (en) | 2007-12-10 | 2010-09-29 | GlaxoSmithKline LLC | Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists |
| TWI404721B (en) | 2009-01-26 | 2013-08-11 | Pfizer | Amino-heterocyclic compounds |
| WO2011011712A1 (en) | 2009-07-24 | 2011-01-27 | Concert Pharmaceuticals, Inc. | Substituted imidazotriazines |
| WO2011028820A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
| AR083058A1 (en) * | 2010-09-20 | 2013-01-30 | Envivo Pharmaceuticals Inc | IMIDAZOTRIAZINONA STRUCTURE COMPOUNDS |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| MX351582B (en) | 2012-01-26 | 2017-10-20 | H Lundbeck As | Pde9 inhibitors with imidazo triazinone backbone. |
-
2013
- 2013-01-25 MX MX2014008912A patent/MX351582B/en active IP Right Grant
- 2013-01-25 CN CN201380006255.2A patent/CN104093720B/en active Active
- 2013-01-25 AU AU2013213603A patent/AU2013213603B2/en active Active
- 2013-01-25 US US14/374,278 patent/US9434733B2/en active Active
- 2013-01-25 WO PCT/EP2013/051451 patent/WO2013110768A1/en active Application Filing
- 2013-01-25 CN CN201710176546.6A patent/CN107082783B/en active Active
- 2013-01-25 AP AP2014007820A patent/AP2014007820A0/en unknown
- 2013-01-25 BR BR112014018199A patent/BR112014018199A8/en active Search and Examination
- 2013-01-25 EP EP17152165.1A patent/EP3178820B1/en active Active
- 2013-01-25 EP EP13701270.4A patent/EP2807163B1/en active Active
- 2013-01-25 SG SG11201403909RA patent/SG11201403909RA/en unknown
-
2014
- 2014-07-24 CR CR20140361A patent/CR20140361A/en unknown
- 2014-07-24 CO CO14161415A patent/CO7020913A2/en unknown
- 2014-07-25 PH PH12014501695A patent/PH12014501695A1/en unknown
- 2014-07-25 DO DO2014000175A patent/DOP2014000175A/en unknown
- 2014-08-25 EC ECIEPI201415609A patent/ECSP14015609A/en unknown
-
2015
- 2015-01-13 HK HK15100346.4A patent/HK1199879A1/en unknown
-
2016
- 2016-04-04 US US15/089,819 patent/US9533992B2/en active Active
- 2016-11-22 US US15/358,168 patent/US9850249B2/en active Active - Reinstated
-
2017
- 2017-02-09 AU AU2017200886A patent/AU2017200886B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP14015609A (en) | 2015-12-31 |
| WO2013110768A1 (en) | 2013-08-01 |
| CR20140361A (en) | 2014-11-11 |
| CN107082783A (en) | 2017-08-22 |
| HK1199879A1 (en) | 2015-07-24 |
| PH12014501695B1 (en) | 2014-10-20 |
| EP2807163B1 (en) | 2017-03-22 |
| US20150045348A1 (en) | 2015-02-12 |
| CN104093720B (en) | 2017-04-12 |
| US9533992B2 (en) | 2017-01-03 |
| US20170081333A1 (en) | 2017-03-23 |
| EP3178820A1 (en) | 2017-06-14 |
| AU2013213603A1 (en) | 2014-07-24 |
| MX2014008912A (en) | 2014-08-26 |
| AU2017200886B2 (en) | 2018-01-18 |
| BR112014018199A8 (en) | 2021-03-02 |
| US9434733B2 (en) | 2016-09-06 |
| EP3178820B1 (en) | 2017-12-20 |
| US20160213674A1 (en) | 2016-07-28 |
| EP2807163A1 (en) | 2014-12-03 |
| CO7020913A2 (en) | 2014-08-11 |
| US9850249B2 (en) | 2017-12-26 |
| AP2014007820A0 (en) | 2014-07-31 |
| CN107082783B (en) | 2019-03-22 |
| CN104093720A (en) | 2014-10-08 |
| AU2013213603B2 (en) | 2017-02-02 |
| AU2017200886A1 (en) | 2017-03-02 |
| DOP2014000175A (en) | 2014-08-31 |
| PH12014501695A1 (en) | 2014-10-20 |
| MX351582B (en) | 2017-10-20 |
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