PL206377B1 - Zastosowanie bakterii z rodzaju Salmonella oraz szczepionka do ochrony zwierząt przeciwko salmonellozie - Google Patents
Zastosowanie bakterii z rodzaju Salmonella oraz szczepionka do ochrony zwierząt przeciwko salmonellozieInfo
- Publication number
- PL206377B1 PL206377B1 PL344851A PL34485100A PL206377B1 PL 206377 B1 PL206377 B1 PL 206377B1 PL 344851 A PL344851 A PL 344851A PL 34485100 A PL34485100 A PL 34485100A PL 206377 B1 PL206377 B1 PL 206377B1
- Authority
- PL
- Poland
- Prior art keywords
- flagellin
- bacterium
- vaccine
- salmonella
- bacteria
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims abstract description 74
- 229960005486 vaccine Drugs 0.000 title claims abstract description 61
- 241000607142 Salmonella Species 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 14
- 241001465754 Metazoa Species 0.000 title claims description 53
- 206010039438 Salmonella Infections Diseases 0.000 title claims description 15
- 206010039447 salmonellosis Diseases 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 108010040721 Flagellin Proteins 0.000 claims description 78
- 210000003495 flagella Anatomy 0.000 claims description 55
- 108090000623 proteins and genes Proteins 0.000 claims description 36
- 230000000890 antigenic effect Effects 0.000 claims description 33
- 208000015181 infectious disease Diseases 0.000 claims description 29
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims description 25
- 230000035772 mutation Effects 0.000 claims description 22
- 239000002671 adjuvant Substances 0.000 claims description 11
- 230000002238 attenuated effect Effects 0.000 claims description 7
- 241001467018 Typhis Species 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 230000001575 pathological effect Effects 0.000 claims description 5
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 4
- 229940031551 inactivated vaccine Drugs 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 229940124590 live attenuated vaccine Drugs 0.000 claims description 3
- 229940023012 live-attenuated vaccine Drugs 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 description 24
- 102100026711 Metalloreductase STEAP2 Human genes 0.000 description 24
- 241000287828 Gallus gallus Species 0.000 description 20
- 235000013330 chicken meat Nutrition 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 235000018102 proteins Nutrition 0.000 description 13
- 210000002966 serum Anatomy 0.000 description 13
- 241000282412 Homo Species 0.000 description 12
- 241000282887 Suidae Species 0.000 description 9
- 239000000427 antigen Substances 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 239000006161 blood agar Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 239000003550 marker Substances 0.000 description 8
- 231100000350 mutagenesis Toxicity 0.000 description 8
- 238000002255 vaccination Methods 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000002703 mutagenesis Methods 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000004520 agglutination Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 230000037361 pathway Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 101100238784 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) mtfA gene Proteins 0.000 description 4
- 230000008436 biogenesis Effects 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 244000144977 poultry Species 0.000 description 4
- 235000013594 poultry meat Nutrition 0.000 description 4
- 238000002741 site-directed mutagenesis Methods 0.000 description 4
- 235000019786 weight gain Nutrition 0.000 description 4
- 230000004584 weight gain Effects 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 101001072091 Homo sapiens ProSAAS Proteins 0.000 description 3
- 102100036366 ProSAAS Human genes 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 3
- 235000006545 Ziziphus mauritiana Nutrition 0.000 description 3
- 240000000038 Ziziphus mauritiana Species 0.000 description 3
- 210000004534 cecum Anatomy 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 244000144992 flock Species 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000004899 motility Effects 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 102000009016 Cholera Toxin Human genes 0.000 description 2
- 108010049048 Cholera Toxin Proteins 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 241001138501 Salmonella enterica Species 0.000 description 2
- 241000607356 Salmonella enterica subsp. arizonae Species 0.000 description 2
- 241000607662 Salmonella enterica subsp. enterica serovar Abortusequi Species 0.000 description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 238000001976 enzyme digestion Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 238000000159 protein binding assay Methods 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 208000000995 spontaneous abortion Diseases 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000252983 Caecum Species 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 241000773293 Rappaport Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 1
- 241000607683 Salmonella enterica subsp. enterica serovar Pullorum Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- PHTAQVMXYWFMHF-QVPNGJTFSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H](O[C@@H](O)[C@H](NC(C)=O)[C@H]2O)CO)O[C@H](CO)[C@H](O)[C@@H]1O PHTAQVMXYWFMHF-QVPNGJTFSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 235000021053 average weight gain Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229960001506 brilliant green Drugs 0.000 description 1
- HXCILVUBKWANLN-UHFFFAOYSA-N brilliant green cation Chemical compound C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 HXCILVUBKWANLN-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002962 chemical mutagen Substances 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 108091008053 gene clusters Proteins 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 238000007692 polyacrylamide-agarose gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000011886 postmortem examination Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204564 | 1999-12-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL344851A1 PL344851A1 (en) | 2001-07-02 |
| PL206377B1 true PL206377B1 (pl) | 2010-08-31 |
Family
ID=8241112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL344851A PL206377B1 (pl) | 1999-12-28 | 2000-12-28 | Zastosowanie bakterii z rodzaju Salmonella oraz szczepionka do ochrony zwierząt przeciwko salmonellozie |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20010021386A1 (https=) |
| EP (1) | EP1112747B1 (https=) |
| JP (1) | JP5745731B2 (https=) |
| AT (1) | ATE269104T1 (https=) |
| AU (1) | AU783508B2 (https=) |
| BR (1) | BR0006291B1 (https=) |
| CA (1) | CA2329676A1 (https=) |
| DE (1) | DE60011560T2 (https=) |
| DK (1) | DK1112747T3 (https=) |
| ES (1) | ES2222152T3 (https=) |
| HU (1) | HU226192B1 (https=) |
| MX (1) | MXPA00012796A (https=) |
| PL (1) | PL206377B1 (https=) |
| PT (1) | PT1112747E (https=) |
| TR (1) | TR200401569T4 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014097154A1 (en) | 2012-12-20 | 2014-06-26 | Zakład Badawczo-Wdrożeniowy Ośrodka Salmonella "Immunolab" Sp. Z O.O. | A polyvalent combined immunising and/or therapeutic preparation for use in bacterial infections or food poisoning, particularly salmonellosis, a method for production of this preparation, its use and a vaccine comprising this preparation |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4751570B2 (ja) * | 2002-09-11 | 2011-08-17 | 東レ・ダウコーニング株式会社 | オルガノポリシロキサン変性多糖類およびその製造方法 |
| PT2066339E (pt) | 2006-09-18 | 2014-10-31 | Texas A & M Univ Sys | Composições e métodos de potenciar respostas imunes |
| US20080260777A1 (en) * | 2007-04-19 | 2008-10-23 | Sotomayor Konky | Composition and method for controlling intestinal pathogenic organisms |
| US7935355B2 (en) * | 2007-04-19 | 2011-05-03 | Nutritional Health Institute Laboratories, Llc | Composition and method for controlling intestinal pathogenic organisms |
| JP2011502165A (ja) * | 2007-10-30 | 2011-01-20 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 鞭毛細菌に対する免疫応答を強化する組成物および方法 |
| DK2214701T3 (en) | 2007-11-01 | 2016-12-12 | Univ Arkansas | CONFIGURATIONS AND METHODS FOR IMPROVING THE IMMUNE RESPONSES TO Eimeria |
| EP2217716A4 (en) | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS ANTIMICROBIAL AGENTS |
| US8956618B2 (en) | 2010-01-21 | 2015-02-17 | The Texas A&M University System | Vaccine vectors and methods of enhancing immune responses |
| NZ604412A (en) | 2010-06-09 | 2015-01-30 | Univ Arkansas | Vaccine and methods to reduce campylobacter infection |
| KR101449417B1 (ko) | 2012-06-20 | 2014-10-27 | 한국외국어대학교 연구산학협력단 | 살모넬라 엔테리카의 박테리오파아지 및 그 용도 |
| HUE047484T2 (hu) | 2013-02-14 | 2020-04-28 | Univ Arkansas | Készítmények és eljárások eimeria elleni immunválasz fokozására vagy eimeria-fertõzés korlátozására |
| WO2014164607A1 (en) | 2013-03-11 | 2014-10-09 | The Brigham And Women's Hospital, Inc. | Vibro-based delivery system and immune suppression |
| CA2906079C (en) | 2013-03-15 | 2022-08-23 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
| KR20190015712A (ko) | 2016-05-03 | 2019-02-14 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법 |
| CN111374094B (zh) * | 2020-03-02 | 2022-04-19 | 扬州大学 | 驴源马流产沙门氏菌经皮下致非妊娠期小鼠子宫感染模型的建立方法 |
| CN118773056B (zh) * | 2024-07-10 | 2025-07-08 | 山东省滨州畜牧兽医研究院 | 一种马流产沙门氏菌灭活疫苗 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1109179A (en) * | 1964-09-30 | 1968-04-10 | Nat Res Dev | Improvements relating to typhoid and paratyphoid vaccines |
| US4886748A (en) * | 1986-03-11 | 1989-12-12 | Shionogi & Co., Ltd. | DNA encoding flagellin and vector having the same |
| US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| ATE121782T1 (de) * | 1988-05-05 | 1995-05-15 | Praxis Biolog Inc | Rekombinante vakzine von flagellin. |
| JP3436756B2 (ja) * | 1988-12-19 | 2003-08-18 | アメリカン・サイアナミド・カンパニー | 髄膜炎菌のクラスｉの外膜タンパク質のワクチン |
| CA2183684C (en) * | 1994-02-18 | 2008-07-15 | Richard D. Hansen | Inoculation of animals with dried, pelleted biological materials |
| GB9621091D0 (en) * | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6190669B1 (en) * | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
-
2000
- 2000-12-19 TR TR2004/01569T patent/TR200401569T4/xx unknown
- 2000-12-19 ES ES00204630T patent/ES2222152T3/es not_active Expired - Lifetime
- 2000-12-19 EP EP00204630A patent/EP1112747B1/en not_active Expired - Lifetime
- 2000-12-19 DK DK00204630T patent/DK1112747T3/da active
- 2000-12-19 DE DE60011560T patent/DE60011560T2/de not_active Expired - Lifetime
- 2000-12-19 PT PT00204630T patent/PT1112747E/pt unknown
- 2000-12-19 MX MXPA00012796A patent/MXPA00012796A/es active IP Right Grant
- 2000-12-19 AT AT00204630T patent/ATE269104T1/de active
- 2000-12-20 JP JP2000387225A patent/JP5745731B2/ja not_active Expired - Fee Related
- 2000-12-21 AU AU72453/00A patent/AU783508B2/en not_active Ceased
- 2000-12-27 US US09/749,025 patent/US20010021386A1/en not_active Abandoned
- 2000-12-27 HU HU0005010A patent/HU226192B1/hu not_active IP Right Cessation
- 2000-12-27 CA CA002329676A patent/CA2329676A1/en not_active Abandoned
- 2000-12-27 BR BRPI0006291-0A patent/BR0006291B1/pt not_active IP Right Cessation
- 2000-12-28 PL PL344851A patent/PL206377B1/pl not_active IP Right Cessation
-
2007
- 2007-10-30 US US11/980,864 patent/US20080069843A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014097154A1 (en) | 2012-12-20 | 2014-06-26 | Zakład Badawczo-Wdrożeniowy Ośrodka Salmonella "Immunolab" Sp. Z O.O. | A polyvalent combined immunising and/or therapeutic preparation for use in bacterial infections or food poisoning, particularly salmonellosis, a method for production of this preparation, its use and a vaccine comprising this preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60011560D1 (de) | 2004-07-22 |
| HU226192B1 (en) | 2008-06-30 |
| EP1112747A1 (en) | 2001-07-04 |
| DK1112747T3 (da) | 2004-10-25 |
| JP5745731B2 (ja) | 2015-07-08 |
| JP2001186874A (ja) | 2001-07-10 |
| PL344851A1 (en) | 2001-07-02 |
| EP1112747B1 (en) | 2004-06-16 |
| MXPA00012796A (es) | 2002-05-23 |
| US20010021386A1 (en) | 2001-09-13 |
| AU783508B2 (en) | 2005-11-03 |
| HUP0005010A3 (en) | 2004-07-28 |
| DE60011560T2 (de) | 2005-08-18 |
| US20080069843A1 (en) | 2008-03-20 |
| PT1112747E (pt) | 2004-10-29 |
| AU7245300A (en) | 2001-07-05 |
| CA2329676A1 (en) | 2001-06-28 |
| ATE269104T1 (de) | 2004-07-15 |
| HU0005010D0 (https=) | 2001-02-28 |
| HUP0005010A2 (en) | 2002-06-29 |
| ES2222152T3 (es) | 2005-02-01 |
| BR0006291A (pt) | 2001-11-27 |
| BR0006291B1 (pt) | 2014-02-18 |
| TR200401569T4 (tr) | 2004-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20080069843A1 (en) | Salmonella vaccine | |
| JP2002521345A (ja) | 鳥類病原体を制御するため生きた弱毒化サルモネラワクチン | |
| EP2528620B1 (en) | Salmonella vaccine | |
| US8778655B2 (en) | Modified gram-negative bacteria for use as vaccines | |
| Meenakshi et al. | Adjuvanted outer membrane protein vaccine protects poultry against infection with Salmonella enteritidis | |
| US11707515B2 (en) | Modified Brucella vaccine strain for the treatment of brucellosis | |
| US20080254062A1 (en) | Use of an avirulent bordetella mutant as a live vaccine vector | |
| US7045122B2 (en) | Salmonella vaccine | |
| JP2009531029A (ja) | 弱毒化サルモネラ生ワクチン | |
| Roland et al. | Expression of Escherichia coli antigens in Salmonella typhimurium as a vaccine to prevent airsacculitis in chickens | |
| Zhang et al. | Protection and immune responses induced by attenuatedSalmonella typhimuriumUK-1 strains | |
| Nandre et al. | Cross-protection against Salmonella Typhimurium infection conferred by a live attenuated Salmonella Enteritidis vaccine | |
| EP3166632B1 (en) | Modified bacteria for improved vaccines against brucellosis | |
| AU776864B2 (en) | Compositions and methods for treating and preventing pathogenic bacterial infection based on the essential role of DNA methylation in bacterial virulence | |
| Ochoa-Repáraz et al. | Protective ability of subcellular extracts from Salmonella Enteritidis and from a rough isogenic mutant against salmonellosis in mice | |
| EP4686480A1 (en) | Live attenuated e. coli vaccine | |
| Pumtang-on | Investigation of Campylobacter jejuni and Campylobacter coli colonisation of commercial free-range chickens | |
| US20030149255A1 (en) | Bird diagnostics and treatments | |
| Whitehead | Development and assessment of an attenuated Rhodococcus equi oral vaccine that produces VapA | |
| Rai | STUDY OF THE PROTEIN PROFILE OF SALMONELLA GALLINARUM | |
| Shao | Effects of Cyclic Adenosine Monophosphate Independent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20111228 |