PL1969118T3 - Wyizolowane komórki macierzyste wątroby - Google Patents
Wyizolowane komórki macierzyste wątrobyInfo
- Publication number
- PL1969118T3 PL1969118T3 PL06819033T PL06819033T PL1969118T3 PL 1969118 T3 PL1969118 T3 PL 1969118T3 PL 06819033 T PL06819033 T PL 06819033T PL 06819033 T PL06819033 T PL 06819033T PL 1969118 T3 PL1969118 T3 PL 1969118T3
- Authority
- PL
- Poland
- Prior art keywords
- stem cells
- liver
- relates
- present
- progenitor stem
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 4
- 210000004185 liver Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000002054 transplantation Methods 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010019663 Hepatic failure Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000010224 hepatic metabolism Effects 0.000 abstract 1
- 208000007903 liver failure Diseases 0.000 abstract 1
- 231100000835 liver failure Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000027 toxicology Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05447286 | 2005-12-21 | ||
EP2006010014 | 2006-10-17 | ||
PCT/EP2006/012046 WO2007071339A1 (en) | 2005-12-21 | 2006-12-14 | Isolated liver stem cells |
EP06819033.9A EP1969118B2 (en) | 2005-12-21 | 2006-12-14 | Isolated liver stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
PL1969118T3 true PL1969118T3 (pl) | 2011-07-29 |
PL1969118T5 PL1969118T5 (pl) | 2015-06-30 |
Family
ID=37775557
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06819033T PL1969118T5 (pl) | 2005-12-21 | 2006-12-14 | Wyizolowane komórki macierzyste wątroby |
PL10192665T PL2281875T3 (pl) | 2005-12-21 | 2006-12-14 | Wyizolowane komórki macierzyste wątroby |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10192665T PL2281875T3 (pl) | 2005-12-21 | 2006-12-14 | Wyizolowane komórki macierzyste wątroby |
Country Status (13)
Country | Link |
---|---|
US (5) | US8673635B2 (pl) |
EP (2) | EP1969118B2 (pl) |
JP (1) | JP5250423B2 (pl) |
CN (1) | CN103989710B (pl) |
AT (1) | ATE498005T1 (pl) |
AU (1) | AU2006328988B2 (pl) |
CA (1) | CA2634510C (pl) |
DE (1) | DE602006020071D1 (pl) |
DK (2) | DK1969118T4 (pl) |
ES (1) | ES2672205T3 (pl) |
PL (2) | PL1969118T5 (pl) |
PT (1) | PT2281875T (pl) |
WO (1) | WO2007071339A1 (pl) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1969118T5 (pl) * | 2005-12-21 | 2015-06-30 | Univ Catholique Louvain | Wyizolowane komórki macierzyste wątroby |
US8951792B2 (en) * | 2007-07-20 | 2015-02-10 | Cellartis Ab | Methods for making definitive endoderm hepatocyte (DE-hep) progenitor cells |
US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
CA2751332C (en) | 2009-02-03 | 2024-04-02 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
JPWO2011102532A1 (ja) * | 2010-02-16 | 2013-06-17 | 国立大学法人九州大学 | 誘導肝細胞 |
WO2012005690A1 (en) * | 2010-07-07 | 2012-01-12 | Massachusetts Institute Of Technology | Methods of reconstituting human hepatocytes and human hematopoietic cells in non-human mammals |
US8858934B2 (en) * | 2010-08-12 | 2014-10-14 | Abag Verwaltungs Gmbh | Method for producing cells having characteristics of hepatocytes |
PT2667878E (pt) * | 2011-01-25 | 2016-06-03 | Univ Catholique Louvain | Composições e métodos para o transplante celular |
JP6095272B2 (ja) * | 2011-03-25 | 2017-03-15 | 国立大学法人京都大学 | 上皮系体性幹細胞の製造方法 |
ES2600321T3 (es) | 2011-08-04 | 2017-02-08 | Ethianum Betriebsgesellschaft Mbh & Co. Kg | Medios para la regeneración del hígado |
EP2762000A4 (en) | 2011-09-30 | 2015-03-11 | Public Univ Corp Yokohama City | METHOD OF INDUCING HEPATOCELLULAR VARIATION AND METHOD OF PRODUCING NON-MENTAL CHIMERIC ANIMALS WITH HUMAN LIVER |
EP2806879B1 (en) | 2012-01-25 | 2019-03-06 | Université Catholique de Louvain | Compositions and methods for cell transplantation |
US20140162355A1 (en) * | 2012-12-07 | 2014-06-12 | Antria, Inc. | Formulations Containing and Kit for Using Adipose-Derived Stem Cells and Use Thereof |
DK3016665T3 (da) * | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
AU2014314152B2 (en) * | 2013-08-28 | 2020-02-06 | Promethera Therapeutics Sa | Method for producing adult liver progenitor cells |
WO2016001839A1 (en) * | 2014-06-30 | 2016-01-07 | Stempeutics Research Pvt. Ltd. | Management of liver disease using pooled mesenchymal stromal cells |
PL3140393T3 (pl) * | 2014-08-28 | 2023-11-06 | Cellaïon SA | Sposób wytwarzania komórek progenitorowych dorosłej wątroby |
GB2548059B (en) * | 2014-11-26 | 2020-09-02 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
FR3035407B1 (fr) | 2015-04-23 | 2022-06-17 | Francais Du Sang Ets | Procede de conservation de cellules, tissus ou organes en hypothermie |
US10179896B2 (en) | 2015-05-12 | 2019-01-15 | Baker Group, LLP | Method and system for a bioartificial organ |
WO2016181885A1 (ja) * | 2015-05-14 | 2016-11-17 | 株式会社再生医療推進機構 | 凍結間葉系細胞の製造方法、及び、移植用治療材の製造方法 |
CN108431209B (zh) | 2015-06-12 | 2023-02-10 | 新加坡科技研究局 | 肝脏干细胞的衍生和成熟肝细胞类型及其用途 |
US10287543B2 (en) * | 2015-11-19 | 2019-05-14 | Miltenyi Biotec, Gmbh | Process and device for isolating cells from biological tissue |
RU2018128598A (ru) * | 2016-01-08 | 2020-02-11 | Кинити Ко., Лтд. | Способ продуцирования стволовых клеток/клеток-предшественников печени из зрелых клеток печени с использованием низкомолекулярного соединения |
JP6704617B2 (ja) * | 2016-01-29 | 2020-06-03 | 北海道公立大学法人 札幌医科大学 | 小型肝細胞の継代培養方法 |
CA3013630A1 (en) | 2016-02-10 | 2017-08-17 | Wake Forest University Health Sciences | Model system of liver fibrosis and method of making and using the same |
MA45274A (fr) * | 2016-03-02 | 2019-01-09 | Univ Catholique Louvain | Préparations améliorées de cellules progénitrices hépatiques adultes |
JP2019516391A (ja) * | 2016-05-24 | 2019-06-20 | リ, アルバートLI, Albert | 新規な細胞培養方法、細胞培養システム、およびそれらの使用 |
WO2018215780A1 (en) | 2017-05-24 | 2018-11-29 | Ammun Limited | Use of glutamine synthetase for treating hyperammonemia |
US11976302B2 (en) | 2017-05-06 | 2024-05-07 | Upside Foods, Inc. | Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure |
WO2019014652A1 (en) * | 2017-07-13 | 2019-01-17 | Memphis Meats, Inc. | COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION |
US11407979B2 (en) | 2017-09-01 | 2022-08-09 | Colorado State University Research Foundation | Intermittent starvation techniques to prolong functional lifetime of liver cells in culture |
EP3766529A4 (en) | 2018-03-14 | 2022-03-23 | Beacon Medcare (HK) Limited | COMPOSITION FOR PURIFICATION OF BIOFLUIDS |
CN108823146A (zh) * | 2018-06-22 | 2018-11-16 | 安徽 | 一种肝脏干细胞制备和提取方法 |
CA3122715A1 (en) | 2018-12-14 | 2020-06-18 | Promethera Therapeutics Sa | Cell composition comprising liver progenitor cells expressing hla-e |
WO2020120666A1 (en) | 2018-12-14 | 2020-06-18 | Promethera Biosciences S.A./N.V. | Liver progenitor cells expressing hla-g, and method for obtaining these cells compositions comprising said cells and their use |
CN109735485B (zh) * | 2019-01-29 | 2021-04-16 | 深圳市拓普生物科技有限公司 | 人源化肝脏动物模型及其构建方法和应用 |
TW202100171A (zh) | 2019-03-26 | 2021-01-01 | 比利時商普羅米修亞生物科技股份有限公司 | 用於治療非酒精性脂肪肝疾病的成人肝臟前驅細胞 |
EP3947644A1 (en) | 2019-03-26 | 2022-02-09 | Promethera Therapeutics Sa | Adult liver progenitor cells for treating acute-on-chronic liver failure |
JP7284985B2 (ja) * | 2019-03-29 | 2023-06-01 | 国立大学法人 長崎大学 | 肝前駆細胞を含む細胞集団を製造する方法 |
PT3963050T (pt) * | 2019-04-30 | 2023-11-16 | Cellaion Sa | Preparação de células progenitoras alogénicas humanas derivadas de fígado |
TW202106874A (zh) | 2019-04-30 | 2021-02-16 | 比利時商普羅米修亞生物科技股份有限公司 | 人類同種異體肝衍生前驅細胞的製備(一) |
EP3966315A1 (en) * | 2019-05-09 | 2022-03-16 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of hepatocytes |
KR20220035926A (ko) * | 2019-07-26 | 2022-03-22 | 앰비스 메디신즈 인코포레이티드 | 간세포 생성을 위한 방법 및 조성물 |
KR20220081368A (ko) | 2019-10-09 | 2022-06-15 | 셀라온 에스에이 | 혈관 과투과성을 특징으로 하는 장애에서 간 전구세포 또는 줄기세포, 이의 용해물 및/또는 조건화 배지의 사용 |
CN115551994A (zh) | 2020-03-11 | 2022-12-30 | 倍特博有限公司 | 产生肝细胞的方法 |
EP3881853A1 (en) | 2020-03-20 | 2021-09-22 | Promethera Therapeutics Sa | Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation |
EP3929280A1 (en) * | 2020-06-26 | 2021-12-29 | Medizinische Hochschule Hannover | Process for producing liver cells |
WO2023180122A1 (en) | 2022-03-24 | 2023-09-28 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence |
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JP2917998B2 (ja) * | 1988-02-05 | 1999-07-12 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 修飾された肝細胞およびその用途 |
US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
PT671923E (pt) | 1992-10-09 | 2001-10-30 | Advanced Tissue Sciences Inc | Celulas de reserva do figado |
US5869243A (en) | 1996-03-05 | 1999-02-09 | Rhode Island Hospital | Immortalized hepatocytes |
CA2266752A1 (en) | 1996-10-01 | 1998-04-09 | Geron Corporation | Telomerase reverse transcriptase |
US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
CN101955906A (zh) * | 2000-01-19 | 2011-01-26 | 查珀尔希尔-北卡罗莱纳大学 | 肝脏组织来源 |
ES2292772T3 (es) | 2001-06-22 | 2008-03-16 | Stemcells, Inc. | Celulas de injerto de higado, analisis, y sus usos. |
US6617152B2 (en) | 2001-09-04 | 2003-09-09 | Corning Inc | Method for creating a cell growth surface on a polymeric substrate |
WO2003033697A1 (en) * | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
JP2006525994A (ja) | 2003-05-12 | 2006-11-16 | サラ ファーバー, | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
CA2444292A1 (en) | 2003-10-03 | 2005-04-03 | Inserm | Bipotential liver cell lines from wild-type mammalian liver tissue |
JP4749331B2 (ja) * | 2003-10-07 | 2011-08-17 | 株式会社バイオマスター | 脂肪由来前駆細胞の細胞分化 |
WO2006126219A1 (en) * | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
PL1969118T5 (pl) * | 2005-12-21 | 2015-06-30 | Univ Catholique Louvain | Wyizolowane komórki macierzyste wątroby |
-
2006
- 2006-12-14 PL PL06819033T patent/PL1969118T5/pl unknown
- 2006-12-14 EP EP06819033.9A patent/EP1969118B2/en active Active
- 2006-12-14 DK DK06819033.9T patent/DK1969118T4/en active
- 2006-12-14 PL PL10192665T patent/PL2281875T3/pl unknown
- 2006-12-14 AU AU2006328988A patent/AU2006328988B2/en active Active
- 2006-12-14 AT AT06819033T patent/ATE498005T1/de not_active IP Right Cessation
- 2006-12-14 CN CN201410143665.8A patent/CN103989710B/zh active Active
- 2006-12-14 PT PT101926657T patent/PT2281875T/pt unknown
- 2006-12-14 WO PCT/EP2006/012046 patent/WO2007071339A1/en active Application Filing
- 2006-12-14 DK DK10192665.7T patent/DK2281875T3/en active
- 2006-12-14 DE DE602006020071T patent/DE602006020071D1/de active Active
- 2006-12-14 EP EP10192665.7A patent/EP2281875B1/en active Active
- 2006-12-14 JP JP2008546208A patent/JP5250423B2/ja active Active
- 2006-12-14 ES ES10192665.7T patent/ES2672205T3/es active Active
- 2006-12-14 US US12/097,743 patent/US8673635B2/en active Active
- 2006-12-14 CA CA2634510A patent/CA2634510C/en active Active
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2014
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US20140127676A1 (en) | 2014-05-08 |
DK2281875T3 (en) | 2018-06-06 |
AU2006328988A1 (en) | 2007-06-28 |
CA2634510A1 (en) | 2007-06-28 |
JP2009520474A (ja) | 2009-05-28 |
EP2281875A1 (en) | 2011-02-09 |
AU2006328988B2 (en) | 2012-08-02 |
DE602006020071D1 (de) | 2011-03-24 |
EP1969118A1 (en) | 2008-09-17 |
PL1969118T5 (pl) | 2015-06-30 |
US20150306147A1 (en) | 2015-10-29 |
CA2634510C (en) | 2018-01-09 |
US20140286917A1 (en) | 2014-09-25 |
CN103989710A (zh) | 2014-08-20 |
EP1969118B2 (en) | 2014-09-10 |
DK1969118T4 (en) | 2014-12-15 |
WO2007071339A1 (en) | 2007-06-28 |
ES2672205T3 (es) | 2018-06-13 |
JP5250423B2 (ja) | 2013-07-31 |
US9931360B2 (en) | 2018-04-03 |
PT2281875T (pt) | 2018-06-11 |
US20170354687A1 (en) | 2017-12-14 |
US9107910B2 (en) | 2015-08-18 |
EP2281875B1 (en) | 2018-03-21 |
DK1969118T3 (da) | 2011-05-16 |
CN103989710B (zh) | 2019-11-15 |
US8673635B2 (en) | 2014-03-18 |
EP1969118B1 (en) | 2011-02-09 |
ATE498005T1 (de) | 2011-02-15 |
US8778607B2 (en) | 2014-07-15 |
US9775863B2 (en) | 2017-10-03 |
US20080311094A1 (en) | 2008-12-18 |
PL2281875T3 (pl) | 2018-08-31 |
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