PL195410B1 - Zastosowanie kompozycji farmaceutycznej zawierającej alginian sodu do wytwarzania leku - Google Patents
Zastosowanie kompozycji farmaceutycznej zawierającej alginian sodu do wytwarzania lekuInfo
- Publication number
- PL195410B1 PL195410B1 PL98378778A PL37877898A PL195410B1 PL 195410 B1 PL195410 B1 PL 195410B1 PL 98378778 A PL98378778 A PL 98378778A PL 37877898 A PL37877898 A PL 37877898A PL 195410 B1 PL195410 B1 PL 195410B1
- Authority
- PL
- Poland
- Prior art keywords
- alginate
- composition
- alginates
- sodium alginate
- sodium
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 5
- 235000010413 sodium alginate Nutrition 0.000 title claims description 41
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims description 34
- 239000000661 sodium alginate Substances 0.000 title claims description 34
- 229940005550 sodium alginate Drugs 0.000 title claims description 34
- 239000003814 drug Substances 0.000 title claims description 4
- 229940079593 drug Drugs 0.000 title description 2
- 229920000615 alginic acid Polymers 0.000 claims abstract description 97
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 96
- 239000000203 mixture Substances 0.000 claims abstract description 93
- 230000002496 gastric effect Effects 0.000 claims abstract description 23
- 125000005613 guluronic acid group Chemical group 0.000 claims abstract description 22
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims abstract description 19
- 239000011253 protective coating Substances 0.000 claims abstract description 15
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 24
- 210000004877 mucosa Anatomy 0.000 claims description 22
- 239000001569 carbon dioxide Substances 0.000 claims description 12
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 12
- 239000006260 foam Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 9
- -1 alkali metal bicarbonate Chemical class 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 9
- 229910021645 metal ion Inorganic materials 0.000 claims description 7
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
- 201000006549 dyspepsia Diseases 0.000 claims description 5
- 210000003736 gastrointestinal content Anatomy 0.000 claims description 5
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 4
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- 239000011241 protective layer Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract description 51
- 229940072056 alginate Drugs 0.000 abstract description 50
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 23
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
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- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 8
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- 239000000463 material Substances 0.000 description 5
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 4
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- 241001598113 Laminaria digitata Species 0.000 description 3
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- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
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- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
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- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229940001593 sodium carbonate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 1
- 239000007892 solid unit dosage form Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 241001478887 unidentified soil bacteria Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9708773.8A GB9708773D0 (en) | 1997-04-30 | 1997-04-30 | Organic compositions |
| GBGB9708772.0A GB9708772D0 (en) | 1997-04-30 | 1997-04-30 | Organic compositions |
| PCT/GB1998/001188 WO1998048814A1 (en) | 1997-04-30 | 1998-04-23 | Pourable alginate compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL195410B1 true PL195410B1 (pl) | 2007-09-28 |
Family
ID=26311463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL98378778A PL195410B1 (pl) | 1997-04-30 | 1998-04-23 | Zastosowanie kompozycji farmaceutycznej zawierającej alginian sodu do wytwarzania leku |
| PL98336724A PL195031B1 (pl) | 1997-04-30 | 1998-04-23 | Ciekła wodna kompozycja nadająca się do nalewaniazawierająca alginian i wodorowęglan metalu alkalicznego |
| PL98378779A PL194696B1 (pl) | 1997-04-30 | 1998-04-23 | Kompozycja w stałej postaci dawkowania zawierająca alginiany |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL98336724A PL195031B1 (pl) | 1997-04-30 | 1998-04-23 | Ciekła wodna kompozycja nadająca się do nalewaniazawierająca alginian i wodorowęglan metalu alkalicznego |
| PL98378779A PL194696B1 (pl) | 1997-04-30 | 1998-04-23 | Kompozycja w stałej postaci dawkowania zawierająca alginiany |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6395307B1 (enExample) |
| EP (2) | EP1842544A3 (enExample) |
| JP (1) | JP2001522368A (enExample) |
| KR (1) | KR20010020438A (enExample) |
| CN (2) | CN1286468C (enExample) |
| AR (1) | AR012621A1 (enExample) |
| AU (1) | AU740972B2 (enExample) |
| BR (1) | BR9809310A (enExample) |
| CA (1) | CA2288743C (enExample) |
| ID (1) | ID23809A (enExample) |
| PL (3) | PL195410B1 (enExample) |
| WO (1) | WO1998048814A1 (enExample) |
| ZA (1) | ZA983707B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0005743D0 (en) * | 2000-03-10 | 2000-05-03 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions including alginates |
| CN1388758A (zh) * | 2000-08-09 | 2003-01-01 | 灵药生物技术有限公司 | 抗结核病药物的新颖的药学组合物及其制备方法 |
| GB0107651D0 (en) * | 2001-03-27 | 2001-05-16 | Syngenta Ltd | Composition |
| CA2460843A1 (en) * | 2001-09-21 | 2003-03-27 | Stryker Corporation | Pore-forming agents for orthopedic cements |
| GB2384986B (en) * | 2002-02-12 | 2004-01-07 | Reckitt Benckiser Healthcare | Compositions for the treatment of disorders of the upper gastrointestinal tract |
| US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| JP4873877B2 (ja) * | 2005-03-30 | 2012-02-08 | 小林製薬株式会社 | アルギン酸ナトリウム含有錠剤の製造方法及び該製造方法により得られる錠剤 |
| PT2268142T (pt) * | 2007-11-27 | 2017-06-02 | Algipharma As | Utilização de oligómeros alginados no combate aos biofilmes |
| WO2010092468A1 (en) * | 2009-02-13 | 2010-08-19 | Carlo Ghisalberti | Composition comprising alginates and d-limonene to treat gerd and dyspepsia |
| RU2586253C2 (ru) | 2009-06-03 | 2016-06-10 | АльгиФарма АС | Обработка акинетобактерий альгинатными олигомерами и антибиотиками |
| CN101933894B (zh) * | 2009-07-03 | 2012-07-11 | 张清 | 胃肠粘膜保护胶 |
| AU2011242177B8 (en) | 2010-04-23 | 2015-06-04 | S-Biotek Holding Aps | A solid pharmaceutical composition for neutralizing stomach acid |
| EA015747B1 (ru) * | 2010-07-08 | 2011-10-31 | Общество С Ограниченной Ответственностью "Вдс" | Состав для профилактики кандидозов |
| DK177435B1 (en) | 2011-06-03 | 2013-05-21 | Biotek Holding Aps S | An aqueous diet product, a unit dosage and a kit comprising at least one alginate, and a method for the preparation of said diet product |
| US9636360B2 (en) * | 2012-09-18 | 2017-05-02 | pH Science Holdings, Inc | Method and composition for treating gastro-esophageal disorders |
| WO2014102801A1 (en) | 2012-12-30 | 2014-07-03 | Hadasit Medical Research Services And Development Ltd. | Use of alginate compositions in preventing or reducing liver damage caused by a hepatotoxic agent |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| ITUB20150279A1 (it) * | 2015-03-09 | 2016-09-09 | S I I T S R L Servizio Int Imballaggi Termosaldanti | Sistema flottante per la cura dei sintomi delle affezioni gastriche |
| US11452798B2 (en) | 2017-09-27 | 2022-09-27 | Cook Medical Technologies Llc | Crosslinking submucosal injectate system |
| EP3707202A1 (en) | 2017-11-08 | 2020-09-16 | Materias S.r.l. | In situ gelifying powder |
| CN108451973A (zh) * | 2018-01-30 | 2018-08-28 | 无锡福尔顺科技有限公司 | 一种消化道凝胶保护剂及其使用方法和应用 |
| WO2023018649A1 (en) * | 2021-08-10 | 2023-02-16 | Bayer Healthcare Llc | Liquid formulations comprising alginic acid, pectin, and carrageenan and methods of using thereof for gastric and gastroesophageal disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1524740A (en) * | 1976-11-09 | 1978-09-13 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions for use in the suppression of gastric reflux |
| GB1566609A (en) * | 1977-03-10 | 1980-05-08 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing cholestyramine and alginic acid |
| JPS5746920A (en) * | 1980-09-03 | 1982-03-17 | Kyosei Seiyaku Kk | Drug for digestive tract |
| DE3152319C2 (de) * | 1980-09-03 | 1986-05-07 | Kyosei Pharmaceutical Co., Ltd., Hokkaido | Verwendung einer Lösung eines Salzes der Alginsäure zur Behandlung von Strahlenschäden und Ulcera |
| DE3586281T2 (de) * | 1984-04-19 | 1992-12-10 | Rhone Poulenc Rorer Int | Antisaeurezusammensetzung. |
| US4869902A (en) * | 1984-04-19 | 1989-09-26 | Rorer Pharmaceutical Corporation | Antacid composition |
| US4744986A (en) * | 1986-03-07 | 1988-05-17 | Rorer Pharmaceutical Corporation | Process for the preparation of a viscosity-stable antacid composition |
| GB8618847D0 (en) * | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
| DK179687D0 (da) * | 1987-04-08 | 1987-04-08 | Farma Food As | Praeparat |
| GB9010039D0 (en) * | 1990-05-03 | 1990-06-27 | Reckitt & Colmann Prod Ltd | Medicament preparation |
| GB9218749D0 (en) * | 1992-09-04 | 1992-10-21 | Courtaulds Plc | Alginate gels |
| US5888540A (en) * | 1993-10-29 | 1999-03-30 | Sugden; Keith | Pharmaceutical products |
| GB9504599D0 (en) * | 1995-03-03 | 1995-04-26 | Reckitt & Colmann Prod Ltd | Improvements in or relating to organic compositions |
| GB2298365B (en) * | 1995-03-03 | 1997-05-07 | Reckitt & Colmann Prod Ltd | A liquid pharmaceutical composition alginate and potassium bicarbonate |
-
1998
- 1998-04-23 BR BR9809310-0A patent/BR9809310A/pt not_active Application Discontinuation
- 1998-04-23 WO PCT/GB1998/001188 patent/WO1998048814A1/en not_active Ceased
- 1998-04-23 EP EP06024990A patent/EP1842544A3/en not_active Withdrawn
- 1998-04-23 PL PL98378778A patent/PL195410B1/pl not_active IP Right Cessation
- 1998-04-23 CN CNB2004100461678A patent/CN1286468C/zh not_active Expired - Fee Related
- 1998-04-23 JP JP54671798A patent/JP2001522368A/ja not_active Ceased
- 1998-04-23 US US09/403,217 patent/US6395307B1/en not_active Expired - Fee Related
- 1998-04-23 AU AU70680/98A patent/AU740972B2/en not_active Expired
- 1998-04-23 KR KR1019997010069A patent/KR20010020438A/ko not_active Withdrawn
- 1998-04-23 EP EP98917452A patent/EP0979091A1/en not_active Ceased
- 1998-04-23 ID IDW991279A patent/ID23809A/id unknown
- 1998-04-23 PL PL98336724A patent/PL195031B1/pl not_active IP Right Cessation
- 1998-04-23 PL PL98378779A patent/PL194696B1/pl not_active IP Right Cessation
- 1998-04-23 CA CA002288743A patent/CA2288743C/en not_active Expired - Fee Related
- 1998-04-23 CN CNB98804594XA patent/CN1197584C/zh not_active Expired - Lifetime
- 1998-04-28 ZA ZA983707A patent/ZA983707B/xx unknown
- 1998-04-29 AR ARP980101993A patent/AR012621A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010020438A (ko) | 2001-03-15 |
| BR9809310A (pt) | 2000-07-04 |
| EP1842544A3 (en) | 2007-10-17 |
| PL336724A1 (en) | 2000-07-03 |
| EP0979091A1 (en) | 2000-02-16 |
| EP1842544A2 (en) | 2007-10-10 |
| CN1197584C (zh) | 2005-04-20 |
| CA2288743C (en) | 2008-04-22 |
| AU7068098A (en) | 1998-11-24 |
| CA2288743A1 (en) | 1998-11-05 |
| ZA983707B (en) | 1999-02-26 |
| CN1253505A (zh) | 2000-05-17 |
| AR012621A1 (es) | 2000-11-08 |
| AU740972B2 (en) | 2001-11-15 |
| CN1286468C (zh) | 2006-11-29 |
| ID23809A (id) | 2000-05-11 |
| PL194696B1 (pl) | 2007-06-29 |
| WO1998048814A1 (en) | 1998-11-05 |
| PL195031B1 (pl) | 2007-08-31 |
| CN1552344A (zh) | 2004-12-08 |
| US6395307B1 (en) | 2002-05-28 |
| JP2001522368A (ja) | 2001-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20100423 |