PL1890680T3 - Formulacje diklofenaku i sposoby użycia - Google Patents

Formulacje diklofenaku i sposoby użycia

Info

Publication number
PL1890680T3
PL1890680T3 PL06743167T PL06743167T PL1890680T3 PL 1890680 T3 PL1890680 T3 PL 1890680T3 PL 06743167 T PL06743167 T PL 06743167T PL 06743167 T PL06743167 T PL 06743167T PL 1890680 T3 PL1890680 T3 PL 1890680T3
Authority
PL
Poland
Prior art keywords
methods
diclofenac formulations
diclofenac
formulations
Prior art date
Application number
PL06743167T
Other languages
English (en)
Inventor
Giorgio Reiner
Alberto Reiner
Andreas Meyer
Original Assignee
Apr Applied Pharma Research S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37396065&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1890680(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Apr Applied Pharma Research S.A. filed Critical Apr Applied Pharma Research S.A.
Publication of PL1890680T3 publication Critical patent/PL1890680T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PL06743167T 2005-06-17 2006-06-16 Formulacje diklofenaku i sposoby użycia PL1890680T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69175705P 2005-06-17 2005-06-17
US69202405P 2005-06-17 2005-06-17
EP06743167.6A EP1890680B1 (en) 2005-06-17 2006-06-16 Diclofenac formulations and methods of use

Publications (1)

Publication Number Publication Date
PL1890680T3 true PL1890680T3 (pl) 2017-08-31

Family

ID=37396065

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06743167T PL1890680T3 (pl) 2005-06-17 2006-06-16 Formulacje diklofenaku i sposoby użycia

Country Status (24)

Country Link
US (7) US7759394B2 (pl)
EP (4) EP1890680B1 (pl)
KR (1) KR101352130B1 (pl)
CN (3) CN112755014A (pl)
AR (1) AR057378A1 (pl)
AU (1) AU2006257072B2 (pl)
BR (1) BRPI0612245A2 (pl)
CA (2) CA2932603C (pl)
EC (1) ECSP077989A (pl)
ES (3) ES2717879T3 (pl)
GT (1) GT200600261A (pl)
HK (1) HK1213814A1 (pl)
JO (1) JO3352B1 (pl)
MX (1) MX2007016072A (pl)
NO (1) NO342336B1 (pl)
NZ (1) NZ564002A (pl)
PE (1) PE20070074A1 (pl)
PL (1) PL1890680T3 (pl)
PT (1) PT1890680T (pl)
RU (1) RU2432160C2 (pl)
TR (1) TR201706038T4 (pl)
TW (1) TW200740470A (pl)
WO (1) WO2006133954A2 (pl)
ZA (1) ZA200710858B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974595B1 (en) * 1996-05-17 2005-12-13 Proethic Pharmaceuticals, Inc. Pharmaceutical compositions based on Diclofenae
JO3352B1 (ar) * 2005-06-17 2019-03-13 Apr Applied Pharma Res Sa صيغ دايكلوفيناك وطرق استخدامه
US7700125B2 (en) * 2006-02-07 2010-04-20 Kowa Pharmaceuticals America, Inc. Moisture resistant container systems for rapidly bioavailable dosage forms
AU2008253125B2 (en) * 2007-05-24 2013-11-07 Novartis Ag Oral dosage form providing fast absorption of drug
SG175315A1 (en) 2009-04-24 2011-11-28 Iceutica Pty Ltd A novel formulation of indomethacin
MX347290B (es) * 2009-04-24 2017-04-17 Iceutica Pty Ltd Una formulacion novedosa de diclofenaco.
WO2011036114A1 (en) * 2009-09-25 2011-03-31 Novartis Ag Oral pharmaceutical composition comprising diclofenac
FR2984165B1 (fr) * 2011-12-16 2014-06-27 Pharmeuro Traitement des crises de migraines, notamment d'algies vasculaires de la face
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
US9855234B2 (en) 2014-07-08 2018-01-02 Insys Development Company, Inc. Diclofenac sublingual spray
CN106580886A (zh) * 2016-12-05 2017-04-26 北京万全德众医药生物技术有限公司 一种双氯芬酸钾散剂及其制备方法
WO2019030773A1 (en) * 2017-08-10 2019-02-14 Sarudbhava Formulations Private Limited DICLOFENAC COMPOSITIONS WITH LOW DOSE
US11260026B2 (en) 2018-12-14 2022-03-01 Apr Applied Pharma Research Sa Ready to use diclofenac stick packs
BR112022025132A2 (pt) 2020-06-10 2022-12-27 Applied Pharma Res Formulações de diclofenaco à base de açúcar biodisponíveis
EP3928766A1 (en) 2020-06-26 2021-12-29 Usso Barnas Pharmaceutical composition and use thereof
US20220241230A1 (en) * 2021-02-03 2022-08-04 Patrin Pharma, Inc. Diclofenac sachet composition
CN115317464B (zh) * 2022-09-01 2023-08-08 苏州弘森药业股份有限公司 一种双氯芬酸钾微胶囊及其制备方法
GB2634218A (en) * 2023-09-29 2025-04-09 Approved Pharma Solutions Ltd Powder for oral solution formulations
GB202401873D0 (en) * 2024-02-12 2024-03-27 Hawkins John Lipophilic drug suspensions

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US4344929A (en) * 1980-04-25 1982-08-17 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57191962A (en) 1981-05-20 1982-11-25 Hitachi Ltd Fuel cell
IT1209667B (it) 1985-11-12 1989-08-30 Zambon Spa Composizione effeverscente adattivita' analgesica.
CH673395A5 (pl) * 1987-01-30 1990-03-15 Ciba Geigy Ag
US5211957A (en) * 1988-03-25 1993-05-18 Ciba-Geigy Corporation Solid rapidly disintegrating dosage form
IT1226549B (it) 1988-07-12 1991-01-24 Resa Farma Composizioni farmaceutiche ad attivita' analgesica ed antiinfiammatoria per uso orale, dotate di ottima palatabilita' ed esenti da effetti irritanti sulle mucose.
GB8824392D0 (en) 1988-10-18 1988-11-23 Ciba Geigy Ag Dispersible formulation
GB8920693D0 (en) 1989-09-13 1989-10-25 Nicholas Kiwi Pty Ltd Non-effervescent ibuprofen compositions
EP0466640B1 (de) 1990-06-28 1995-05-24 Ciba-Geigy Ag Alpha-Carbonylphenylacetonitrilderivate als Stabilisatoren für organische Materialien
EP0466650A2 (en) 1990-07-11 1992-01-15 Warner-Lambert Company Improvements in non-steroidal anti-inflammatory therapy
MX9300110A (es) * 1992-01-13 1994-07-29 Gerhard Gergely Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.
CA2141582C (en) * 1992-08-05 2003-09-30 Angelo Mario Morella Pelletised pharmaceutical composition
IT1264696B1 (it) * 1993-07-09 1996-10-04 Applied Pharma Res Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata
DE59408273D1 (de) * 1993-09-07 1999-06-24 Gergely Gerhard Brausemischung mit Alkalisalzen oder Lysinaten saurer, unlöslicher oder schwer löslicher Wirkstoffe
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
JPH10500982A (ja) 1994-05-27 1998-01-27 ファーマーク、ネダーランド、ベスローテン、フェンノートシャップ 医薬組成物
ZA959469B (en) * 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
IT1283029B1 (it) * 1996-05-17 1998-04-03 Resa Farma Composizioni farmaceutiche a base di diclofenac
DE19538555A1 (de) 1995-10-17 1997-04-24 Beiersdorf Ag Gegen Akne und entzündete Comedonen wirksame Wirkstoffkombinationen
ATE260646T1 (de) * 1996-04-16 2004-03-15 Novartis Consumer Health Sa Schnell zerfallende orale dosierungsform
US7687542B2 (en) * 1996-05-17 2010-03-30 Kowa Pharmaeuticals America, Inc. Rapidly bioavailable tablet and capsule formulations of diclofenac
US6974595B1 (en) 1996-05-17 2005-12-13 Proethic Pharmaceuticals, Inc. Pharmaceutical compositions based on Diclofenae
US20060013896A1 (en) 1996-05-17 2006-01-19 Giorgio Reiner Methods of treating acute pain using diclofenac
US5854279A (en) * 1996-06-04 1998-12-29 Eisai Co., Ltd Therapeutic agent for dermatosis
US5914129A (en) 1996-07-23 1999-06-22 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5788987A (en) 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
EP1109534B1 (en) 1998-09-10 2003-02-12 Nycomed Danmark A/S Quick release pharmaceutical compositions of drug substances
DK1312355T3 (da) * 2001-11-20 2003-10-06 Applied Pharma Res Vandopløselige, ikke-brusende farmaceutiske præparater omfattende ikke-steroide antiinflammatoriske medikamenter
RU2202359C1 (ru) * 2002-05-18 2003-04-20 Агафонов Сергей Александрович Лечебно-профилактическое средство
BRPI0409962A (pt) 2003-05-08 2006-04-25 Nektar Therapeutics Uk Ltd co-formulação particulada de uma substáncia ativa e um excipiente, composição farmacêutica ou nutricêutrica, produto farmacêutico ou nutricêutico, método para preparar uma co-formulação particulada de uma substáncia ativa e um excipiente, e, uso de uma substáncia ativa e um excipiente
JO3352B1 (ar) * 2005-06-17 2019-03-13 Apr Applied Pharma Res Sa صيغ دايكلوفيناك وطرق استخدامه
US7700125B2 (en) * 2006-02-07 2010-04-20 Kowa Pharmaceuticals America, Inc. Moisture resistant container systems for rapidly bioavailable dosage forms
US7939561B2 (en) * 2006-02-07 2011-05-10 Apr Applied Pharma Research S.A. Blister packaging for acute pain regimens

Also Published As

Publication number Publication date
US20090197961A1 (en) 2009-08-06
KR101352130B1 (ko) 2014-02-06
TR201706038T4 (tr) 2019-02-21
KR20080024202A (ko) 2008-03-17
HK1213814A1 (zh) 2016-07-15
EP3103441A1 (en) 2016-12-14
EP2705837B1 (en) 2019-02-20
EP1890680A2 (en) 2008-02-27
TW200740470A (en) 2007-11-01
US9827197B2 (en) 2017-11-28
EP2705837A1 (en) 2014-03-12
ECSP077989A (es) 2008-03-26
EP2402003A3 (en) 2012-05-09
NZ564002A (en) 2011-03-31
ES2641889T3 (es) 2017-11-14
CN104856959A (zh) 2015-08-26
RU2008101784A (ru) 2009-07-27
PT1890680T (pt) 2017-05-05
WO2006133954A3 (en) 2007-07-26
EP1890680B1 (en) 2017-03-08
EP2402003B1 (en) 2020-05-06
NO20080352L (no) 2008-03-17
AU2006257072A1 (en) 2006-12-21
US20200323776A1 (en) 2020-10-15
US20150064258A1 (en) 2015-03-05
ES2912897T3 (es) 2022-05-30
US20170319484A1 (en) 2017-11-09
US8097651B2 (en) 2012-01-17
EP2402003A2 (en) 2012-01-04
US7759394B2 (en) 2010-07-20
ZA200710858B (en) 2008-12-31
US20100204330A1 (en) 2010-08-12
CN112755014A (zh) 2021-05-07
NO342336B1 (no) 2018-05-07
CA2632375C (en) 2016-08-16
US20130245122A1 (en) 2013-09-19
BRPI0612245A2 (pt) 2010-10-26
ES2717879T3 (es) 2019-06-26
US8927604B2 (en) 2015-01-06
MX2007016072A (es) 2008-03-10
CA2632375A1 (en) 2006-12-21
RU2432160C2 (ru) 2011-10-27
US20070015831A1 (en) 2007-01-18
JO3352B1 (ar) 2019-03-13
CN101272768A (zh) 2008-09-24
CA2932603C (en) 2017-08-08
EP3103441B1 (en) 2022-03-16
PE20070074A1 (es) 2007-02-08
CA2932603A1 (en) 2006-12-21
WO2006133954A2 (en) 2006-12-21
AR057378A1 (es) 2007-11-28
GT200600261A (es) 2007-02-05
AU2006257072B2 (en) 2012-08-16

Similar Documents

Publication Publication Date Title
ZA200710858B (en) Diclofenac formulations and methods of use
IL184735A0 (en) Pharmaceutical formulations and methods of use
IL189602A0 (en) Indenoisoquinolinone analogs and methods of use thereof
IL186616A (en) Spyro-oxa-indoles and their use as drugs
IL191072A0 (en) Therapeutic compositions and methods
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
IL196462A0 (en) Substituted acylanilides and methods of use thereof
IL197185A0 (en) Substituted acylanilides and methods of use thereof
IL182734A0 (en) 4-aminotetracyclines and methods of use thereof
IL190885A0 (en) Immunogenic compositions and methods of use
IL197060A0 (en) Aza-benzothiophenyl compounds and methods of use
IL185309A0 (en) Isoqunoline compounds and methods of use thereof
IL194028A0 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
IL185723A0 (en) Controlled release pharmaceutical compositions of liothyronine and methods of making and using the same
PL2012805T3 (pl) Kompozycja lecznicza i jej zastosowanie
IL190583A0 (en) Pth formulations and methods of use
ZA200907727B (en) Cinnamaldehyde formulations and methods of use
ZA200900896B (en) Aza-benzofuranyl compounds and methods of use
PT1812072E (pt) Formulações de benzotiazole e sua utilização
PT1786431E (pt) Formulações melhoradas de fotossensibilizador e o seu uso
IL185575A0 (en) Benzoxazocines and their therapeutic use
IL186277A0 (en) Dnt-maleate and methods of preparation thereof
ZA200901009B (en) Aza-benzothiophenyl compounds and methods of use
EP1906950A4 (en) ANSAMYCIN FORMULATIONS AND METHODS OF USE
ZA200703998B (en) Benzothiazole formulations and use thereof