PL1794163T3 - Sposób wytwarzania inhibitorów poli(adp-rybozo)polimerazy - Google Patents
Sposób wytwarzania inhibitorów poli(adp-rybozo)polimerazyInfo
- Publication number
- PL1794163T3 PL1794163T3 PL05783113T PL05783113T PL1794163T3 PL 1794163 T3 PL1794163 T3 PL 1794163T3 PL 05783113 T PL05783113 T PL 05783113T PL 05783113 T PL05783113 T PL 05783113T PL 1794163 T3 PL1794163 T3 PL 1794163T3
- Authority
- PL
- Poland
- Prior art keywords
- adp
- ribose
- preparing poly
- inhibitors
- polymerases
- Prior art date
Links
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 title abstract 2
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 title abstract 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 238000003477 Sonogashira cross-coupling reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61245704P | 2004-09-22 | 2004-09-22 | |
| EP05783113A EP1794163B1 (en) | 2004-09-22 | 2005-09-12 | Method of preparing poly(adp-ribose) polymerases inhibitors |
| PCT/IB2005/002881 WO2006033003A1 (en) | 2004-09-22 | 2005-09-12 | Method of preparing poly(adp-ribose) polymerases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1794163T3 true PL1794163T3 (pl) | 2010-06-30 |
Family
ID=35432127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05783113T PL1794163T3 (pl) | 2004-09-22 | 2005-09-12 | Sposób wytwarzania inhibitorów poli(adp-rybozo)polimerazy |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7323562B2 (pl) |
| EP (1) | EP1794163B1 (pl) |
| JP (1) | JP4966858B2 (pl) |
| KR (2) | KR20080097497A (pl) |
| CN (1) | CN101027306B (pl) |
| AT (1) | ATE452895T1 (pl) |
| AU (1) | AU2005286187B2 (pl) |
| BR (1) | BRPI0515255A (pl) |
| CA (1) | CA2580833C (pl) |
| CY (1) | CY1109945T1 (pl) |
| DE (1) | DE602005018506D1 (pl) |
| DK (1) | DK1794163T3 (pl) |
| ES (1) | ES2337275T3 (pl) |
| IL (1) | IL181322A (pl) |
| MX (1) | MX2007003311A (pl) |
| NO (1) | NO339357B1 (pl) |
| NZ (1) | NZ553201A (pl) |
| PL (1) | PL1794163T3 (pl) |
| PT (1) | PT1794163E (pl) |
| RU (1) | RU2344138C2 (pl) |
| SI (1) | SI1794163T1 (pl) |
| WO (1) | WO2006033003A1 (pl) |
| ZA (1) | ZA200701266B (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2647545C (en) * | 2006-04-03 | 2016-02-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors |
| EP2805945B1 (en) * | 2007-01-10 | 2019-04-03 | MSD Italia S.r.l. | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors |
| JP5989965B2 (ja) | 2008-01-08 | 2016-09-07 | メルク シャープ エンド ドーム リミテッド | ２−｛４−［（３ｓ）−ピペリジン−３−イル］フェニル｝−２ｈ−インダゾール−７−カルボキサミドの薬学的に許容される塩 |
| RS55487B2 (sr) | 2010-02-12 | 2024-06-28 | Pfizer | Soli i polimorfi 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona |
| US8835472B2 (en) * | 2010-09-02 | 2014-09-16 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| CN103242273B (zh) * | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
| DK3182975T3 (da) | 2014-08-22 | 2025-10-20 | Pharma& Schweiz Gmbh | Tabletter med høj doseringsstyrke af rucaparib |
| WO2017013593A1 (en) | 2015-07-22 | 2017-01-26 | Lupin Limited | Isoquinolinone derivatives as parp inhibitors |
| ES2879434T3 (es) | 2015-07-23 | 2021-11-22 | Inst Curie | Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| ES2985767T3 (es) | 2017-01-24 | 2024-11-07 | Assia Chem Ind Ltd | Formas en estado sólido de rucaparib y de sales de rucaparib |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| IT201700085789A1 (it) * | 2017-07-26 | 2019-01-26 | Olon Spa | Metodo per la preparazione di rucaparib ad elevata purezza |
| WO2019115000A1 (en) | 2017-12-15 | 2019-06-20 | Advitech Advisory And Technologies Sa | Process for the preparation of rucaparib and novel synthesis intermediates |
| WO2019130229A1 (en) | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| KR20200121800A (ko) | 2018-01-05 | 2020-10-26 | 싸이브렉사 1, 인크. | 산성 또는 저산소성 질환에 걸린 조직에 관련된 질환의 치료를 위한 화합물, 조성물 및 방법 |
| CN110229162B (zh) * | 2018-03-05 | 2020-08-11 | 新发药业有限公司 | 一种瑞卡帕布的简便制备方法 |
| US20200407720A1 (en) | 2018-03-13 | 2020-12-31 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
| EP3778590A4 (en) | 2018-04-09 | 2021-12-22 | ShanghaiTech University | ANTI PROTEIN DEGRADATION COMPOUND, ANTITUMOR APPLICATION, INTERMEDIATE THEREOF, AND INTERMEDIATE USE |
| CN108752353B (zh) * | 2018-04-28 | 2020-05-08 | 程春晓 | 抗卵巢癌药物Rucaparib关键中间体1408282‐26‐7的制备方法 |
| WO2020072796A1 (en) | 2018-10-03 | 2020-04-09 | Tesaro, Inc. | Crystalline forms of niraparib freebase |
| CN109824677B (zh) * | 2019-04-03 | 2021-09-03 | 江苏开元药业有限公司 | 治疗卵巢癌药物瑞卡帕布的制备方法 |
| MY209459A (en) | 2019-07-10 | 2025-07-09 | Cybrexa 3 Inc | Peptide conjugates of microtubule-targeting agents as therapeutics |
| CA3146560A1 (en) | 2019-07-10 | 2021-01-14 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| CN112321566B (zh) | 2019-08-05 | 2022-06-10 | 上海科技大学 | Egfr蛋白降解剂及其抗肿瘤应用 |
| CN111004244A (zh) * | 2019-12-27 | 2020-04-14 | 重庆市碚圣医药科技股份有限公司 | 一种瑞卡帕布樟脑磺酸盐的合成方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| KR20230002487A (ko) | 2020-04-28 | 2023-01-05 | 리젠 파마슈티컬스 아게 | 폴리(adp-리보스) 폴리머라제(parp) 억제제로서 유용한 신규 화합물 |
| HRP20251324T1 (hr) | 2020-07-14 | 2025-12-05 | Assia Chemical Industries Ltd. | Oblici soli rukapariba u krutom stanju |
| WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
| BR112023020615A2 (pt) | 2021-04-08 | 2023-12-19 | Incozen Therapeutics Pvt Ltd | Inibidores de poli(adp-ribose) polimerase |
| KR102638023B1 (ko) * | 2021-08-03 | 2024-02-19 | 고려대학교 산학협력단 | 신규한 루카파립의 제조방법 |
| KR102589441B1 (ko) * | 2021-08-03 | 2023-10-16 | 고려대학교 산학협력단 | Parp 저해제인 루카파립과 그 중간체의 신규한 제조방법 |
| US20250223295A1 (en) | 2022-01-11 | 2025-07-10 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib tosylate |
| KR102677962B1 (ko) * | 2022-03-02 | 2024-06-25 | 고려대학교 산학협력단 | 루카파립의 개선된 제조방법 |
| CN114874127B (zh) * | 2022-05-23 | 2023-06-09 | 中国药科大学 | 一种二氟羰基化吲哚酮类化合物的制备方法 |
| CN121398822A (zh) | 2023-06-21 | 2026-01-23 | 四方生物科学有限公司 | 用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4125292A1 (de) * | 1991-07-31 | 1993-02-04 | Kali Chemie Pharma Gmbh | 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| HRP20010573B1 (en) * | 1999-01-11 | 2006-04-30 | Agouron Pharmaceuticals | Tricyclic inhibitors of poly(adp-ribose) polymerases |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| CA2520997A1 (en) | 2003-03-31 | 2004-10-14 | Stacie Sara Canan-Koch | Salts of tricyclic inhibitors of poly(adp-ribose) polymerases |
-
2005
- 2005-09-12 PL PL05783113T patent/PL1794163T3/pl unknown
- 2005-09-12 EP EP05783113A patent/EP1794163B1/en not_active Expired - Lifetime
- 2005-09-12 PT PT05783113T patent/PT1794163E/pt unknown
- 2005-09-12 AT AT05783113T patent/ATE452895T1/de active
- 2005-09-12 CA CA2580833A patent/CA2580833C/en not_active Expired - Lifetime
- 2005-09-12 WO PCT/IB2005/002881 patent/WO2006033003A1/en not_active Ceased
- 2005-09-12 DE DE602005018506T patent/DE602005018506D1/de not_active Expired - Lifetime
- 2005-09-12 DK DK05783113.3T patent/DK1794163T3/da active
- 2005-09-12 KR KR1020087026159A patent/KR20080097497A/ko not_active Withdrawn
- 2005-09-12 BR BRPI0515255-0A patent/BRPI0515255A/pt not_active Application Discontinuation
- 2005-09-12 MX MX2007003311A patent/MX2007003311A/es active IP Right Grant
- 2005-09-12 KR KR1020077006426A patent/KR100876520B1/ko not_active Expired - Fee Related
- 2005-09-12 RU RU2007106973/04A patent/RU2344138C2/ru active
- 2005-09-12 CN CN2005800320140A patent/CN101027306B/zh not_active Expired - Fee Related
- 2005-09-12 SI SI200530924T patent/SI1794163T1/sl unknown
- 2005-09-12 NZ NZ553201A patent/NZ553201A/en not_active IP Right Cessation
- 2005-09-12 AU AU2005286187A patent/AU2005286187B2/en not_active Ceased
- 2005-09-12 ES ES05783113T patent/ES2337275T3/es not_active Expired - Lifetime
- 2005-09-12 JP JP2007532991A patent/JP4966858B2/ja not_active Expired - Fee Related
- 2005-09-21 US US11/233,845 patent/US7323562B2/en not_active Expired - Lifetime
-
2007
- 2007-02-13 ZA ZA200701266A patent/ZA200701266B/en unknown
- 2007-02-13 IL IL181322A patent/IL181322A/en active IP Right Grant
- 2007-02-15 NO NO20070858A patent/NO339357B1/no unknown
-
2010
- 2010-03-22 CY CY20101100269T patent/CY1109945T1/el unknown
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