PL1745064T3 - Związki do hamowania enzymu proteazomu - Google Patents
Związki do hamowania enzymu proteazomuInfo
- Publication number
- PL1745064T3 PL1745064T3 PL05735686T PL05735686T PL1745064T3 PL 1745064 T3 PL1745064 T3 PL 1745064T3 PL 05735686 T PL05735686 T PL 05735686T PL 05735686 T PL05735686 T PL 05735686T PL 1745064 T3 PL1745064 T3 PL 1745064T3
- Authority
- PL
- Poland
- Prior art keywords
- peptide
- compounds
- based compounds
- activities
- ntn
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 title abstract 2
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000037012 chymotrypsin-like activity Effects 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 238000007306 functionalization reaction Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56234004P | 2004-04-15 | 2004-04-15 | |
| US56909604P | 2004-05-07 | 2004-05-07 | |
| US59940104P | 2004-08-06 | 2004-08-06 | |
| US61000204P | 2004-09-14 | 2004-09-14 | |
| US61015904P | 2004-09-14 | 2004-09-14 | |
| US61000104P | 2004-09-14 | 2004-09-14 | |
| US62057304P | 2004-10-20 | 2004-10-20 | |
| EP05735686A EP1745064B1 (en) | 2004-04-15 | 2005-04-14 | Compounds for proteasome enzyme inhibition |
| PCT/US2005/012740 WO2005105827A2 (en) | 2004-04-15 | 2005-04-14 | Compounds for proteasome enzyme inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1745064T3 true PL1745064T3 (pl) | 2011-06-30 |
Family
ID=34965899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05735686T PL1745064T3 (pl) | 2004-04-15 | 2005-04-14 | Związki do hamowania enzymu proteazomu |
Country Status (17)
| Country | Link |
|---|---|
| US (9) | US8129346B2 (forum.php) |
| EP (1) | EP1745064B1 (forum.php) |
| JP (3) | JP5616569B2 (forum.php) |
| CN (2) | CN102174076A (forum.php) |
| AT (1) | ATE494298T1 (forum.php) |
| AU (1) | AU2005238445B2 (forum.php) |
| BE (1) | BE2016C014I2 (forum.php) |
| BR (1) | BRPI0509879A (forum.php) |
| CA (1) | CA2562411A1 (forum.php) |
| CY (1) | CY1117244T1 (forum.php) |
| DE (1) | DE602005025750D1 (forum.php) |
| DK (1) | DK1745064T3 (forum.php) |
| IL (3) | IL178400A (forum.php) |
| PL (1) | PL1745064T3 (forum.php) |
| PT (1) | PT1745064E (forum.php) |
| SG (2) | SG185306A1 (forum.php) |
| WO (1) | WO2005105827A2 (forum.php) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| ATE494298T1 (de) * | 2004-04-15 | 2011-01-15 | Proteolix Inc | Verbindungen zur proteasomenzymhemmung |
| AU2012203602B2 (en) * | 2004-04-15 | 2015-08-27 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| US8088741B2 (en) | 2004-05-10 | 2012-01-03 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| AU2005313975B2 (en) * | 2004-12-07 | 2012-09-06 | Onyx Therapeutics, Inc. | Composition for proteasome inhibition |
| MY145757A (en) | 2005-11-09 | 2012-04-13 | Proteolix Inc | Compounds for enzyme inhibition |
| BRPI0713309A2 (pt) | 2006-06-19 | 2012-04-17 | Proteolix Inc | compostos para inibição de enzimas |
| CL2008002966A1 (es) | 2007-10-04 | 2010-06-25 | Onyx Therapeutics Inc | Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros. |
| CN102256616A (zh) | 2008-10-21 | 2011-11-23 | 欧尼斯治疗公司 | 与肽环氧酮的联合疗法 |
| ES2634431T3 (es) | 2009-03-16 | 2017-09-27 | The Governing Council Of The University Of Toronto | Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| GB0914883D0 (en) | 2009-08-26 | 2009-09-30 | Univ Belfast | Compound |
| JP5919196B2 (ja) | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 転移抑制のためのペプチドエポキシケトンの使用 |
| MA34133B1 (fr) | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
| SG185359A1 (en) | 2010-04-07 | 2012-12-28 | Onyx Therapeutics Inc | Crystalline peptide epoxyketone immunoproteasome inhibitor |
| US10159746B2 (en) * | 2012-05-08 | 2018-12-25 | Onyx Therapeutics, Inc. | Cyclodextrin complexation methods for formulating peptide proteasome inhibitors |
| JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| CA2904630A1 (en) | 2013-03-13 | 2014-10-02 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
| JP6851826B2 (ja) | 2013-07-19 | 2021-03-31 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | がんの治療のためのｐｉｍキナーゼ阻害剤と組み合わせたペプチドエポキシケトンプロテアソーム阻害剤 |
| CN103360348B (zh) * | 2013-07-25 | 2015-06-24 | 苏州鹏旭医药科技有限公司 | 一种Carfilzomib中间体及其制备方法和制备Carfilzomib的方法 |
| EP3041832A1 (en) * | 2013-09-06 | 2016-07-13 | Sandoz AG | Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib |
| CN105518019A (zh) * | 2013-09-06 | 2016-04-20 | 桑多斯股份公司 | 肽环氧基酮的合成 |
| CN104710507B (zh) * | 2013-12-11 | 2018-08-14 | 深圳翰宇药业股份有限公司 | 一种卡非佐米的制备方法 |
| WO2015121769A1 (en) | 2014-02-13 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of methyl n-[(benzyloxy)-carbonyl]-l-leucyl-l-phenylalaninate |
| ES2704056T3 (es) * | 2014-07-14 | 2019-03-14 | Centrax Int Inc | Compuestos de epoxicetona para la inhibición de enzimas |
| WO2016046843A1 (en) | 2014-09-24 | 2016-03-31 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of (s)-4-methyl-n-((s)-1-(((s)-4-methyl-1-((r)-2-methyloxiran-2-yl)-1-oxo pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((s)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide |
| WO2016069479A1 (en) | 2014-10-27 | 2016-05-06 | Apicore Us Llc | Methods of making carfilzomib and intermediates thereof |
| US10253066B2 (en) | 2014-12-02 | 2019-04-09 | Fresenius Kabi Oncology Limited | Process for purification of Carfilzomib |
| EP3240575A4 (en) | 2014-12-31 | 2018-07-25 | Dr. Reddy's Laboratories Ltd. | Co-crystal of carfilzomib with maleic acid and process for the preparation of pure carfilzomib |
| WO2016116882A2 (en) * | 2015-01-23 | 2016-07-28 | Leiutis Pharmaceuticals Pvt Ltd | Novel compositions of carfilzomib |
| WO2016170544A1 (en) * | 2015-04-22 | 2016-10-27 | Msn Laboratories Private Limited | Process for the preparation of (2s)-n-((s)-1-((s)-4-methyl-1-((r)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((s)-2-(2-morpholino acetamido)-4-phenylbutanamido)-4-methylpentanamide |
| WO2016170489A1 (en) | 2015-04-24 | 2016-10-27 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of proteasome inhibitor |
| US10364269B2 (en) | 2015-05-21 | 2019-07-30 | Laurus Labs Limited | Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof |
| WO2017079820A1 (en) | 2015-11-11 | 2017-05-18 | Encycle Therapeutics, Inc. | CYCLIC PEPTIDES TARGETING α4β7 INTEGRIN |
| WO2018024645A1 (en) | 2016-08-02 | 2018-02-08 | Synthon B.V. | Process for making carfilzomib |
| WO2018051237A1 (en) | 2016-09-14 | 2018-03-22 | Fresenius Kabi Oncology Limited | A process for purification of carfilzomib intermediate |
| EP3538542B1 (en) | 2016-11-11 | 2021-08-04 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha 4beta 7 integrin |
| EP3330260A1 (en) | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib |
| CN106946981B (zh) * | 2017-03-08 | 2020-08-21 | 南京陵瑞医药科技有限公司 | 一种四肽环氧丙烷衍生物及其制备方法和用途 |
| AU2018266248B2 (en) | 2017-05-10 | 2022-01-27 | Zealand Pharma A/S | Homodetic cyclic peptides targeting a4β7 integrin |
| EP3694878A1 (en) | 2017-09-14 | 2020-08-19 | GlaxoSmithKline Intellectual Property Development Limited | Combination treatment for cancer |
| CN113185575B (zh) * | 2021-05-11 | 2022-07-12 | 四川大学 | 一种花生抗氧化多肽及其制备方法 |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| KR20250008774A (ko) | 2022-05-11 | 2025-01-15 | 셀진 코포레이션 | T 세포 요법 및 그의 생산과 관련된 방법 및 용도 |
| WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
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2005
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- 2005-04-14 BR BRPI0509879-3A patent/BRPI0509879A/pt not_active Application Discontinuation
- 2005-04-14 DE DE602005025750T patent/DE602005025750D1/de not_active Expired - Lifetime
- 2005-04-14 US US11/578,626 patent/US8129346B2/en active Active
- 2005-04-14 DK DK05735686.7T patent/DK1745064T3/da active
- 2005-04-14 AU AU2005238445A patent/AU2005238445B2/en not_active Expired
- 2005-04-14 EP EP05735686A patent/EP1745064B1/en not_active Expired - Lifetime
- 2005-04-14 CN CN201110037869XA patent/CN102174076A/zh active Pending
- 2005-04-14 WO PCT/US2005/012740 patent/WO2005105827A2/en active Application Filing
- 2005-04-14 JP JP2007508543A patent/JP5616569B2/ja not_active Expired - Lifetime
- 2005-04-14 CN CN201310512372.8A patent/CN103554222A/zh active Pending
- 2005-04-14 SG SG2012076659A patent/SG185306A1/en unknown
- 2005-04-14 SG SG200902548-7A patent/SG152239A1/en unknown
- 2005-04-14 PL PL05735686T patent/PL1745064T3/pl unknown
- 2005-04-14 PT PT05735686T patent/PT1745064E/pt unknown
- 2005-04-14 CA CA002562411A patent/CA2562411A1/en not_active Abandoned
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2006
- 2006-09-28 IL IL178400A patent/IL178400A/en active IP Right Grant
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2011
- 2011-02-18 CY CY20111100205T patent/CY1117244T1/el unknown
- 2011-09-12 JP JP2011198810A patent/JP2012041346A/ja active Pending
- 2011-12-22 US US13/334,469 patent/US8207297B2/en not_active Expired - Lifetime
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- 2011-12-22 US US13/334,544 patent/US8207127B2/en not_active Expired - Lifetime
- 2011-12-22 US US13/334,372 patent/US8324174B2/en not_active Expired - Lifetime
- 2011-12-22 US US13/334,288 patent/US8207125B2/en not_active Expired - Lifetime
- 2011-12-22 US US13/334,466 patent/US8207126B2/en not_active Expired - Lifetime
- 2011-12-26 IL IL217210A patent/IL217210A0/en unknown
- 2011-12-26 IL IL217211A patent/IL217211A0/en unknown
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2012
- 2012-03-02 US US13/411,044 patent/US20120277146A1/en not_active Abandoned
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