PL1628965T3 - Związki hydroksyamidynowe i hydroksyguanidynowe jako inhibitory urokinazy - Google Patents

Związki hydroksyamidynowe i hydroksyguanidynowe jako inhibitory urokinazy

Info

Publication number
PL1628965T3
PL1628965T3 PL04734821T PL04734821T PL1628965T3 PL 1628965 T3 PL1628965 T3 PL 1628965T3 PL 04734821 T PL04734821 T PL 04734821T PL 04734821 T PL04734821 T PL 04734821T PL 1628965 T3 PL1628965 T3 PL 1628965T3
Authority
PL
Poland
Prior art keywords
hydroxyamidine
urokinase inhibitors
hydroxyguanidine compounds
hydroxyguanidine
compounds
Prior art date
Application number
PL04734821T
Other languages
English (en)
Inventor
Stefan Sperl
Markus Bürgle
Wolfgang Schmalix
Katja Wosikowski
Bernd Clement
Original Assignee
Wilex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilex Ag filed Critical Wilex Ag
Publication of PL1628965T3 publication Critical patent/PL1628965T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
PL04734821T 2003-05-26 2004-05-26 Związki hydroksyamidynowe i hydroksyguanidynowe jako inhibitory urokinazy PL1628965T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10323898A DE10323898A1 (de) 2003-05-26 2003-05-26 Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
EP04734821.4A EP1628965B1 (de) 2003-05-26 2004-05-26 Hydroxyamidin- und hydroxyguanidin-verbindungen als urokinase-hemmstoffe
PCT/EP2004/005682 WO2004103984A1 (de) 2003-05-26 2004-05-26 Hydroxyamidin- und hydroxyguanidin-verbindungen als urokinase-hemmstoffe

Publications (1)

Publication Number Publication Date
PL1628965T3 true PL1628965T3 (pl) 2016-02-29

Family

ID=33461890

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04734821T PL1628965T3 (pl) 2003-05-26 2004-05-26 Związki hydroksyamidynowe i hydroksyguanidynowe jako inhibitory urokinazy

Country Status (15)

Country Link
US (3) US7608623B2 (pl)
EP (2) EP1628965B1 (pl)
JP (1) JP4621676B2 (pl)
CN (2) CN101791394A (pl)
AU (2) AU2004240771B2 (pl)
BR (1) BRPI0410663B8 (pl)
CA (1) CA2526989C (pl)
DE (1) DE10323898A1 (pl)
DK (1) DK1628965T3 (pl)
ES (1) ES2550611T3 (pl)
HU (1) HUE025940T2 (pl)
MX (1) MXPA05012675A (pl)
PL (1) PL1628965T3 (pl)
PT (1) PT1628965E (pl)
WO (1) WO2004103984A1 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838560B2 (en) * 2002-03-11 2010-11-23 The Medicines Company (Leipzig) Gmbh Urokinase inhibitors, production and use thereof
DE10301300B4 (de) * 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102004045720A1 (de) * 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
DE102004057195A1 (de) 2004-11-26 2006-06-01 Wilex Ag Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
JP2008543900A (ja) 2005-06-24 2008-12-04 ヴィレックス アクチェンゲゼルシャフト 神経病理学的疾患の処置及び／又は予防のためのウロキナーゼ阻害剤の使用
DE102006050672A1 (de) * 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
US20080226624A1 (en) * 2007-03-07 2008-09-18 Wolfgang Schmalix Combined treatment of cancer by urokinase inhibition and a cytostatic anti-cancer agent for enhancing the anti-metastatic effect
WO2008143342A1 (ja) * 2007-05-23 2008-11-27 Dainippon Sumitomo Pharma Co., Ltd. ３－アミノ－２，５－ジオキソピロリジン誘導体の製造方法
US9662308B2 (en) 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
DE102008007381A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten
CN102319241B (zh) * 2011-07-06 2016-02-10 中山大学 一种针对ccl18靶标的化合物在制备抗乳腺癌药物中的应用
DE102011108346A1 (de) * 2011-07-25 2013-01-31 Philipps-Universität Marburg Verwendung von Hemmstoffen der TMPRSS2 als Arzneimittel
US9844540B2 (en) 2015-10-06 2017-12-19 Redhill Biopharma Ltd. Combination therapies for treating cancer
SG11201912043QA (en) * 2017-07-21 2020-02-27 Redhill Biopharma Ltd Use of wx-uk1 and its prodrug, wx-671, for the treatment of non-cancerous medical conditions
EP4117630A4 (en) 2020-03-10 2024-07-03 Redhill Biopharma Ltd TREATMENT OF CORONAVIRUS INFECTIONS
US11471448B2 (en) 2020-12-15 2022-10-18 Redhill Biopharma Ltd. Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia
CN114105910B (zh) * 2021-11-02 2024-04-12 北京悦康科创医药科技股份有限公司 一种羟基脒基苯丙氨酸衍生物、药物组合物与用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
DE4321444A1 (de) 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
JP2852192B2 (ja) 1994-07-08 1999-01-27 カンセアフォースクニングスフォンデン・アフ・１９８９（フォンデン・チル・フレメ・アフ・エクスペリメンテル・カンセアフォースクニング） ｕＰＡＲのドメイン２＋３のｕＰＡ結合部位および抗体
JP4603162B2 (ja) 1998-07-20 2010-12-22 ヴィレックス アクチェンゲゼルシャフト 新規ウロキナーゼインヒビター
AU9059798A (en) * 1998-09-18 2000-04-10 Pentapharm Ag Urokinase inhibitors
DE10029014A1 (de) 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase-Hemmstoffe
US6410005B1 (en) * 2000-06-15 2002-06-25 Pmd Holdings Corp. Branched/block copolymers for treatment of keratinous substrates
AU2001281899A1 (en) 2000-06-27 2002-01-08 D. Collen Research Foundation Vzw Use of urokinase inhibitors for the treatment and/or prevention of pulmonary hypertension and/or cardiac remodelling
EP1808440B1 (en) * 2000-08-11 2011-07-27 Wilex AG Non-covalent inhibitors of urokinase and blood vessel formation
NZ518195A (en) 2000-08-11 2005-04-29 Corvas Int Inc Non-covalent inhibitors of urokinase and blood vessel formation
HUP0400651A2 (hu) * 2000-11-07 2004-06-28 Bristol-Myers Squibb Company Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények
WO2002063303A1 (en) * 2001-02-07 2002-08-15 Graffinity Pharmaceuticals Ag Screening method using solid supports modified with self-assembled monolayers
DE50211672D1 (de) * 2001-03-21 2008-03-27 Wilex Ag Urokinase-inhibitoren
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
US7247724B2 (en) 2002-07-25 2007-07-24 Wilex Ag Method for the production of phenylalanine derivatives

Also Published As

Publication number Publication date
BRPI0410663B1 (pt) 2019-05-21
EP1628965B1 (de) 2015-07-22
BRPI0410663A (pt) 2006-06-20
EP1628965A1 (de) 2006-03-01
AU2004240771A1 (en) 2004-12-02
ES2550611T3 (es) 2015-11-11
DK1628965T3 (en) 2015-11-02
CN101791394A (zh) 2010-08-04
BRPI0410663B8 (pt) 2021-05-25
CA2526989C (en) 2012-12-04
HUE025940T2 (en) 2016-05-30
CA2526989A1 (en) 2004-12-02
US7608623B2 (en) 2009-10-27
AU2009201816A1 (en) 2009-05-28
JP2007513062A (ja) 2007-05-24
US20060142305A1 (en) 2006-06-29
EP2243774A1 (de) 2010-10-27
US20100068272A1 (en) 2010-03-18
CN1795183B (zh) 2010-04-28
DE10323898A1 (de) 2004-12-23
MXPA05012675A (es) 2006-02-22
CN1795183A (zh) 2006-06-28
JP4621676B2 (ja) 2011-01-26
US20080261998A1 (en) 2008-10-23
US7807681B2 (en) 2010-10-05
PT1628965E (pt) 2015-11-04
WO2004103984A1 (de) 2004-12-02
AU2004240771B2 (en) 2009-02-19

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