PL1601450T3 - Ciekły preparat tkankowy z próbek biologicznych, tkanek i komórek poddanych obróbce histopatologicznej - Google Patents

Ciekły preparat tkankowy z próbek biologicznych, tkanek i komórek poddanych obróbce histopatologicznej

Info

Publication number
PL1601450T3
PL1601450T3 PL04719188T PL04719188T PL1601450T3 PL 1601450 T3 PL1601450 T3 PL 1601450T3 PL 04719188 T PL04719188 T PL 04719188T PL 04719188 T PL04719188 T PL 04719188T PL 1601450 T3 PL1601450 T3 PL 1601450T3
Authority
PL
Poland
Prior art keywords
histopatologically
tissues
cells
biological samples
tissue preparation
Prior art date
Application number
PL04719188T
Other languages
English (en)
Inventor
Marlene M Darfler
David B Krizman
Original Assignee
Expression Pathology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Pathology Inc filed Critical Expression Pathology Inc
Publication of PL1601450T3 publication Critical patent/PL1601450T3/pl

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4044Concentrating samples by chemical techniques; Digestion; Chemical decomposition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44Sample treatment involving radiation, e.g. heat
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
PL04719188T 2003-03-10 2004-03-10 Ciekły preparat tkankowy z próbek biologicznych, tkanek i komórek poddanych obróbce histopatologicznej PL1601450T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45295603P 2003-03-10 2003-03-10
EP04719188.7A EP1601450B1 (en) 2003-03-10 2004-03-10 Liquid tissue preparation from histopatologically processed biological samples, tissues and cells
PCT/US2004/007142 WO2004080579A2 (en) 2003-03-10 2004-03-10 Liquid tissue preparation from histopatologically processed biological samples, tissues and cells

Publications (1)

Publication Number Publication Date
PL1601450T3 true PL1601450T3 (pl) 2014-03-31

Family

ID=32990709

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04719188T PL1601450T3 (pl) 2003-03-10 2004-03-10 Ciekły preparat tkankowy z próbek biologicznych, tkanek i komórek poddanych obróbce histopatologicznej

Country Status (9)

Country Link
US (5) US7473532B2 (pl)
EP (1) EP1601450B1 (pl)
JP (1) JP4579234B2 (pl)
CA (1) CA2518569C (pl)
DK (1) DK1601450T3 (pl)
ES (1) ES2428941T3 (pl)
PL (1) PL1601450T3 (pl)
PT (1) PT1601450E (pl)
WO (1) WO2004080579A2 (pl)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
PT1601450E (pt) 2003-03-10 2013-09-06 Expression Pathology Inc Preparação líquida de tecido a partir de amostras biológicas, de tecidos e de células tratados histopatologicamente
US7381440B2 (en) * 2003-06-06 2008-06-03 The United States Of America As Represented By The Secretary Of The Navy Biological laser printing for tissue microdissection via indirect photon-biomaterial interactions
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
DE102005023011A1 (de) * 2005-05-19 2006-11-23 Qiagen Gmbh Quantitative Proteinbestimmung von Formalin fixiertem Gewebe
EP1883705A4 (en) * 2005-05-25 2009-02-25 Expression Pathology Inc MULTIPLEX PROCESS FOR INCREASING PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY TREATED BIOLOGICAL SAMPLES USING LIQUID TISSUE PREPARATIONS
EP1907845A4 (en) * 2005-05-25 2009-03-04 Expression Pathology Inc DIAGNOSIS OF ILLNESSES AND SUFFERING BY ANALYSIS OF HISTOPATHOLOGICALLY PREPARED BIOLOGICAL SAMPLES USING LIQUID TISSUE PREPARATIONS
WO2006130632A2 (en) * 2005-05-31 2006-12-07 Invitrogen Corporation Separation and purification of nucleic acid from paraffin-containing samples
DE102005027172A1 (de) 2005-06-13 2006-12-14 Merck Patent Gmbh Verwendung von Ionischen Flüssigkeiten zur Proteinextraktion
AU2006261624B2 (en) * 2005-06-16 2012-02-02 Solventum Intellectual Properties Company Method of classifying chemically crosslinked cellular samples using mass spectra
DE102005060738A1 (de) * 2005-12-16 2007-06-21 Qiagen Gmbh Verfahren zur Extraktion von Biomolekülen aus fixierten Geweben
WO2007112350A2 (en) * 2006-03-24 2007-10-04 Expression Pathology Method of assessing the metastatic status of a primary tumor
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
US20100075372A1 (en) * 2006-09-28 2010-03-25 Taka-Aki Sato Method for deparaffinization of paraffin-embedded specimen and method for analysis of paraffin-embedded specimen
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
WO2009012353A2 (en) 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
EP2193831A1 (de) * 2008-12-05 2010-06-09 Qiagen GmbH Parallel-Extraktion von unterschiedlichen Biomolekülen aus Formalin-fixiertem Gewebe
DE102009031434B4 (de) * 2009-07-01 2015-03-05 Axagarius Gmbh & Co. Kg Verwendung eines Kits für die Isolierung von Biomolekülen aus biologischen Proben sowie Kit hierfür
CA2785552C (en) * 2009-12-22 2018-02-27 Expression Pathology, Inc. Insulin-like growth factor 1 receptor (igf-1r) protein srm/mrm assay
WO2011087862A1 (en) * 2009-12-22 2011-07-21 Expression Pathology, Inc. Insulin receptor substrate 1 (irs1) protein srm/mrm assay
EP3267194B1 (en) 2009-12-22 2019-06-05 Expression Pathology, Inc. Secreted protein acidic and rich in cysteine (sparc) protein srm/mrm assay
AU2010341485B2 (en) * 2009-12-22 2016-11-17 Expression Pathology, Inc. Epidermal growth factor receptor (EGFR) protein SRM/MRM assay
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
JP2013528284A (ja) * 2010-05-26 2013-07-08 エクスプレッション、パソロジー、インコーポレイテッド ウロキナーゼ型プラスミノーゲン活性化因子タンパク質/プラスミノーゲン活性化因子阻害物質1型タンパク質選択反応モニタリングアッセイ
AU2011282546B2 (en) * 2010-07-30 2016-11-17 Expression Pathology, Inc. c-Src selected reaction monitoring assay
US9427410B2 (en) 2010-10-08 2016-08-30 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
ES2750326T3 (es) 2010-12-27 2020-03-25 Expression Pathology Inc Ensayo SRM/MRM de proteína c-MET
AU2012205337B2 (en) 2011-01-13 2017-04-13 Expression Pathology, Inc. Bcl-2-like protein 11 SRM/MRM assay
CN102146112B (zh) * 2011-01-25 2013-07-10 天根生化科技(北京)有限公司 从福尔马林固定石蜡包埋组织中提取脱氧核糖核酸的方法
US9372196B2 (en) 2011-03-08 2016-06-21 Bioproximity, Llc Formalin-fixed isotope-labeled reference standards and methods for fabrication and use thereof
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
ES2649977T3 (es) 2011-09-22 2018-01-16 Expression Pathology, Inc. Ensayo MRM/SRM para la proteína receptor de muerte 5
CA3045682A1 (en) 2011-09-22 2013-03-28 Expression Pathology, Inc. Multiplex mrm assay for evaluation of cancer
JP6073337B2 (ja) 2011-10-04 2017-02-01 エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. レセプター型チロシンキナーゼerbB−4タンパク質(HER4)に対するSRM/MRMアッセイ
EP2788484B1 (en) 2011-12-06 2017-11-01 Qiagen GmbH Recovery of a biomolecule comprising aqueous phase from a multiphasic mixture
AU2013207952B2 (en) * 2012-01-10 2017-03-09 Expression Pathology, Inc. SRM/MRM assay for the insulin receptor protein
CN103207107B (zh) * 2012-01-16 2016-09-07 中国医学科学院北京协和医院 硝酸纤维素膜富集体液蛋白质组蛋白的用途
EP2850229A4 (en) 2012-05-16 2016-02-17 Expression Pathology Inc SRM / MRM METHOD FOR HISTOLOGICAL SUBTYPING OF PULMONARY TUMORS
US9982290B2 (en) * 2012-10-04 2018-05-29 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
EP2730653A1 (en) 2012-11-07 2014-05-14 QIAGEN GmbH Method for lysing a fixed biological sample
EP3474014B1 (en) 2013-03-15 2020-06-17 Expression Pathology, Inc. Srm assay to indicate cancer therapy
CA2916660C (en) 2013-06-25 2022-05-17 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
JP2017503503A (ja) 2014-01-06 2017-02-02 エクスプレッション、パソロジー、インコーポレイテッド Pd−l1に対するsrmアッセイ
JP6668256B2 (ja) * 2014-04-30 2020-03-25 エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. チロシンプロテインキナーゼ受容体ufo(axl)タンパク質のsrm/mrmアッセイ
EP3137632B1 (en) 2014-04-30 2020-03-25 Expression Pathology, Inc. Srm/mrm assay for the androgen receptor (ar) protein
WO2016004233A2 (en) 2014-07-01 2016-01-07 Expression Pathology, Inc. Srm assays to chemotherapy targets
CN106489075B (zh) * 2014-07-11 2019-10-15 爱科谱迅病理研究公司 针对GTP酶KRas蛋白质(KRas)的SRM/MRM测定
US20190099475A1 (en) 2015-04-08 2019-04-04 Nantomics, Llc Cancer neoepitopes
US10774374B2 (en) 2015-04-10 2020-09-15 Spatial Transcriptomics AB and Illumina, Inc. Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CA2988388C (en) 2015-04-23 2022-11-22 Nantomics, Llc Cancer neoepitopes
CA2986120A1 (en) 2015-05-14 2016-11-17 Expression Pathology, Inc. Srm/mrm assay for the mesothelin (msln) protein
WO2016183597A1 (en) * 2015-05-14 2016-11-17 Expression Pathology, Inc. Srm/mrm assay for the fibroblast growth factor receptor 2 (fgfr2) protein
US10060927B2 (en) 2015-05-14 2018-08-28 Expression Pathology, Inc. SRM/MRM assay for the 6-O-methylguanine-DNA methyltransferase (MGMT) protein
KR102062149B1 (ko) 2015-05-22 2020-01-03 익스프레션 패톨로지, 인크. 사이클린-의존성 키나제 억제제 2A(p16) 단백질에 대한 SRM/MRM 분석법
EP3304072A4 (en) 2015-05-29 2018-12-05 Expression Pathology, Inc. Quantifying her2 protein for optimal cancer therapy
CN108135902A (zh) 2015-07-30 2018-06-08 爱科谱迅病理研究公司 用于最优癌症治疗的定量FR-α和GART蛋白质
WO2017053983A1 (en) 2015-09-24 2017-03-30 Expression Pathology, Inc. Quantifying met protein for cancer treatment
AU2016339022B2 (en) 2015-10-12 2020-09-10 Nantomics, Llc Iterative discovery of neoepitopes and adaptive immunotherapy and methods therefor
CN108701173A (zh) 2015-10-12 2018-10-23 南托米克斯有限责任公司 用于发现预测对检查点抑制剂敏感的msi和新表位的系统、组合物和方法
CA3003302A1 (en) 2015-10-12 2017-04-20 Nantomics, Llc Compositions and methods for viral cancer neoepitopes
TWI733719B (zh) 2015-12-07 2021-07-21 美商河谷控股Ip有限責任公司 改善的組合物及用於新表位之病毒遞送的方法及其應用
EP3414692A4 (en) 2016-02-12 2020-07-29 Nantomics, LLC HIGH-RATE IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES
JP2019513021A (ja) 2016-03-24 2019-05-23 ナントセル,インコーポレイテッド ネオエピトープ提示のための配列の配置および配列
PL3222719T3 (pl) * 2016-03-24 2020-09-21 Allflex Europe Sa Zastosowanie wodnej kompozycji do rozpuszczania biomolekuł z próbki tkanki
US20180172690A1 (en) * 2016-04-20 2018-06-21 Expression Pathology, Inc. Method for improved hepatocellular cancer diagnosis
EP3463452A1 (en) 2016-05-24 2019-04-10 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
EP3500966B1 (en) 2016-08-25 2021-04-21 Nantomics, LLC Immunotherapy markers and uses therefor
US20190321481A1 (en) 2016-11-11 2019-10-24 Nantbio, Inc. Immunomodulatory compositions, processes for making the same, and methods for inhibiting cytokine storms
CN110214275B (zh) 2016-12-01 2022-12-06 南托米克斯有限责任公司 肿瘤抗原性加工和呈递
US10617717B2 (en) 2016-12-04 2020-04-14 Expression Pathology, Inc. Methods of treating lung cancer by predicting responders to cisplatin-pemetrexed combination therapy
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
AU2018226852A1 (en) * 2017-03-03 2019-10-17 Expression Pathology, Inc. Immune profiling of tumor tissue
SG11201909882SA (en) 2017-04-24 2019-11-28 Nantcell Inc Targeted neoepitope vectors and methods therefor
US20200150109A1 (en) 2017-05-05 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
EP3631471A4 (en) 2017-05-30 2021-06-30 Nant Holdings IP, LLC ENRICHMENT OF CIRCULATING TUMOR CELLS USING NEO-EPITOPIA
US10722509B2 (en) 2018-01-16 2020-07-28 Nantomics, Llc Predicting optimal chemotherapy for CRC
US10725045B2 (en) 2018-02-13 2020-07-28 Nantomics, Llc Quantifying MGMT protein for optimal cancer therapy of glioblastoma
US10722531B2 (en) 2018-02-13 2020-07-28 Nantomics, Llc OPRT expression and cancer treatment outcome
AU2019201463A1 (en) 2018-03-09 2019-09-26 Nantomics, Llc Srm/mrm assays for profiling tumor tissue
US20190353660A1 (en) 2018-05-17 2019-11-21 Nantomics, Llc Identification of cancer patients sensitive or resistant to 5-fluorouracil (5-fu)
KR20200050374A (ko) 2018-10-30 2020-05-11 익스프레션 패톨로지, 인크. 노치 경로 단백질용 srm/mrm 분석
EP3894591A2 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Imaging system hardware
EP3906415A1 (en) 2019-01-03 2021-11-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
KR20200087700A (ko) 2019-01-11 2020-07-21 난토믹스, 엘엘씨 질량 분석법에 의한 sdhb 단백질 발현의 평가
JP2022527972A (ja) 2019-04-02 2022-06-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前悪性病変を有する患者において癌を予測及び予防する方法
EP3952850A1 (en) 2019-04-09 2022-02-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
SG11202112712RA (en) 2019-06-03 2021-12-30 Inst Nat Sante Rech Med Methods for modulating a treatment regimen
JP7215467B2 (ja) * 2019-08-19 2023-01-31 株式会社島津製作所 ホルマリン固定パラフィン包埋組織試料からの抗体の分離、検出及び/又は分析方法
WO2021074391A1 (en) 2019-10-17 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing nasal intestinal type adenocarcinomas
EP4045912A1 (en) 2019-10-18 2022-08-24 Reccan Diagnostics AB Apparatuses and methods for detection of pancreatic cancer
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
DK3891300T3 (da) 2019-12-23 2023-05-22 10X Genomics Inc Fremgangsmåder til rumlig analyse ved anvendelse af rna-template-ligering
EP4081777A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Reversible fixing reagents and methods of use thereof
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US20230113705A1 (en) 2020-02-28 2023-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
EP4127164A1 (en) 2020-03-31 2023-02-08 QIAGEN GmbH Nucleic acid purification from fixed biological samples
WO2021207610A1 (en) 2020-04-10 2021-10-14 10X Genomics, Inc. Cold protease treatment method for preparing biological samples
CN115916972A (zh) 2020-04-16 2023-04-04 10X基因组学有限公司 用于被固定样品的组合物和方法
CN115916999A (zh) 2020-04-22 2023-04-04 10X基因组学有限公司 用于使用靶向rna耗竭进行空间分析的方法
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775A1 (en) 2020-05-22 2023-03-29 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
AU2021294334A1 (en) 2020-06-25 2023-02-02 10X Genomics, Inc. Spatial analysis of DNA methylation
JP2023531290A (ja) 2020-06-30 2023-07-21 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び/又は死亡のリスクを予測するための方法
US20230235408A1 (en) 2020-06-30 2023-07-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US20230287475A1 (en) 2020-07-31 2023-09-14 10X Genomics, Inc. De-crosslinking compounds and methods of use for spatial analysis
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022103712A1 (en) 2020-11-13 2022-05-19 10X Genomics, Inc. Nano-partitions (encapsulated nucleic acid processing enzymes) for cell-lysis and multiple reactions in partition-based assays
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
JP2024512567A (ja) 2021-03-23 2024-03-19 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) T細胞リンパ腫の診断および治療方法
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023121449A1 (en) 2021-12-21 2023-06-29 Koninklijke Nederlandse Akademie Van Wetenschappen Central nervous system organoids
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023175366A1 (en) 2022-03-17 2023-09-21 Veracyte Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer
WO2023198648A1 (en) 2022-04-11 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
WO2024018046A1 (en) 2022-07-22 2024-01-25 Institut National de la Santé et de la Recherche Médicale Garp as a biomarker and biotarget in t-cell malignancies
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162504A (en) * 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5225325A (en) * 1990-03-02 1993-07-06 Ventana Medical Systems, Inc. Immunohistochemical staining method and reagents therefor
US5422261A (en) * 1993-04-16 1995-06-06 Baxter International Inc. Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells
US5843657A (en) * 1994-03-01 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Isolation of cellular material under microscopic visualization
US6251467B1 (en) * 1994-03-01 2001-06-26 The United States Of America As Represented By The Department Of Health And Human Services Isolation of cellular material under microscopic visualization
JP3125633B2 (ja) * 1994-07-06 2001-01-22 和光純薬工業株式会社 遺伝子分析用試料としてのパラフィン包埋組織標本の処理方法及び処理用キット
CA2153215A1 (en) * 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
US6274309B1 (en) * 1996-07-26 2001-08-14 Richard Kolesnick Method for the modulation of acid-sphingomyelinase-related apoptosis
US6573043B1 (en) * 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6469159B1 (en) * 1999-04-26 2002-10-22 Robert T. Belly Methods for extracting nucleic acids from tissue samples and paraffin-embedded tissues
US6248535B1 (en) * 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
DE19963198B4 (de) 1999-12-27 2004-12-30 Schulz-Schaeffer, Walter, Dr. Verfahren zum topographischen Proteinnachweis an formalinfixierten Gewebeschnitten
US7001724B1 (en) * 2000-11-28 2006-02-21 Applera Corporation Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
GB2369822A (en) 2000-12-05 2002-06-12 Genovar Diagnostics Ltd Nucleic acid extraction method and kit
WO2002062971A1 (en) * 2001-02-07 2002-08-15 Korea Atomic Energy Research Institute Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells or the preconditioned cells
US6833270B2 (en) * 2001-11-27 2004-12-21 Biorep Technologies, Inc. Apparatus and method for isolating cells from organs
EP2290098A1 (en) * 2002-01-28 2011-03-02 Ambion, Inc. Preparing crude biological extracts using protease, suitable for preparing cDNA
US20040161845A1 (en) * 2003-02-14 2004-08-19 Poo Ramon E. Heating apparatus
DE10306237A1 (de) 2003-02-14 2004-09-02 Daimlerchrysler Ag Verfahren zum Steuern eines Brennstoffzellensystems und Anordnungen zur Durchführung des Vefahrens
PT1601450E (pt) * 2003-03-10 2013-09-06 Expression Pathology Inc Preparação líquida de tecido a partir de amostras biológicas, de tecidos e de células tratados histopatologicamente
CN1878866B (zh) * 2003-07-25 2012-08-01 安比恩股份有限公司 用于从固定的样品中制备rna的方法和组合物
US8012693B2 (en) * 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples

Also Published As

Publication number Publication date
WO2004080579A2 (en) 2004-09-23
EP1601450B1 (en) 2013-06-05
CA2518569A1 (en) 2004-09-23
US20160018304A1 (en) 2016-01-21
CA2518569C (en) 2011-11-15
PT1601450E (pt) 2013-09-06
JP2006519996A (ja) 2006-08-31
EP1601450A4 (en) 2007-10-10
US20130252840A1 (en) 2013-09-26
DK1601450T3 (da) 2013-09-08
US7473532B2 (en) 2009-01-06
WO2004080579A3 (en) 2005-03-31
US8455215B2 (en) 2013-06-04
US20090197776A1 (en) 2009-08-06
US10444126B2 (en) 2019-10-15
JP4579234B2 (ja) 2010-11-10
EP1601450A2 (en) 2005-12-07
US9163275B2 (en) 2015-10-20
US20050014203A1 (en) 2005-01-20
ES2428941T3 (es) 2013-11-12
US20190368986A1 (en) 2019-12-05

Similar Documents

Publication Publication Date Title
PL1601450T3 (pl) Ciekły preparat tkankowy z próbek biologicznych, tkanek i komórek poddanych obróbce histopatologicznej
GB2423151B (en) Examination systems for biological samples
EP1604614A4 (en) CLIP AND CLIP APPLICATOR FOR BIOLOGICAL TISSUE
IL186434A0 (en) Microwave devices for treating biological samples and tissue and methods for using the same
PL1641914T3 (pl) Komórki pochodzące z poporodowej tkanki łożyska oraz sposoby uzyskiwania i zastosowania tych komórek
GB2412913B (en) Compositions and methods for preserving rna in biological samples
HK1080483A1 (en) Rapid extraction of rna from cells and tissues
EP1907845A4 (en) DIAGNOSIS OF ILLNESSES AND SUFFERING BY ANALYSIS OF HISTOPATHOLOGICALLY PREPARED BIOLOGICAL SAMPLES USING LIQUID TISSUE PREPARATIONS
GB2399291B (en) Electrode rod for treating biological tissue
IL180497A0 (en) Biological tissue closure device and method
HK1108913A1 (en) Method and device for the treatment of biological samples
EP1883705A4 (en) MULTIPLEX PROCESS FOR INCREASING PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY TREATED BIOLOGICAL SAMPLES USING LIQUID TISSUE PREPARATIONS
EP1459759A4 (en) MEDICAMENT FOR THE MOBILIZATION OF PLURIPOTENTIAL STEM CELLS FROM TISSUE IN THE PERIPHERAL BLOOD
EP1613959A4 (en) PROCESS FOR DETECTING CANCER CELLS IN BIOLOGICAL SAMPLES
ZA200603566B (en) Tissue sampling needle
EP1581646A3 (en) Extraction of dna from biological samples
AU2003249106A8 (en) Method and apparatus for analyzing biological tissues
EP1869170A4 (en) ISOLATED POPULATIONS OF MYELOID-TYPE BONE MARROW CELL AND METHODS OF TREATMENT THEREOF
EP1651760A4 (en) HUMAN BLOOD PROTEINS EXPRESSED IN MONOCOTYLEDONE SEEDS
EP1603467A4 (en) BLOOD VESSEL-COLLECTING DEVICE
AU2003281309A1 (en) Novel undifferentiated stem cells contained in cord blood, bone marrow, peripheral blood or the like
EP1415601B8 (en) Blood vessel knife
AU2003242360A1 (en) Culture apparatus, artificial tissue and blood preparation
EP1648488A4 (en) MEMBRANE PROTEIN EXPRESSED IN HUMAN MASTOCYTES
EP1887862A4 (en) PRESERVATION SOLUTION FOR ORGANS AND BIOLOGICAL TISSUE