DK1601450T3 - Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler - Google Patents

Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler

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Publication number
DK1601450T3
DK1601450T3 DK04719188.7T DK04719188T DK1601450T3 DK 1601450 T3 DK1601450 T3 DK 1601450T3 DK 04719188 T DK04719188 T DK 04719188T DK 1601450 T3 DK1601450 T3 DK 1601450T3
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DK
Denmark
Prior art keywords
tissues
cells
biological samples
tissue preparation
liquid tissue
Prior art date
Application number
DK04719188.7T
Other languages
English (en)
Inventor
Marlene M Darfler
David B Krizman
Original Assignee
Expression Pathology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Pathology Inc filed Critical Expression Pathology Inc
Application granted granted Critical
Publication of DK1601450T3 publication Critical patent/DK1601450T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4044Concentrating samples by chemical techniques; Digestion; Chemical decomposition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44Sample treatment involving radiation, e.g. heat
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
DK04719188.7T 2003-03-10 2004-03-10 Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler DK1601450T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45295603P 2003-03-10 2003-03-10
PCT/US2004/007142 WO2004080579A2 (en) 2003-03-10 2004-03-10 Liquid tissue preparation from histopatologically processed biological samples, tissues and cells

Publications (1)

Publication Number Publication Date
DK1601450T3 true DK1601450T3 (da) 2013-09-08

Family

ID=32990709

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04719188.7T DK1601450T3 (da) 2003-03-10 2004-03-10 Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler

Country Status (9)

Country Link
US (5) US7473532B2 (da)
EP (1) EP1601450B1 (da)
JP (1) JP4579234B2 (da)
CA (1) CA2518569C (da)
DK (1) DK1601450T3 (da)
ES (1) ES2428941T3 (da)
PL (1) PL1601450T3 (da)
PT (1) PT1601450E (da)
WO (1) WO2004080579A2 (da)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
DK1601450T3 (da) 2003-03-10 2013-09-08 Expression Pathology Inc Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler
US7381440B2 (en) * 2003-06-06 2008-06-03 The United States Of America As Represented By The Secretary Of The Navy Biological laser printing for tissue microdissection via indirect photon-biomaterial interactions
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
DE102005023011A1 (de) * 2005-05-19 2006-11-23 Qiagen Gmbh Quantitative Proteinbestimmung von Formalin fixiertem Gewebe
US8609345B2 (en) * 2005-05-25 2013-12-17 Expression Pathology Incorporated Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations
WO2006127860A2 (en) * 2005-05-25 2006-11-30 Expression Pathology, Inc. Multiplex method for increased proteomic coverage from histopathologically processed biological samples using liquid tissue preparations
JP2008541761A (ja) * 2005-05-31 2008-11-27 インヴィトロジェン コーポレーション パラフィン含有試料からの核酸の分離及び精製
DE102005027172A1 (de) 2005-06-13 2006-12-14 Merck Patent Gmbh Verwendung von Ionischen Flüssigkeiten zur Proteinextraktion
US20110177492A1 (en) * 2005-06-16 2011-07-21 3M Innovative Properties Company Method of classifying chemically crosslinked cellular samples using mass spectra
DE102005060738A1 (de) * 2005-12-16 2007-06-21 Qiagen Gmbh Verfahren zur Extraktion von Biomolekülen aus fixierten Geweben
WO2007112350A2 (en) * 2006-03-24 2007-10-04 Expression Pathology Method of assessing the metastatic status of a primary tumor
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
WO2008038813A1 (fr) * 2006-09-28 2008-04-03 Shimadzu Corporation Procédé de déparaffinage d'un échantillon noyé dans de la paraffine et procédé d'analyse d'un échantillon noyé dans de la paraffine
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
EP2193831A1 (de) * 2008-12-05 2010-06-09 Qiagen GmbH Parallel-Extraktion von unterschiedlichen Biomolekülen aus Formalin-fixiertem Gewebe
DE102009031434B4 (de) * 2009-07-01 2015-03-05 Axagarius Gmbh & Co. Kg Verwendung eines Kits für die Isolierung von Biomolekülen aus biologischen Proben sowie Kit hierfür
JP5731539B2 (ja) * 2009-12-22 2015-06-10 エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. インスリン様増殖因子1受容体(igf−1r)タンパク質srm/mrmアッセイ
ES2643850T3 (es) 2009-12-22 2017-11-24 Expression Pathology, Inc. Ensayo SRM/MRM de la Proteína Secretada Ácida y Rica en Cisteína (SPARC)
CA2785534C (en) * 2009-12-22 2019-07-30 Expression Pathology, Inc. Epidermal growth factor receptor (egfr) protein srm/mrm assay
JP5871816B2 (ja) * 2009-12-22 2016-03-01 エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. インスリン受容体基質1(irs1)タンパク質srm/mrmアッセイ
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
EP2577291A4 (en) * 2010-05-26 2014-11-26 Expression Pathology Inc SELECTIVE REACTION MONITORING OF TYPE-1 PROTEIN INHIBITOR OF PLASMINOGEN ACTIVATOR / UROKINASE PLASMINOGEN ACTIVATORY PROTEIN
ES2655104T3 (es) * 2010-07-30 2018-02-16 Expression Pathology, Inc. Ensayo para controlar una reacción seleccionada con c-Src
US9427410B2 (en) 2010-10-08 2016-08-30 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
WO2012092302A1 (en) 2010-12-27 2012-07-05 Expression Pathology, Inc. Cmet protein srm/mrm assay
CA2824752C (en) 2011-01-13 2018-08-14 Expression Pathology, Inc. Bcl-2-like protein 11 srm/mrm assay
CN102146112B (zh) * 2011-01-25 2013-07-10 天根生化科技(北京)有限公司 从福尔马林固定石蜡包埋组织中提取脱氧核糖核酸的方法
US9372196B2 (en) 2011-03-08 2016-06-21 Bioproximity, Llc Formalin-fixed isotope-labeled reference standards and methods for fabrication and use thereof
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CA2849301C (en) 2011-09-22 2019-07-30 Expression Pathology, Inc. Multiplex mrm assay for evaluation of cancer
WO2013044261A2 (en) 2011-09-22 2013-03-28 Expression Pathology, Inc. Mrm/srm assay for death receptor 5 protein
CA2850667A1 (en) 2011-10-04 2013-04-11 Expression Pathology, Inc. Srm/mrm assay for the receptor tyrosine-protein kinase erbb-4 protein (her4)
CN103998608A (zh) * 2011-12-06 2014-08-20 恰根有限公司 从多相混合物回收包含生物分子的水相
ES2676829T3 (es) * 2012-01-10 2018-07-25 Expression Pathology, Inc. Ensayo de SRM/MRM para la proteína receptor de insulina
CN103207107B (zh) * 2012-01-16 2016-09-07 中国医学科学院北京协和医院 硝酸纤维素膜富集体液蛋白质组蛋白的用途
CA2873632A1 (en) 2012-05-16 2013-11-21 Expression Pathology, Inc. Srm/mrm assay for subtyping lung histology
WO2014055832A1 (en) * 2012-10-04 2014-04-10 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
EP2730653A1 (en) 2012-11-07 2014-05-14 QIAGEN GmbH Method for lysing a fixed biological sample
JP6412100B2 (ja) 2013-03-15 2018-10-24 エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc. 癌療法を示すためのsrmアッセイ
WO2014210223A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
WO2015103645A2 (en) 2014-01-06 2015-07-09 Expression Pathology, Inc. Srm assay for pd-l1
US10126307B2 (en) 2014-04-30 2018-11-13 Expression Pathology, Inc. SRM/MRM assay for the androgen receptor (AR) protein
CN106255765B (zh) * 2014-04-30 2020-07-21 爱科谱迅病理研究公司 针对酪氨酸蛋白激酶受体ufo(axl)蛋白质的srm/mrm测定
WO2016004233A2 (en) 2014-07-01 2016-01-07 Expression Pathology, Inc. Srm assays to chemotherapy targets
CA2954692A1 (en) * 2014-07-11 2016-01-14 Expression Pathology, Inc. Srm/mrm assay for the gtpase kras protein (kras)
WO2016164833A1 (en) 2015-04-08 2016-10-13 Nantomics, Llc Cancer neoepitopes
CN107532207B (zh) 2015-04-10 2021-05-07 空间转录公司 生物样本的空间区别、多重核酸分析
RU2719033C2 (ru) 2015-04-23 2020-04-16 Нантомикс, Ллс Способ получения фармацевтического агента для иммунотерапии рака
US10060927B2 (en) 2015-05-14 2018-08-28 Expression Pathology, Inc. SRM/MRM assay for the 6-O-methylguanine-DNA methyltransferase (MGMT) protein
WO2016183597A1 (en) * 2015-05-14 2016-11-17 Expression Pathology, Inc. Srm/mrm assay for the fibroblast growth factor receptor 2 (fgfr2) protein
KR102071121B1 (ko) 2015-05-14 2020-01-29 익스프레션 패톨로지, 인크. 메소텔린(msln) 단백질에 대한 srm/mrm 분석법
CN107847866B (zh) 2015-05-22 2020-06-30 爱科谱迅病理研究公司 细胞周期蛋白依赖性激酶抑制剂2A(p16)的SRM/MRM测定
CN108027360A (zh) 2015-05-29 2018-05-11 爱科谱迅病理研究公司 用于最优癌症治疗的定量Her2蛋白质
US9746477B2 (en) 2015-07-30 2017-08-29 Expression Pathology, Inc. Quantifying FR-α and GART proteins for optimal cancer therapy
CA2999895A1 (en) 2015-09-24 2017-03-30 Expression Pathology, Inc. Quantifying met protein for cancer treatment
WO2017066357A1 (en) 2015-10-12 2017-04-20 Nantomics, Llc Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors
WO2017066256A2 (en) 2015-10-12 2017-04-20 Nantomics, Llc Compositions and methods for viral cancer neoepitopes
EP3855444A1 (en) 2015-10-12 2021-07-28 Nantomics, LLC Iterative discovery of neoepitopes and adaptive immunotherapy and methods therefor
TWI733719B (zh) 2015-12-07 2021-07-21 美商河谷控股Ip有限責任公司 改善的組合物及用於新表位之病毒遞送的方法及其應用
JP2019511907A (ja) 2016-02-12 2019-05-09 ナントミクス,エルエルシー 癌免疫療法の治療標的としての患者特異的ネオエピトープのハイスループット同定
WO2017222619A2 (en) 2016-03-24 2017-12-28 Nantcell, Inc. Sequence arrangements and sequences for neoepitope presentation
PL3222719T3 (pl) * 2016-03-24 2020-09-21 Allflex Europe Sa Zastosowanie wodnej kompozycji do rozpuszczania biomolekuł z próbki tkanki
US20180172690A1 (en) * 2016-04-20 2018-06-21 Expression Pathology, Inc. Method for improved hepatocellular cancer diagnosis
US20190292259A1 (en) 2016-05-24 2019-09-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
EP3500966B1 (en) 2016-08-25 2021-04-21 Nantomics, LLC Immunotherapy markers and uses therefor
WO2018089637A1 (en) 2016-11-11 2018-05-17 Nantbio, Inc. Immunomodulatory compositions, processes for making the same, and methods for inhibiting cytokine storms
CA3045811A1 (en) 2016-12-01 2018-06-07 Nantomics, Llc Tumor antigenicity processing and presentation
WO2018102827A1 (en) 2016-12-04 2018-06-07 Expression Pathology, Inc. Improved methods of treating lung cancer by predicting responders to cisplatin-pemetrexed combination therapy
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
EP3589744A1 (en) * 2017-03-03 2020-01-08 Expression Pathology, Inc. Immune profiling of tumor tissue
EP3615675A4 (en) 2017-04-24 2021-03-03 Nantcell, Inc. TARGETED NEOEPITOP VECTORS AND METHOD FOR THEREFORE
CA3061429A1 (en) 2017-05-05 2018-11-08 Inserm (Institut National De La Sante Et De La Recherche Medicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
WO2018222433A2 (en) 2017-05-30 2018-12-06 Nant Holdings Ip, Llc Circulating tumor cell enrichment using neoepitopes
US10722509B2 (en) * 2018-01-16 2020-07-28 Nantomics, Llc Predicting optimal chemotherapy for CRC
US10725045B2 (en) 2018-02-13 2020-07-28 Nantomics, Llc Quantifying MGMT protein for optimal cancer therapy of glioblastoma
US10722531B2 (en) 2018-02-13 2020-07-28 Nantomics, Llc OPRT expression and cancer treatment outcome
AU2019201463A1 (en) 2018-03-09 2019-09-26 Nantomics, Llc Srm/mrm assays for profiling tumor tissue
US20190353660A1 (en) 2018-05-17 2019-11-21 Nantomics, Llc Identification of cancer patients sensitive or resistant to 5-fluorouracil (5-fu)
KR20200050374A (ko) 2018-10-30 2020-05-11 익스프레션 패톨로지, 인크. 노치 경로 단백질용 srm/mrm 분석
WO2020123319A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods of using master / copy arrays for spatial detection
BR112021013157A8 (pt) 2019-01-03 2022-12-06 Inst Nat Sante Rech Med Usos de um inibidor de nrp-1, uso de uma combinação, uso de um anticorpo multiespecífico, método ex vivo para predizer, uso de um inibidor, anticorpo multiespecífico, população de células modificadas, método ex vivo de produção e uso de uma população de células t
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
KR20200087700A (ko) 2019-01-11 2020-07-21 난토믹스, 엘엘씨 질량 분석법에 의한 sdhb 단백질 발현의 평가
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
BR112021024374A8 (pt) 2019-06-03 2022-12-06 Inst Nat Sante Rech Med Método para modular um regime de tratamento
JP7215467B2 (ja) * 2019-08-19 2023-01-31 株式会社島津製作所 ホルマリン固定パラフィン包埋組織試料からの抗体の分離、検出及び/又は分析方法
EP4045686A1 (en) 2019-10-17 2022-08-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for diagnosing nasal intestinal type adenocarcinomas
EP4045912A1 (en) 2019-10-18 2022-08-24 Reccan Diagnostics AB Apparatuses and methods for detection of pancreatic cancer
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
CN115135984A (zh) 2019-12-23 2022-09-30 10X基因组学有限公司 可逆固定试剂及其使用方法
SG11202106899SA (en) 2019-12-23 2021-09-29 10X Genomics Inc Methods for spatial analysis using rna-templated ligation
US20210190770A1 (en) 2019-12-23 2021-06-24 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
EP4110955A1 (en) 2020-02-28 2023-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
JP2023521579A (ja) 2020-03-31 2023-05-25 キアゲン ゲーエムベーハー 固定された生体試料からの核酸精製
WO2021207610A1 (en) 2020-04-10 2021-10-14 10X Genomics, Inc. Cold protease treatment method for preparing biological samples
EP4136227A1 (en) 2020-04-16 2023-02-22 10X Genomics, Inc. Compositions and methods for use with fixed samples
EP4242325A3 (en) 2020-04-22 2023-10-04 10X Genomics, Inc. Methods for spatial analysis using targeted rna depletion
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
CN116034166A (zh) 2020-06-25 2023-04-28 10X基因组学有限公司 Dna甲基化的空间分析
EP4172621A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
CN115843335A (zh) 2020-06-30 2023-03-24 国家医疗保健研究所 用于预测患有实体癌的患者在术前辅助治疗和根治性手术后复发和/或死亡风险的方法
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
WO2022025965A1 (en) 2020-07-31 2022-02-03 10X Genomics, Inc. De-crosslinking compounds and methods of use for spatial analysis
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
EP4244379A1 (en) 2020-11-13 2023-09-20 10X Genomics, Inc. Nano-partitions (encapsulated nucleic acid processing enzymes) for cell-lysis and multiple reactions in partition-based assays
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
JP2024512567A (ja) 2021-03-23 2024-03-19 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) T細胞リンパ腫の診断および治療方法
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023121449A1 (en) 2021-12-21 2023-06-29 Koninklijke Nederlandse Akademie Van Wetenschappen Central nervous system organoids
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023175366A1 (en) 2022-03-17 2023-09-21 Veracyte Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer
WO2023198648A1 (en) 2022-04-11 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2023245190A1 (en) 2022-06-17 2023-12-21 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
WO2024018046A1 (en) 2022-07-22 2024-01-25 Institut National de la Santé et de la Recherche Médicale Garp as a biomarker and biotarget in t-cell malignancies
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
WO2024079192A1 (en) 2022-10-12 2024-04-18 Institut National de la Santé et de la Recherche Médicale Cd81 as a biomarker and biotarget in t-cell malignancies

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162504A (en) * 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5225325A (en) 1990-03-02 1993-07-06 Ventana Medical Systems, Inc. Immunohistochemical staining method and reagents therefor
US5422261A (en) 1993-04-16 1995-06-06 Baxter International Inc. Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells
US5843657A (en) * 1994-03-01 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Isolation of cellular material under microscopic visualization
US6251467B1 (en) 1994-03-01 2001-06-26 The United States Of America As Represented By The Department Of Health And Human Services Isolation of cellular material under microscopic visualization
JP3125633B2 (ja) * 1994-07-06 2001-01-22 和光純薬工業株式会社 遺伝子分析用試料としてのパラフィン包埋組織標本の処理方法及び処理用キット
CA2153215A1 (en) * 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
US6274309B1 (en) * 1996-07-26 2001-08-14 Richard Kolesnick Method for the modulation of acid-sphingomyelinase-related apoptosis
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6469159B1 (en) * 1999-04-26 2002-10-22 Robert T. Belly Methods for extracting nucleic acids from tissue samples and paraffin-embedded tissues
US6248535B1 (en) * 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
DE19963198B4 (de) 1999-12-27 2004-12-30 Schulz-Schaeffer, Walter, Dr. Verfahren zum topographischen Proteinnachweis an formalinfixierten Gewebeschnitten
US7001724B1 (en) 2000-11-28 2006-02-21 Applera Corporation Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
GB2369822A (en) * 2000-12-05 2002-06-12 Genovar Diagnostics Ltd Nucleic acid extraction method and kit
JP2004522446A (ja) 2001-02-07 2004-07-29 コリア アトミック エネルギー リサーチ インスティテュート 上皮細胞の分離方法、細胞を前条件付けする方法、およびバイオ人工皮膚もしくは真皮を上皮細胞または条件付けされた細胞を用いて調製する方法
US6833270B2 (en) 2001-11-27 2004-12-21 Biorep Technologies, Inc. Apparatus and method for isolating cells from organs
EP2163652B2 (en) 2002-01-28 2023-05-31 Life Technologies Corporation Preparing crude biological extracts using protease, suitable for preparing cDNA
DE10306237A1 (de) 2003-02-14 2004-09-02 Daimlerchrysler Ag Verfahren zum Steuern eines Brennstoffzellensystems und Anordnungen zur Durchführung des Vefahrens
US20040161845A1 (en) 2003-02-14 2004-08-19 Poo Ramon E. Heating apparatus
DK1601450T3 (da) * 2003-03-10 2013-09-08 Expression Pathology Inc Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler
CN1882688B (zh) 2003-07-25 2014-07-16 安比恩股份有限公司 用于分离小rna分子的方法和组合物
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples

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