PL116947B1 - Process for manufacturing novel derivatives of cyproheptadine - Google Patents
Process for manufacturing novel derivatives of cyproheptadine Download PDFInfo
- Publication number
- PL116947B1 PL116947B1 PL1976222973A PL22297376A PL116947B1 PL 116947 B1 PL116947 B1 PL 116947B1 PL 1976222973 A PL1976222973 A PL 1976222973A PL 22297376 A PL22297376 A PL 22297376A PL 116947 B1 PL116947 B1 PL 116947B1
- Authority
- PL
- Poland
- Prior art keywords
- piperidine
- cycloheptenylidene
- dibenzo
- trifluoromethylthio
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/642,863 US4031222A (en) | 1975-12-22 | 1975-12-22 | Trifluoromethylthio (and sulfonyl) derivatives of cyproheptadine analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL116947B1 true PL116947B1 (en) | 1981-07-31 |
Family
ID=24578354
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1976222973A PL116947B1 (en) | 1975-12-22 | 1976-12-20 | Process for manufacturing novel derivatives of cyproheptadine |
| PL1976222975A PL116941B1 (en) | 1975-12-22 | 1976-12-20 | Process for manufacturing novel derivatives of cyproheptadine |
| PL1976194577A PL116346B1 (en) | 1975-12-22 | 1976-12-20 | Process for preparing novel derivatives of cyproheptadine |
| PL1976222974A PL122145B1 (en) | 1975-12-22 | 1976-12-20 | Process for preparing /-/ isomer of novel derivatives of cyproheptadineogeptadina |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1976222975A PL116941B1 (en) | 1975-12-22 | 1976-12-20 | Process for manufacturing novel derivatives of cyproheptadine |
| PL1976194577A PL116346B1 (en) | 1975-12-22 | 1976-12-20 | Process for preparing novel derivatives of cyproheptadine |
| PL1976222974A PL122145B1 (en) | 1975-12-22 | 1976-12-20 | Process for preparing /-/ isomer of novel derivatives of cyproheptadineogeptadina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4031222A (OSRAM) |
| JP (1) | JPS5278880A (OSRAM) |
| AT (1) | AT363936B (OSRAM) |
| AU (1) | AU506996B2 (OSRAM) |
| BE (1) | BE849678A (OSRAM) |
| CA (1) | CA1085823A (OSRAM) |
| CH (7) | CH625790A5 (OSRAM) |
| DE (1) | DE2657978C3 (OSRAM) |
| DK (1) | DK550976A (OSRAM) |
| ES (6) | ES454468A1 (OSRAM) |
| FI (1) | FI763545A7 (OSRAM) |
| FR (1) | FR2336133A1 (OSRAM) |
| GB (1) | GB1519080A (OSRAM) |
| GR (1) | GR62010B (OSRAM) |
| HU (1) | HU175018B (OSRAM) |
| IE (1) | IE44362B1 (OSRAM) |
| IL (1) | IL51103A (OSRAM) |
| LU (1) | LU76382A1 (OSRAM) |
| NL (1) | NL7613713A (OSRAM) |
| NO (1) | NO146359C (OSRAM) |
| NZ (1) | NZ182868A (OSRAM) |
| PH (1) | PH14088A (OSRAM) |
| PL (4) | PL116947B1 (OSRAM) |
| PT (1) | PT65956B (OSRAM) |
| SE (1) | SE7613796L (OSRAM) |
| ZA (1) | ZA767579B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| US4132796A (en) * | 1977-12-01 | 1979-01-02 | Merck & Co., Inc. | Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine |
| US4285956A (en) * | 1978-05-12 | 1981-08-25 | Kefalas A/S | Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith |
| US4195091A (en) * | 1978-11-15 | 1980-03-25 | Merck & Co., Inc. | Appetite stimulating pyrrolo[2,1-b][3]benzazepines |
| DK538979A (da) * | 1979-01-02 | 1980-07-03 | Merck & Co Inc | Fremgangsmaade til fremstilling af 3-halogencyproheptadiner |
| EP0019797A1 (en) * | 1979-05-21 | 1980-12-10 | Merck & Co. Inc. | Levorotatory and dextrorotatory enantiomers of 3-methoxycyproheptadine and analogs thereof, process for their preparation and antipsychotic pharmaceutical compositions |
| US4275070A (en) * | 1979-05-21 | 1981-06-23 | Merck & Co., Inc. | Antipsychotic pharmaceutical compositions of the levorotatory enantiomers of 3-methoxycyproheptadine and an analog thereof |
| US4220651A (en) * | 1979-05-21 | 1980-09-02 | Merck & Co., Inc. | Antipsychotic levorotatory enantiomers of 3-halocyproheptadines, analogs and derivatives |
| US5231105A (en) * | 1987-06-02 | 1993-07-27 | Ajinomoto Co., Inc. | Ethylamine derivatives and antihypertensives containing the same |
| US5250681A (en) * | 1988-06-02 | 1993-10-05 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US5393890A (en) | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| US4996321A (en) * | 1990-02-26 | 1991-02-26 | Merck & Co., Inc. | Dibenzo[a,d]cycloheptenylidene compounds |
| US5114919A (en) * | 1990-02-26 | 1992-05-19 | Merck & Co., Inc. | Adjuncts in cancer chemotherapy |
| US5021426A (en) * | 1990-02-26 | 1991-06-04 | Merck & Co., Inc. | Method of traeting malaria with cyproheptadine derivatives |
| CN103130708B (zh) * | 2011-12-01 | 2016-08-10 | 上海药明康德新药开发有限公司 | 一种n-叔丁氧羰基-4-硝基哌啶的制备方法 |
| WO2022235813A1 (en) * | 2021-05-04 | 2022-11-10 | The Texas A&M University System | Inhibitors of sars-cov-2 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3851059A (en) * | 1970-02-05 | 1974-11-26 | Merck & Co Inc | Method for the stimulation of appetite in patients |
-
1975
- 1975-12-22 US US05/642,863 patent/US4031222A/en not_active Expired - Lifetime
-
1976
- 1976-12-08 DK DK550976A patent/DK550976A/da unknown
- 1976-12-08 SE SE7613796A patent/SE7613796L/xx not_active Application Discontinuation
- 1976-12-09 NO NO764188A patent/NO146359C/no unknown
- 1976-12-09 FI FI763545A patent/FI763545A7/fi not_active Application Discontinuation
- 1976-12-09 NL NL7613713A patent/NL7613713A/xx unknown
- 1976-12-13 NZ NZ182868A patent/NZ182868A/xx unknown
- 1976-12-13 HU HU76ME2035A patent/HU175018B/hu unknown
- 1976-12-13 PT PT65956A patent/PT65956B/pt unknown
- 1976-12-14 IL IL51103A patent/IL51103A/xx unknown
- 1976-12-14 AU AU20528/76A patent/AU506996B2/en not_active Expired
- 1976-12-14 CH CH1571276A patent/CH625790A5/de not_active IP Right Cessation
- 1976-12-14 LU LU76382A patent/LU76382A1/xx unknown
- 1976-12-16 GR GR52418A patent/GR62010B/el unknown
- 1976-12-16 GB GB52626/76A patent/GB1519080A/en not_active Expired
- 1976-12-16 FR FR7637940A patent/FR2336133A1/fr active Granted
- 1976-12-16 CA CA267,998A patent/CA1085823A/en not_active Expired
- 1976-12-17 IE IE2771/76A patent/IE44362B1/en unknown
- 1976-12-20 AT AT0943376A patent/AT363936B/de not_active IP Right Cessation
- 1976-12-20 PL PL1976222973A patent/PL116947B1/pl unknown
- 1976-12-20 PL PL1976222975A patent/PL116941B1/pl unknown
- 1976-12-20 PL PL1976194577A patent/PL116346B1/pl unknown
- 1976-12-20 PL PL1976222974A patent/PL122145B1/pl unknown
- 1976-12-21 ZA ZA00767579A patent/ZA767579B/xx unknown
- 1976-12-21 ES ES454468A patent/ES454468A1/es not_active Expired
- 1976-12-21 DE DE2657978A patent/DE2657978C3/de not_active Expired
- 1976-12-21 PH PH19273A patent/PH14088A/en unknown
- 1976-12-21 BE BE173486A patent/BE849678A/xx not_active IP Right Cessation
- 1976-12-22 JP JP51153529A patent/JPS5278880A/ja active Pending
-
1978
- 1978-02-01 ES ES466549A patent/ES466549A1/es not_active Expired
- 1978-02-01 ES ES466553A patent/ES466553A1/es not_active Expired
- 1978-02-01 ES ES466550A patent/ES466550A1/es not_active Expired
- 1978-02-01 ES ES466552A patent/ES466552A1/es not_active Expired
- 1978-02-01 ES ES466551A patent/ES466551A1/es not_active Expired
-
1980
- 1980-11-26 CH CH876880A patent/CH627167A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877280A patent/CH626346A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877180A patent/CH626345A5/de not_active IP Right Cessation
- 1980-11-26 CH CH877080A patent/CH626344A5/de not_active IP Right Cessation
- 1980-11-26 CH CH876980A patent/CH626343A5/de not_active IP Right Cessation
-
1981
- 1981-06-01 CH CH357381A patent/CH631164A5/de not_active IP Right Cessation
Also Published As
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