PL111419B1 - Proces for the preparation of novel 5-substituted 1,2-dihydro-3h-pyrolo/1,2-a/-pyrolo-1-carboxylic acids - Google Patents
Proces for the preparation of novel 5-substituted 1,2-dihydro-3h-pyrolo/1,2-a/-pyrolo-1-carboxylic acids Download PDFInfo
- Publication number
- PL111419B1 PL111419B1 PL1978208576A PL20857678A PL111419B1 PL 111419 B1 PL111419 B1 PL 111419B1 PL 1978208576 A PL1978208576 A PL 1978208576A PL 20857678 A PL20857678 A PL 20857678A PL 111419 B1 PL111419 B1 PL 111419B1
- Authority
- PL
- Poland
- Prior art keywords
- dihydro
- pyrrolo
- pyrrole
- dimethyl
- thienoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81837777A | 1977-07-25 | 1977-07-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL208576A1 PL208576A1 (pl) | 1979-05-07 |
| PL111419B1 true PL111419B1 (en) | 1980-08-30 |
Family
ID=25225403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1978208576A PL111419B1 (en) | 1977-07-25 | 1978-07-21 | Proces for the preparation of novel 5-substituted 1,2-dihydro-3h-pyrolo/1,2-a/-pyrolo-1-carboxylic acids |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4140698A (Direct) |
| EP (1) | EP0000649B1 (Direct) |
| JP (1) | JPS5424889A (Direct) |
| AT (1) | AT364843B (Direct) |
| AU (1) | AU515352B2 (Direct) |
| CA (1) | CA1111431A (Direct) |
| CS (1) | CS201015B2 (Direct) |
| DD (1) | DD137229A5 (Direct) |
| DE (1) | DE2860560D1 (Direct) |
| DK (1) | DK146720C (Direct) |
| ES (1) | ES472002A1 (Direct) |
| FI (1) | FI64597C (Direct) |
| GR (1) | GR63733B (Direct) |
| HK (1) | HK17186A (Direct) |
| HU (1) | HU178354B (Direct) |
| IE (1) | IE47138B1 (Direct) |
| IL (1) | IL55181A (Direct) |
| IT (1) | IT1160443B (Direct) |
| MY (1) | MY8800142A (Direct) |
| NO (2) | NO166863C (Direct) |
| NZ (1) | NZ187924A (Direct) |
| PL (1) | PL111419B1 (Direct) |
| PT (1) | PT68328A (Direct) |
| SG (1) | SG31884G (Direct) |
| SU (1) | SU1138029A3 (Direct) |
| YU (1) | YU40717B (Direct) |
| ZA (1) | ZA784216B (Direct) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
| ATE7694T1 (de) * | 1980-02-14 | 1984-06-15 | Grigg, Ronald Ernest | Derivate von 2-methyl-5-thiazolmethylamin und carboxamid. |
| US4344943A (en) * | 1980-06-09 | 1982-08-17 | Syntex (U.S.A.) Inc. | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
| US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
| US4397862A (en) * | 1981-10-13 | 1983-08-09 | Syntex (U.S.A.) Inc. | Gastrointestinal sparing thioester drugs |
| WO1983001382A1 (en) * | 1981-10-13 | 1983-04-28 | Mroszczak, Edward | Gastrointestinal sparing thioester pro-drugs |
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4457941A (en) * | 1982-03-22 | 1984-07-03 | Syntex (U.S.A.) Inc. | Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes |
| EP0117675B1 (en) * | 1983-02-19 | 1986-07-23 | Beecham Group Plc | Benzofuran and benzothiophene-carboxylic-acid derivatives |
| US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
| JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体 |
| CA2166780A1 (en) * | 1993-07-08 | 1995-01-19 | Ooi Wong | Monolithic matrix transdermal delivery system |
| US5621115A (en) * | 1996-02-21 | 1997-04-15 | Ohmeda Pharmaceutical Products Division Inc. | Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids |
| US6191285B1 (en) | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
| WO2000002855A2 (en) * | 1998-07-10 | 2000-01-20 | Mallinckrodt Inc. | Synthesis of compounds useful in the manufacture of ketorolac |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087539A (en) * | 1976-07-14 | 1978-05-02 | Syntex (U.S.A.) Inc. | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| JPS539789A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative |
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
| US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
-
1978
- 1978-05-30 US US05/910,979 patent/US4140698A/en not_active Expired - Lifetime
- 1978-07-20 CS CS784851A patent/CS201015B2/cs unknown
- 1978-07-20 YU YU1741/78A patent/YU40717B/xx unknown
- 1978-07-20 PT PT68328A patent/PT68328A/pt unknown
- 1978-07-20 DE DE7878300174T patent/DE2860560D1/de not_active Expired
- 1978-07-20 DK DK325078A patent/DK146720C/da not_active IP Right Cessation
- 1978-07-20 EP EP78300174A patent/EP0000649B1/en not_active Expired
- 1978-07-20 IL IL55181A patent/IL55181A/xx active IP Right Grant
- 1978-07-20 CA CA307,762A patent/CA1111431A/en not_active Expired
- 1978-07-20 AT AT0528978A patent/AT364843B/de not_active IP Right Cessation
- 1978-07-21 HU HU78SI1640A patent/HU178354B/hu unknown
- 1978-07-21 PL PL1978208576A patent/PL111419B1/pl unknown
- 1978-07-21 NZ NZ187924A patent/NZ187924A/xx unknown
- 1978-07-21 JP JP8852578A patent/JPS5424889A/ja active Granted
- 1978-07-21 FI FI782307A patent/FI64597C/fi not_active IP Right Cessation
- 1978-07-21 IE IE1473/78A patent/IE47138B1/en not_active IP Right Cessation
- 1978-07-21 DD DD78206857A patent/DD137229A5/xx not_active IP Right Cessation
- 1978-07-24 NO NO78782545A patent/NO166863C/no unknown
- 1978-07-24 ES ES472002A patent/ES472002A1/es not_active Expired
- 1978-07-24 AU AU38269/78A patent/AU515352B2/en not_active Expired
- 1978-07-24 SU SU782641055A patent/SU1138029A3/ru active
- 1978-07-24 IT IT68765/78A patent/IT1160443B/it active
- 1978-07-24 GR GR56852A patent/GR63733B/el unknown
- 1978-07-25 ZA ZA784216A patent/ZA784216B/xx unknown
-
1984
- 1984-04-19 SG SG318/84A patent/SG31884G/en unknown
-
1985
- 1985-05-14 NO NO85851935A patent/NO155244C/no unknown
-
1986
- 1986-03-13 HK HK171/86A patent/HK17186A/en not_active IP Right Cessation
-
1988
- 1988-12-30 MY MY78300174.6A patent/MY8800142A/xx unknown
Also Published As
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