PH30242A - Serotonin 5htia agonists - Google Patents

Serotonin 5htia agonists

Info

Publication number
PH30242A
PH30242A PH43017A PH43017A PH30242A PH 30242 A PH30242 A PH 30242A PH 43017 A PH43017 A PH 43017A PH 43017 A PH43017 A PH 43017A PH 30242 A PH30242 A PH 30242A
Authority
PH
Philippines
Prior art keywords
serotonin
agonists
5htia agonists
serotonin 5htia
directed
Prior art date
Application number
PH43017A
Other languages
English (en)
Inventor
Ian A Mcdonald
Ronald C Bernotas
Jeffrey S Sprouse
Mark W Dudley
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PH30242A publication Critical patent/PH30242A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
PH43017A 1990-08-29 1991-08-29 Serotonin 5htia agonists PH30242A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57471090A 1990-08-29 1990-08-29
US07/735,700 US5189179A (en) 1990-08-29 1991-07-30 Serotonin 5ht1a agonists

Publications (1)

Publication Number Publication Date
PH30242A true PH30242A (en) 1997-02-05

Family

ID=27076473

Family Applications (1)

Application Number Title Priority Date Filing Date
PH43017A PH30242A (en) 1990-08-29 1991-08-29 Serotonin 5htia agonists

Country Status (21)

Country Link
US (3) US5189179A (fr)
EP (1) EP0478954B1 (fr)
JP (1) JPH04270264A (fr)
KR (1) KR920004345A (fr)
CN (1) CN1030766C (fr)
AT (1) ATE197040T1 (fr)
AU (1) AU641535B2 (fr)
CA (1) CA2049803A1 (fr)
DE (1) DE69132450T2 (fr)
DK (1) DK0478954T3 (fr)
ES (1) ES2153346T3 (fr)
FI (1) FI914065A (fr)
GR (1) GR3035062T3 (fr)
HU (1) HU208955B (fr)
IE (1) IE913036A1 (fr)
IL (1) IL99306A (fr)
NO (1) NO175430C (fr)
NZ (1) NZ239521A (fr)
PH (1) PH30242A (fr)
PT (1) PT98800B (fr)
TW (1) TW200457B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
USRE38506E1 (en) 1991-10-04 2004-04-20 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US6406859B1 (en) 1992-01-08 2002-06-18 Synaptic Pharmaceutical Corporation DNA encoding a 5-HT 1F receptor and uses thereof
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9304632D0 (en) * 1993-03-06 1993-04-21 Wyeth John & Brother Ltd Amide derivatives
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
US5478572A (en) * 1994-09-06 1995-12-26 Bristol-Myers Squibb Co. Gepirone dosage form
EP0894085B1 (fr) 1996-03-29 2005-08-17 Pfizer Inc. Derives du benzyl(diene)-lactame, leur preparation et leur utilisation comme antagonistes/agonistes des recepteurs 5-ht1a- et/ou 5-ht1d
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6121307A (en) * 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CA2327360A1 (fr) * 1998-04-08 1999-10-14 Richard Eric Mewshaw Derives d'amine indol-3-yl-cyclhexyle utilises dans le traitement de la depression (antagonistes du recepteur 5-ht1)
AU3479299A (en) * 1998-04-08 1999-10-25 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CA2327359A1 (fr) * 1998-04-08 1999-10-14 Wyeth N-aryloxyethyl-indoly-alkylamines utilisees pour le traitement de la depression (principes actifs de recepteurs du type 5-ht1a)
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US7588029B2 (en) * 2000-03-21 2009-09-15 Fisher & Paykel Healthcare Limited Humidified gases delivery apparatus
AU2002325712C1 (en) 2001-08-30 2008-07-31 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use theeof
AR036401A1 (es) * 2001-09-14 2004-09-08 Stem Cell Therapeutics Inc Incremento de la cantidad de celulas madre neuronales inducido por prolactina.
US20030054551A1 (en) * 2001-09-18 2003-03-20 Stem Cell Therapeutics Inc. Effect of growth hormone and IGF-1 on neural stem cells
EP1546198A1 (fr) * 2002-07-31 2005-06-29 Stem Cell Therapeutics Inc. Procede d'amelioration de la proliferation, de la differentiation et de la survie de cellules souches neurales au moyen du polypeptide d'activation d'adenylate cyclase hypophysaire (pacap)
ATE546134T1 (de) * 2002-12-26 2012-03-15 Pozen Inc Mehrschichtige dosierformen enthaltend naproxen und triptane
KR20060015641A (ko) * 2003-06-06 2006-02-17 글락소 그룹 리미티드 트립탄 및 ｎｓａｉｄ를 포함하는 조성물
WO2005018541A2 (fr) * 2003-07-11 2005-03-03 Pharmacia Corporation Compositions renfermant un inhibiteur selectif de la cyclo-oxygenase-2 et un agent modulant la serotonine destinees au traitement de lesions du systeme nerveux central
US20070111932A1 (en) * 2003-07-31 2007-05-17 Stem Cell Therapeutics Inc. Method of enhancing and/or inducing neuronal migration using erythropoietin
EP1660079A2 (fr) * 2003-08-22 2006-05-31 Pharmacia Corporation Compositions d'un inhibiteur selectif de la cyclo-oxygenase 2 et d'un agent de modulation de la serotonine pour le traitement de la neoplasie
CN1325673C (zh) * 2003-12-30 2007-07-11 上海交通大学 利用废旧紫铜生产无氧铜的装置
US7846898B2 (en) * 2004-02-13 2010-12-07 Stem Cell Therapeutics Corp. Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
JP2008545650A (ja) 2005-05-20 2008-12-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ スルファミド誘導体の製造方法
JP2009509943A (ja) 2005-09-27 2009-03-12 ステム セル セラピューティクス コーポレイション プロラクチンにより制御される乏突起膠細胞前駆体細胞の増殖
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
AU2007229301B2 (en) * 2006-03-17 2013-08-01 Stem Cell Therapeutics Corp. Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents
TW200812573A (en) 2006-05-19 2008-03-16 Janssen Pharmaceutica Nv Co-therapy for the treatment of epilepsy and related disorders
MX2011000090A (es) 2008-06-23 2011-03-02 Janssen Pharmaceutica Nv Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]diox in-2-ilmetil)sulfamida.
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CN111116451A (zh) * 2020-01-16 2020-05-08 宁波大学 一种多取代色胺基苯甲酰胺类化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725386A (en) * 1953-02-13 1955-11-29 Fond Emanuele Paterno 2-(1, 4-benzodioxan) methyl derivatives of amino-lower fatty acid amides and preparation thereof
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4684739A (en) * 1980-12-15 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene derivatives and acid addition salts thereof
US4614807A (en) * 1984-10-04 1986-09-30 Eli Lilly And Company 6,7-dihalomelatonins
ATE65084T1 (de) * 1986-06-26 1991-07-15 Ciba Geigy Ag Hydrierte 1-benzooxacycloalkylpyridincarbons|ureverbindungen.
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
US5120758A (en) * 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors

Also Published As

Publication number Publication date
AU8266491A (en) 1992-03-05
CA2049803A1 (fr) 1992-03-01
AU641535B2 (en) 1993-09-23
US5387604A (en) 1995-02-07
CN1030766C (zh) 1996-01-24
EP0478954B1 (fr) 2000-10-18
GR3035062T3 (en) 2001-03-30
FI914065A0 (fi) 1991-08-28
FI914065A (fi) 1992-03-01
KR920004345A (ko) 1992-03-27
NO913384L (no) 1992-03-02
US5189179A (en) 1993-02-23
EP0478954A1 (fr) 1992-04-08
TW200457B (fr) 1993-02-21
IE913036A1 (en) 1992-03-11
DE69132450D1 (de) 2000-11-23
NO913384D0 (no) 1991-08-28
HUT59092A (en) 1992-04-28
NO175430C (no) 1994-10-12
PT98800B (pt) 1999-01-29
IL99306A0 (en) 1992-07-15
IL99306A (en) 1995-03-30
CN1059717A (zh) 1992-03-25
PT98800A (pt) 1992-08-31
NO175430B (no) 1994-07-04
ATE197040T1 (de) 2000-11-15
US5559143A (en) 1996-09-24
JPH04270264A (ja) 1992-09-25
DK0478954T3 (da) 2001-01-08
DE69132450T2 (de) 2001-05-03
NZ239521A (en) 1993-07-27
ES2153346T3 (es) 2001-03-01
HU208955B (en) 1994-02-28

Similar Documents

Publication Publication Date Title
PH30242A (en) Serotonin 5htia agonists
NZ240230A (en) Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
MX9203338A (es) Nuevos derivados del oxico a_nor-esteroide-3-carboxilico.
NO901392D0 (no) Immunomodulerende azaspiraner.
GR3023040T3 (en) Substituted indoles as anti-aids pharmaceuticals
IL89921A (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
ES2107998T3 (es) Alcanolaminas derivatizadas como agentes cardiovasculares.
DK0406211T3 (da) Fucosidase-inhibitorer
AP8800109A0 (en) "Heterocyclic insecticides".
PT81933A (en) Process for preparing improved antiinflammatory compositions containing pyroxicam and inositol
DE69328774D1 (de) Herstellung von körnigen alkalimetallborat-zusammensetzungen
HUT64517A (en) Process for producing 1-piperidinyl-alkanoyl-aryl-sulfonamide derivatives and pharmaceutical compositions containing them
GR3019047T3 (en) Heterocyclic-NMDA antagonists.
DK0673913T3 (da) Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler
DE3781986D1 (de) Substituierte chinoxaline.
ES2027507A6 (es) Procedimiento de preparacion de derivados selenofenicos.
ATE42280T1 (de) Derivate des bicyclo(3.3.0>oktans und ihre herstellung.
DE69002027D1 (de) (3-diethylaminopropyl)-1-amino-5-methyldipyrido(4,3-b)(3,4-f)indoltrihydrochlorid.