PH27573A - New heterocyclic derivatives - Google Patents

New heterocyclic derivatives

Info

Publication number
PH27573A
PH27573A PH41927A PH41927A PH27573A PH 27573 A PH27573 A PH 27573A PH 41927 A PH41927 A PH 41927A PH 41927 A PH41927 A PH 41927A PH 27573 A PH27573 A PH 27573A
Authority
PH
Philippines
Prior art keywords
heterocyclic derivatives
new heterocyclic
new
derivatives
heterocyclic
Prior art date
Application number
PH41927A
Other languages
English (en)
Inventor
John W Petterson
Bruce H Devens
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of PH27573A publication Critical patent/PH27573A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PH41927A 1990-02-02 1991-02-01 New heterocyclic derivatives PH27573A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/474,430 US5001124A (en) 1990-02-02 1990-02-02 4-isoxazolecarboxamide derivatives

Publications (1)

Publication Number Publication Date
PH27573A true PH27573A (en) 1993-08-18

Family

ID=23883499

Family Applications (1)

Application Number Title Priority Date Filing Date
PH41927A PH27573A (en) 1990-02-02 1991-02-01 New heterocyclic derivatives

Country Status (16)

Country Link
US (2) US5001124A (de)
EP (1) EP0440503A1 (de)
JP (1) JPH06340641A (de)
KR (1) KR910021388A (de)
AU (1) AU643494B2 (de)
CA (1) CA2035544A1 (de)
FI (1) FI910503A (de)
HU (1) HUT60479A (de)
IE (1) IE910348A1 (de)
IL (1) IL97050A0 (de)
NO (1) NO910395L (de)
NZ (1) NZ236985A (de)
PH (1) PH27573A (de)
PT (1) PT96633A (de)
TW (1) TW207534B (de)
ZA (1) ZA91782B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464860A (en) * 1988-11-30 1995-11-07 Novapharme N(pyrazol-3-yl) benzamides and pharmaceutical compositions
US5258397A (en) * 1988-11-30 1993-11-02 Novapharme 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
US5201932A (en) * 1989-09-22 1993-04-13 Basf Aktiengesellschaft Carboxamides
DE4209849A1 (de) * 1992-03-26 1993-09-30 Basf Ag Herstellung von Isoxazol-3-carbonsäureamid-4-carbonsäureestern durch selektive Amidierung
DE4214010A1 (de) * 1992-04-29 1993-11-04 Basf Ag Isoxazolcarbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
GB9209330D0 (en) * 1992-04-30 1992-06-17 Roussel Lab Ltd Chemical compounds
TW314467B (de) * 1993-03-31 1997-09-01 Hoechst Ag
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
CA2117413C (en) * 1993-07-30 2006-11-21 Neil Geach Herbicidal isoxazole-4-yl-methanone derivatives
US5430536A (en) * 1993-10-12 1995-07-04 Xerox Corporation Automatic duplex and simplex document handler for electronic input
CA2202904C (en) * 1994-10-17 2006-12-19 Yukio Amano Pharmaceutical composition for prophylaxis and treatment of type i allergic diseases
JPH10158192A (ja) 1996-10-03 1998-06-16 Eisai Co Ltd 移植片対宿主疾患(gvhd)の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物
US6206913B1 (en) * 1998-08-12 2001-03-27 Vascular Innovations, Inc. Method and system for attaching a graft to a blood vessel
WO2003006424A1 (en) * 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
DE10162684A1 (de) * 2001-12-19 2003-07-10 Bayer Ag Verfahren zur Herstellung von Aminen
US7365094B2 (en) 2002-12-23 2008-04-29 4Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP1541198A1 (de) * 2003-12-05 2005-06-15 4Sc Ag Cycloalkyl-Verbindungen als anti-inflammatorischen, immunomodulatorischen und antiproliferativen Mittel
US7247736B2 (en) 2002-12-23 2007-07-24 4Sc Ag Method of identifying inhibitors of DHODH
WO2004056747A1 (en) * 2002-12-23 2004-07-08 4Sc Ag Dhodh-inhibitors and method for their identification
WO2004056746A1 (en) 2002-12-23 2004-07-08 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP1715334A1 (de) 2005-04-22 2006-10-25 Adamant Technologies SA Verfahren unter Verwendung eines Elektrochemischen Sensors und Elektroden, die diesen Sensor bilden
EP1894919B1 (de) * 2005-06-07 2012-03-28 Shionogi & Co., Ltd. Heterocyclische verbindung mit typ-i-11-beta-hydroxysteroiddehydrogenasehemmender wirkung
WO2007114124A1 (ja) * 2006-03-30 2007-10-11 Shionogi & Co., Ltd. I型11βヒドロキシステロイド脱水素酵素阻害活性を有するイソキサゾール誘導体およびイソチアゾール誘導体
CN104350051B (zh) * 2011-11-23 2017-03-08 德克萨斯大学系统董事会 用于糖尿病的异噁唑治疗剂
CN105622537A (zh) * 2016-03-01 2016-06-01 青岛大学 一种3,4,5-三取代异恶唑类化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1013906A (en) * 1961-08-18 1965-12-22 Pfizer & Co C Cyclization process and product
ES448386A1 (es) * 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
DE2854439A1 (de) * 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
US4284785A (en) * 1979-12-19 1981-08-18 American Cyanamid Company Substituted phenyl esters of isoxazolecarboxylic acids
DE3247454A1 (de) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides

Also Published As

Publication number Publication date
US5328907A (en) 1994-07-12
HU910354D0 (en) 1991-08-28
NZ236985A (en) 1993-04-28
US5001124A (en) 1991-03-19
PT96633A (pt) 1991-10-31
EP0440503A1 (de) 1991-08-07
FI910503A0 (fi) 1991-02-01
CA2035544A1 (en) 1991-08-03
NO910395L (no) 1991-08-05
AU643494B2 (en) 1993-11-18
ZA91782B (en) 1992-10-28
FI910503A (fi) 1991-08-03
NO910395D0 (no) 1991-02-01
IL97050A0 (en) 1992-03-29
JPH06340641A (ja) 1994-12-13
IE910348A1 (en) 1991-08-14
KR910021388A (ko) 1991-12-20
HUT60479A (en) 1992-09-28
TW207534B (de) 1993-06-11
AU7016591A (en) 1991-08-08

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