PH26199A - Poly-kringle plasmogen activator - Google Patents

Poly-kringle plasmogen activator Download PDF

Info

Publication number
PH26199A
PH26199A PH34127A PH34127A PH26199A PH 26199 A PH26199 A PH 26199A PH 34127 A PH34127 A PH 34127A PH 34127 A PH34127 A PH 34127A PH 26199 A PH26199 A PH 26199A
Authority
PH
Philippines
Prior art keywords
dna
kringle
ser
plasminogen activator
hybrid
Prior art date
Application number
PH34127A
Other languages
English (en)
Inventor
Paul Porwen Hung
Narender Kumar Kalyan
Shawguang Lin Lee
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of PH26199A publication Critical patent/PH26199A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PH34127A 1985-08-14 1986-08-12 Poly-kringle plasmogen activator PH26199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76616385A 1985-08-14 1985-08-14
US06/884,835 US4916071A (en) 1985-08-14 1986-07-11 Poly-kringle plasminogen activator

Publications (1)

Publication Number Publication Date
PH26199A true PH26199A (en) 1992-03-18

Family

ID=27117699

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34127A PH26199A (en) 1985-08-14 1986-08-12 Poly-kringle plasmogen activator

Country Status (15)

Country Link
US (1) US4916071A (de)
EP (1) EP0213794B1 (de)
JP (2) JPH0829086B2 (de)
KR (1) KR900007649B1 (de)
AU (1) AU596369B2 (de)
CA (1) CA1341449C (de)
DE (1) DE3676760D1 (de)
DK (1) DK175420B1 (de)
GB (1) GB2179948B (de)
GR (1) GR862076B (de)
HU (1) HU200795B (de)
IE (1) IE59380B1 (de)
IL (1) IL79644A (de)
PH (1) PH26199A (de)
PT (1) PT83170B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
JP2581668B2 (ja) * 1985-11-27 1997-02-12 三井東圧化学株式会社 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
EP0231624B1 (de) * 1985-12-20 1993-01-27 The Upjohn Company Analoge des gewebespezifischen Plasminogenaktivators
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
EP0299053A1 (de) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermale wachstumsfaktor-plasminogenaktivatoren
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
GB8711957D0 (en) * 1987-05-20 1987-06-24 Beecham Group Plc Compounds
EP0292009A1 (de) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytische Proteine
ZA884012B (en) * 1987-06-04 1989-02-22 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
EP0297882B1 (de) * 1987-07-01 1993-08-25 Beecham Group Plc Hybride Plasminogenaktivatoren
EP0394261A4 (en) * 1987-07-06 1991-09-11 Genetics Institute, Inc. Novel thrombolytic proteins
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
AU3410289A (en) * 1988-04-22 1989-11-24 Collaborative Research Inc. Plasminogen activators with increased fibrin selectivity
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
WO2003087393A2 (en) * 2002-04-09 2003-10-23 Global Biotech Inc. Human tissue urokinase type plasminogen activator production
WO2009086552A1 (en) * 2008-01-02 2009-07-09 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
US11629198B2 (en) 2017-12-05 2023-04-18 The Trustees Of The University Of Pennsylvania Fusion proteins and antibodies targeting human red blood cell antigens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78180B (de) * 1982-04-15 1984-09-26 Genentech Inc
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
AR241654A1 (es) 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
EP0231883B1 (de) * 1986-01-31 1992-09-02 Sagami Chemical Research Center Hybrides Plasminogenaktivatorähnliches Polypeptid

Also Published As

Publication number Publication date
JP2610783B2 (ja) 1997-05-14
GB2179948B (en) 1989-08-16
JPH0829086B2 (ja) 1996-03-27
KR870002264A (ko) 1987-03-30
DK385686A (da) 1987-02-15
HUT41443A (en) 1987-04-28
DE3676760D1 (de) 1991-02-14
CA1341449C (en) 2003-12-09
GB8619154D0 (en) 1986-09-17
HU200795B (en) 1990-08-28
EP0213794B1 (de) 1991-01-09
GR862076B (en) 1986-12-24
IE59380B1 (en) 1994-02-23
KR900007649B1 (ko) 1990-10-17
US4916071A (en) 1990-04-10
AU6110286A (en) 1987-02-19
AU596369B2 (en) 1990-05-03
IL79644A (en) 1991-06-10
IE862178L (en) 1987-02-14
DK175420B1 (da) 2004-10-04
GB2179948A (en) 1987-03-18
JPH07147984A (ja) 1995-06-13
JPS62104577A (ja) 1987-05-15
PT83170A (en) 1986-09-01
IL79644A0 (en) 1986-11-30
DK385686D0 (da) 1986-08-13
EP0213794A1 (de) 1987-03-11
PT83170B (pt) 1988-07-29

Similar Documents

Publication Publication Date Title
US4916071A (en) Poly-kringle plasminogen activator
Van Zonneveld et al. Autonomous functions of structural domains on human tissue-type plasminogen activator.
EP0093619B2 (de) Plasminogenaktivator für menschliches Gewebe, diesen Aktivator enthaltende pharmazeutische Zusammensetzungen, Verfahren zur Herstellung des Aktivators sowie DNA und transformierte Zellzwischenprodukte hierfür
US5147643A (en) DNA sequences encoding human t-PA substituted at position 275 or at positions 275 and 277 and pharmaceutical compositions
EP0092182B1 (de) Herstellung von funktionellen menschlichen Urokinasepolypeptiden
EP0234051B1 (de) Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen
Kalyan et al. Structure-function analysis with tissue-type plasminogen activator. Effect of deletion of NH2-terminal domains on its biochemical and biological properties.
US5200340A (en) Thrombin-activated tissue plasminogen activators
US5504001A (en) Hybrid plasminogen activator
IL89500A (en) Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them
KR970005251B1 (ko) 크링글 치환이 있는 돌연변이 이체 티-피에이
US5073494A (en) Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
US5112755A (en) Preparation of functional human urokinase proteins
EP0424405B1 (de) Plasminogenaktivator-varianten und verfahren zu ihrer herstellung
HK1007333B (en) Variants of plasminogen activators and processes for their production
EP0299706A2 (de) Unglicosilierter Plasminogen-Aktivator und Methode zu seiner Herstellung
US5376547A (en) Des-epidermal growth factor plasminogen activators
US4997766A (en) Poly-kringle plasminogen activator
US5045315A (en) Process for treating thrombosis by administering poly-kringle plasminogen activator
EP0316068A1 (de) Modifizierter Plasminogenaktivator mit niedrigem Molekulargewicht und Verfahren zu seiner Herstellung
WO1989010401A1 (en) Plasminogene activators with increased fibrin selectivity
Piérard et al. Production in eukaryotic cells and characterization of four hybrids of tissue-type and urokinase-type plasminogen activators
CA1341444C (en) Modified tissue plasminogen activator
US5047241A (en) Tris-Kringle plasminogen activator with novel K2 insert
AU3275593A (en) Novel tissue plasminogen activator variants