PH26080A - Novel antihypertensive benzopyran derivatives - Google Patents
Novel antihypertensive benzopyran derivatives Download PDFInfo
- Publication number
- PH26080A PH26080A PH37725A PH37725A PH26080A PH 26080 A PH26080 A PH 26080A PH 37725 A PH37725 A PH 37725A PH 37725 A PH37725 A PH 37725A PH 26080 A PH26080 A PH 26080A
- Authority
- PH
- Philippines
- Prior art keywords
- dihydro
- trifluoromethoxy
- benzopyran
- compound
- carbon atoms
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title claims description 5
- 150000001562 benzopyrans Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 46
- 150000003839 salts Chemical class 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 206010020772 Hypertension Diseases 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000012453 solvate Substances 0.000 claims description 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
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- 239000003826 tablet Substances 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000011269 tar Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 description 1
- 239000005052 trichlorosilane Substances 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000550349A CA1308108C (en) | 1987-10-27 | 1987-10-27 | Antihypertensive benzopyran derivatives |
| US14687588A | 1988-01-22 | 1988-01-22 | |
| US07/210,970 US4925839A (en) | 1987-10-27 | 1988-06-24 | Novel antihypertensive benzopyran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26080A true PH26080A (en) | 1992-02-06 |
Family
ID=27167796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH37725A PH26080A (en) | 1987-10-27 | 1988-10-26 | Novel antihypertensive benzopyran derivatives |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0314446B1 (xx) |
| JP (1) | JP2879147B2 (xx) |
| AU (1) | AU613674B2 (xx) |
| DE (1) | DE3884133T2 (xx) |
| DK (1) | DK595388A (xx) |
| ES (1) | ES2059534T3 (xx) |
| FI (1) | FI94954C (xx) |
| GB (1) | GB2211501B (xx) |
| HU (1) | HU205755B (xx) |
| IE (1) | IE63206B1 (xx) |
| IL (1) | IL88035A0 (xx) |
| PH (1) | PH26080A (xx) |
| PT (1) | PT88778B (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3823533A1 (de) * | 1988-07-12 | 1990-02-08 | Beiersdorf Ag | Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate |
| ES2071668T3 (es) * | 1988-12-13 | 1995-07-01 | Beecham Group Plc | Benzopirano y compuestos relacionados. |
| US4983612A (en) * | 1989-10-05 | 1991-01-08 | American Home Products Corporation | Antihypertensive benzopyran derivatives |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| US5254578A (en) * | 1990-10-24 | 1993-10-19 | Sankyo Company, Limited | Benzopyran derivatives having anti-hypertensive and vasodilatory activity and their therapeutic use |
| CA2053928A1 (en) * | 1990-10-24 | 1992-04-25 | Toshihiko Hashimoto | Benzopyran derivatives having anti-hypertensive and vasodilartory activity, their preparation and their therapeutic use |
| IL101456A0 (en) * | 1991-04-15 | 1992-12-30 | Squibb & Sons Inc | Indole and dihydroquinoline derivatives,and pharmaceutical compositions containing the same |
| US5310932A (en) * | 1991-04-15 | 1994-05-10 | E. R. Squibb & Sons, Inc. | Chromanyl substituted indole potassium channel openers |
| DE4115465A1 (de) * | 1991-05-11 | 1992-11-12 | Beiersdorf Ag | Neue in 4-stellung durch aryl oder n-heteroaryl substituierte 2h-benzo(b)pyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| DE4115521A1 (de) * | 1991-05-11 | 1992-11-12 | Beiersdorf Ag | Isoindolyl- und isochinolylsubstituierte benzopyran-derivate, zwischenprodukte, sowie verfahren zu ihrer herstellung |
| US5263346A (en) * | 1991-10-15 | 1993-11-23 | Kato Hatsujo Kaisha, Ltd. | Locking device for lid |
| GB9207400D0 (en) * | 1992-04-02 | 1992-05-13 | Smithkline Beecham Plc | Novel use |
| ES2145129T3 (es) * | 1992-08-17 | 2000-07-01 | Chugai Pharmaceutical Co Ltd | Derivados de benzopirano y benzoxazina. |
| TW533073B (en) | 1997-03-03 | 2003-05-21 | Chugai Pharmaceutical Co Ltd | Therapeutic agents for peripheral vascular disease |
| GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
| RU2557236C2 (ru) * | 2009-10-09 | 2015-07-20 | Селджин Корпорейшн | Способ получения соединений 2-(1-фенилэтил)изоиндолин-1-она |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ183551A (en) * | 1976-04-02 | 1978-09-20 | Beecham Group Ltd | Aminochromanols and pharmaceutical compositions containingthem |
| ATE23718T1 (de) * | 1981-09-25 | 1986-12-15 | Beecham Group Plc | Benzopyran-verbindungen mit pharmazeutischer wirkung. |
| DE3479726D1 (de) * | 1983-05-18 | 1989-10-19 | Beecham Group Plc | Benzopyran derivatives. |
| GB8409745D0 (en) * | 1984-04-14 | 1984-05-23 | Beecham Group Plc | Active compounds |
| DE3823533A1 (de) * | 1988-07-12 | 1990-02-08 | Beiersdorf Ag | Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate |
-
1988
- 1988-10-13 IL IL88035A patent/IL88035A0/xx not_active IP Right Cessation
- 1988-10-17 PT PT88778A patent/PT88778B/pt not_active IP Right Cessation
- 1988-10-24 FI FI884910A patent/FI94954C/fi not_active IP Right Cessation
- 1988-10-26 HU HU885597A patent/HU205755B/hu not_active IP Right Cessation
- 1988-10-26 AU AU24373/88A patent/AU613674B2/en not_active Ceased
- 1988-10-26 JP JP63270618A patent/JP2879147B2/ja not_active Expired - Lifetime
- 1988-10-26 DK DK595388A patent/DK595388A/da not_active Application Discontinuation
- 1988-10-26 EP EP19880310046 patent/EP0314446B1/en not_active Expired - Lifetime
- 1988-10-26 IE IE324888A patent/IE63206B1/en not_active IP Right Cessation
- 1988-10-26 DE DE88310046T patent/DE3884133T2/de not_active Expired - Fee Related
- 1988-10-26 GB GB8825080A patent/GB2211501B/en not_active Expired - Fee Related
- 1988-10-26 ES ES88310046T patent/ES2059534T3/es not_active Expired - Lifetime
- 1988-10-26 PH PH37725A patent/PH26080A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2437388A (en) | 1989-04-27 |
| PT88778B (pt) | 1992-12-31 |
| IE63206B1 (en) | 1995-04-05 |
| DK595388D0 (da) | 1988-10-26 |
| IL88035A0 (en) | 1989-06-30 |
| FI94954B (fi) | 1995-08-15 |
| HUT53897A (en) | 1990-12-28 |
| DE3884133T2 (de) | 1994-02-03 |
| DE3884133D1 (de) | 1993-10-21 |
| FI94954C (fi) | 1995-11-27 |
| HU205755B (en) | 1992-06-29 |
| IE883248L (en) | 1989-04-27 |
| JPH01151571A (ja) | 1989-06-14 |
| GB8825080D0 (en) | 1988-11-30 |
| JP2879147B2 (ja) | 1999-04-05 |
| ES2059534T3 (es) | 1994-11-16 |
| GB2211501A (en) | 1989-07-05 |
| FI884910A (fi) | 1989-04-28 |
| EP0314446B1 (en) | 1993-09-15 |
| AU613674B2 (en) | 1991-08-08 |
| EP0314446A3 (en) | 1990-06-20 |
| GB2211501B (en) | 1991-08-21 |
| EP0314446A2 (en) | 1989-05-03 |
| DK595388A (da) | 1989-04-28 |
| FI884910A0 (fi) | 1988-10-24 |
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