PH23606A - Omega-((hetero)alkyl)benz(cd)indol-2-amines - Google Patents

Omega-((hetero)alkyl)benz(cd)indol-2-amines

Info

Publication number
PH23606A
PH23606A PH34708A PH34708A PH23606A PH 23606 A PH23606 A PH 23606A PH 34708 A PH34708 A PH 34708A PH 34708 A PH34708 A PH 34708A PH 23606 A PH23606 A PH 23606A
Authority
PH
Philippines
Prior art keywords
benz
indol
omega
hetero
alkyl
Prior art date
Application number
PH34708A
Other languages
English (en)
Inventor
Andrew Stephen Tomcufcik
Walter Edward Meyer
Peter Sinchun Chan
David Leroy Crandall
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of PH23606A publication Critical patent/PH23606A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
PH34708A 1986-01-13 1987-01-12 Omega-((hetero)alkyl)benz(cd)indol-2-amines PH23606A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/818,315 US4728663A (en) 1986-01-13 1986-01-13 N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme

Publications (1)

Publication Number Publication Date
PH23606A true PH23606A (en) 1989-09-11

Family

ID=25225236

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34708A PH23606A (en) 1986-01-13 1987-01-12 Omega-((hetero)alkyl)benz(cd)indol-2-amines

Country Status (15)

Country Link
US (1) US4728663A (de)
EP (1) EP0230035B1 (de)
JP (1) JPS62215582A (de)
KR (1) KR900002756B1 (de)
AT (1) ATE112771T1 (de)
AU (1) AU604223B2 (de)
CA (1) CA1317948C (de)
DE (1) DE3650096D1 (de)
DK (1) DK12487A (de)
FI (1) FI92063C (de)
HU (1) HU198924B (de)
NO (1) NO168035C (de)
NZ (1) NZ218879A (de)
PH (1) PH23606A (de)
ZA (1) ZA87185B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081131A (en) * 1986-01-13 1992-01-14 American Cyanamid Company Omega-((hetero)alkyl)benz(cd)-indol-2-amines
IT1229237B (it) * 1989-05-08 1991-07-26 Prodotti Formenti Sali di (2-(piridil)etil) metilammina
US5079247A (en) * 1990-03-14 1992-01-07 American Cyanamid Company N1 -substituted benz(cd)indol-2-imine compounds as cardiovascular agents
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
DE19628893A1 (de) * 1996-07-17 1998-01-22 Basf Ag Verwendung von 1-Amidoalkylimidazolen als Korrosionsinhibitoren in der petrochemischen Industrie und Verfahren zu deren Herstellung
US6077460A (en) * 1996-07-17 2000-06-20 Basf Aktiengesellschaft Corrosion inhibition
BR9907170A (pt) 1998-04-02 2000-12-26 Reynolds Tobacco Co R Composições farmacêuticas e métodos para uso
US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
US6403581B1 (en) 2000-01-19 2002-06-11 American Cyanamid Company Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
CN105985282B (zh) * 2015-01-28 2020-12-08 中国科学院广州生物医药与健康研究院 一种2-氧代-1,2-二氢苯并[cd]吲哚类化合物及其应用
CN114349684B (zh) * 2022-01-19 2023-03-28 西南林业大学 一种苯并[c,d]吲哚亚胺衍生物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1388599A (fr) * 1963-04-20 1965-02-05 Bayer Ag Colorants nouveaux et procédé pour les fabriquer et les appliquer
DE2608020A1 (de) * 1976-02-27 1977-09-01 Bayer Ag Naphthostyrilfarbstoffe
DE2733440A1 (de) * 1976-08-03 1978-02-09 Sandoz Ag Benz eckige klammer auf cd eckige klammer zu indolyl-derivate, ihre verwendung und herstellung
US4261896A (en) * 1979-11-23 1981-04-14 American Cyanamid Company 1-Substituted-2-(substituted-imino)-1H-1,2-dihydrobenz[cd]indoles
US4259490A (en) * 1980-06-23 1981-03-31 American Cyanamid Company 2-(Substituted amino)benz[cd]indoles

Also Published As

Publication number Publication date
EP0230035A3 (en) 1990-01-10
FI92063C (fi) 1994-09-26
DE3650096D1 (de) 1994-11-17
CA1317948C (en) 1993-05-18
NO168035B (no) 1991-09-30
DK12487D0 (da) 1987-01-12
ZA87185B (en) 1988-07-27
NO870111D0 (no) 1987-01-12
FI870100A0 (fi) 1987-01-12
KR900002756B1 (ko) 1990-04-28
EP0230035A2 (de) 1987-07-29
NO168035C (no) 1992-01-08
JPS62215582A (ja) 1987-09-22
FI870100A (fi) 1987-07-14
DK12487A (da) 1987-07-14
NZ218879A (en) 1990-12-21
KR870007158A (ko) 1987-08-17
AU6749387A (en) 1987-07-16
NO870111L (no) 1987-07-14
EP0230035B1 (de) 1994-10-12
HUT43059A (en) 1987-09-28
ATE112771T1 (de) 1994-10-15
US4728663A (en) 1988-03-01
FI92063B (fi) 1994-06-15
HU198924B (en) 1989-12-28
AU604223B2 (en) 1990-12-13

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