PH22439A - Novel cyclosporins - Google Patents

Novel cyclosporins

Info

Publication number
PH22439A
PH22439A PH33501A PH33501A PH22439A PH 22439 A PH22439 A PH 22439A PH 33501 A PH33501 A PH 33501A PH 33501 A PH33501 A PH 33501A PH 22439 A PH22439 A PH 22439A
Authority
PH
Philippines
Prior art keywords
residue
formula
cyclosporins
mebmt
protonated
Prior art date
Application number
PH33501A
Other languages
English (en)
Inventor
Dieter Seebach
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27262613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH22439(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506230A external-priority patent/GB8506230D0/en
Priority claimed from GB858511029A external-priority patent/GB8511029D0/en
Priority claimed from GB868602370A external-priority patent/GB8602370D0/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of PH22439A publication Critical patent/PH22439A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
PH33501A 1985-03-11 1986-03-10 Novel cyclosporins PH22439A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858506230A GB8506230D0 (en) 1985-03-11 1985-03-11 Organic compounds
GB858511029A GB8511029D0 (en) 1985-05-01 1985-05-01 Organic compounds
GB868602370A GB8602370D0 (en) 1986-01-31 1986-01-31 Organic compounds

Publications (1)

Publication Number Publication Date
PH22439A true PH22439A (en) 1988-09-12

Family

ID=27262613

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33501A PH22439A (en) 1985-03-11 1986-03-10 Novel cyclosporins

Country Status (16)

Country Link
US (2) US4703033A (de)
EP (1) EP0194972B1 (de)
JP (1) JPH0759594B2 (de)
KR (1) KR860007285A (de)
AT (1) ATE78832T1 (de)
AU (1) AU588860B2 (de)
DE (1) DE3686183T2 (de)
DK (1) DK109486A (de)
ES (2) ES8900141A1 (de)
FI (1) FI860993A (de)
GR (1) GR860646B (de)
HU (1) HUT47137A (de)
IL (1) IL78083A0 (de)
NZ (1) NZ215414A (de)
PH (1) PH22439A (de)
PT (1) PT82164B (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
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DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
GB2207678A (en) * 1987-08-03 1989-02-08 Merck & Co Inc Novel immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Res Found Cyclosporin-augenmittel.
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5271935A (en) * 1988-02-05 1993-12-21 Hoechst Aktiengesellschaft Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
EP0484281B2 (de) 1990-11-02 2000-11-22 Novartis AG Zyklosporine
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
ATE209216T1 (de) * 1995-07-17 2001-12-15 Chem Ag C Cyclosporin-derivate mit anti-hiv-wirkung
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
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FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
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FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE423130T1 (de) 1997-10-08 2009-03-15 Isotechnika Inc Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien
FR2772768B1 (fr) * 1997-12-19 2000-01-14 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
ATE254630T1 (de) * 1998-06-12 2003-12-15 Chem Ag C Cyclosporine
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
JP4350898B2 (ja) 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン
AU7353300A (en) 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
WO2002042259A2 (en) 2000-11-27 2002-05-30 University Of Maryland, Baltimore Methods of synthesizing and using derivatives of [2-(2-aminoethoxy)ethoxy] acetic acid
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KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US6593362B2 (en) 2001-05-21 2003-07-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
DK1714977T3 (da) * 2001-10-19 2009-07-06 Isotechnika Inc Syntese af cyclosporinanaloger
KR100978836B1 (ko) 2001-10-19 2010-08-30 이소테크니카 인코포레이티드 신규한 시클로스포린 유사체 미세유화액 예비농축물
US6987090B2 (en) * 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
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BRPI0509755A (pt) * 2004-04-08 2007-10-16 Applied Research Systems composição compreendendo um inibidor de jnk e ciclosporina
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
US20060035821A1 (en) * 2004-08-16 2006-02-16 Hunt Kevin W Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
RU2399628C2 (ru) * 2004-10-01 2010-09-20 Скайнексис, Инк. Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
WO2007041631A1 (en) * 2005-09-30 2007-04-12 Scynexis, Inc. ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
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EP2027761A1 (de) * 2006-06-02 2009-02-25 Claude Annie Perrichon Verwaltung von aktieven elektronen
US20080206287A1 (en) * 2006-09-18 2008-08-28 Reed John C Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
WO2008069917A2 (en) * 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
WO2010002428A2 (en) * 2008-06-06 2010-01-07 Scynexis, Inc. Novel macrocyclic peptides
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
CN102307892A (zh) * 2008-12-31 2012-01-04 西尼克斯公司 环孢菌素a的衍生物
WO2010088573A1 (en) * 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
JP2012528163A (ja) * 2009-05-27 2012-11-12 アラーガン、インコーポレイテッド 炎症性疾患および状態を処置するためのシクロスポリン誘導体
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU549876B2 (en) * 1977-05-10 1986-02-20 Sandoz Ltd. Dihydrocyclosporin d and isocyclosporin d
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
GB8407618D0 (en) * 1984-03-23 1984-05-02 Sandoz Ltd Organic compounds
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4685566A (en) * 1985-12-24 1987-08-11 Manville Sales Corporation Sleeve-type carrier

Also Published As

Publication number Publication date
DK109486A (da) 1986-09-12
KR860007285A (ko) 1986-10-10
HUT47137A (en) 1989-01-30
JPH0759594B2 (ja) 1995-06-28
AU5448586A (en) 1986-09-18
FI860993A (fi) 1986-09-12
EP0194972A2 (de) 1986-09-17
DK109486D0 (da) 1986-03-10
JPS61212599A (ja) 1986-09-20
ES557619A0 (es) 1988-07-16
ES552855A0 (es) 1989-01-16
US4771122A (en) 1988-09-13
PT82164B (en) 1988-01-04
PT82164A (en) 1986-04-01
US4703033A (en) 1987-10-27
ES8900141A1 (es) 1989-01-16
DE3686183D1 (en) 1992-09-03
EP0194972B1 (de) 1992-07-29
DE3686183T2 (de) 1993-01-14
AU588860B2 (en) 1989-09-28
EP0194972A3 (en) 1989-07-12
ES8802527A1 (es) 1988-07-16
ATE78832T1 (de) 1992-08-15
NZ215414A (en) 1990-08-28
FI860993A0 (fi) 1986-03-10
IL78083A0 (en) 1986-07-31
GR860646B (en) 1986-07-11

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