ES8900141A1 - Procedimiento para la produccion de una ciclosporina - Google Patents

Procedimiento para la produccion de una ciclosporina

Info

Publication number
ES8900141A1
ES8900141A1 ES552855A ES552855A ES8900141A1 ES 8900141 A1 ES8900141 A1 ES 8900141A1 ES 552855 A ES552855 A ES 552855A ES 552855 A ES552855 A ES 552855A ES 8900141 A1 ES8900141 A1 ES 8900141A1
Authority
ES
Spain
Prior art keywords
residue
formula
alpha
cyclosporins
mebmt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552855A
Other languages
English (en)
Other versions
ES552855A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27262613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8900141(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858506230A external-priority patent/GB8506230D0/en
Priority claimed from GB858511029A external-priority patent/GB8511029D0/en
Priority claimed from GB868602370A external-priority patent/GB8602370D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8900141A1 publication Critical patent/ES8900141A1/es
Publication of ES552855A0 publication Critical patent/ES552855A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

SE HACE REACCIONAR UN POLIANION DE UNA CICLOSPORINA QUE TIENE EN LA POSICION 3 UN RESTO SARCOSILO DES-PROTONADO PREFERIBLEMENTE DE FORMULA (I) DONDE R ELEVADO A A ES CH3-X-Y-CH2-CH(CH3)-CH(RE)-; RE SIGNIFICA HIDROXI O E; RB ES C2-H5-, CH3-CH-RE; RC ES I-C4-H9, RD ES I-C3H7 Y E ES [-O-M+] CON M+ ION DE METAL ALCALINO EN PARTICULAR 4+, CON UN ELECTROFILO PARA INTRODUCIR UN GRUPO R ES EL RESTO SARCOSILO EN PRESENCIA DE UN DISOLVENTE O DILUYENTE INERTE A UNA TEMPERATURA ENTRE -90GC Y -40GC SEGUIDO POR TEMPLADO DE LA ESPECIE IONICA. LA CICLOSPORINA RESULTANTE, PREFERIBLEMENTE DE FORMULA (II) CON X-ME BMTO -DIHIDRO-ME BMT-: Y UN -ALFA ABU-; -THR-, -VALO -NVAY Z ES UN RESTO DE FORMULA (III); TIENE ACTIVIDAD INMUNOSUPRESORA, ANTI-INFLAMATORIA Y ANTI-PARASITARIA. *FORMULA*
ES552855A 1985-03-11 1986-03-10 Procedimiento para la produccion de una ciclosporina Expired ES8900141A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858506230A GB8506230D0 (en) 1985-03-11 1985-03-11 Organic compounds
GB858511029A GB8511029D0 (en) 1985-05-01 1985-05-01 Organic compounds
GB868602370A GB8602370D0 (en) 1986-01-31 1986-01-31 Organic compounds

Publications (2)

Publication Number Publication Date
ES8900141A1 true ES8900141A1 (es) 1989-01-16
ES552855A0 ES552855A0 (es) 1989-01-16

Family

ID=27262613

Family Applications (2)

Application Number Title Priority Date Filing Date
ES552855A Expired ES8900141A1 (es) 1985-03-11 1986-03-10 Procedimiento para la produccion de una ciclosporina
ES557619A Expired ES8802527A1 (es) 1985-03-11 1987-07-01 Procedimiento para la produccion de un polianion de una ciclosporina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557619A Expired ES8802527A1 (es) 1985-03-11 1987-07-01 Procedimiento para la produccion de un polianion de una ciclosporina.

Country Status (16)

Country Link
US (2) US4703033A (es)
EP (1) EP0194972B1 (es)
JP (1) JPH0759594B2 (es)
KR (1) KR860007285A (es)
AT (1) ATE78832T1 (es)
AU (1) AU588860B2 (es)
DE (1) DE3686183T2 (es)
DK (1) DK109486A (es)
ES (2) ES8900141A1 (es)
FI (1) FI860993A (es)
GR (1) GR860646B (es)
HU (1) HUT47137A (es)
IL (1) IL78083A0 (es)
NZ (1) NZ215414A (es)
PH (1) PH22439A (es)
PT (1) PT82164B (es)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
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US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) * 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
EP0296122B1 (en) * 1987-06-17 1993-09-29 Sandoz Ag Cyclosporins and their use as pharmaceuticals
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
GB2206119B (en) * 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
GB2207678A (en) * 1987-08-03 1989-02-08 Merck & Co Inc Novel immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
EP0391909B1 (en) * 1987-09-03 1994-08-17 The University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US5271935A (en) * 1988-02-05 1993-12-21 Hoechst Aktiengesellschaft Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
ES2095926T5 (es) * 1990-11-02 2001-02-16 Novartis Ag Cyclosporins.
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
WO1997004005A2 (de) * 1995-07-17 1997-02-06 C-Chem Ag Cyclosporin-derivate mit anti-hiv-wirkung
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DK0991660T3 (da) 1997-10-08 2006-02-13 Isotechnika Inc Deuterede og udeuterede cyclosporinanaloger og deres anvendelse som immunmodulerende midler
FR2772768B1 (fr) * 1997-12-19 2000-01-14 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
PT1086124E (pt) 1998-06-12 2004-04-30 Chem Ag C Ciclosporinas novas
FR2780061B1 (fr) 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
EP1214293A1 (en) 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
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US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
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US20080206287A1 (en) * 2006-09-18 2008-08-28 Reed John C Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
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Also Published As

Publication number Publication date
ATE78832T1 (de) 1992-08-15
EP0194972A3 (en) 1989-07-12
AU588860B2 (en) 1989-09-28
DK109486D0 (da) 1986-03-10
DE3686183T2 (de) 1993-01-14
US4771122A (en) 1988-09-13
DE3686183D1 (en) 1992-09-03
JPH0759594B2 (ja) 1995-06-28
PH22439A (en) 1988-09-12
JPS61212599A (ja) 1986-09-20
DK109486A (da) 1986-09-12
US4703033A (en) 1987-10-27
AU5448586A (en) 1986-09-18
HUT47137A (en) 1989-01-30
GR860646B (en) 1986-07-11
ES8802527A1 (es) 1988-07-16
IL78083A0 (en) 1986-07-31
KR860007285A (ko) 1986-10-10
PT82164A (en) 1986-04-01
PT82164B (en) 1988-01-04
ES552855A0 (es) 1989-01-16
ES557619A0 (es) 1988-07-16
EP0194972B1 (en) 1992-07-29
FI860993A0 (fi) 1986-03-10
FI860993A (fi) 1986-09-12
EP0194972A2 (en) 1986-09-17
NZ215414A (en) 1990-08-28

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