PH22243A - Trisubstituted pyrimido(5,4-d)pyrimidines and salts thereof - Google Patents

Trisubstituted pyrimido(5,4-d)pyrimidines and salts thereof

Info

Publication number
PH22243A
PH22243A PH26758A PH26758A PH22243A PH 22243 A PH22243 A PH 22243A PH 26758 A PH26758 A PH 26758A PH 26758 A PH26758 A PH 26758A PH 22243 A PH22243 A PH 22243A
Authority
PH
Philippines
Prior art keywords
optionally substituted
salts
pyrimidines
compounds
imino group
Prior art date
Application number
PH26758A
Other languages
English (en)
Inventor
Roch Josef
Mueller Erich
Narr Berthold
Nickl Josef
Haarmann Walter
Weisenberger Johann Maximilian
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of PH22243A publication Critical patent/PH22243A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH26758A 1980-12-27 1981-12-23 Trisubstituted pyrimido(5,4-d)pyrimidines and salts thereof PH22243A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803049207 DE3049207A1 (de) 1980-12-27 1980-12-27 Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
PH22243A true PH22243A (en) 1988-07-01

Family

ID=6120399

Family Applications (1)

Application Number Title Priority Date Filing Date
PH26758A PH22243A (en) 1980-12-27 1981-12-23 Trisubstituted pyrimido(5,4-d)pyrimidines and salts thereof

Country Status (19)

Country Link
US (1) US4478833A (xx)
EP (1) EP0055444B1 (xx)
JP (1) JPS57134485A (xx)
AT (1) ATE12232T1 (xx)
AU (1) AU547792B2 (xx)
CA (1) CA1176247A (xx)
DE (2) DE3049207A1 (xx)
DK (1) DK548981A (xx)
ES (1) ES8300768A1 (xx)
FI (1) FI71151C (xx)
GB (1) GB2090833B (xx)
GR (1) GR76356B (xx)
IE (1) IE52323B1 (xx)
IL (1) IL64647A (xx)
NO (1) NO158256C (xx)
NZ (1) NZ199376A (xx)
PH (1) PH22243A (xx)
PT (1) PT74199B (xx)
ZA (1) ZA818934B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
JPH075594B2 (ja) * 1986-03-25 1995-01-25 三井石油化学工業株式会社 新規ピリドピリミジン誘導体
DE3631294A1 (de) * 1986-09-13 1988-03-24 Thomae Gmbh Dr K Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
CN1984660B (zh) 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
CA2576299A1 (en) * 2004-08-24 2006-03-02 Sumitomo Chemical Company, Limited Method for producing 2-(4-methyl-2-phenylpiperazine-1-yl)-3-cyanopiridine
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807826A (en) * 1955-03-14 1959-01-21 Thomae Gmbh Dr K Derivatives of pyrimido[5,4-d] pyrimidine and production thereof
DE1150086B (de) * 1956-04-25 1963-06-12 Thomae Gmbh Dr K Verfahren zur Herstellung von 2-Morpholino-4, 8-bis-(3'-methoxy-propylamino)-pyrimido [5, 4-d] pyrimidin
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
DE1168439B (de) * 1959-06-25 1964-04-23 Thomae Gmbh Dr K Verfahren zur Herstellung von Estern von Hydroxyalkylamino-pyrimido [5, 4-d] pyrimidinen
FR1292943A (fr) * 1960-04-27 1962-05-11 Thomae Gmbh Dr K Procédé pour la fabrication de dérivés de la pyrimido-[5, 4-d]-pyrimidine
GB1051218A (xx) * 1963-03-09
US3322755A (en) * 1964-03-10 1967-05-30 Boehringer Sohn Ingelheim Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel

Also Published As

Publication number Publication date
FI71151C (fi) 1986-11-24
PT74199B (de) 1984-01-05
IE813078L (en) 1982-06-27
PT74199A (de) 1982-01-01
IL64647A (en) 1985-10-31
EP0055444B1 (de) 1985-03-20
EP0055444A3 (en) 1982-08-04
GB2090833B (en) 1984-10-31
FI814148L (fi) 1982-06-28
NO158256C (no) 1988-08-10
DK548981A (da) 1982-06-28
ATE12232T1 (de) 1985-04-15
JPS57134485A (en) 1982-08-19
IL64647A0 (en) 1982-03-31
DE3049207A1 (de) 1982-07-29
IE52323B1 (en) 1987-09-16
GR76356B (xx) 1984-08-06
NO158256B (no) 1988-05-02
EP0055444A2 (de) 1982-07-07
US4478833A (en) 1984-10-23
NZ199376A (en) 1985-12-13
NO814299L (no) 1982-06-28
FI71151B (fi) 1986-08-14
ES508343A0 (es) 1982-11-01
ES8300768A1 (es) 1982-11-01
AU7904181A (en) 1982-07-08
GB2090833A (en) 1982-07-21
DE3169480D1 (en) 1985-04-25
CA1176247A (en) 1984-10-16
ZA818934B (en) 1983-09-28
AU547792B2 (en) 1985-11-07

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