PH19431A - Isoquinoline derivatives and pharmaceutical composition containing them - Google Patents

Isoquinoline derivatives and pharmaceutical composition containing them

Info

Publication number
PH19431A
PH19431A PH30299A PH30299A PH19431A PH 19431 A PH19431 A PH 19431A PH 30299 A PH30299 A PH 30299A PH 30299 A PH30299 A PH 30299A PH 19431 A PH19431 A PH 19431A
Authority
PH
Philippines
Prior art keywords
isoquinoline derivatives
pharmaceutical composition
composition containing
antihypertonic
neuroleptic
Prior art date
Application number
PH30299A
Other languages
English (en)
Inventor
Elmar Konz
Hansjorg Kruse
Franz Hock
Joachim Kaiser
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PH19431A publication Critical patent/PH19431A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH30299A 1980-09-10 1984-02-24 Isoquinoline derivatives and pharmaceutical composition containing them PH19431A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803034001 DE3034001A1 (de) 1980-09-10 1980-09-10 Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Publications (1)

Publication Number Publication Date
PH19431A true PH19431A (en) 1986-04-15

Family

ID=6111554

Family Applications (1)

Application Number Title Priority Date Filing Date
PH30299A PH19431A (en) 1980-09-10 1984-02-24 Isoquinoline derivatives and pharmaceutical composition containing them

Country Status (20)

Country Link
US (1) US4590273A (https=)
EP (1) EP0047923B1 (https=)
JP (1) JPS5780372A (https=)
KR (1) KR830007622A (https=)
AT (1) ATE7389T1 (https=)
AU (1) AU541976B2 (https=)
CA (1) CA1168232A (https=)
DE (2) DE3034001A1 (https=)
DK (1) DK400681A (https=)
ES (3) ES505191A0 (https=)
FI (1) FI71734C (https=)
GR (1) GR74978B (https=)
HU (1) HU187357B (https=)
IE (1) IE51551B1 (https=)
IL (1) IL63765A (https=)
NO (1) NO813066L (https=)
NZ (1) NZ198308A (https=)
PH (1) PH19431A (https=)
PT (1) PT73629B (https=)
ZA (1) ZA816237B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4843077A (en) * 1987-06-09 1989-06-27 Ortho Pharmaceutical Corporation Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
US5972945A (en) * 1997-06-13 1999-10-26 Neurogen Corporation 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands
US6313141B1 (en) 1997-06-13 2001-11-06 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
ATE404539T1 (de) * 1997-10-02 2008-08-15 Eisai R&D Man Co Ltd Kondensierte pyridinderivate
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
ATE491689T1 (de) 1997-10-27 2011-01-15 Neurosearch As Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
US6613901B2 (en) 2000-03-08 2003-09-02 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
US20100016293A1 (en) * 2006-07-03 2010-01-21 Rogier Adriaan Smits Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use
TW201307292A (zh) * 2010-12-17 2013-02-16 Hoffmann La Roche 經取代之６，６－稠合含氮雜環化合物及其用途
RU2019133646A (ru) 2017-03-30 2021-04-30 Ф. Хоффманн-Ля Рош Аг Изохинолины в качестве ингибиторов hpk1
CN112601584A (zh) 2018-07-24 2021-04-02 豪夫迈·罗氏有限公司 异喹啉化合物及其用途
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
DE2030675A1 (en) * 1969-06-23 1971-02-11 Arthur D Little, Inc , Cambridge, Mass (V St A) 3-amino-4-phenyl-isoquinoline derivs
US3932412A (en) * 1970-12-07 1976-01-13 Sandoz, Inc. 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates
DE2503961C3 (de) * 1975-01-31 1980-02-28 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
DE2420012C3 (de) * 1974-04-25 1980-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
DE2811312A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln
DE2818403A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HU187357B (en) 1985-12-28
ES8305351A1 (es) 1983-04-01
US4590273A (en) 1986-05-20
ATE7389T1 (de) 1984-05-15
IE812094L (en) 1982-03-10
ES506584A0 (es) 1983-03-01
IL63765A0 (en) 1981-12-31
NO813066L (no) 1982-03-11
EP0047923B1 (de) 1984-05-09
EP0047923A1 (de) 1982-03-24
JPS5780372A (en) 1982-05-19
ZA816237B (en) 1982-08-25
AU7509181A (en) 1982-03-18
GR74978B (https=) 1984-07-12
DE3163510D1 (en) 1984-06-14
FI812783L (fi) 1982-03-11
AU541976B2 (en) 1985-01-31
ES8304563A1 (es) 1983-03-01
ES8206511A1 (es) 1982-08-16
IE51551B1 (en) 1987-01-07
FI71734B (fi) 1986-10-31
IL63765A (en) 1985-05-31
FI71734C (fi) 1987-02-09
DK400681A (da) 1982-03-11
DE3034001A1 (de) 1982-04-22
PT73629A (de) 1981-10-01
ES506583A0 (es) 1983-04-01
CA1168232A (en) 1984-05-29
NZ198308A (en) 1984-03-30
PT73629B (de) 1983-04-29
KR830007622A (ko) 1983-11-04
ES505191A0 (es) 1982-08-16

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