PH12022551776A1 - Engineered leucine decarboxylases - Google Patents

Engineered leucine decarboxylases

Info

Publication number
PH12022551776A1
PH12022551776A1 PH1/2022/551776A PH12022551776A PH12022551776A1 PH 12022551776 A1 PH12022551776 A1 PH 12022551776A1 PH 12022551776 A PH12022551776 A PH 12022551776A PH 12022551776 A1 PH12022551776 A1 PH 12022551776A1
Authority
PH
Philippines
Prior art keywords
engineered
ldc
polypeptides
optimized
compositions
Prior art date
Application number
PH1/2022/551776A
Other languages
English (en)
Inventor
Nikki Dellas
Faye Loan Du
Stephan Jenne
Joyce Liu
Kerryn Mccluskie
Leann Quertinmont Teadt
Kristen Jean Vallieu
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of PH12022551776A1 publication Critical patent/PH12022551776A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
PH1/2022/551776A 2020-02-04 2021-02-03 Engineered leucine decarboxylases PH12022551776A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062970039P 2020-02-04 2020-02-04
PCT/US2021/016450 WO2021158686A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Publications (1)

Publication Number Publication Date
PH12022551776A1 true PH12022551776A1 (en) 2023-11-29

Family

ID=77061734

Family Applications (1)

Application Number Title Priority Date Filing Date
PH1/2022/551776A PH12022551776A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Country Status (12)

Country Link
US (2) US12241100B2 (https=)
EP (1) EP4103711A4 (https=)
JP (2) JP2023512683A (https=)
KR (1) KR20220137057A (https=)
CN (1) CN116113691A (https=)
AU (1) AU2021216389A1 (https=)
BR (1) BR112022015139A2 (https=)
CA (1) CA3168922A1 (https=)
IL (1) IL295169A (https=)
MX (1) MX2022009531A (https=)
PH (1) PH12022551776A1 (https=)
WO (1) WO2021158686A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023512683A (ja) 2020-02-04 2023-03-28 コデクシス， インコーポレイテッド 操作されたロイシンデカルボキシラーゼ
JP2024540358A (ja) * 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
WO2023102499A1 (en) * 2021-12-02 2023-06-08 Codexis, Inc. Engineered threonine aldolases and amino acid decarboxylases

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Also Published As

Publication number Publication date
MX2022009531A (es) 2022-09-09
AU2021216389A1 (en) 2022-08-11
BR112022015139A2 (pt) 2022-10-11
US20210238575A1 (en) 2021-08-05
US12241100B2 (en) 2025-03-04
JP2025143444A (ja) 2025-10-01
US20240018504A1 (en) 2024-01-18
CN116113691A (zh) 2023-05-12
EP4103711A1 (en) 2022-12-21
CA3168922A1 (en) 2021-08-12
EP4103711A4 (en) 2024-02-28
KR20220137057A (ko) 2022-10-11
IL295169A (en) 2022-09-01
JP2023512683A (ja) 2023-03-28
WO2021158686A1 (en) 2021-08-12
WO2021158686A8 (en) 2022-03-17

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