BR112022015139A2 - Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso - Google Patents

Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso

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Publication number
BR112022015139A2
BR112022015139A2 BR112022015139A BR112022015139A BR112022015139A2 BR 112022015139 A2 BR112022015139 A2 BR 112022015139A2 BR 112022015139 A BR112022015139 A BR 112022015139A BR 112022015139 A BR112022015139 A BR 112022015139A BR 112022015139 A2 BR112022015139 A2 BR 112022015139A2
Authority
BR
Brazil
Prior art keywords
leukine
engineered
engineering
decarboxylase polypeptide
ldc
Prior art date
Application number
BR112022015139A
Other languages
English (en)
Portuguese (pt)
Inventor
Liu Joyce
Quertinmont Teadt Leann
DELLAS Nikki
JENNE Stephan
Loan Du Faye
Jean Vallieu Kristen
Mccluskie Kerryn
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of BR112022015139A2 publication Critical patent/BR112022015139A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BR112022015139A 2020-02-04 2021-02-03 Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso BR112022015139A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062970039P 2020-02-04 2020-02-04
PCT/US2021/016450 WO2021158686A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Publications (1)

Publication Number Publication Date
BR112022015139A2 true BR112022015139A2 (pt) 2022-10-11

Family

ID=77061734

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022015139A BR112022015139A2 (pt) 2020-02-04 2021-02-03 Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso

Country Status (12)

Country Link
US (2) US12241100B2 (https=)
EP (1) EP4103711A4 (https=)
JP (2) JP2023512683A (https=)
KR (1) KR20220137057A (https=)
CN (1) CN116113691A (https=)
AU (1) AU2021216389A1 (https=)
BR (1) BR112022015139A2 (https=)
CA (1) CA3168922A1 (https=)
IL (1) IL295169A (https=)
MX (1) MX2022009531A (https=)
PH (1) PH12022551776A1 (https=)
WO (1) WO2021158686A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023512683A (ja) 2020-02-04 2023-03-28 コデクシス， インコーポレイテッド 操作されたロイシンデカルボキシラーゼ
JP2024540358A (ja) * 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
WO2023102499A1 (en) * 2021-12-02 2023-06-08 Codexis, Inc. Engineered threonine aldolases and amino acid decarboxylases

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Also Published As

Publication number Publication date
MX2022009531A (es) 2022-09-09
AU2021216389A1 (en) 2022-08-11
US20210238575A1 (en) 2021-08-05
US12241100B2 (en) 2025-03-04
JP2025143444A (ja) 2025-10-01
US20240018504A1 (en) 2024-01-18
PH12022551776A1 (en) 2023-11-29
CN116113691A (zh) 2023-05-12
EP4103711A1 (en) 2022-12-21
CA3168922A1 (en) 2021-08-12
EP4103711A4 (en) 2024-02-28
KR20220137057A (ko) 2022-10-11
IL295169A (en) 2022-09-01
JP2023512683A (ja) 2023-03-28
WO2021158686A1 (en) 2021-08-12
WO2021158686A8 (en) 2022-03-17

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