BR112022026248A2 - Conjugados de citocinas - Google Patents

Conjugados de citocinas

Info

Publication number
BR112022026248A2
BR112022026248A2 BR112022026248A BR112022026248A BR112022026248A2 BR 112022026248 A2 BR112022026248 A2 BR 112022026248A2 BR 112022026248 A BR112022026248 A BR 112022026248A BR 112022026248 A BR112022026248 A BR 112022026248A BR 112022026248 A2 BR112022026248 A2 BR 112022026248A2
Authority
BR
Brazil
Prior art keywords
compositions
cytokine conjugates
conjugates
cytokine
xten
Prior art date
Application number
BR112022026248A
Other languages
English (en)
Inventor
Schellenberger Volker
Johansen Eric
Henkensiefken Angela
Irving Bryan
Young Tracy
Chauhan Vibha
Yeung Valentine
Original Assignee
Amunix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amunix Pharmaceuticals Inc filed Critical Amunix Pharmaceuticals Inc
Publication of BR112022026248A2 publication Critical patent/BR112022026248A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

CONJUGADOS DE CITOCINAS. A presente invenção refere-se a composições que compreendem proteínas biologicamente ativas, tais como citocinas, ligadas ao polipeptídeo recombinante estendido (XTEN), ácidos nucleicos isolados que codificam as composições e vetores e células hospedeiras que contêm os mesmos, e métodos de uso de tais composições no tratamento de transtornos e condições relacionados.
BR112022026248A 2020-06-25 2021-06-24 Conjugados de citocinas BR112022026248A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063044335P 2020-06-25 2020-06-25
US202163197875P 2021-06-07 2021-06-07
US202163197944P 2021-06-07 2021-06-07
PCT/US2021/038909 WO2021262985A1 (en) 2020-06-25 2021-06-24 Cytokine conjugates

Publications (1)

Publication Number Publication Date
BR112022026248A2 true BR112022026248A2 (pt) 2023-01-17

Family

ID=79281847

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022026248A BR112022026248A2 (pt) 2020-06-25 2021-06-24 Conjugados de citocinas

Country Status (12)

Country Link
US (1) US20230265146A1 (pt)
EP (1) EP4171609A1 (pt)
JP (1) JP2023531496A (pt)
KR (1) KR20230042014A (pt)
CN (1) CN116096730A (pt)
AU (1) AU2021296605A1 (pt)
BR (1) BR112022026248A2 (pt)
CA (1) CA3180251A1 (pt)
CO (1) CO2023000048A2 (pt)
IL (1) IL298626A (pt)
MX (1) MX2022016389A (pt)
WO (1) WO2021262985A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4372000A2 (en) * 2022-02-15 2024-05-22 Tagworks Pharmaceuticals B.V. Masked il12 protein
WO2024086619A2 (en) * 2022-10-19 2024-04-25 Kalivir Immunotherapeutics, Inc. Nucleic acids encoding tgf-beta inhibitor and il-12 and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
SG11201405276PA (en) * 2012-02-27 2014-10-30 Amunix Operating Inc Xten conjugate compositions and methods of making same
EA038329B1 (ru) * 2015-08-28 2021-08-10 Амьюникс Фармасьютикалз, Инк. Химерный полипептидный комплекс и способы его получения и применения
CA3063723A1 (en) * 2017-05-18 2018-11-22 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
BR112020012220A2 (pt) * 2017-12-21 2021-01-26 Amunix Pharmaceuticals, Inc. segmentos de liberação e composições de ligação que compreende os mesmos

Also Published As

Publication number Publication date
KR20230042014A (ko) 2023-03-27
IL298626A (en) 2023-01-01
AU2021296605A9 (en) 2023-03-09
EP4171609A1 (en) 2023-05-03
AU2021296605A1 (en) 2023-02-23
JP2023531496A (ja) 2023-07-24
US20230265146A1 (en) 2023-08-24
CO2023000048A2 (es) 2023-03-27
CA3180251A1 (en) 2021-12-30
WO2021262985A1 (en) 2021-12-30
MX2022016389A (es) 2023-04-11
CN116096730A (zh) 2023-05-09

Similar Documents

Publication Publication Date Title
EA201170993A1 (ru) Удлиненные рекомбинантные полипептиды и содержащие их композиции
BR112022026248A2 (pt) Conjugados de citocinas
Abdi et al. Free IL-12p40 monomer Is a polyfunctional adaptor for generating novel IL-12–like heterodimers extracellularly
BRPI0412799A (pt) imunógeno, composição, ácido nucleico, célula recombinante, métodos para preparar um polipeptìdeo, para induzir um a resposta imune protetora em um paciente e para induzir uma resposta anamnésica em um paciente, e, seqüência de ácido nucleico otimizada de levedura
AR108442A1 (es) Proteínas de fusión gdf15 y usos de estas
EA201190326A8 (ru) Полипептиды гормона роста и способы их получения и применения
BR112021022874A2 (pt) Proteínas de ligação epcam e métodos de uso
DE60125381D1 (de) Zusammensetzungen und verfahren mit analogen von g-csf
ATE426024T1 (de) C-c chemokin rezeptor 3: ckr-3 oder eos-l2
BRPI0411363A (pt) seqüências de ácidos nucléicos codificando e composições compreendendo peptìdeo sinal ige e/ou il-15 e processos para uso das mesmas
WO2021198706A3 (en) Coronavirus vaccines
EA202190267A1 (ru) Способы и композиции с использованием рекомбинантных дендритных клеток для терапии рака
ATE246247T1 (de) Varianten des humanen rekombinanten interferon- gamma (rhu-ifn-gamma) mit erhöhter thermischer stabilität
PE20231439A1 (es) Proteinas f de hmpv estabilizadas por prefusion
BR112017022076A2 (pt) fusões de mesotelina-variante iii de receptor de fator de crescimento epidérmico e métodos de uso das mesmas
EA202191735A1 (ru) Варианты альфа-галактозидазы человека
DE60039677D1 (de) Akt-3 nukleinsäure, polypeptide und deren verwendung
DE60235985D1 (de) Ntb-a, ein oberflächenmolekül impliziert in der aktivität natürlicher killerzellen (nk)
BR112022006842A2 (pt) Construtos de igf2 variante
ZA202308985B (en) Constructs and methods for increased expression of polypeptides
BR9914922A (pt) Métodos para reduzir a extensão de degradação de protease de uma proteìna aplicada a ou produzida por uma planta, para inibir o crescimento de um patógeno vegetal e para produzir uma planta, peptìdeo, molécula de ácido nucleico, segmento de ácido nucleico, construção de ácido nucleico, planta transgênica, semente, célula vegetal, e, composição para o uso na proteção de um peptìdeo, polipeptìdeo ou proteìna da degradação da protease.
ES2058565T3 (es) Retrovirus recombinante defectivo, su aplicacion en la integracion de secuencias que codifican proteinas determinadas en el genoma de cultivos celulares infectables por el retrovirus salvaje correspondiente y adns recombinantes para la produccion de dicho retrovirus recombinante.
EA202092065A1 (ru) ЭКСПРЕССИЯ ПНЕВМОКОККОВОГО ПОВЕРХНОСТНОГО БЕЛКА А (PspA)
BR112023026782A2 (pt) Formulações de proteínas quiméricas de fator viii e usos das mesmas
CO2022004535A2 (es) Secuencia de extensión n-terminal para la expresión de péptidos terapéuticos recombinantes