EA202190267A1 - Способы и композиции с использованием рекомбинантных дендритных клеток для терапии рака - Google Patents

Способы и композиции с использованием рекомбинантных дендритных клеток для терапии рака

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Publication number
EA202190267A1
EA202190267A1 EA202190267A EA202190267A EA202190267A1 EA 202190267 A1 EA202190267 A1 EA 202190267A1 EA 202190267 A EA202190267 A EA 202190267A EA 202190267 A EA202190267 A EA 202190267A EA 202190267 A1 EA202190267 A1 EA 202190267A1
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Eurasian Patent Office
Prior art keywords
dendritic cells
compositions
methods
cancer therapy
recombinant dendritic
Prior art date
Application number
EA202190267A
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English (en)
Inventor
Серхат Гумруксу
Original Assignee
Инокиан Байофарма, Инк.
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Application filed by Инокиан Байофарма, Инк. filed Critical Инокиан Байофарма, Инк.
Publication of EA202190267A1 publication Critical patent/EA202190267A1/ru

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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

В настоящем изобретении раскрыты способы и композиции для лечения рака посредством индукции иммунного ответа путем введения дендритных клеток, экспрессирующих гетерологичные белки. В некоторых вариантах осуществления дендритная клетка включает одну или более гетерологичных молекул нуклеиновых кислот, кодирующих CD40L и CXCL13. В некоторых вариантах осуществления дендритная клетка дополнительно включает гетерологичную молекулу нуклеиновой кислоты, кодирующую CD93. В других дополнительных вариантах осуществления дендритные клетки, экспрессирующие гетерологичные белки, активированы.
EA202190267A 2018-07-15 2019-07-15 Способы и композиции с использованием рекомбинантных дендритных клеток для терапии рака EA202190267A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862698254P 2018-07-15 2018-07-15
PCT/US2019/041786 WO2020018413A1 (en) 2018-07-15 2019-07-15 Methods and compositions using recombinant dendritic cells for cancer therapy

Publications (1)

Publication Number Publication Date
EA202190267A1 true EA202190267A1 (ru) 2021-05-17

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EA202190267A EA202190267A1 (ru) 2018-07-15 2019-07-15 Способы и композиции с использованием рекомбинантных дендритных клеток для терапии рака

Country Status (14)

Country Link
US (1) US11413338B2 (ru)
EP (1) EP3820486A4 (ru)
JP (1) JP7520806B2 (ru)
KR (1) KR20210044207A (ru)
CN (1) CN112703004A (ru)
AU (1) AU2019306504A1 (ru)
BR (1) BR112021000620A2 (ru)
CA (1) CA3106403A1 (ru)
EA (1) EA202190267A1 (ru)
IL (1) IL280145A (ru)
MX (1) MX2021000421A (ru)
SG (1) SG11202100315TA (ru)
WO (1) WO2020018413A1 (ru)
ZA (1) ZA202100234B (ru)

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Publication number Publication date
WO2020018413A1 (en) 2020-01-23
JP2021531765A (ja) 2021-11-25
IL280145A (en) 2021-03-01
CN112703004A (zh) 2021-04-23
ZA202100234B (en) 2022-07-27
CA3106403A1 (en) 2020-01-23
AU2019306504A1 (en) 2021-03-11
BR112021000620A2 (pt) 2021-04-20
KR20210044207A (ko) 2021-04-22
EP3820486A4 (en) 2022-05-04
US20200016250A1 (en) 2020-01-16
EP3820486A1 (en) 2021-05-19
SG11202100315TA (en) 2021-02-25
US11413338B2 (en) 2022-08-16
MX2021000421A (es) 2021-05-12
JP7520806B2 (ja) 2024-07-23

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