EA202092065A1 - ЭКСПРЕССИЯ ПНЕВМОКОККОВОГО ПОВЕРХНОСТНОГО БЕЛКА А (PspA) - Google Patents
ЭКСПРЕССИЯ ПНЕВМОКОККОВОГО ПОВЕРХНОСТНОГО БЕЛКА А (PspA)Info
- Publication number
- EA202092065A1 EA202092065A1 EA202092065A EA202092065A EA202092065A1 EA 202092065 A1 EA202092065 A1 EA 202092065A1 EA 202092065 A EA202092065 A EA 202092065A EA 202092065 A EA202092065 A EA 202092065A EA 202092065 A1 EA202092065 A1 EA 202092065A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pspa
- expression
- surface protein
- pneumococcal surface
- discloses
- Prior art date
Links
- 108010040473 pneumococcal surface protein A Proteins 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к экспрессии пневмококкового поверхностного белка A (PspA). Изобретение представляет собой усовершенствование в области генной инженерии и технологии вакцин. В изобретении раскрыты экспрессионные векторы и рекомбинантные клетки-хозяева для экспрессии усеченного пептида PspA. В изобретении также раскрыты вакцинные композиции, содержащие усеченные пептиды в качестве белка-носителя.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201841007814 | 2018-03-01 | ||
PCT/IB2019/051655 WO2019167008A1 (en) | 2018-03-01 | 2019-03-01 | Expression of pneumococcal surface protein a (pspa) |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202092065A1 true EA202092065A1 (ru) | 2020-11-19 |
Family
ID=66440079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092065A EA202092065A1 (ru) | 2018-03-01 | 2019-03-01 | ЭКСПРЕССИЯ ПНЕВМОКОККОВОГО ПОВЕРХНОСТНОГО БЕЛКА А (PspA) |
Country Status (18)
Country | Link |
---|---|
US (2) | US11725029B2 (ru) |
EP (1) | EP3758746A1 (ru) |
JP (2) | JP7334176B2 (ru) |
KR (1) | KR20200129121A (ru) |
CN (1) | CN112118865A (ru) |
AU (1) | AU2019226487A1 (ru) |
BR (1) | BR112020017431A2 (ru) |
CA (1) | CA3091583A1 (ru) |
CL (1) | CL2020002246A1 (ru) |
CU (1) | CU24709B1 (ru) |
EA (1) | EA202092065A1 (ru) |
IL (1) | IL277023A (ru) |
MX (1) | MX2020009049A (ru) |
PH (1) | PH12020551357A1 (ru) |
SA (1) | SA520420041B1 (ru) |
SG (1) | SG11202008124XA (ru) |
WO (1) | WO2019167008A1 (ru) |
ZA (1) | ZA202005414B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
CA3231684A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5476929A (en) * | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
JP4712716B2 (ja) * | 2004-09-09 | 2011-06-29 | 財団法人地球環境産業技術研究機構 | プロモーター機能を有するdna断片 |
KR101813824B1 (ko) | 2008-06-25 | 2017-12-29 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
WO2010141312A2 (en) * | 2009-06-01 | 2010-12-09 | Wake Forest University Health Sciences | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same |
GB201003924D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
CN107674118A (zh) * | 2016-08-02 | 2018-02-09 | 中国食品药品检定研究院 | 重组蛋白PspA1、PspA2和PspA3以及包含其的多糖结合疫苗 |
-
2019
- 2019-03-01 WO PCT/IB2019/051655 patent/WO2019167008A1/en active Application Filing
- 2019-03-01 JP JP2020545584A patent/JP7334176B2/ja active Active
- 2019-03-01 EA EA202092065A patent/EA202092065A1/ru unknown
- 2019-03-01 CA CA3091583A patent/CA3091583A1/en active Pending
- 2019-03-01 MX MX2020009049A patent/MX2020009049A/es unknown
- 2019-03-01 US US16/976,794 patent/US11725029B2/en active Active
- 2019-03-01 BR BR112020017431-9A patent/BR112020017431A2/pt unknown
- 2019-03-01 KR KR1020207028234A patent/KR20200129121A/ko not_active Application Discontinuation
- 2019-03-01 CN CN201980027604.6A patent/CN112118865A/zh active Pending
- 2019-03-01 CU CU2020000064A patent/CU24709B1/es unknown
- 2019-03-01 SG SG11202008124XA patent/SG11202008124XA/en unknown
- 2019-03-01 EP EP19722677.2A patent/EP3758746A1/en active Pending
- 2019-03-01 AU AU2019226487A patent/AU2019226487A1/en active Pending
-
2020
- 2020-08-25 SA SA520420041A patent/SA520420041B1/ar unknown
- 2020-08-28 PH PH12020551357A patent/PH12020551357A1/en unknown
- 2020-08-31 CL CL2020002246A patent/CL2020002246A1/es unknown
- 2020-08-31 ZA ZA2020/05414A patent/ZA202005414B/en unknown
- 2020-08-31 IL IL277023A patent/IL277023A/en unknown
-
2023
- 2023-06-21 US US18/338,584 patent/US20230322871A1/en active Pending
- 2023-08-16 JP JP2023132515A patent/JP2023154063A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3091583A1 (en) | 2019-09-06 |
WO2019167008A1 (en) | 2019-09-06 |
ZA202005414B (en) | 2022-02-23 |
US20210009641A1 (en) | 2021-01-14 |
JP2023154063A (ja) | 2023-10-18 |
SA520420041B1 (ar) | 2024-03-14 |
IL277023A (en) | 2020-10-29 |
CN112118865A (zh) | 2020-12-22 |
AU2019226487A1 (en) | 2020-09-10 |
CL2020002246A1 (es) | 2021-01-15 |
US20230322871A1 (en) | 2023-10-12 |
SG11202008124XA (en) | 2020-09-29 |
JP7334176B2 (ja) | 2023-08-28 |
BR112020017431A2 (pt) | 2021-01-19 |
CU20200064A7 (es) | 2021-04-07 |
MX2020009049A (es) | 2020-10-12 |
KR20200129121A (ko) | 2020-11-17 |
EP3758746A1 (en) | 2021-01-06 |
PH12020551357A1 (en) | 2021-08-23 |
JP2021516050A (ja) | 2021-07-01 |
US11725029B2 (en) | 2023-08-15 |
CU24709B1 (es) | 2024-06-11 |
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