MX2022013963A - Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas. - Google Patents

Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.

Info

Publication number
MX2022013963A
MX2022013963A MX2022013963A MX2022013963A MX2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A
Authority
MX
Mexico
Prior art keywords
methods
adeno
associated virus
cross
species compatible
Prior art date
Application number
MX2022013963A
Other languages
English (en)
Inventor
Aravind Asokan
Trevor Gonzalez
Lawrence Patrick Havlik
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of MX2022013963A publication Critical patent/MX2022013963A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente divulgación proporciona vectores de virus adenoasociados (AAV), que comprenden proteínas variantes de la cápside co-desarroladas, composiciones farmacéuticas, métodos de preparación, y métodos para administrarlas a un sujeto.
MX2022013963A 2020-05-05 2021-05-05 Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas. MX2022013963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020062P 2020-05-05 2020-05-05
PCT/US2021/030937 WO2021226267A2 (en) 2020-05-05 2021-05-05 Cross-species compatible adeno-associated virus compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022013963A true MX2022013963A (es) 2023-02-22

Family

ID=78468375

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013963A MX2022013963A (es) 2020-05-05 2021-05-05 Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.

Country Status (13)

Country Link
US (3) US20230151389A1 (es)
EP (1) EP4125977A4 (es)
JP (1) JP2023524291A (es)
KR (1) KR20230029616A (es)
CN (1) CN116096377A (es)
AR (1) AR122013A1 (es)
AU (1) AU2021268946A1 (es)
BR (1) BR112022022644A2 (es)
CA (1) CA3177869A1 (es)
IL (1) IL297577A (es)
MX (1) MX2022013963A (es)
TW (1) TW202208631A (es)
WO (1) WO2021226267A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116096377A (zh) * 2020-05-05 2023-05-09 杜克大学 跨物种相容的腺相关病毒组合物及其使用方法
WO2024044725A2 (en) * 2022-08-24 2024-02-29 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024168043A1 (en) * 2023-02-08 2024-08-15 Ginkgo Bioworks, Inc. Gene therapy for angelman syndrome
WO2024191778A1 (en) 2023-03-10 2024-09-19 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
CA2348382C (en) 1998-11-10 2013-09-17 The University Of North Carolina At Chapel Hill Chimeric parvovirus vectors and methods of making and administering the same
US7314912B1 (en) 1999-06-21 2008-01-01 Medigene Aktiengesellschaft AAv scleroprotein, production and use thereof
ATE318923T1 (de) 2000-06-01 2006-03-15 Univ North Carolina Doppelsträngige parvovirus-vektoren
CA3072423A1 (en) * 2003-09-30 2005-04-14 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
CN105247044B (zh) * 2013-05-31 2021-05-07 加利福尼亚大学董事会 腺相关病毒变体及其使用方法
US10746742B2 (en) * 2014-04-25 2020-08-18 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
US10577627B2 (en) * 2014-06-09 2020-03-03 Voyager Therapeutics, Inc. Chimeric capsids
PL3356390T3 (pl) * 2015-09-28 2021-07-05 The University Of North Carolina At Chapel Hill Sposoby i kompozycje dla wektorów wirusowych unikających przeciwciał
US12091435B2 (en) * 2018-04-03 2024-09-17 Ginkgo Bioworks, Inc. Antibody-evading virus vectors
US20210214749A1 (en) 2018-05-16 2021-07-15 Voyager Therapeutics, Inc. Directed evolution
WO2020191300A1 (en) 2019-03-21 2020-09-24 Stridebio, Inc. Recombinant adeno-associated virus vectors
CN116096377A (zh) * 2020-05-05 2023-05-09 杜克大学 跨物种相容的腺相关病毒组合物及其使用方法

Also Published As

Publication number Publication date
AU2021268946A1 (en) 2022-12-01
EP4125977A2 (en) 2023-02-08
JP2023524291A (ja) 2023-06-09
WO2021226267A2 (en) 2021-11-11
EP4125977A4 (en) 2024-09-25
US20240076695A1 (en) 2024-03-07
CA3177869A1 (en) 2021-11-11
US12037598B2 (en) 2024-07-16
TW202208631A (zh) 2022-03-01
WO2021226267A3 (en) 2021-12-16
US20230151389A1 (en) 2023-05-18
IL297577A (en) 2022-12-01
KR20230029616A (ko) 2023-03-03
US20240067988A1 (en) 2024-02-29
BR112022022644A2 (pt) 2023-01-17
AR122013A1 (es) 2022-08-03
CN116096377A (zh) 2023-05-09

Similar Documents

Publication Publication Date Title
MX2022013963A (es) Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.
PH12020551938A1 (en) Liver targeting adeno-associated viral vectors
MX2017012097A (es) Variantes de virus adenoasociado y métodos de uso de estas.
PH12019500068A1 (en) Novel adeno-associated virus capsid proteins
PH12018500594A1 (en) Adeno-associated virus factor viii vectors, associated viral particles and therapeutic formulations comprising the same
MX2021006646A (es) Vector viral adenoasociado recombinante para el suministro de genes.
PH12020550094A1 (en) Adeno-associated virus variant capsids and methods of use thereof
UA124343C2 (uk) Капсиди аденоасоційованого вірусу і спосіб його використання
MX2019009720A (es) Metodos y composiciones para la transferencia de genes a traves de la vasculatura.
MX2019010275A (es) Novedoso vector del subtipo f del virus adenoasociado (aav) y usos de este.
MX2022014256A (es) Redirección del tropismo de las cápsides de aav.
AU2018298422A1 (en) Novel nucleic acid molecules
WO2017058892A3 (en) Methods and compositions for antibody-evading virus vectors
WO2018191502A3 (en) Anti-cd137 antibodies and methods of use thereof
MX2020010464A (es) Vectores de virus que evitan anticuerpos.
BR112021020957A2 (pt) Capsídeos de vírus adenoassociado (aav) variante para liberação intravítrea
WO2019210267A3 (en) Engineered aav capsids with increased tropism and aav vectors comprising the engineered capsids and methods of making and using same
MX2024004936A (es) Variantes de capsides de aav y sus usos.
SA521421715B1 (ar) تركيبات سيماجلوتيد ثابتة واستخداماتها
MX2019008105A (es) Virus.
MX2021009696A (es) Vectores de genoterapia para el tratamiento de la enfermedad de danon.
EA201890110A1 (ru) Рекомбинантные вирусные векторы, содержащие минорные белки prrsv, и способы их получения и применения
PH12020551642A1 (en) Aav compositions, methods of making and methods of use
MX2020002148A (es) Vectores adenoasociados recombinantes.
MX2018000023A (es) Particulas semejantes a virus recombinantes que utilizan la proteina gag del virus de inmunodeficiencia bovina.