BR112022022644A2 - Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas - Google Patents

Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas

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Publication number
BR112022022644A2
BR112022022644A2 BR112022022644A BR112022022644A BR112022022644A2 BR 112022022644 A2 BR112022022644 A2 BR 112022022644A2 BR 112022022644 A BR112022022644 A BR 112022022644A BR 112022022644 A BR112022022644 A BR 112022022644A BR 112022022644 A2 BR112022022644 A2 BR 112022022644A2
Authority
BR
Brazil
Prior art keywords
adeno
cross
associated virus
species compatible
virus compositions
Prior art date
Application number
BR112022022644A
Other languages
English (en)
Inventor
Asokan Aravind
Gonzalez Trevor
Patrick Havlik Lawrence
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of BR112022022644A2 publication Critical patent/BR112022022644A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

COMPOSIÇÕES DE VÍRUS ADENO-ASSOCIADOS COMPATÍVEIS COM ESPÉCIES CRUZADAS E MÉTODO DE USO DESTAS. A presente divulgação fornece vetores de vírus adeno-associados (AAV), compreendendo proteínas variantes do capsídeo coevoluídas, composições farmacêuticas, métodos de fabricação, e métodos para distribuição para um sujeito.
BR112022022644A 2020-05-05 2021-05-05 Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas BR112022022644A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020062P 2020-05-05 2020-05-05
PCT/US2021/030937 WO2021226267A2 (en) 2020-05-05 2021-05-05 Cross-species compatible adeno-associated virus compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112022022644A2 true BR112022022644A2 (pt) 2023-01-17

Family

ID=78468375

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022644A BR112022022644A2 (pt) 2020-05-05 2021-05-05 Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas

Country Status (13)

Country Link
US (3) US20230151389A1 (pt)
EP (1) EP4125977A2 (pt)
JP (1) JP2023524291A (pt)
KR (1) KR20230029616A (pt)
CN (1) CN116096377A (pt)
AR (1) AR122013A1 (pt)
AU (1) AU2021268946A1 (pt)
BR (1) BR112022022644A2 (pt)
CA (1) CA3177869A1 (pt)
IL (1) IL297577A (pt)
MX (1) MX2022013963A (pt)
TW (1) TW202208631A (pt)
WO (1) WO2021226267A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024044725A2 (en) * 2022-08-24 2024-02-29 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298926A1 (en) * 2003-09-30 2011-03-23 The Trustees of The University of Pennsylvania Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
US10746742B2 (en) * 2014-04-25 2020-08-18 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping

Also Published As

Publication number Publication date
IL297577A (en) 2022-12-01
KR20230029616A (ko) 2023-03-03
TW202208631A (zh) 2022-03-01
AU2021268946A1 (en) 2022-12-01
CN116096377A (zh) 2023-05-09
EP4125977A2 (en) 2023-02-08
MX2022013963A (es) 2023-02-22
US20240067988A1 (en) 2024-02-29
JP2023524291A (ja) 2023-06-09
AR122013A1 (es) 2022-08-03
CA3177869A1 (en) 2021-11-11
WO2021226267A2 (en) 2021-11-11
US20240076695A1 (en) 2024-03-07
WO2021226267A3 (en) 2021-12-16
US20230151389A1 (en) 2023-05-18

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