BR112022022644A2 - Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas - Google Patents

Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas

Info

Publication number
BR112022022644A2
BR112022022644A2 BR112022022644A BR112022022644A BR112022022644A2 BR 112022022644 A2 BR112022022644 A2 BR 112022022644A2 BR 112022022644 A BR112022022644 A BR 112022022644A BR 112022022644 A BR112022022644 A BR 112022022644A BR 112022022644 A2 BR112022022644 A2 BR 112022022644A2
Authority
BR
Brazil
Prior art keywords
adeno
cross
associated virus
species compatible
virus compositions
Prior art date
Application number
BR112022022644A
Other languages
English (en)
Inventor
Asokan Aravind
Gonzalez Trevor
Patrick Havlik Lawrence
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of BR112022022644A2 publication Critical patent/BR112022022644A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

COMPOSIÇÕES DE VÍRUS ADENO-ASSOCIADOS COMPATÍVEIS COM ESPÉCIES CRUZADAS E MÉTODO DE USO DESTAS. A presente divulgação fornece vetores de vírus adeno-associados (AAV), compreendendo proteínas variantes do capsídeo coevoluídas, composições farmacêuticas, métodos de fabricação, e métodos para distribuição para um sujeito.
BR112022022644A 2020-05-05 2021-05-05 Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas BR112022022644A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020062P 2020-05-05 2020-05-05
PCT/US2021/030937 WO2021226267A2 (en) 2020-05-05 2021-05-05 Cross-species compatible adeno-associated virus compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112022022644A2 true BR112022022644A2 (pt) 2023-01-17

Family

ID=78468375

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022644A BR112022022644A2 (pt) 2020-05-05 2021-05-05 Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas

Country Status (13)

Country Link
US (3) US20230151389A1 (pt)
EP (1) EP4125977A4 (pt)
JP (1) JP2023524291A (pt)
KR (1) KR20230029616A (pt)
CN (1) CN116096377A (pt)
AR (1) AR122013A1 (pt)
AU (1) AU2021268946A1 (pt)
BR (1) BR112022022644A2 (pt)
CA (1) CA3177869A1 (pt)
IL (1) IL297577A (pt)
MX (1) MX2022013963A (pt)
TW (1) TW202208631A (pt)
WO (1) WO2021226267A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230029616A (ko) * 2020-05-05 2023-03-03 듀크 유니버시티 종간 호환가능한 아데노-관련 바이러스 조성물 및 이의 사용 방법
WO2023060264A1 (en) 2021-10-08 2023-04-13 Dyno Therapeutics, Inc. Capsid variants and methods of using the same
WO2024044725A2 (en) * 2022-08-24 2024-02-29 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024168043A1 (en) * 2023-02-08 2024-08-15 Ginkgo Bioworks, Inc. Gene therapy for angelman syndrome
WO2024191778A1 (en) 2023-03-10 2024-09-19 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
ES2340230T3 (es) 1998-11-10 2010-05-31 University Of North Carolina At Chapel Hill Vectores viricos y sus procedimientos de preparacion y administracion.
US7314912B1 (en) 1999-06-21 2008-01-01 Medigene Aktiengesellschaft AAv scleroprotein, production and use thereof
WO2001092551A2 (en) 2000-06-01 2001-12-06 University Of North Carolina At Chapel Hill Duplexed parvovirus vectors
ES2648241T3 (es) 2003-09-30 2017-12-29 The Trustees Of The University Of Pennsylvania Clados de virus adenoasociados (AAV), secuencias, vectores que contienen el mismo, y usos de los mismos
US11136557B2 (en) * 2013-05-31 2021-10-05 The Regents Of The University Of California Adeno-associated virus variants and methods of use thereof
WO2015164757A1 (en) * 2014-04-25 2015-10-29 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
US10577627B2 (en) * 2014-06-09 2020-03-03 Voyager Therapeutics, Inc. Chimeric capsids
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors
MX2020010466A (es) * 2018-04-03 2021-01-08 Vectores de virus que evitan anticuerpos.
WO2019222444A2 (en) 2018-05-16 2019-11-21 Voyager Therapeutics, Inc. Directed evolution
KR20220011616A (ko) 2019-03-21 2022-01-28 스트라이드바이오 인코포레이티드 재조합 아데노 관련 바이러스 벡터
KR20230029616A (ko) * 2020-05-05 2023-03-03 듀크 유니버시티 종간 호환가능한 아데노-관련 바이러스 조성물 및 이의 사용 방법

Also Published As

Publication number Publication date
WO2021226267A3 (en) 2021-12-16
EP4125977A2 (en) 2023-02-08
JP2023524291A (ja) 2023-06-09
CA3177869A1 (en) 2021-11-11
WO2021226267A2 (en) 2021-11-11
US20240076695A1 (en) 2024-03-07
AR122013A1 (es) 2022-08-03
US20240067988A1 (en) 2024-02-29
EP4125977A4 (en) 2024-09-25
TW202208631A (zh) 2022-03-01
IL297577A (en) 2022-12-01
KR20230029616A (ko) 2023-03-03
MX2022013963A (es) 2023-02-22
US12037598B2 (en) 2024-07-16
CN116096377A (zh) 2023-05-09
US20230151389A1 (en) 2023-05-18
AU2021268946A1 (en) 2022-12-01

Similar Documents

Publication Publication Date Title
BR112022022644A2 (pt) Composições de vírus adeno-associados compatíveis com espécies cruzadas e método de uso destas
BR112022023106A2 (pt) Redirecionamento de tropismo de capsídeos de aav
CO2020004738A2 (es) Variantes de cápsides de virus adenoasociados y métodos de uso de estas
CL2023000264A1 (es) Nuevos vectores virales adeno-asociados dirigidos al hígado
BR112018011711A2 (pt) peptídeos de direcionamento para direcionar virus adeno-associados (aav)
BR112018071180A2 (pt) métodos de reforço potência biológica de baculovirus system-produzido vírus adeno-associado recombinante
BR112018003665A2 (pt) métodos e composições para vetores virais de evasão de anticorpo
CL2018002825A1 (es) Vacuna contra vrs
CL2018003196A1 (es) Cápsides variantes de virus adenoasociados y métodos de uso de estas.
AR118465A1 (es) Vectores de virus adenoasociados recombinantes
CL2018000587A1 (es) Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017)
MX2017012097A (es) Variantes de virus adenoasociado y métodos de uso de estas.
BR112021020957A2 (pt) Capsídeos de vírus adenoassociado (aav) variante para liberação intravítrea
EA202091712A1 (ru) МОДИФИЦИРОВАННЫЙ КАПСИДНЫЙ БЕЛОК rAAV ДЛЯ ГЕННОЙ ТЕРАПИИ
BR112019002904A2 (pt) métodos e composições para transferência gênica direcionada
AR116569A1 (es) Terapia génica para tratar la acidemia propiónica
UY37198A (es) Vacuna universal para enfermedades virales
MX2024009660A (es) Variantes de capside de aav y usos de las mismas.
BR112017024283A8 (pt) Vacinas contra a dengue
EA201890187A1 (ru) Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита
MX2019007924A (es) Vacunas contra la influenza.
CO2020009043A2 (es) Anticuerpos humanos contra hemaglutinina de influenza
MX2019010045A (es) Metodos para determinar la potencia de preparaciones de virus adeno-asociados.
BR112022003751A2 (pt) Análogos de hemoglobina reticulada com tiosuccinila e métodos de uso e preparação dos mesmos
BR112019008584A2 (pt) vacinas de mosaico para vírus de doença de pé-e-boca de sorotipo a