BR112019008584A2 - vacinas de mosaico para vírus de doença de pé-e-boca de sorotipo a - Google Patents

vacinas de mosaico para vírus de doença de pé-e-boca de sorotipo a

Info

Publication number
BR112019008584A2
BR112019008584A2 BR112019008584A BR112019008584A BR112019008584A2 BR 112019008584 A2 BR112019008584 A2 BR 112019008584A2 BR 112019008584 A BR112019008584 A BR 112019008584A BR 112019008584 A BR112019008584 A BR 112019008584A BR 112019008584 A2 BR112019008584 A2 BR 112019008584A2
Authority
BR
Brazil
Prior art keywords
fmdv
mosaic
polypeptides
serotype
foot
Prior art date
Application number
BR112019008584A
Other languages
English (en)
Inventor
E Rieder Aida
K Rai Devendra
m fischer William
Original Assignee
Los Alamos Nat Security Llc
Us Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Alamos Nat Security Llc, Us Agriculture filed Critical Los Alamos Nat Security Llc
Publication of BR112019008584A2 publication Critical patent/BR112019008584A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

são descritos polipeptídeos de mosaico sintéticos de vírus de doença de pé-e-boca (fmdv), e de moléculas de ácido nucleico que codificam os polipeptídeos de mosaico. os polipeptídeos de mosaico têm maior cobertura de epítopo de célula t que os polipeptídeos de fmdv de ocorrência natural, e incluem epítopos de fmdv comuns, mas excluem epítopos de fmdv raros. quando incluídos como parte de um genoma de fmdv, os polipeptídeos de mosaico permitem a replicação viral e a montagem em partículas de fmdv. o polipeptídeo de mosaico e as composições de ácido nucleico podem ser usados para provocar respostas imunes que fornecem proteção contra uma ampla faixa de cepas de fmdv de sorotipo a.
BR112019008584A 2016-10-31 2017-10-25 vacinas de mosaico para vírus de doença de pé-e-boca de sorotipo a BR112019008584A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662415124P 2016-10-31 2016-10-31
US15/785,875 US10172933B2 (en) 2016-10-31 2017-10-17 Mosaic vaccines for serotype a foot-and-mouth disease virus
PCT/US2017/058295 WO2018081274A1 (en) 2016-10-31 2017-10-25 Mosaic vaccines for serotype a foot-and-mouth disease virus

Publications (1)

Publication Number Publication Date
BR112019008584A2 true BR112019008584A2 (pt) 2019-09-17

Family

ID=62020851

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019008584A BR112019008584A2 (pt) 2016-10-31 2017-10-25 vacinas de mosaico para vírus de doença de pé-e-boca de sorotipo a

Country Status (10)

Country Link
US (1) US10172933B2 (pt)
EP (1) EP3532484A4 (pt)
JP (1) JP7137276B2 (pt)
CN (1) CN110382518B (pt)
AU (1) AU2017350853B2 (pt)
BR (1) BR112019008584A2 (pt)
CA (1) CA3041809A1 (pt)
MX (1) MX2019005045A (pt)
RU (1) RU2019113940A (pt)
WO (1) WO2018081274A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3244920T3 (pl) 2015-01-16 2023-09-25 Zoetis Services Llc Szczepionka przeciw pryszczycy

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
WO1996002555A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
JP2001513776A (ja) 1997-02-28 2001-09-04 ユニバーシティ オブ アイオワ リサーチ ファウンデーション ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
ATE370740T1 (de) 1997-05-20 2007-09-15 Ottawa Health Research Inst Verfahren zur herstellung von nukleinsäurekonstrukten
ES2284247T3 (es) 1998-04-03 2007-11-01 University Of Iowa Research Foundation Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
CN1408434A (zh) * 2002-09-16 2003-04-09 复旦大学 抗家畜口蹄疫的多肽和dna联合疫苗及其制备方法
US20110014232A1 (en) * 2009-07-16 2011-01-20 Agricultural Research Council Chimeric foot and mouth disease viruses
KR101965337B1 (ko) * 2009-11-02 2019-04-03 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 구제역 바이러스(ｆｍｄｖ) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신
GB201014965D0 (en) 2010-09-08 2010-10-20 Animal Health Inst Vaccine
CN102406929B (zh) * 2011-11-25 2013-09-04 青岛红桥明勤生物科技有限公司 一种共表达分子佐剂加强型二价口蹄疫蛋白工程疫苗
WO2014077825A1 (en) 2012-11-16 2014-05-22 United Biomedical, Inc. Synthetic peptide-based emergency vaccine against foot and mouth disease (fmd)
BR112015024391A2 (pt) 2013-03-26 2017-10-24 The Pirbright Inst mutante de proteína, capsídeo, método para melhorar a estabilidade de um capsídeo, molécula de ácido nucleico isolada, célula hospedeira, micro-organismo recombinante carreador vivo, vacina, uso de um mutante da proteína vp2, e, métodos para preparar uma vacina e um mutante da proteína
US10010605B2 (en) 2014-09-23 2018-07-03 Merial, Inc. FMDV recombinant vaccines and uses thereof

Also Published As

Publication number Publication date
JP7137276B2 (ja) 2022-09-14
EP3532484A4 (en) 2020-07-01
EP3532484A1 (en) 2019-09-04
US10172933B2 (en) 2019-01-08
MX2019005045A (es) 2019-10-14
JP2019533465A (ja) 2019-11-21
RU2019113940A3 (pt) 2020-12-21
AU2017350853B2 (en) 2021-11-25
CN110382518B (zh) 2022-11-29
CN110382518A (zh) 2019-10-25
CA3041809A1 (en) 2018-05-03
AU2017350853A1 (en) 2019-05-23
RU2019113940A (ru) 2020-11-09
US20180117138A1 (en) 2018-05-03
WO2018081274A1 (en) 2018-05-03

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