CL2020002246A1 - Expresión de proteína de superficie a neumocócica (pspa) - Google Patents
Expresión de proteína de superficie a neumocócica (pspa)Info
- Publication number
- CL2020002246A1 CL2020002246A1 CL2020002246A CL2020002246A CL2020002246A1 CL 2020002246 A1 CL2020002246 A1 CL 2020002246A1 CL 2020002246 A CL2020002246 A CL 2020002246A CL 2020002246 A CL2020002246 A CL 2020002246A CL 2020002246 A1 CL2020002246 A1 CL 2020002246A1
- Authority
- CL
- Chile
- Prior art keywords
- pspa
- surface protein
- pneumococcal surface
- protein expression
- expression
- Prior art date
Links
- 102000018697 Membrane Proteins Human genes 0.000 title 1
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 108010040473 pneumococcal surface protein A Proteins 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a la expresión de proteína de superficie A neumocócica (PspA). La invención representa un avance en el campo de ingeniería genética y tecnología de vacunas. La invención describe vectores de expresión y células hospederas recombinantes para la expresión del péptido PspA truncado. La invención también describe composiciones de vacuna que comprenden los péptidos truncados como proteína portadora.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201841007814 | 2018-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020002246A1 true CL2020002246A1 (es) | 2021-01-15 |
Family
ID=66440079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020002246A CL2020002246A1 (es) | 2018-03-01 | 2020-08-31 | Expresión de proteína de superficie a neumocócica (pspa) |
Country Status (17)
Country | Link |
---|---|
US (2) | US11725029B2 (es) |
EP (1) | EP3758746A1 (es) |
JP (2) | JP7334176B2 (es) |
KR (1) | KR20200129121A (es) |
CN (1) | CN112118865A (es) |
AU (1) | AU2019226487A1 (es) |
BR (1) | BR112020017431A2 (es) |
CA (1) | CA3091583A1 (es) |
CL (1) | CL2020002246A1 (es) |
CU (1) | CU20200064A7 (es) |
EA (1) | EA202092065A1 (es) |
IL (1) | IL277023A (es) |
MX (1) | MX2020009049A (es) |
PH (1) | PH12020551357A1 (es) |
SG (1) | SG11202008124XA (es) |
WO (1) | WO2019167008A1 (es) |
ZA (1) | ZA202005414B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
WO2023039223A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5476929A (en) * | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
ES2444785T3 (es) | 2004-09-09 | 2014-02-26 | Research Institute Of Innovative Technology For The Earth | Fragmento de ADN que tiene función promotora |
CN105483067A (zh) | 2008-06-25 | 2016-04-13 | 瓦克星治疗有限责任公司 | 可调型基因自杀机制组合物和方法 |
WO2010141312A2 (en) | 2009-06-01 | 2010-12-09 | Wake Forest University Health Sciences | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
CN107674118A (zh) | 2016-08-02 | 2018-02-09 | 中国食品药品检定研究院 | 重组蛋白PspA1、PspA2和PspA3以及包含其的多糖结合疫苗 |
-
2019
- 2019-03-01 BR BR112020017431-9A patent/BR112020017431A2/pt unknown
- 2019-03-01 CU CU2020000064A patent/CU20200064A7/es unknown
- 2019-03-01 WO PCT/IB2019/051655 patent/WO2019167008A1/en active Application Filing
- 2019-03-01 AU AU2019226487A patent/AU2019226487A1/en active Pending
- 2019-03-01 US US16/976,794 patent/US11725029B2/en active Active
- 2019-03-01 JP JP2020545584A patent/JP7334176B2/ja active Active
- 2019-03-01 CA CA3091583A patent/CA3091583A1/en active Pending
- 2019-03-01 EA EA202092065A patent/EA202092065A1/ru unknown
- 2019-03-01 MX MX2020009049A patent/MX2020009049A/es unknown
- 2019-03-01 SG SG11202008124XA patent/SG11202008124XA/en unknown
- 2019-03-01 KR KR1020207028234A patent/KR20200129121A/ko active Search and Examination
- 2019-03-01 CN CN201980027604.6A patent/CN112118865A/zh active Pending
- 2019-03-01 EP EP19722677.2A patent/EP3758746A1/en active Pending
-
2020
- 2020-08-28 PH PH12020551357A patent/PH12020551357A1/en unknown
- 2020-08-31 IL IL277023A patent/IL277023A/en unknown
- 2020-08-31 CL CL2020002246A patent/CL2020002246A1/es unknown
- 2020-08-31 ZA ZA2020/05414A patent/ZA202005414B/en unknown
-
2023
- 2023-06-21 US US18/338,584 patent/US20230322871A1/en active Pending
- 2023-08-16 JP JP2023132515A patent/JP2023154063A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3091583A1 (en) | 2019-09-06 |
MX2020009049A (es) | 2020-10-12 |
AU2019226487A1 (en) | 2020-09-10 |
WO2019167008A1 (en) | 2019-09-06 |
EP3758746A1 (en) | 2021-01-06 |
JP7334176B2 (ja) | 2023-08-28 |
IL277023A (en) | 2020-10-29 |
ZA202005414B (en) | 2022-02-23 |
JP2023154063A (ja) | 2023-10-18 |
US20210009641A1 (en) | 2021-01-14 |
PH12020551357A1 (en) | 2021-08-23 |
CU20200064A7 (es) | 2021-04-07 |
BR112020017431A2 (pt) | 2021-01-19 |
EA202092065A1 (ru) | 2020-11-19 |
US11725029B2 (en) | 2023-08-15 |
CN112118865A (zh) | 2020-12-22 |
SG11202008124XA (en) | 2020-09-29 |
JP2021516050A (ja) | 2021-07-01 |
KR20200129121A (ko) | 2020-11-17 |
US20230322871A1 (en) | 2023-10-12 |
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