ES2058565T3 - Retrovirus recombinante defectivo, su aplicacion en la integracion de secuencias que codifican proteinas determinadas en el genoma de cultivos celulares infectables por el retrovirus salvaje correspondiente y adns recombinantes para la produccion de dicho retrovirus recombinante. - Google Patents

Retrovirus recombinante defectivo, su aplicacion en la integracion de secuencias que codifican proteinas determinadas en el genoma de cultivos celulares infectables por el retrovirus salvaje correspondiente y adns recombinantes para la produccion de dicho retrovirus recombinante.

Info

Publication number
ES2058565T3
ES2058565T3 ES89400890T ES89400890T ES2058565T3 ES 2058565 T3 ES2058565 T3 ES 2058565T3 ES 89400890 T ES89400890 T ES 89400890T ES 89400890 T ES89400890 T ES 89400890T ES 2058565 T3 ES2058565 T3 ES 2058565T3
Authority
ES
Spain
Prior art keywords
retrovirus
recombinant
genome
adns
infectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89400890T
Other languages
English (en)
Inventor
Thierry Heidmann
Jean-Francois Nicolas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of ES2058565T3 publication Critical patent/ES2058565T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Saccharide Compounds (AREA)

Abstract

RETROVIRUS RECOMBINANTE DEFECTIVO CODIFICANTE PARA UNA PROTEINA DETERMINADA EN EL GENOMA DE LAS CELULAS. EL ADN DEL RETROVIRUS RECOMBINANTE CONTIENE LA SECUENCIA CODIFICANTE PARA LA PROTEINA Y LA SECUENCIA, INTERCALADA ENTRE UN PUNTO ACEPTOR DE UNION, Y UN PUNTO DONADOR DE UNION APTO PARA BLOQUEAR LA TRANSCRIPCION DE LA SECUENCIA CODIFICANTE, ESTANDO SITUADO EL CONJUNTO BAJO EL CONTROL DE UN PROMOTOR APROPIADO, Y ELLO EN CONDICIONES TALES QUE LA INFECCION DE DICHAS CELULAS POR ESTE VIRUS RECOMBINANTE ESTE ACOMPAÑADA DE LA INCORPORACION DE LA SECUENCIA CODANTE PARA LA PROTEINA EN EL GENOMA DE LAS CELULAS INFECTADAS.
ES89400890T 1988-03-31 1989-03-30 Retrovirus recombinante defectivo, su aplicacion en la integracion de secuencias que codifican proteinas determinadas en el genoma de cultivos celulares infectables por el retrovirus salvaje correspondiente y adns recombinantes para la produccion de dicho retrovirus recombinante. Expired - Lifetime ES2058565T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8804332A FR2629469B1 (fr) 1988-03-31 1988-03-31 Retrovirus recombinant defectif, son application a l'integration de sequences codantes pour des proteines determinees dans le genome de cultures cellulaires infectables par le retrovirus sauvage correspondant et adns recombinants pour la production de ce retrovirus recombinant

Publications (1)

Publication Number Publication Date
ES2058565T3 true ES2058565T3 (es) 1994-11-01

Family

ID=9364870

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89400890T Expired - Lifetime ES2058565T3 (es) 1988-03-31 1989-03-30 Retrovirus recombinante defectivo, su aplicacion en la integracion de secuencias que codifican proteinas determinadas en el genoma de cultivos celulares infectables por el retrovirus salvaje correspondiente y adns recombinantes para la produccion de dicho retrovirus recombinante.

Country Status (10)

Country Link
US (1) US5583022A (es)
EP (1) EP0336822B1 (es)
JP (1) JPH0213384A (es)
AT (1) ATE109831T1 (es)
CA (1) CA1341258C (es)
DE (1) DE68917349T2 (es)
DK (1) DK158389A (es)
ES (1) ES2058565T3 (es)
FR (1) FR2629469B1 (es)
PT (1) PT90185B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69230491T2 (de) * 1991-10-30 2000-08-03 Univ Paris Curie Transformierte zellen zur verhütung oder zur behandlung von virus-induzierten erkrankungen,besonders pathogenen retroviren
AU758262B2 (en) * 1995-08-07 2003-03-20 Institut Pasteur Natural or synthetic retroelements enabling nucleotide sequence insertion into a eukaryotic cell
FR2737731B1 (fr) * 1995-08-07 1997-10-10 Pasteur Institut Sequence de retroelements naturels ou synthetiques ayant pour fonction de permettre l'insertion de sequences nucleotidiques dans une cellule eucaryote
US5994136A (en) * 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
CA2350124A1 (en) * 1998-11-13 2000-05-25 Cell Genesys, Inc. A sensitive screening system for envelope-defective recombinant virus
EP1849873B1 (en) * 1999-04-29 2011-10-12 Gbp Ip, Llc Method and means for producing high titer, safe, recombinant lentivirus vectors
AU2002252370A1 (en) * 2001-03-12 2002-09-24 Irm, Llc. Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
AU2002254212A1 (en) * 2001-03-12 2002-09-24 Irm, Llc Identification of cellular targets for biologically active molecules
DE60233047D1 (de) * 2001-05-14 2009-09-03 Gbp Ip Llc Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60224492A (ja) * 1984-04-24 1985-11-08 Yuu Honshiyo 異種遺伝子の結合法
WO1986000922A1 (en) * 1984-07-30 1986-02-13 The Salk Institute For Biological Studies Retroviral gene transfer vectors
GB8424757D0 (en) * 1984-10-01 1984-11-07 Pasteur Institut Retroviral vector
AU582288B2 (en) * 1986-03-07 1989-03-16 Damon Biotech Inc. Vector and method for achieving high level expression in eukaryotic cells

Also Published As

Publication number Publication date
JPH0213384A (ja) 1990-01-17
DK158389D0 (da) 1989-03-31
DK158389A (da) 1989-10-01
US5583022A (en) 1996-12-10
CA1341258C (fr) 2001-06-19
DE68917349T2 (de) 1995-02-02
PT90185A (pt) 1989-11-10
ATE109831T1 (de) 1994-08-15
DE68917349D1 (de) 1994-09-15
FR2629469A1 (fr) 1989-10-06
PT90185B (pt) 1994-10-31
FR2629469B1 (fr) 1990-12-21
EP0336822A1 (fr) 1989-10-11
EP0336822B1 (fr) 1994-08-10

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