AU2021216389A1 - Engineered leucine decarboxylases - Google Patents

Engineered leucine decarboxylases Download PDF

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Publication number
AU2021216389A1
AU2021216389A1 AU2021216389A AU2021216389A AU2021216389A1 AU 2021216389 A1 AU2021216389 A1 AU 2021216389A1 AU 2021216389 A AU2021216389 A AU 2021216389A AU 2021216389 A AU2021216389 A AU 2021216389A AU 2021216389 A1 AU2021216389 A1 AU 2021216389A1
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AU
Australia
Prior art keywords
polypeptide
engineered
sequence
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021216389A
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English (en)
Inventor
Nikki DELLAS
Faye Loan Du
Stephan JENNE
Joyce Liu
Kerryn Mccluskie
Leann Quertinmont Teadt
Kristen Jean Vallieu
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Syntis Bio Inc
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Syntis Bio Inc
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Publication date
Application filed by Syntis Bio Inc filed Critical Syntis Bio Inc
Publication of AU2021216389A1 publication Critical patent/AU2021216389A1/en
Assigned to SYNTIS BIO, INC. reassignment SYNTIS BIO, INC. Request for Assignment Assignors: CODEXIS, INC.
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01014—Valine decarboxylase (4.1.1.14)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2021216389A 2020-02-04 2021-02-03 Engineered leucine decarboxylases Pending AU2021216389A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970039P 2020-02-04 2020-02-04
US62/970,039 2020-02-04
PCT/US2021/016450 WO2021158686A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Publications (1)

Publication Number Publication Date
AU2021216389A1 true AU2021216389A1 (en) 2022-08-11

Family

ID=77061734

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021216389A Pending AU2021216389A1 (en) 2020-02-04 2021-02-03 Engineered leucine decarboxylases

Country Status (12)

Country Link
US (2) US12241100B2 (https=)
EP (1) EP4103711A4 (https=)
JP (2) JP2023512683A (https=)
KR (1) KR20220137057A (https=)
CN (1) CN116113691A (https=)
AU (1) AU2021216389A1 (https=)
BR (1) BR112022015139A2 (https=)
CA (1) CA3168922A1 (https=)
IL (1) IL295169A (https=)
MX (1) MX2022009531A (https=)
PH (1) PH12022551776A1 (https=)
WO (1) WO2021158686A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023512683A (ja) 2020-02-04 2023-03-28 コデクシス， インコーポレイテッド 操作されたロイシンデカルボキシラーゼ
JP2024540358A (ja) * 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
WO2023102499A1 (en) * 2021-12-02 2023-06-08 Codexis, Inc. Engineered threonine aldolases and amino acid decarboxylases

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Also Published As

Publication number Publication date
MX2022009531A (es) 2022-09-09
BR112022015139A2 (pt) 2022-10-11
US20210238575A1 (en) 2021-08-05
US12241100B2 (en) 2025-03-04
JP2025143444A (ja) 2025-10-01
US20240018504A1 (en) 2024-01-18
PH12022551776A1 (en) 2023-11-29
CN116113691A (zh) 2023-05-12
EP4103711A1 (en) 2022-12-21
CA3168922A1 (en) 2021-08-12
EP4103711A4 (en) 2024-02-28
KR20220137057A (ko) 2022-10-11
IL295169A (en) 2022-09-01
JP2023512683A (ja) 2023-03-28
WO2021158686A1 (en) 2021-08-12
WO2021158686A8 (en) 2022-03-17

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