PH12020550745A1 - Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases - Google Patents
Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseasesInfo
- Publication number
- PH12020550745A1 PH12020550745A1 PH12020550745A PH12020550745A PH12020550745A1 PH 12020550745 A1 PH12020550745 A1 PH 12020550745A1 PH 12020550745 A PH12020550745 A PH 12020550745A PH 12020550745 A PH12020550745 A PH 12020550745A PH 12020550745 A1 PH12020550745 A1 PH 12020550745A1
- Authority
- PH
- Philippines
- Prior art keywords
- sglt
- inhibitor
- combination
- treatment
- related diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017081050 | 2017-11-30 | ||
| PCT/EP2018/082947 WO2019106066A1 (en) | 2017-11-30 | 2018-11-29 | Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12020550745A1 true PH12020550745A1 (en) | 2021-04-26 |
Family
ID=64606962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12020550745A PH12020550745A1 (en) | 2017-11-30 | 2020-05-29 | Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US12144811B2 (enExample) |
| EP (1) | EP3716979B1 (enExample) |
| JP (2) | JP7404235B2 (enExample) |
| KR (1) | KR20200094187A (enExample) |
| CN (1) | CN111405899B (enExample) |
| AU (1) | AU2018376263B2 (enExample) |
| BR (1) | BR112020010831A2 (enExample) |
| CA (1) | CA3083327A1 (enExample) |
| CL (1) | CL2020001394A1 (enExample) |
| DK (1) | DK3716979T3 (enExample) |
| EA (1) | EA202091324A1 (enExample) |
| ES (1) | ES3035734T3 (enExample) |
| FI (1) | FI3716979T3 (enExample) |
| HR (1) | HRP20250732T1 (enExample) |
| HU (1) | HUE071739T2 (enExample) |
| IL (1) | IL274943B2 (enExample) |
| LT (1) | LT3716979T (enExample) |
| MA (1) | MA51203A (enExample) |
| MX (1) | MX2020005543A (enExample) |
| MY (1) | MY210547A (enExample) |
| PH (1) | PH12020550745A1 (enExample) |
| PL (1) | PL3716979T3 (enExample) |
| PT (1) | PT3716979T (enExample) |
| RS (1) | RS66980B1 (enExample) |
| SG (1) | SG11202004862XA (enExample) |
| SI (1) | SI3716979T1 (enExample) |
| TW (1) | TWI809009B (enExample) |
| UA (1) | UA127083C2 (enExample) |
| WO (1) | WO2019106066A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201907435PA (en) | 2017-02-27 | 2019-09-27 | Idorsia Pharmaceuticals Ltd | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases |
| US11723929B2 (en) | 2017-06-13 | 2023-08-15 | The Regents Of The University Of California | Methods of improving cell-based therapy |
| AU2020378025A1 (en) * | 2019-11-07 | 2022-06-23 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of Aprocitentan, preparation method therefor and use thereof |
| JP2022554344A (ja) * | 2019-11-07 | 2022-12-28 | インクレベット，インコーポレイティド | コンパニオンアニマルにおける慢性腎疾患、高血圧、及び心不全の管理のためのナトリウム－グルコース共輸送体阻害剤 |
| KR20220104802A (ko) * | 2019-11-26 | 2022-07-26 | 액테리온 파마슈티칼 리미티드 | 폰탄-완화 환자의 폐 혈관 질환 및/또는 심장 기능장애의 치료를 위한 약제학적 조성물 |
| CN116173014A (zh) | 2019-12-17 | 2023-05-30 | 奇努克医疗公司 | 用阿曲生坦治疗IgA肾病的方法 |
| CR20230083A (es) * | 2020-07-10 | 2023-05-16 | Astrazeneca Ab | Combinación de zibotentan y dapagliflozina para el tratamiento de la enfermedad renal crónica |
| WO2022022865A1 (en) | 2020-07-27 | 2022-02-03 | Astrazeneca Ab | Methods of treating chronic kidney disease with dapagliflozin |
| CN116392472B (zh) * | 2020-07-27 | 2025-06-20 | 阿斯利康(瑞典)有限公司 | 用达格列净治疗慢性肾脏病的方法 |
| CN114644595A (zh) * | 2020-12-19 | 2022-06-21 | 普济生物科技（台州）有限公司 | 阿普昔腾坦的无定型态、其药物组合物和用途 |
| AU2022340358A1 (en) * | 2021-09-02 | 2024-01-04 | Daewoong Therapeutics Inc. | Pharmaceutical composition for preventing or treating diabetic eye disease comprising sglt-2 inhibitor |
| JP7396579B2 (ja) * | 2022-01-31 | 2023-12-12 | 壽製薬株式会社 | 左室駆出率が保たれた心不全に対する医薬組成物 |
| KR20250016196A (ko) | 2022-05-22 | 2025-02-03 | 이도르시아 파마슈티컬스 리미티드 | 고혈압의 치료를 위한 아프로시텐탄 |
| IL317162A (en) | 2022-05-25 | 2025-01-01 | Idorsia Pharmaceuticals Ltd | Crystalline forms of sodium (5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)(sulfamoyl)amide |
| JP2025537256A (ja) * | 2022-11-10 | 2025-11-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンジオポエチン様３（ａｎｇｐｔｌ３）阻害剤と溶質担体ファミリー５メンバー２（ｓｌｃ５ａ２）阻害剤の組み合わせによる腎疾患の治療 |
| WO2024136184A1 (ko) * | 2022-12-20 | 2024-06-27 | 주식회사 티에치팜 | 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 경구용 약학 제제 |
| WO2025089933A1 (ko) * | 2023-10-24 | 2025-05-01 | 주식회사 레드엔비아 | Sglt-2 저해제 및 dpp-4 저해제를 포함하는 혈관 또는 판막 협착증의 예방 또는 치료용 병용제제 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| US6515117B2 (en) * | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| CN100432070C (zh) | 2000-12-18 | 2008-11-12 | 埃科特莱茵药品有限公司 | 新颖的磺酰胺类化合物及其作为内皮素受体拮抗剂的应用 |
| WO2002053573A1 (en) | 2000-12-28 | 2002-07-11 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and use thereof in medicines |
| EP1364958B1 (en) * | 2001-02-27 | 2010-09-08 | Kissei Pharmaceutical Co., Ltd. | Glycopyranosyloxypyrazole derivatives and medicinal use thereof |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| UA86042C2 (en) | 2003-08-01 | 2009-03-25 | Янссен Фармацевтика Н.В. | Substituted indazole-o-glucosides |
| ES2649737T5 (es) | 2003-08-01 | 2021-07-07 | Mitsubishi Tanabe Pharma Corp | Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio |
| EP1724277A4 (en) | 2004-03-04 | 2012-05-02 | Kissei Pharmaceutical | ACCOLE HETEROCYCLIC DERIVATIVE, DRUG-CONTAINING COMPOSITION THEREOF, AND THE USE THEREOF |
| CN103030617A (zh) | 2004-03-16 | 2013-04-10 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| US20070196510A1 (en) | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
| WO2007146900A2 (en) | 2006-06-15 | 2007-12-21 | Gilead Colorado, Inc. | Antihypertensive therapy method |
| AR061627A1 (es) | 2006-06-27 | 2008-09-10 | Novartis Ag | Formas de dosificacion solidas de valsartan, amlodipina, e hidroclorotiazida, y metodo para elaborarlas |
| UY30730A1 (es) | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| MX2010001837A (es) * | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| MX2011002166A (es) | 2008-08-28 | 2011-04-07 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,1-triol. |
| JP2012528170A (ja) | 2009-05-27 | 2012-11-12 | ブリストル−マイヤーズ スクイブ カンパニー | 別の抗糖尿病薬を用いた先の治療に抵抗性を有する２型糖尿病患者をｓｇｌｔ２阻害剤およびその組成物を用いて治療する方法 |
| CA2812016A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CN113181161A (zh) * | 2013-04-18 | 2021-07-30 | 勃林格殷格翰国际有限公司 | 药物组合物、治疗方法及其用途 |
| AU2015210898A1 (en) | 2014-01-31 | 2016-07-28 | Janssen Pharmaceutica Nv | Methods for the treatment and prevention of renal disorders and fatty liver disorders |
| EP2907811A1 (en) | 2014-02-14 | 2015-08-19 | Actelion Pharmaceuticals Ltd. | Process for manufacturing pyrimidine sulfamide derivatives |
| US10174010B2 (en) * | 2014-03-19 | 2019-01-08 | Hangzhou Pushai Pharmaceutical Technology Co., Ltd. | Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof |
| RU2016143092A (ru) * | 2014-04-04 | 2018-05-08 | Санофи | Замещенные соединения инданона в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных с ними нарушений |
| JP2017515908A (ja) | 2014-05-16 | 2017-06-15 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | Ｓｇｌｔ２インヒビター誘発性グルカゴン分泌の抑制方法 |
| CA2966756A1 (en) | 2014-11-07 | 2016-05-12 | Donald K. Kohan | Methods of treating ckd using predictors of fluid retention |
| WO2017064679A1 (en) | 2015-10-15 | 2017-04-20 | Lupin Limited | Process for the preparation of amorphous canagliflozin |
| SG11201907435PA (en) | 2017-02-27 | 2019-09-27 | Idorsia Pharmaceuticals Ltd | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases |
-
2018
- 2018-11-29 ES ES18814821T patent/ES3035734T3/es active Active
- 2018-11-29 FI FIEP18814821.7T patent/FI3716979T3/fi active
- 2018-11-29 RS RS20250663A patent/RS66980B1/sr unknown
- 2018-11-29 DK DK18814821.7T patent/DK3716979T3/da active
- 2018-11-29 PL PL18814821.7T patent/PL3716979T3/pl unknown
- 2018-11-29 CN CN201880076562.0A patent/CN111405899B/zh active Active
- 2018-11-29 US US16/768,604 patent/US12144811B2/en active Active
- 2018-11-29 EP EP18814821.7A patent/EP3716979B1/en active Active
- 2018-11-29 IL IL274943A patent/IL274943B2/en unknown
- 2018-11-29 SI SI201831245T patent/SI3716979T1/sl unknown
- 2018-11-29 JP JP2020529550A patent/JP7404235B2/ja active Active
- 2018-11-29 HR HRP20250732TT patent/HRP20250732T1/hr unknown
- 2018-11-29 TW TW107142595A patent/TWI809009B/zh active
- 2018-11-29 EA EA202091324A patent/EA202091324A1/ru unknown
- 2018-11-29 SG SG11202004862XA patent/SG11202004862XA/en unknown
- 2018-11-29 BR BR112020010831-6A patent/BR112020010831A2/pt unknown
- 2018-11-29 HU HUE18814821A patent/HUE071739T2/hu unknown
- 2018-11-29 MX MX2020005543A patent/MX2020005543A/es unknown
- 2018-11-29 KR KR1020207018658A patent/KR20200094187A/ko not_active Ceased
- 2018-11-29 PT PT188148217T patent/PT3716979T/pt unknown
- 2018-11-29 MY MYPI2020002671A patent/MY210547A/en unknown
- 2018-11-29 LT LTEPPCT/EP2018/082947T patent/LT3716979T/lt unknown
- 2018-11-29 CA CA3083327A patent/CA3083327A1/en active Pending
- 2018-11-29 MA MA051203A patent/MA51203A/fr unknown
- 2018-11-29 UA UAA202003789A patent/UA127083C2/uk unknown
- 2018-11-29 WO PCT/EP2018/082947 patent/WO2019106066A1/en not_active Ceased
- 2018-11-29 AU AU2018376263A patent/AU2018376263B2/en active Active
-
2020
- 2020-05-27 CL CL2020001394A patent/CL2020001394A1/es unknown
- 2020-05-29 PH PH12020550745A patent/PH12020550745A1/en unknown
-
2023
- 2023-12-13 JP JP2023209979A patent/JP7635355B2/ja active Active
-
2024
- 2024-10-28 US US18/929,609 patent/US20250120973A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020550745A1 (en) | Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases | |
| PH12019501937A1 (en) | Crystalline forms of a 4-pyrimidinesulfamide derivative aprocitentan | |
| JOP20200122B1 (ar) | مركبات مفيدة لتثبيط cdk7 | |
| MX2018005340A (es) | Proteolisis de direccionamiento a compuestos de quimera y metodos de preparacion y uso de los mismos. | |
| MX2022001655A (es) | Dispersiones solidas que comprenden estimulador de heme guanilato ciclasa soluble (sgc). | |
| PH12018500284A1 (en) | 5-bromo-2,6-di-(1h-pyrazol-1-yl)pyrimidin-4-amine for use in the treatment of cancer | |
| PH12019550235A1 (en) | Kinase inhibitors and uses thereof | |
| PH12017500834A1 (en) | Methods and formulations for treating vascular eye diseases | |
| MX2020004894A (es) | Composiciones que comprenden un inhibidor de demetilasa-1 especifico de lisina. | |
| MY186908A (en) | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof | |
| NZ729618A (en) | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds | |
| UA114531C2 (uk) | Противірусні сполуки проти rsv | |
| MX2016012574A (es) | Compuestos heteroarilo sustituidos y metodos de uso. | |
| PH12017502051A1 (en) | TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF | |
| NZ725399A (en) | Macrocylic pyrimidine derivatives | |
| PH12019550249A1 (en) | Solid compositions for oral administration | |
| PH12020550616A1 (en) | Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases | |
| NZ732402A (en) | Nitrification inhibitor compositions and methods for preparing the same | |
| PH12016502347A1 (en) | 1 -(cyclopent-2-en-1 -yl)-3-(2-hydroxy-3-(arylsulfonyl)phenyl)urea derivatives as cxcr2 inhibitors | |
| PH12017501397B1 (en) | (2s, 4r)-5-(5`-chloro-2`-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor | |
| ZA201907789B (en) | Solid compositions for oral administration | |
| IN2014DE00700A (enExample) |