PH12014501937B1 - Pharmaceutical composition containing an antivirally active dihydroquinazoline derivative - Google Patents
Pharmaceutical composition containing an antivirally active dihydroquinazoline derivativeInfo
- Publication number
- PH12014501937B1 PH12014501937B1 PH1/2014/501937A PH12014501937A PH12014501937B1 PH 12014501937 B1 PH12014501937 B1 PH 12014501937B1 PH 12014501937 A PH12014501937 A PH 12014501937A PH 12014501937 B1 PH12014501937 B1 PH 12014501937B1
- Authority
- PH
- Philippines
- Prior art keywords
- pharmaceutical composition
- composition containing
- antivirally active
- dihydroquinazoline
- dihydroquinazoline derivative
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical class C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- FWYSMLBETOMXAG-UHFFFAOYSA-N 2-[8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetic acid Chemical compound COC1=CC=CC(N2CCN(CC2)C=2N(C(CC(O)=O)C3=CC=CC(F)=C3N=2)C=2C(=CC=C(C=2)C(F)(F)F)OC)=C1 FWYSMLBETOMXAG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012101680A DE102012101680A1 (de) | 2012-02-29 | 2012-02-29 | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| PCT/EP2013/054114 WO2013127970A1 (de) | 2012-02-29 | 2013-02-28 | Pharmazeutische zubereitung enthaltend ein antiviral wirksames dihydrochinazolinderivat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014501937A1 PH12014501937A1 (en) | 2014-11-24 |
| PH12014501937B1 true PH12014501937B1 (en) | 2022-07-15 |
Family
ID=47757622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2014/501937A PH12014501937B1 (en) | 2012-02-29 | 2013-02-28 | Pharmaceutical composition containing an antivirally active dihydroquinazoline derivative |
Country Status (37)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| MD4673C1 (ro) * | 2013-06-19 | 2020-11-30 | Aicuris Anti-Infective Cures Gmbh | Letermovir amorf şi forme preparative farmaceutice solide ale acestuia pentru administrare orală |
| AU2017274722A1 (en) | 2016-06-03 | 2019-01-17 | Atreya Innovations Private Limited | A device for the detection and reliable capturing of the pulse characteristics |
| PH12019502037B1 (en) * | 2017-03-06 | 2024-06-05 | Everest Medicines Singapore Pte Ltd | Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof |
| DK3886798T3 (da) | 2018-11-29 | 2026-04-20 | Basilea Pharmaceutica Int Ag Allschwil | Kombinationssammensætninger, som omfatter en beta-lactamase-hæmmer, og anvendelser deraf |
| UY39097A (es) | 2020-02-27 | 2021-09-30 | Aic246 Gmbh & Co Kg | Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético |
| AR121438A1 (es) | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio |
| UY39099A (es) * | 2020-02-27 | 2021-08-31 | Aic246 Gmbh & Co Kg | 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo |
| CN114539085B (zh) * | 2020-11-26 | 2023-10-20 | 山东诚创蓝海医药科技有限公司 | 一种脲基衍生物的制备 |
| CN115403528B (zh) * | 2021-05-27 | 2025-01-07 | 南京正大天晴制药有限公司 | 无定形3,4-二氢喹唑啉衍生物的制备方法 |
| CN113880776B (zh) * | 2021-11-16 | 2023-06-16 | 山东诚创蓝海医药科技有限公司 | 一种莱特莫韦中间体的制备方法 |
| UY40078A (es) | 2021-12-21 | 2023-06-30 | Aic246 Ag & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin |
| EP4467126A4 (en) * | 2022-02-23 | 2025-04-30 | LG Chem, Ltd. | Injectable formulation containing isoxazoline derivative and method for producing the same |
| CN115322157B (zh) * | 2022-06-02 | 2023-12-05 | 浙江车头制药股份有限公司 | 来特莫韦中间体化合物及其制备方法和应用 |
| CN119731157A (zh) * | 2022-08-15 | 2025-03-28 | 上海迪赛诺化学制药有限公司 | 一种来特莫韦无定形的制备方法 |
| CN115677539B (zh) * | 2022-11-01 | 2023-10-24 | 南京工业大学 | 一种温和条件下钴催化脲基导向芳烃的高选择性单烯基化的方法 |
| CN119015222B (zh) * | 2024-08-28 | 2025-12-09 | 石家庄四药有限公司 | 一种来特莫韦注射液及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1242699A (en) * | 1985-02-01 | 1988-10-04 | Bristol-Myers Company | Cefbuperazone and derivatives thereof |
| CA1284994C (en) * | 1985-08-05 | 1991-06-18 | Murray Arthur Kaplan | Cephalosporin salts and injectable compositions |
| JP3552240B2 (ja) * | 1993-02-23 | 2004-08-11 | 第一製薬株式会社 | 高濃度ｔｃｆ製剤 |
| JPH11209277A (ja) * | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
| IT1304190B1 (it) * | 1998-12-18 | 2001-03-08 | Euphar Group Srl | Clatrati di deidroepiandrosterone e relative composizionifarmaceutiche |
| DE60010448T2 (de) * | 1999-03-17 | 2005-04-07 | Astrazeneca Ab | Amid-derivate |
| WO2001091751A1 (en) * | 2000-05-30 | 2001-12-06 | Novo Nordisk A/S | New pharmaceutical composition and the process for its preparation |
| DE10319612A1 (de) * | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| SI1689724T1 (sl) * | 2003-11-25 | 2012-04-30 | Novartis Ag | Spojine kinazolinona kot sredstva proti raku |
| WO2006086464A2 (en) * | 2005-02-10 | 2006-08-17 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5ht modulators |
| DE102005027517A1 (de) | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| US8743287B2 (en) * | 2009-07-24 | 2014-06-03 | Broadcom Corporation | Method and system for mitigating motion trail artifacts and improving low contrast contours in temporal filtering based noise reduction |
-
2012
- 2012-02-29 DE DE102012101680A patent/DE102012101680A1/de not_active Ceased
-
2013
- 2013-02-28 MY MYPI2014002461A patent/MY172310A/en unknown
- 2013-02-28 ME MEP-2019-219A patent/ME03448B/me unknown
- 2013-02-28 IN IN1892MUN2014 patent/IN2014MN01892A/en unknown
- 2013-02-28 CN CN201910661203.8A patent/CN110433166A/zh active Pending
- 2013-02-28 PH PH1/2014/501937A patent/PH12014501937B1/en unknown
- 2013-02-28 MX MX2014010364A patent/MX369666B/es active IP Right Grant
- 2013-02-28 EA EA201400963A patent/EA026584B1/ru unknown
- 2013-02-28 HU HUE13707000A patent/HUE045949T2/hu unknown
- 2013-02-28 EP EP13707000.9A patent/EP2819648B1/de active Active
- 2013-02-28 CA CA2865203A patent/CA2865203C/en active Active
- 2013-02-28 US US14/381,290 patent/US10603384B2/en active Active
- 2013-02-28 PL PL13707000T patent/PL2819648T3/pl unknown
- 2013-02-28 EP EP19176985.0A patent/EP3556350B1/de active Active
- 2013-02-28 BR BR112014020946-4A patent/BR112014020946B1/pt active IP Right Grant
- 2013-02-28 ES ES19176985T patent/ES2972133T3/es active Active
- 2013-02-28 SM SM20190458T patent/SMT201900458T1/it unknown
- 2013-02-28 LT LTEP19176985.0T patent/LT3556350T/lt unknown
- 2013-02-28 SG SG11201405294XA patent/SG11201405294XA/en unknown
- 2013-02-28 JP JP2014559233A patent/JP6387486B2/ja active Active
- 2013-02-28 LT LTEP13707000.9T patent/LT2819648T/lt unknown
- 2013-02-28 SI SI201332077T patent/SI3556350T1/sl unknown
- 2013-02-28 RS RSP20191076 patent/RS59157B1/sr unknown
- 2013-02-28 SI SI201331541T patent/SI2819648T1/sl unknown
- 2013-02-28 UA UAA201410519A patent/UA111415C2/uk unknown
- 2013-02-28 ES ES13707000T patent/ES2741698T3/es active Active
- 2013-02-28 WO PCT/EP2013/054114 patent/WO2013127970A1/de not_active Ceased
- 2013-02-28 FI FIEP19176985.0T patent/FI3556350T3/fi active
- 2013-02-28 KR KR1020147023803A patent/KR102149561B1/ko active Active
- 2013-02-28 HR HRP20240197TT patent/HRP20240197T1/hr unknown
- 2013-02-28 PT PT13707000T patent/PT2819648T/pt unknown
- 2013-02-28 HR HRP20191369 patent/HRP20191369T1/hr unknown
- 2013-02-28 DK DK13707000.9T patent/DK2819648T3/da active
- 2013-02-28 SM SM20240068T patent/SMT202400068T1/it unknown
- 2013-02-28 NZ NZ628444A patent/NZ628444A/en unknown
- 2013-02-28 RS RS20240135A patent/RS65137B1/sr unknown
- 2013-02-28 PT PT191769850T patent/PT3556350T/pt unknown
- 2013-02-28 CN CN201380011670.7A patent/CN104144678A/zh active Pending
- 2013-02-28 HU HUE19176985A patent/HUE065553T2/hu unknown
- 2013-02-28 EP EP24150976.9A patent/EP4328218A3/de active Pending
- 2013-02-28 DK DK19176985.0T patent/DK3556350T3/da active
- 2013-02-28 AU AU2013224947A patent/AU2013224947B2/en active Active
- 2013-02-28 PL PL19176985.0T patent/PL3556350T3/pl unknown
-
2014
- 2014-08-08 TN TNP2014000345A patent/TN2014000345A1/fr unknown
- 2014-08-13 ZA ZA2014/05949A patent/ZA201405949B/en unknown
- 2014-08-28 CO CO14189543A patent/CO7061076A2/es unknown
- 2014-08-28 IL IL234363A patent/IL234363B/en active IP Right Grant
- 2014-08-29 CL CL2014002306A patent/CL2014002306A1/es unknown
- 2014-09-17 MA MA37360A patent/MA35941B1/fr unknown
-
2019
- 2019-08-20 CY CY20191100885T patent/CY1121910T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TN2014000345A1 (en) | Pharmaceutical preparation containing an antivirally active dihydroquinazoline derivative | |
| WO2014028589A3 (en) | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | |
| IN2014DN09434A (enExample) | ||
| UA109868C2 (ru) | Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar) | |
| JO3475B1 (ar) | ناهضات مستقبل سوماتوستاتين نوع فرعي 4 (sstr4) جديدة | |
| EP3682875A3 (en) | Methods of treating pediatric metabolic syndrome | |
| WO2014205389A8 (en) | Nuclear transport modulators and uses thereof | |
| NZ720328A (en) | Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or inflammatory disease | |
| PH12013500301A1 (en) | Oxadiazole inhibitors of leukotriene production | |
| NZ719169A (en) | Heteroaryl butanoic acid derivatives as lta4h inhibitors | |
| PH12014501967A1 (en) | Benzodioxanes in combination with other actives for inhibiting leukotriene production | |
| WO2013061004A8 (fr) | Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines | |
| HK1215190A1 (zh) | 载体连接型前列腺素类前药 | |
| IN2014DN09347A (enExample) | ||
| PH12014501545A1 (en) | Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof | |
| WO2013142182A3 (en) | Combination therapy of a mek inhibitor and igf1r inhibitor | |
| MX357888B (es) | Sales basicas de adicion de nitroxolina y usos de las mismas. | |
| PH12013500545A1 (en) | Oxadiazole inhibitors of leukotriene production | |
| MX2013013436A (es) | Derivados de indol sustituidos para el tratamiento de transtornos inmunologicos. | |
| WO2014104989A8 (en) | Pharmaceutical compositions comprising aripiprazole | |
| MX2014001860A (es) | Hidrazidas del acido 3-piridin carboxilico como agentes elevadores del colesterol de lipoproteina de alta densidad (hdl). | |
| WO2014024013A8 (en) | Pseudouridimycin (pum) and its derivates | |
| HK1205509A1 (zh) | 二氢喹唑啉衍生物的钠化和钙化盐及它们用作抗病毒媒介的使用 | |
| TN2013000243A1 (en) | Substituted 1-benzylcycloalkylcarboxlic acids and use thereof | |
| HK1205511A1 (zh) | 二氢喹唑啉衍生物的苯磺酸盐和甲苯磺酸盐及它们作为抗病毒剂的用途 |