PE64698A1 - Derivados del benzofurilo y su uso - Google Patents
Derivados del benzofurilo y su usoInfo
- Publication number
- PE64698A1 PE64698A1 PE1997000334A PE00033497A PE64698A1 PE 64698 A1 PE64698 A1 PE 64698A1 PE 1997000334 A PE1997000334 A PE 1997000334A PE 00033497 A PE00033497 A PE 00033497A PE 64698 A1 PE64698 A1 PE 64698A1
- Authority
- PE
- Peru
- Prior art keywords
- sean
- sea
- benzofuran
- compounds
- carbonitrile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1, R2, R3 Y R4 SON H, HALOGENO, ALCOXILO C1-C7 O ALQUILO C1-C7-SULFANILO-ALQUILO C1-C7, ENTRE OTROS, O R1 Y R2 JUNTOS FORMAN -O-(CH2)2- o -(CH2)2-O- [SIENDO PREFERIDO, QUE: (a) R1 Y R4 SEAN H; R2 Y R3 SEAN F; (b) R2, R3 Y R4 SEAN H, R1 SEA ETOXI O METILOXIETILO; (c) R1, R2 Y R4 SEAN H, R3 SEA F; (d) R1, R3 Y R4 SEAN H, R2 SEA F; (e) R1, R2 Y R3 SEAN H, R4 SEA F]; R5 ES H o OH. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I), QUE COMPRENDEN: (Ia) SI R5 ES H, (A) HACER REACCIONAR UN BENZOFURANO-2-CARBOXAMIDA (OPCIONALMENTE R1, R2, R3 Y R4 SUSTITUIDOS, COMO PARA (I)) CON UNA SAL DE OXONIO, TAL COMO TETRAFLUOROBORATO DE TRIETILOXONIO, EN PRESENCIA DE UN HALURO DE AMONIO; (B) HACER PASAR UNA CORRIENTE DE H2S SOBRE UN BENZOFURANO-2-CARBONITRILO (OPCIONALMENTE R1, R2, R3 Y R4 SUSTITUIDOS, COMO PARA (I)) OBTENIENDOSE UNA TIOAMIDA, LA CUAL SE TRATA CON UNA SAL DE AMONIO, EN PRESENCIA DE UN HALURO DE ALQUILO; (C) HIDROGENAR UN COMPUESTO (Ib); (Ib) SI R5 ES OH, (D) HACER REACCIONAR UN BENZOFURANO-2-CARBONITRILO CON HIDROXILAMINA. LOS COMPUESTOS OBTENIDOS ACTUAN UNIENDOSE A LOS RECEPTORES DE SEROTONINA, SIENDO UTILES EN EL CONTROL Y PREVENCION DE TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL TALES COMO ESQUIZOFRENIA, ANSIEDAD, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96106990 | 1996-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE64698A1 true PE64698A1 (es) | 1998-10-27 |
Family
ID=8222741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000334A PE64698A1 (es) | 1996-05-03 | 1997-04-30 | Derivados del benzofurilo y su uso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5955495A (es) |
| EP (1) | EP0906301B1 (es) |
| JP (1) | JP3148253B2 (es) |
| KR (1) | KR100343060B1 (es) |
| CN (1) | CN100347164C (es) |
| AR (1) | AR006915A1 (es) |
| AT (1) | ATE225342T1 (es) |
| AU (1) | AU712056B2 (es) |
| BR (1) | BR9708902A (es) |
| CA (1) | CA2253547C (es) |
| CO (1) | CO4940471A1 (es) |
| DE (1) | DE69716062T2 (es) |
| DK (1) | DK0906301T3 (es) |
| ES (1) | ES2182070T3 (es) |
| HR (1) | HRP970225A2 (es) |
| MA (1) | MA24168A1 (es) |
| PE (1) | PE64698A1 (es) |
| PT (1) | PT906301E (es) |
| TR (1) | TR199802206T2 (es) |
| WO (1) | WO1997042183A1 (es) |
| ZA (1) | ZA973708B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786184B1 (fr) * | 1998-11-24 | 2002-09-20 | Hoechst Marion Roussel Inc | Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| EP1343768A1 (en) | 2000-12-20 | 2003-09-17 | Bristol-Myers Squibb Pharma Company | Aryl and aminoaryl substituted serotonin receptor agonist and antagonist ligands |
| FR2822463B1 (fr) | 2001-03-21 | 2004-07-30 | Lipha | Derives bicycliques de guanidines et leurs applications en therapeutique |
| US20060058364A1 (en) * | 2002-03-29 | 2006-03-16 | Antti Haapalinna | Treatment of dependence and dependence related withdrawal symptoms |
| FR2845992B1 (fr) * | 2002-10-16 | 2005-02-04 | Pf Medicament | Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie |
| DE10257357A1 (de) * | 2002-12-09 | 2004-06-24 | Bayer Ag | Fluorhaltige Benzaldehyde |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050215644A1 (en) * | 2004-03-19 | 2005-09-29 | Interhealth Nutraceuticals, Inc. | Methods for increasing neurotransmitter levels using hydroxycitric acid |
| EP2248524A3 (en) | 2004-08-25 | 2011-03-09 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| ME02461B (me) | 2005-05-10 | 2017-02-20 | Incyte Holdings Corp | Modulatori indoleamina 2,3-dioksigenaze i metode za upotrebu istih |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| EP2742936A1 (en) | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP2650288A1 (en) * | 2007-05-29 | 2013-10-16 | Osaka Bioscience Institute | Sleep-improving agent |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| MY171866A (en) | 2008-07-08 | 2019-11-05 | Incyte Holdings Corp | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
| UY32940A (es) * | 2009-10-27 | 2011-05-31 | Bayer Cropscience Ag | Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas |
| EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
| CN104045631A (zh) * | 2013-03-13 | 2014-09-17 | 无锡万全医药技术有限公司 | 一种制备5-(4-(4-(5-氰基-1h-吲哚-3-基)丁基)哌嗪-1-基)苯并呋喃-2-甲酰胺的新方法 |
| CN103360374B (zh) * | 2013-07-12 | 2016-03-09 | 苏州永健生物医药有限公司 | 维拉唑酮及其盐的合成方法 |
| PL3066085T3 (pl) | 2013-11-08 | 2020-11-02 | Incyte Holdings Corporation | Sposób syntezy inhibitora 2,3-dioksygenazy indoloaminowej |
| EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE |
| CN114315773B (zh) * | 2020-09-29 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种哌嗪化合物及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68901424D1 (de) * | 1988-07-05 | 1992-06-11 | Akzo Nv | Verbindungen mit bronchodilatatorischer aktivitaet. |
| US5026726A (en) * | 1989-12-11 | 1991-06-25 | The University Of New Mexico | Gossylic iminolactones and gossylic lactones and their anti-viral activities |
-
1997
- 1997-04-14 US US08/837,140 patent/US5955495A/en not_active Expired - Fee Related
- 1997-04-24 ES ES97921737T patent/ES2182070T3/es not_active Expired - Lifetime
- 1997-04-24 AU AU27696/97A patent/AU712056B2/en not_active Ceased
- 1997-04-24 WO PCT/EP1997/002092 patent/WO1997042183A1/en active IP Right Grant
- 1997-04-24 BR BR9708902A patent/BR9708902A/pt not_active IP Right Cessation
- 1997-04-24 AT AT97921737T patent/ATE225342T1/de not_active IP Right Cessation
- 1997-04-24 CA CA002253547A patent/CA2253547C/en not_active Expired - Fee Related
- 1997-04-24 DE DE69716062T patent/DE69716062T2/de not_active Expired - Fee Related
- 1997-04-24 DK DK97921737T patent/DK0906301T3/da active
- 1997-04-24 TR TR1998/02206T patent/TR199802206T2/xx unknown
- 1997-04-24 PT PT97921737T patent/PT906301E/pt unknown
- 1997-04-24 KR KR1019980708809A patent/KR100343060B1/ko not_active IP Right Cessation
- 1997-04-24 JP JP53947997A patent/JP3148253B2/ja not_active Expired - Fee Related
- 1997-04-24 EP EP97921737A patent/EP0906301B1/en not_active Expired - Lifetime
- 1997-04-24 CN CNB971943575A patent/CN100347164C/zh not_active Expired - Fee Related
- 1997-04-29 ZA ZA9703708A patent/ZA973708B/xx unknown
- 1997-04-30 AR ARP970101780A patent/AR006915A1/es not_active Application Discontinuation
- 1997-04-30 CO CO97023102A patent/CO4940471A1/es unknown
- 1997-04-30 PE PE1997000334A patent/PE64698A1/es not_active Application Discontinuation
- 1997-05-02 HR HR96106990.3A patent/HRP970225A2/xx not_active Application Discontinuation
- 1997-05-02 MA MA24589A patent/MA24168A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR006915A1 (es) | 1999-09-29 |
| JP3148253B2 (ja) | 2001-03-19 |
| BR9708902A (pt) | 1999-08-03 |
| HRP970225A2 (en) | 1998-04-30 |
| DE69716062T2 (de) | 2003-06-18 |
| EP0906301B1 (en) | 2002-10-02 |
| US5955495A (en) | 1999-09-21 |
| KR20000010708A (ko) | 2000-02-25 |
| ATE225342T1 (de) | 2002-10-15 |
| ZA973708B (en) | 1997-11-03 |
| DE69716062D1 (de) | 2002-11-07 |
| EP0906301A1 (en) | 1999-04-07 |
| CA2253547A1 (en) | 1997-11-13 |
| CO4940471A1 (es) | 2000-07-24 |
| MA24168A1 (fr) | 1997-12-31 |
| AU2769697A (en) | 1997-11-26 |
| CA2253547C (en) | 2006-10-17 |
| WO1997042183A1 (en) | 1997-11-13 |
| ES2182070T3 (es) | 2003-03-01 |
| PT906301E (pt) | 2003-02-28 |
| JPH11508283A (ja) | 1999-07-21 |
| DK0906301T3 (da) | 2003-02-10 |
| AU712056B2 (en) | 1999-10-28 |
| CN100347164C (zh) | 2007-11-07 |
| CN1217720A (zh) | 1999-05-26 |
| KR100343060B1 (ko) | 2002-09-18 |
| TR199802206T2 (xx) | 2001-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |