PE55596A1 - Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo - Google Patents

Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Info

Publication number
PE55596A1
PE55596A1 PE1995286554A PE28655495A PE55596A1 PE 55596 A1 PE55596 A1 PE 55596A1 PE 1995286554 A PE1995286554 A PE 1995286554A PE 28655495 A PE28655495 A PE 28655495A PE 55596 A1 PE55596 A1 PE 55596A1
Authority
PE
Peru
Prior art keywords
piperadinyl
piperazinyl
aids
alkyl
substituted
Prior art date
Application number
PE1995286554A
Other languages
English (en)
Inventor
Richard C Thomas
Toni-Jo Poel
Donna L Romero
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE55596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE55596A1 publication Critical patent/PE55596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE AL COMPUESTO DE FORMULA I DONDE R1 PUEDE SER (A) o (B); SI ES (A): R1-1 ES H, F, Cl ENTRE OTROS; R1-2 ES H, F, Cl ENTRE OTROS; R1-3 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1-1, R1-2 y R1-3 SON -H; SI ES (B): R1-4 ES H o CH3, DE PREFERENCIA EL PRIMERO; R1-5 ES H, F, Cl ENTRE OTROS; R1-6 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1 ES (A); R2 ES -CO- o -CH2-; R3 ES (R3-I), (R3-II), (R3-III) ENTRE OTROS; R4 ES -N=, -CH=, -CF= ENTRE OTROS; R5 ES -N=, -CH=, -CF= ENTRE OTROS; R6 ES -N=, -CH=, -CF= ENTRE OTROS; R7 ES -N= o -CH=; R8 ES C1-C6 ALQUILO, C3-C5 CICLOALQUILO, -CH2-O-R8-1 EN DONDE R8-1 ES C1-C3 ALQUILO, -CH2-CH2-CF3 ENTRE OTROS
PE1995286554A 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo PE55596A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35492594A 1994-12-13 1994-12-13
US40009595A 1995-03-07 1995-03-07

Publications (1)

Publication Number Publication Date
PE55596A1 true PE55596A1 (es) 1996-12-11

Family

ID=26998606

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995286554A PE55596A1 (es) 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Country Status (10)

Country Link
US (1) US5866589A (es)
EP (1) EP0797576A1 (es)
JP (1) JPH10510530A (es)
AR (1) AR003106A1 (es)
AU (1) AU4151696A (es)
CO (1) CO4700295A1 (es)
IL (1) IL116310A (es)
PE (1) PE55596A1 (es)
TW (1) TW406075B (es)
WO (1) WO1996018628A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1265660A (zh) * 1997-08-15 2000-09-06 辉瑞产品公司 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物
AU1600599A (en) * 1998-02-27 1999-09-15 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
PT1363705E (pt) * 2001-02-02 2012-08-17 Bristol Myers Squibb Co Composição e actividade antiviral de derivados de piperazina azaindoleoxoacética substituídos
TW200302088A (en) * 2001-11-14 2003-08-01 Schering Corp Cannabinoid receptor ligands
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
US8247442B2 (en) * 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
TW200815353A (en) * 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
EP2148872A1 (en) * 2007-04-23 2010-02-03 Janssen Pharmaceutica, N.V. Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
CN101663299A (zh) * 2007-04-23 2010-03-03 詹森药业有限公司 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物
EP2148873B1 (en) 2007-04-23 2012-08-29 Janssen Pharmaceutica, N.V. 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2009051119A1 (ja) * 2007-10-16 2009-04-23 Daiichi Sankyo Company, Limited ピリミジルインドリン化合物
WO2010000456A1 (en) * 2008-07-03 2010-01-07 Janssen Pharmaceutica Nv Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
JP5457450B2 (ja) 2008-07-31 2014-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 迅速解離性ドーパミン２受容体拮抗薬としてのピペラジン−１−イル−トリフルオロメチル−置換−ピリジン
KR102531217B1 (ko) 2014-07-31 2023-05-10 바스프 에스이 피라졸의 제조 방법
ES2882543T3 (es) 2015-05-11 2021-12-02 Basf Se Proceso para la preparación de 4-amino-piridazinas
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686188A (en) * 1970-06-30 1972-08-22 Ciba Geigy Corp N-benzofurylmethyl-arylalkyleneimines
AU654808B2 (en) * 1989-12-28 1994-11-24 Pharmacia & Upjohn Company Diaromatic substituted anti-aids compounds
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
WO1992018089A2 (en) * 1991-04-09 1992-10-29 The Upjohn Company Use of steroidal and non-steroidal amines to sensitize multidrug-resistant cells
ES2097341T3 (es) * 1991-07-03 1997-04-01 Upjohn Co Indoles sustituidos como farmacos para el tratamiento del sida.
DE4307883A1 (en) * 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
WO1994009781A1 (en) * 1992-10-28 1994-05-11 The Upjohn Company Use of bhap compounds in combination with other non-nucleoside reverse transcriptase inhibitors for the treatment of hiv infection
EP0757398A1 (de) * 1995-07-25 1997-02-05 DORNIER GmbH Anordnung von mehreren Brennstoffzellen-Stacks zu einem Modul

Also Published As

Publication number Publication date
IL116310A (en) 2000-08-31
US5866589A (en) 1999-02-02
IL116310A0 (en) 1996-03-31
CO4700295A1 (es) 1998-12-29
JPH10510530A (ja) 1998-10-13
AU4151696A (en) 1996-07-03
AR003106A1 (es) 1998-07-08
TW406075B (en) 2000-09-21
EP0797576A1 (en) 1997-10-01
WO1996018628A1 (en) 1996-06-20

Similar Documents

Publication Publication Date Title
PE55596A1 (es) Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo
AR011502A1 (es) Un compuesto substituido de acido 4-hidroxi-fenilalcanoico con actividad agonista a ppar-gamma, un metodo para prepararlo una composicion farmaceutica que lo contiene y uso del compuesto para la fabricacion de un medicamento
DK249089A (da) Benzamid-forbindelser, der er nyttige som protease-inhibitorer
KR850004757A (ko) 치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물의 제법
ATE8612T1 (de) Fluorhaltige 4,4'-bis-(cyclohexyl)biphenylderivate, diese enthaltende dielektrika und elektrooptisches anzeigeelement.
ATE29516T1 (de) Hydroterphenyle, ihre herstellung und verwendung fuer fluessigkristalline dielektrika.
DK38982A (da) Fremgangsmaade til fremstilling af 2-penemforbindelser
PE20040574A1 (es) Agonistas de los receptores cannabinoides
DE69405864D1 (de) Verfahren zur Herstellung von quaternären Diestern
BR8106299A (pt) Processo para preparar sob todas as formas isomeras possiveis ou sob forma de misturas de isomeros compostos aplicacao desses compostos e composicoes a base dos mesmos
FR2398718A1 (fr) Nouvelles amines primaires utiles a la preparation de derives d'aminoalkyl benzenes
ECSP941068A (es) Derivados de la cefalosporina
DK351788A (da) Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister
BR8704389A (pt) Composicao de pintura e processo para a protecao de uma substancia de pintura
ES2040213T3 (es) Nuevos derivados de 3-oxadiazol- y 3-(ester de acido carboxilico)-beta-carbolina, su preparacion y su utilizacion como medicamentos.
ES440426A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
JPS5611718B2 (es)
PE20020599A1 (es) Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d
MX20597A (es) 1-arilimidazoles plaguicidas y procedimiento para su preparacion.
PE35396A1 (es) Antagonista de neuroquinina
ES2033297T3 (es) Un metodo para preparar heterociclos de 5 atomos substituidos con fenilo y pirrolidin-2-ilo.
ES455909A1 (es) Procedimiento para preparar derivados de piperacina.
ATE148153T1 (de) 1,4-substituierter abkömmling von cis-2-buten
ES456400A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
ATE79119T1 (de) 7-((meta-substituiert)-phenylglycin>-1-carba-1dethia-cephalosporine.

Legal Events

Date Code Title Description
FD Application declared void or lapsed