PE55596A1 - Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo - Google Patents

Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Info

Publication number
PE55596A1
PE55596A1 PE1995286554A PE28655495A PE55596A1 PE 55596 A1 PE55596 A1 PE 55596A1 PE 1995286554 A PE1995286554 A PE 1995286554A PE 28655495 A PE28655495 A PE 28655495A PE 55596 A1 PE55596 A1 PE 55596A1
Authority
PE
Peru
Prior art keywords
piperadinyl
piperazinyl
aids
alkyl
substituted
Prior art date
Application number
PE1995286554A
Other languages
English (en)
Inventor
Richard C Thomas
Toni-Jo Poel
Donna L Romero
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE55596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE55596A1 publication Critical patent/PE55596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE AL COMPUESTO DE FORMULA I DONDE R1 PUEDE SER (A) o (B); SI ES (A): R1-1 ES H, F, Cl ENTRE OTROS; R1-2 ES H, F, Cl ENTRE OTROS; R1-3 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1-1, R1-2 y R1-3 SON -H; SI ES (B): R1-4 ES H o CH3, DE PREFERENCIA EL PRIMERO; R1-5 ES H, F, Cl ENTRE OTROS; R1-6 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1 ES (A); R2 ES -CO- o -CH2-; R3 ES (R3-I), (R3-II), (R3-III) ENTRE OTROS; R4 ES -N=, -CH=, -CF= ENTRE OTROS; R5 ES -N=, -CH=, -CF= ENTRE OTROS; R6 ES -N=, -CH=, -CF= ENTRE OTROS; R7 ES -N= o -CH=; R8 ES C1-C6 ALQUILO, C3-C5 CICLOALQUILO, -CH2-O-R8-1 EN DONDE R8-1 ES C1-C3 ALQUILO, -CH2-CH2-CF3 ENTRE OTROS
PE1995286554A 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo PE55596A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35492594A 1994-12-13 1994-12-13
US40009595A 1995-03-07 1995-03-07

Publications (1)

Publication Number Publication Date
PE55596A1 true PE55596A1 (es) 1996-12-11

Family

ID=26998606

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995286554A PE55596A1 (es) 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Country Status (10)

Country Link
US (1) US5866589A (es)
EP (1) EP0797576A1 (es)
JP (1) JPH10510530A (es)
AR (1) AR003106A1 (es)
AU (1) AU4151696A (es)
CO (1) CO4700295A1 (es)
IL (1) IL116310A (es)
PE (1) PE55596A1 (es)
TW (1) TW406075B (es)
WO (1) WO1996018628A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9811557A (pt) * 1997-08-15 2000-08-22 Pfizer Prod Inc Derivados do 2-)4-aril ou heteroaril-piperazin-1-ilmetil)-1h-indol
US6251919B1 (en) * 1998-02-27 2001-06-26 Warner-Lambert Heterocyclic substituted aniline calcium channel blockers
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
JP4328527B2 (ja) * 2001-02-02 2009-09-09 ブリストル−マイヤーズ スクイブ カンパニー 置換アザインドールオキソアセチックピペラジン誘導体の組成物と抗ウイルス活性
AR037352A1 (es) * 2001-11-14 2004-11-03 Schering Corp Compuestos ligandos de los receptores de los cannabinoides, una composicion farmaceutica , y el uso de dichos compuestos para la manufactura de medicamentos
AU2003287160A1 (en) * 2002-10-15 2004-05-04 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
TW200815353A (en) * 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
RU2480462C2 (ru) * 2007-04-23 2013-04-27 Янссен Фармацевтика Н.В. Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2
MX2009011415A (es) 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion.
JP5431306B2 (ja) 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのチア（ジア）ゾール
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
JP5317354B2 (ja) * 2007-10-16 2013-10-16 第一三共株式会社 ピリミジルインドリン化合物
RU2502734C2 (ru) * 2008-07-03 2013-12-27 Янссен Фармацевтика Нв Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора
JP5457450B2 (ja) 2008-07-31 2014-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 迅速解離性ドーパミン２受容体拮抗薬としてのピペラジン−１−イル−トリフルオロメチル−置換−ピリジン
JP6625610B2 (ja) 2014-07-31 2019-12-25 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ピラゾールの調製方法
KR102585412B1 (ko) 2015-05-11 2023-10-05 바스프 에스이 4-아미노-피리다진의 제조 방법
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686188A (en) * 1970-06-30 1972-08-22 Ciba Geigy Corp N-benzofurylmethyl-arylalkyleneimines
RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
EP0579754A1 (en) * 1991-04-09 1994-01-26 The Upjohn Company Use of amines to sensitize multidrug-resistant cells
WO1993001181A1 (en) * 1991-07-03 1993-01-21 The Upjohn Company Substituted indoles as anti-aids pharmaceuticals
DE4307883A1 (en) * 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
PL308551A1 (en) * 1992-10-28 1995-08-21 Upjohn Co Application of bhpa compounds in combination with other nucleosidal inhibitors of reverse transcriptase in treating hiv infections
EP0757398A1 (de) * 1995-07-25 1997-02-05 DORNIER GmbH Anordnung von mehreren Brennstoffzellen-Stacks zu einem Modul

Also Published As

Publication number Publication date
AR003106A1 (es) 1998-07-08
TW406075B (en) 2000-09-21
IL116310A (en) 2000-08-31
US5866589A (en) 1999-02-02
EP0797576A1 (en) 1997-10-01
AU4151696A (en) 1996-07-03
JPH10510530A (ja) 1998-10-13
WO1996018628A1 (en) 1996-06-20
CO4700295A1 (es) 1998-12-29
IL116310A0 (en) 1996-03-31

Similar Documents

Publication Publication Date Title
PE55596A1 (es) Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo
PT90623A (pt) Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease
AR011502A1 (es) Un compuesto substituido de acido 4-hidroxi-fenilalcanoico con actividad agonista a ppar-gamma, un metodo para prepararlo una composicion farmaceutica que lo contiene y uso del compuesto para la fabricacion de un medicamento
KR850004757A (ko) 치환 트란스-1, 2-디아미노싸이클로헥실 아미드 화합물의 제법
ATE8612T1 (de) Fluorhaltige 4,4'-bis-(cyclohexyl)biphenylderivate, diese enthaltende dielektrika und elektrooptisches anzeigeelement.
ATE29516T1 (de) Hydroterphenyle, ihre herstellung und verwendung fuer fluessigkristalline dielektrika.
DK38982A (da) Fremgangsmaade til fremstilling af 2-penemforbindelser
PE20040574A1 (es) Agonistas de los receptores cannabinoides
DE69405864D1 (de) Verfahren zur Herstellung von quaternären Diestern
BR8106299A (pt) Processo para preparar sob todas as formas isomeras possiveis ou sob forma de misturas de isomeros compostos aplicacao desses compostos e composicoes a base dos mesmos
FR2398718A1 (fr) Nouvelles amines primaires utiles a la preparation de derives d'aminoalkyl benzenes
ECSP941068A (es) Derivados de la cefalosporina
DK351788A (da) Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister
ES2040213T3 (es) Nuevos derivados de 3-oxadiazol- y 3-(ester de acido carboxilico)-beta-carbolina, su preparacion y su utilizacion como medicamentos.
ES440426A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
PE20020599A1 (es) Derivados de acido amino-furan-2-il-acetico sustituido o de acido amino-tien-2-il-acetico sustituido, procedimiento para su preparacion, medicamentos que los contienen, uso de estos compuestos para la preparacion de medicamentos para el tratamiento d
MX9301045A (es) Procedimiento para preparar antagonistas receptores de fibrinogeno.
PE35396A1 (es) Antagonista de neuroquinina
ES2033297T3 (es) Un metodo para preparar heterociclos de 5 atomos substituidos con fenilo y pirrolidin-2-ilo.
SE7601206L (sv) Acetylenderivat
ATE148153T1 (de) 1,4-substituierter abkömmling von cis-2-buten
ES456400A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
ATE79119T1 (de) 7-((meta-substituiert)-phenylglycin>-1-carba-1dethia-cephalosporine.
DE68921198D1 (de) Benzothiadiazepin-derivate.
FI932691A (fi) Nya benzyl- och benzhydrylalkoholer

Legal Events

Date Code Title Description
FD Application declared void or lapsed