AR003106A1 - Compuestos anti-sida de piperadinil y piperazinil alquil substituidos. - Google Patents
Compuestos anti-sida de piperadinil y piperazinil alquil substituidos.Info
- Publication number
- AR003106A1 AR003106A1 ARP950100537A AR10053795A AR003106A1 AR 003106 A1 AR003106 A1 AR 003106A1 AR P950100537 A ARP950100537 A AR P950100537A AR 10053795 A AR10053795 A AR 10053795A AR 003106 A1 AR003106 A1 AR 003106A1
- Authority
- AR
- Argentina
- Prior art keywords
- piperazinyl
- aids
- piperadinyl
- substituted
- aids compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de Anti-SIDA de piperadinilo y piperazinilo sustituidos por alquilo de la fórmula (I), en donde el anillo aromático/heteroaromático estáunido a un átomo de carbono del substituyente R8, como también piridinas Anti-SIDA específicas (V), donde R1 entre otros significados puede ser (A),(B), (C), (D), (E), (F).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35492594A | 1994-12-13 | 1994-12-13 | |
US40009595A | 1995-03-07 | 1995-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR003106A1 true AR003106A1 (es) | 1998-07-08 |
Family
ID=26998606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP950100537A AR003106A1 (es) | 1994-12-13 | 1995-12-13 | Compuestos anti-sida de piperadinil y piperazinil alquil substituidos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5866589A (es) |
EP (1) | EP0797576A1 (es) |
JP (1) | JPH10510530A (es) |
AR (1) | AR003106A1 (es) |
AU (1) | AU4151696A (es) |
CO (1) | CO4700295A1 (es) |
IL (1) | IL116310A (es) |
PE (1) | PE55596A1 (es) |
TW (1) | TW406075B (es) |
WO (1) | WO1996018628A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1265660A (zh) * | 1997-08-15 | 2000-09-06 | 辉瑞产品公司 | 2-(4-芳基或杂芳基-哌嗪-1-基甲基)-1h-吲哚衍生物 |
AU1600599A (en) * | 1998-02-27 | 1999-09-15 | Warner-Lambert Company | Heterocyclic substituted aniline calcium channel blockers |
SE9803773D0 (sv) * | 1998-11-05 | 1998-11-05 | Astra Pharma Prod | Compounds |
GB0016453D0 (en) * | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Pyrrole derivatives |
HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
PT1363705E (pt) * | 2001-02-02 | 2012-08-17 | Bristol Myers Squibb Co | Composição e actividade antiviral de derivados de piperazina azaindoleoxoacética substituídos |
TW200302088A (en) * | 2001-11-14 | 2003-08-01 | Schering Corp | Cannabinoid receptor ligands |
JP2006505571A (ja) * | 2002-10-15 | 2006-02-16 | リゲル ファーマシューテイカルズ、インコーポレイテッド | 置換されたインドール及びhcv阻害剤としてのその使用 |
US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
WO2007118854A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
EP2148872A1 (en) * | 2007-04-23 | 2010-02-03 | Janssen Pharmaceutica, N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
CN101663299A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物 |
EP2148873B1 (en) | 2007-04-23 | 2012-08-29 | Janssen Pharmaceutica, N.V. | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
WO2009051119A1 (ja) * | 2007-10-16 | 2009-04-23 | Daiichi Sankyo Company, Limited | ピリミジルインドリン化合物 |
WO2010000456A1 (en) * | 2008-07-03 | 2010-01-07 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
JP5457450B2 (ja) | 2008-07-31 | 2014-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 迅速解離性ドーパミン2受容体拮抗薬としてのピペラジン−1−イル−トリフルオロメチル−置換−ピリジン |
KR102531217B1 (ko) | 2014-07-31 | 2023-05-10 | 바스프 에스이 | 피라졸의 제조 방법 |
ES2882543T3 (es) | 2015-05-11 | 2021-12-02 | Basf Se | Proceso para la preparación de 4-amino-piridazinas |
WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
CN114605303A (zh) * | 2022-03-14 | 2022-06-10 | 武汉工程大学 | 一种地拉韦啶及其中间体的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3686188A (en) * | 1970-06-30 | 1972-08-22 | Ciba Geigy Corp | N-benzofurylmethyl-arylalkyleneimines |
AU654808B2 (en) * | 1989-12-28 | 1994-11-24 | Pharmacia & Upjohn Company | Diaromatic substituted anti-aids compounds |
US5563142A (en) * | 1989-12-28 | 1996-10-08 | The Upjohn Company | Diaromatic substituted compounds as anti-HIV-1 agents |
WO1992018089A2 (en) * | 1991-04-09 | 1992-10-29 | The Upjohn Company | Use of steroidal and non-steroidal amines to sensitize multidrug-resistant cells |
ES2097341T3 (es) * | 1991-07-03 | 1997-04-01 | Upjohn Co | Indoles sustituidos como farmacos para el tratamiento del sida. |
DE4307883A1 (en) * | 1992-03-12 | 1993-09-23 | Westarp Martin Egon Dr Med | Use of anti-retroviral substances - to treat motor-neuronal diseases |
WO1994009781A1 (en) * | 1992-10-28 | 1994-05-11 | The Upjohn Company | Use of bhap compounds in combination with other non-nucleoside reverse transcriptase inhibitors for the treatment of hiv infection |
EP0757398A1 (de) * | 1995-07-25 | 1997-02-05 | DORNIER GmbH | Anordnung von mehreren Brennstoffzellen-Stacks zu einem Modul |
-
1995
- 1995-11-15 TW TW084112064A patent/TW406075B/zh active
- 1995-11-28 WO PCT/US1995/014558 patent/WO1996018628A1/en not_active Application Discontinuation
- 1995-11-28 US US08/860,178 patent/US5866589A/en not_active Expired - Fee Related
- 1995-11-28 AU AU41516/96A patent/AU4151696A/en not_active Abandoned
- 1995-11-28 EP EP95939852A patent/EP0797576A1/en not_active Ceased
- 1995-11-28 JP JP8518811A patent/JPH10510530A/ja active Pending
- 1995-12-07 PE PE1995286554A patent/PE55596A1/es not_active Application Discontinuation
- 1995-12-10 IL IL11631095A patent/IL116310A/xx not_active IP Right Cessation
- 1995-12-11 CO CO95058438A patent/CO4700295A1/es unknown
- 1995-12-13 AR ARP950100537A patent/AR003106A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL116310A (en) | 2000-08-31 |
US5866589A (en) | 1999-02-02 |
IL116310A0 (en) | 1996-03-31 |
CO4700295A1 (es) | 1998-12-29 |
JPH10510530A (ja) | 1998-10-13 |
AU4151696A (en) | 1996-07-03 |
TW406075B (en) | 2000-09-21 |
EP0797576A1 (en) | 1997-10-01 |
WO1996018628A1 (en) | 1996-06-20 |
PE55596A1 (es) | 1996-12-11 |
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