PE20231096A1 - Polimorfos de un inhibidor de ssao - Google Patents
Polimorfos de un inhibidor de ssaoInfo
- Publication number
- PE20231096A1 PE20231096A1 PE2023000721A PE2023000721A PE20231096A1 PE 20231096 A1 PE20231096 A1 PE 20231096A1 PE 2023000721 A PE2023000721 A PE 2023000721A PE 2023000721 A PE2023000721 A PE 2023000721A PE 20231096 A1 PE20231096 A1 PE 20231096A1
- Authority
- PE
- Peru
- Prior art keywords
- polymorph
- present
- polymorphs
- refers
- ssao inhibitor
- Prior art date
Links
- 102100027159 Membrane primary amine oxidase Human genes 0.000 title 1
- 101710132836 Membrane primary amine oxidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 238000000113 differential scanning calorimetry Methods 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Refiere a un polimorfo de (2E)-3-fluoro-2-({[2-(4-metoxipiperidin-1-il)pirimidin-5- il]oxi}metil)prop-2-en-1-aminio 4-metilbencenosulfonato, que se caracteriza por presentar un patron de difraccion de rayos X (XRPD) con picos en angulos 2-theta de 8.3±0.2, 13.7±0.2, 18.0±0.2, 18.3±0.2 y 25.5±0.2 grados, y un inicio endotermico de 123°C a 174°C determinado por calorimetria diferencial de barrido (DSC). Tambien, la presente reivindica una composicion farmaceutica a base del presente polimorfo y sustancialmente libre de otras formas polimorficas; ademas refiere a metodos para preparacion del polimorfo y para el tratamiento de trastornos hepaticos como la esteatopatitis no alcoholica (NASH).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063070147P | 2020-08-25 | 2020-08-25 | |
PCT/US2021/047363 WO2022046779A1 (en) | 2020-08-25 | 2021-08-24 | Polymorphs of an ssao inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20231096A1 true PE20231096A1 (es) | 2023-07-18 |
Family
ID=80355663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2023000721A PE20231096A1 (es) | 2020-08-25 | 2021-08-24 | Polimorfos de un inhibidor de ssao |
Country Status (14)
Country | Link |
---|---|
US (1) | US11820754B2 (es) |
EP (1) | EP4204405A4 (es) |
JP (1) | JP2023539639A (es) |
KR (1) | KR20230058112A (es) |
CN (1) | CN116615416A (es) |
AU (1) | AU2021332217A1 (es) |
CA (1) | CA3193057A1 (es) |
CL (1) | CL2023000537A1 (es) |
CO (1) | CO2023002085A2 (es) |
IL (1) | IL300853A (es) |
MX (1) | MX2023002308A (es) |
PE (1) | PE20231096A1 (es) |
TW (1) | TW202227406A (es) |
WO (1) | WO2022046779A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL300853A (en) | 2020-08-25 | 2023-04-01 | Lilly Co Eli | SSAO inhibitor polymorphs |
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US20070293548A1 (en) | 2006-03-31 | 2007-12-20 | Wang Eric Y | Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases |
WO2008123469A1 (ja) | 2007-03-30 | 2008-10-16 | Japan Tobacco Inc. | 6員環アミド化合物およびその用途 |
DK2170403T3 (da) | 2007-06-27 | 2014-06-16 | Quark Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til hæmning af ekspressionen af proapoptotiske gener |
TW200906823A (en) | 2007-07-16 | 2009-02-16 | Lilly Co Eli | Compounds and methods for modulating FXR |
AU2008280784A1 (en) | 2007-07-20 | 2009-01-29 | Merck Frosst Canada Ltd | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
US8426587B2 (en) | 2007-11-21 | 2013-04-23 | Pharmaxis Ltd. | Haloallylamine inhibitors of SSAO/VAP-1 and uses therefor |
WO2010084944A1 (ja) | 2009-01-22 | 2010-07-29 | 田辺三菱製薬株式会社 | 新規ピロロ[2,3-d]ピリミジン化合物 |
US20110014558A1 (en) | 2009-07-15 | 2011-01-20 | Kabushiki Kaisha Toshiba | Developing agent and method for producing the same |
JP2011136942A (ja) | 2009-12-28 | 2011-07-14 | Kowa Co | 新規な置換ピリミジン誘導体およびこれを含有する医薬 |
HUE028394T2 (en) | 2011-03-15 | 2016-12-28 | Astellas Pharma Inc | Guanidin Compound |
GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
SG10201707020TA (en) | 2012-05-02 | 2017-10-30 | Boehringer Ingelheim Int | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
JP6322202B2 (ja) | 2012-11-16 | 2018-05-09 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ピロリジンgpr40修飾因子 |
GB201304527D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
US8962641B2 (en) | 2013-04-17 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof |
WO2014184104A1 (en) | 2013-05-17 | 2014-11-20 | Boehringer Ingelheim International Gmbh | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof |
AU2014337064B2 (en) | 2013-10-18 | 2019-03-14 | Celgene Quanticel Research, Inc. | Bromodomain inhibitors |
GB201416444D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
BR112018069789A2 (pt) | 2016-03-28 | 2019-01-29 | Intercept Pharmaceuticals Inc | medicamento obtido pela combinação do agonista de fxr e arb |
MX2021015783A (es) | 2016-03-31 | 2022-12-09 | Genfit | Metodos de tratamiento de enfermedades colestaticas. |
SG10202011660RA (en) | 2016-05-25 | 2020-12-30 | Akarna Therapeutics Ltd | Combination therapies with farnesoid x receptor (fxr) modulators |
WO2018027892A1 (en) * | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
AU2017344882A1 (en) | 2016-10-19 | 2019-03-28 | Boehringer Ingelheim International Gmbh | Combinations comprising an SSAO/VAP-1 inhibitor and a SGLT2 inhibitor, uses thereof |
CN108883185B (zh) | 2016-12-06 | 2021-10-08 | 江苏恒瑞医药股份有限公司 | 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途 |
CN108341752B (zh) | 2017-01-21 | 2022-12-23 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
JP2020508316A (ja) | 2017-02-21 | 2020-03-19 | ジェンフィGenfit | Pparアゴニストとfxrアゴニストとの組合せ |
CA3054103A1 (en) | 2017-03-13 | 2018-09-20 | Genfit | Pharmaceutical compositions for combination therapy |
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CA3057940A1 (en) | 2017-04-18 | 2018-10-25 | Genfit | Combination of elafibranor or derivatives thereof with an anti-nash, anti-fibrotic or anti-cholestatic agent |
CN109251166B (zh) | 2017-07-13 | 2021-11-05 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
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WO2019053235A1 (en) | 2017-09-15 | 2019-03-21 | Genfit | NON-INVASIVE DIAGNOSIS OF NON ALCOHOLIC LIVER DISEASES, NON ALCOHOLIC STHEATHEPATITIS AND / OR HEPATIC FIBROSIS |
EP3684954A1 (en) | 2017-09-18 | 2020-07-29 | Genfit | Non-invasive diagnostic of non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis and/or liver fibrosis |
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KR20210002573A (ko) | 2018-04-24 | 2021-01-08 | 주식회사 피에이치파마 | 간 질환에 호중구 엘라스타제 저해제의 사용 |
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KR20230024277A (ko) | 2020-05-13 | 2023-02-20 | 테른스 파마슈티칼스, 인크. | 간 장애의 조합 치료 |
IL300853A (en) | 2020-08-25 | 2023-04-01 | Lilly Co Eli | SSAO inhibitor polymorphs |
US20230241071A1 (en) | 2021-11-11 | 2023-08-03 | Terns Pharmaceuticals, Inc. | Combination treatment of liver disorders |
CA3238102A1 (en) | 2021-11-11 | 2023-05-19 | Terns Pharmaceuticals, Inc. | Treating liver disorders with an ssao inhibitor |
-
2021
- 2021-08-24 IL IL300853A patent/IL300853A/en unknown
- 2021-08-24 KR KR1020237010171A patent/KR20230058112A/ko unknown
- 2021-08-24 JP JP2023513750A patent/JP2023539639A/ja active Pending
- 2021-08-24 MX MX2023002308A patent/MX2023002308A/es unknown
- 2021-08-24 CA CA3193057A patent/CA3193057A1/en active Pending
- 2021-08-24 AU AU2021332217A patent/AU2021332217A1/en active Pending
- 2021-08-24 EP EP21862577.0A patent/EP4204405A4/en active Pending
- 2021-08-24 PE PE2023000721A patent/PE20231096A1/es unknown
- 2021-08-24 US US17/445,792 patent/US11820754B2/en active Active
- 2021-08-24 WO PCT/US2021/047363 patent/WO2022046779A1/en active Application Filing
- 2021-08-24 CN CN202180072876.5A patent/CN116615416A/zh active Pending
- 2021-08-25 TW TW110131421A patent/TW202227406A/zh unknown
-
2023
- 2023-02-23 CL CL2023000537A patent/CL2023000537A1/es unknown
- 2023-02-24 CO CONC2023/0002085A patent/CO2023002085A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230058112A (ko) | 2023-05-02 |
CN116615416A (zh) | 2023-08-18 |
MX2023002308A (es) | 2023-07-11 |
JP2023539639A (ja) | 2023-09-15 |
WO2022046779A1 (en) | 2022-03-03 |
CL2023000537A1 (es) | 2023-12-15 |
EP4204405A4 (en) | 2024-05-29 |
EP4204405A1 (en) | 2023-07-05 |
CA3193057A1 (en) | 2022-03-03 |
US11820754B2 (en) | 2023-11-21 |
TW202227406A (zh) | 2022-07-16 |
US20220089563A1 (en) | 2022-03-24 |
AU2021332217A1 (en) | 2023-05-11 |
IL300853A (en) | 2023-04-01 |
CO2023002085A2 (es) | 2023-03-07 |
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