PE20211979A1 - Anticuerpos anti-trem2 y metodos para utilizarlos - Google Patents
Anticuerpos anti-trem2 y metodos para utilizarlosInfo
- Publication number
- PE20211979A1 PE20211979A1 PE2021001367A PE2021001367A PE20211979A1 PE 20211979 A1 PE20211979 A1 PE 20211979A1 PE 2021001367 A PE2021001367 A PE 2021001367A PE 2021001367 A PE2021001367 A PE 2021001367A PE 20211979 A1 PE20211979 A1 PE 20211979A1
- Authority
- PE
- Peru
- Prior art keywords
- trem2
- disease
- expressed
- receptor
- myeloid cell
- Prior art date
Links
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 abstract 4
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 abstract 4
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 208000021320 Nasu-Hakola disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000274 microglia Anatomy 0.000 abstract 1
- 210000000066 myeloid cell Anatomy 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 208000031334 polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly Diseases 0.000 abstract 1
- 230000000770 proinflammatory effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 102000027257 transmembrane receptors Human genes 0.000 abstract 1
- 108091008578 transmembrane receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962808141P | 2019-02-20 | 2019-02-20 | |
| PCT/US2020/019093 WO2020172450A1 (en) | 2019-02-20 | 2020-02-20 | Anti-trem2 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20211979A1 true PE20211979A1 (es) | 2021-10-05 |
Family
ID=69844940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021001367A PE20211979A1 (es) | 2019-02-20 | 2020-02-20 | Anticuerpos anti-trem2 y metodos para utilizarlos |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US12240902B2 (enExample) |
| EP (1) | EP3927743A1 (enExample) |
| JP (2) | JP7543290B2 (enExample) |
| KR (1) | KR20210135518A (enExample) |
| CN (1) | CN113614110B (enExample) |
| AR (1) | AR118144A1 (enExample) |
| AU (1) | AU2020226754A1 (enExample) |
| BR (1) | BR112021015656A2 (enExample) |
| CA (1) | CA3130086A1 (enExample) |
| CL (1) | CL2021002206A1 (enExample) |
| CO (1) | CO2021012230A2 (enExample) |
| EA (1) | EA202192294A1 (enExample) |
| EC (1) | ECSP21069105A (enExample) |
| IL (1) | IL285651A (enExample) |
| MA (1) | MA55025A (enExample) |
| MX (1) | MX2021009722A (enExample) |
| PE (1) | PE20211979A1 (enExample) |
| PH (1) | PH12021552002A1 (enExample) |
| SG (1) | SG11202108734VA (enExample) |
| TW (1) | TWI879756B (enExample) |
| WO (2) | WO2020172450A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| CN113544152B (zh) * | 2018-12-18 | 2024-10-15 | 勃林格殷格翰国际加拿大公司 | Flt3激动剂抗体及其用途 |
| AR118144A1 (es) | 2019-02-20 | 2021-09-22 | Denali Therapeutics Inc | Anticuerpos anti-trem2 y métodos para utilizarlos |
| MX2022008582A (es) | 2020-01-13 | 2022-08-10 | Denali Therapeutics Inc | Anticuerpos anti-trem2 y metodos para utilizarlos. |
| US20240002503A1 (en) * | 2020-10-21 | 2024-01-04 | Immune-Onc Therapeutics, Inc. | Novel anti-lilrb2 antibodies and derivative products |
| BR112023023777A2 (pt) * | 2021-05-14 | 2024-01-30 | Genentech Inc | Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo |
| JP2025508757A (ja) | 2022-02-23 | 2025-04-10 | アレクトル エルエルシー | 抗ｔｒｅｍ２抗体の使用方法 |
| WO2023192282A1 (en) | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Methods for treating brain glucose hypometabolism |
| US20250215077A1 (en) | 2022-03-28 | 2025-07-03 | Denali Therapeutics Inc. | Monovalent anti-trem2 binding molecules and methods of use thereof |
| WO2024160736A1 (en) | 2023-01-30 | 2024-08-08 | Isar Bioscience Gmbh | Human anti-trem2 antibody for treating neurodegenerative disorders |
| WO2025032069A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| WO2025032071A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| WO2025046298A2 (en) | 2023-09-01 | 2025-03-06 | iTeos Belgium SA | Anti-trem2 antibodies and methods of use |
| WO2025106361A1 (en) * | 2023-11-15 | 2025-05-22 | Merck Sharp & Dohme Llc | Human nectin-4 binders |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8231878B2 (en) | 2001-03-20 | 2012-07-31 | Cosmo Research & Development S.P.A. | Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| MX2011006268A (es) | 2009-01-06 | 2011-10-06 | Nestec Sa | Procesamiento de macronutrientes. |
| PE20160651A1 (es) | 2009-03-05 | 2016-07-24 | Abbvie Inc | Proteinas de union a il-17 |
| US10087408B2 (en) | 2010-07-07 | 2018-10-02 | The University Of British Columbia | System and method for microfluidic cell culture |
| US9188593B2 (en) | 2010-07-16 | 2015-11-17 | The University Of British Columbia | Methods for assaying cellular binding interactions |
| KR20140033152A (ko) * | 2011-06-20 | 2014-03-17 | 교와 핫꼬 기린 가부시키가이샤 | 항erbB3 항체 |
| FI3677591T3 (fi) | 2013-04-29 | 2023-04-03 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd38-vasta-aineet ja fuusiot heikennetylle interferonille alfa-2b |
| CA2922979A1 (en) | 2013-09-03 | 2015-03-12 | Novimmune S.A. | Readily isolated bispecific binding molecules with native format having mutated constant regions |
| CN105218669A (zh) | 2014-06-10 | 2016-01-06 | 河北翰林生物科技有限公司 | 制备抗人r47h-trem2突变体的人单克隆抗体的方法 |
| CA2955086A1 (en) * | 2014-08-08 | 2016-02-11 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
| US10428143B2 (en) | 2014-09-28 | 2019-10-01 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
| CN107207579B (zh) * | 2015-03-31 | 2022-02-25 | 豪夫迈·罗氏有限公司 | 包含三聚体tnf家族配体的抗原结合分子 |
| WO2017058866A1 (en) * | 2015-09-28 | 2017-04-06 | Precision Immune, Inc. | Anti-trem2 antibodies and uses thereof |
| CN108738323B (zh) * | 2015-10-06 | 2023-05-26 | 艾利妥 | 抗trem2抗体及其使用方法 |
| WO2017147509A1 (en) | 2016-02-25 | 2017-08-31 | Marco Colonna | Compositions comprising trem2 and methods of use thereof |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CA3030785A1 (en) | 2016-07-22 | 2018-01-25 | Deutsches Zentrum Fur Neurodegenerative Erkrankungen E.V. (Dzne) | Trem2 cleavage modulators and uses thereof |
| JP7264482B2 (ja) | 2016-12-23 | 2023-04-25 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｓｅｚ６ｌ２抗体および抗体薬物コンジュゲート |
| US20190367623A1 (en) | 2017-01-17 | 2019-12-05 | Yeda Research And Development Co. Ltd. | Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells |
| WO2018152359A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| US10457717B2 (en) | 2017-02-17 | 2019-10-29 | Denali Therapeutics Inc. | Engineered polypeptides |
| MY205898A (en) | 2017-02-17 | 2024-11-19 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
| JOP20190248A1 (ar) * | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| EP3658577A1 (en) | 2017-07-27 | 2020-06-03 | Novartis AG | Sheddase resistant trem2 variants |
| TWI811229B (zh) * | 2017-08-03 | 2023-08-11 | 美商阿列克特有限責任公司 | 抗trem2抗體及其使用方法 |
| CA3072035A1 (en) | 2017-08-10 | 2019-02-14 | Denali Therapeutics Inc. | Engineered transferrin receptor binding polypeptides |
| WO2019055841A1 (en) | 2017-09-14 | 2019-03-21 | Denali Therapeutics Inc. | ANTI-TREM2 ANTIBODIES AND METHODS OF USE |
| EP3692070A1 (en) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
| WO2019079529A1 (en) | 2017-10-17 | 2019-04-25 | The Translational Genomics Research Institute | TREM2 AGONISTS FOR STIMULATING MICROGLIA AND IDENTIFICATION METHODS |
| WO2019094608A1 (en) | 2017-11-08 | 2019-05-16 | Denali Therapeutics Inc. | Anti-bace1 antibodies and methods of use thereof |
| EP3723803A4 (en) | 2017-12-12 | 2021-09-15 | Pionyr Immunotherapeutics, Inc. | ANTI-TREM2 ANTIBODIES AND RELATED PROCEDURES |
| BR112020013921A2 (pt) | 2018-01-10 | 2020-12-01 | Denali Therapeutics Inc. | polipeptídeos de ligação ao receptor de transferrina e usos destes |
| TWI874321B (zh) | 2018-06-18 | 2025-03-01 | 美商戴納立製藥公司 | 包含顆粒蛋白前體之融合蛋白 |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| EP3850007A4 (en) | 2018-08-16 | 2022-08-10 | Denali Therapeutics Inc. | Engineered bispecific proteins |
| BR112021002953A2 (pt) | 2018-08-22 | 2021-05-11 | Denali Therapeutics Inc. | polipeptídeos anti-her2 e métodos de uso dos mesmos |
| KR20210057113A (ko) | 2018-09-11 | 2021-05-20 | 워싱턴 유니버시티 | 항-trem-2 작용제 항체 |
| UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
| KR102156165B1 (ko) | 2018-10-29 | 2020-09-15 | 재단법인대구경북과학기술원 | 인간 ｔｒｅｍ２ 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도 |
| CA3120970A1 (en) | 2018-11-26 | 2020-06-04 | Denali Therapeutics Inc. | Methods for treating dysregulated lipid metabolism |
| WO2020121195A1 (en) | 2018-12-10 | 2020-06-18 | Mor Research Applications | Trem2 antibodies and uses thereof |
| CN120044247A (zh) | 2018-12-10 | 2025-05-27 | 戴纳立制药公司 | 溶酶体贮积症的生物标志物及其使用方法 |
| WO2020123664A1 (en) | 2018-12-11 | 2020-06-18 | Pionyr Immunotherapeutics, Inc. | Methods of using anti-trem2 antibodies |
| AR118144A1 (es) | 2019-02-20 | 2021-09-22 | Denali Therapeutics Inc | Anticuerpos anti-trem2 y métodos para utilizarlos |
| WO2020194317A1 (en) | 2019-03-28 | 2020-10-01 | Yeda Research And Development Co. Ltd. | Method of treating lipid-related disorders |
| AU2020252554A1 (en) | 2019-04-03 | 2021-10-28 | Denali Therapeutics Inc. | Formulations of protein molecules comprising iduronate 2-sulfatase |
| PE20230036A1 (es) | 2019-12-23 | 2023-01-10 | Denali Therapeutics Inc | Variantes de progranulina |
| TWI890727B (zh) | 2020-01-13 | 2025-07-21 | 美商戴納立製藥公司 | 抗trem2 抗體及其使用方法 |
| MX2022008582A (es) | 2020-01-13 | 2022-08-10 | Denali Therapeutics Inc | Anticuerpos anti-trem2 y metodos para utilizarlos. |
| WO2021158986A1 (en) | 2020-02-07 | 2021-08-12 | Denali Therapeutics Inc. | Methods for the treatment of hunter syndrome |
| AU2021224200A1 (en) | 2020-02-19 | 2022-09-08 | Denali Therapeutics Inc. | Engineered anti-HER2 bispecific proteins |
| KR20230086703A (ko) | 2020-10-14 | 2023-06-15 | 데날리 테라퓨틱스 인크. | 설포글루코사민 설포하이드롤라제 효소를 포함하는 융합 단백질 및 이의 방법 |
-
2020
- 2020-02-20 AR ARP200100461A patent/AR118144A1/es unknown
- 2020-02-20 KR KR1020217028927A patent/KR20210135518A/ko active Pending
- 2020-02-20 JP JP2021548668A patent/JP7543290B2/ja active Active
- 2020-02-20 CN CN202080015804.2A patent/CN113614110B/zh active Active
- 2020-02-20 WO PCT/US2020/019093 patent/WO2020172450A1/en not_active Ceased
- 2020-02-20 PH PH1/2021/552002A patent/PH12021552002A1/en unknown
- 2020-02-20 CA CA3130086A patent/CA3130086A1/en active Pending
- 2020-02-20 PE PE2021001367A patent/PE20211979A1/es unknown
- 2020-02-20 MX MX2021009722A patent/MX2021009722A/es unknown
- 2020-02-20 EP EP20711737.5A patent/EP3927743A1/en active Pending
- 2020-02-20 EA EA202192294A patent/EA202192294A1/ru unknown
- 2020-02-20 SG SG11202108734VA patent/SG11202108734VA/en unknown
- 2020-02-20 AU AU2020226754A patent/AU2020226754A1/en active Pending
- 2020-02-20 TW TW109105560A patent/TWI879756B/zh active
- 2020-02-20 BR BR112021015656-9A patent/BR112021015656A2/pt unknown
- 2020-02-20 MA MA055025A patent/MA55025A/fr unknown
- 2020-02-20 WO PCT/US2020/019104 patent/WO2020172457A1/en not_active Ceased
-
2021
- 2021-08-16 IL IL285651A patent/IL285651A/en unknown
- 2021-08-16 US US17/402,986 patent/US12240902B2/en active Active
- 2021-08-16 US US17/403,406 patent/US20220073609A1/en not_active Abandoned
- 2021-08-18 CL CL2021002206A patent/CL2021002206A1/es unknown
- 2021-09-17 EC ECSENADI202169105A patent/ECSP21069105A/es unknown
- 2021-09-17 CO CONC2021/0012230A patent/CO2021012230A2/es unknown
-
2024
- 2024-08-21 JP JP2024139367A patent/JP2024164116A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI879756B (zh) | 2025-04-11 |
| SG11202108734VA (en) | 2021-09-29 |
| US20220119522A1 (en) | 2022-04-21 |
| US12240902B2 (en) | 2025-03-04 |
| WO2020172457A1 (en) | 2020-08-27 |
| IL285651A (en) | 2021-09-30 |
| ECSP21069105A (es) | 2021-11-18 |
| JP2024164116A (ja) | 2024-11-26 |
| BR112021015656A2 (pt) | 2021-10-05 |
| CL2021002206A1 (es) | 2022-04-22 |
| CO2021012230A2 (es) | 2021-09-30 |
| MA55025A (fr) | 2021-12-29 |
| AU2020226754A1 (en) | 2021-09-16 |
| WO2020172450A1 (en) | 2020-08-27 |
| EA202192294A1 (ru) | 2021-12-24 |
| CA3130086A1 (en) | 2020-08-27 |
| JP2022520868A (ja) | 2022-04-01 |
| JP7543290B2 (ja) | 2024-09-02 |
| MX2021009722A (es) | 2021-09-14 |
| CN113614110B (zh) | 2025-03-25 |
| PH12021552002A1 (en) | 2022-09-19 |
| KR20210135518A (ko) | 2021-11-15 |
| EP3927743A1 (en) | 2021-12-29 |
| US20220073609A1 (en) | 2022-03-10 |
| TW202045543A (zh) | 2020-12-16 |
| AR118144A1 (es) | 2021-09-22 |
| CN113614110A (zh) | 2021-11-05 |
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