JP7543290B2 - 抗ｔｒｅｍ２抗体及びその使用方法 - Google Patents

抗ｔｒｅｍ２抗体及びその使用方法 Download PDF

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JP7543290B2
JP7543290B2 JP2021548668A JP2021548668A JP7543290B2 JP 7543290 B2 JP7543290 B2 JP 7543290B2 JP 2021548668 A JP2021548668 A JP 2021548668A JP 2021548668 A JP2021548668 A JP 2021548668A JP 7543290 B2 JP7543290 B2 JP 7543290B2
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seq
sequence
amino acid
cdr
trem2
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JPWO2020172450A5 (enExample
JP2022520868A (ja
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マーク エス． デニス
シェリー ダンカン
キャスリーン リサインゴ
キャサリン エム． モンロー
ジョシュア アイ． パーク
レイチェル プロロク
ジュ シー
アンキタ スリヴァスタヴァ
レンゲリッチ ベティーナ ヴァン
ライリー ウォルシュ
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Denali Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021548668A 2019-02-20 2020-02-20 抗ｔｒｅｍ２抗体及びその使用方法 Active JP7543290B2 (ja)

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US201962808141P 2019-02-20 2019-02-20
US62/808,141 2019-02-20
PCT/US2020/019093 WO2020172450A1 (en) 2019-02-20 2020-02-20 Anti-trem2 antibodies and methods of use thereof

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WO2025032071A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
WO2025032069A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
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AU2020226754A1 (en) 2021-09-16
US20220073609A1 (en) 2022-03-10
MX2021009722A (es) 2021-09-14
US20220119522A1 (en) 2022-04-21
AR118144A1 (es) 2021-09-22
TW202045543A (zh) 2020-12-16
TWI879756B (zh) 2025-04-11
CN113614110A (zh) 2021-11-05
MA55025A (fr) 2021-12-29
BR112021015656A2 (pt) 2021-10-05
CL2021002206A1 (es) 2022-04-22
PE20211979A1 (es) 2021-10-05
WO2020172450A1 (en) 2020-08-27
WO2020172457A1 (en) 2020-08-27
CO2021012230A2 (es) 2021-09-30
ECSP21069105A (es) 2021-11-18
PH12021552002A1 (en) 2022-09-19
CN113614110B (zh) 2025-03-25
KR20210135518A (ko) 2021-11-15
US12240902B2 (en) 2025-03-04
CA3130086A1 (en) 2020-08-27
SG11202108734VA (en) 2021-09-29
JP2022520868A (ja) 2022-04-01
EP3927743A1 (en) 2021-12-29
EA202192294A1 (ru) 2021-12-24
JP2024164116A (ja) 2024-11-26
IL285651A (en) 2021-09-30

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