PE20190106A1 - Inhibidores del potenciador del homologo zeste 2 - Google Patents
Inhibidores del potenciador del homologo zeste 2Info
- Publication number
- PE20190106A1 PE20190106A1 PE2018002174A PE2018002174A PE20190106A1 PE 20190106 A1 PE20190106 A1 PE 20190106A1 PE 2018002174 A PE2018002174 A PE 2018002174A PE 2018002174 A PE2018002174 A PE 2018002174A PE 20190106 A1 PE20190106 A1 PE 20190106A1
- Authority
- PE
- Peru
- Prior art keywords
- zeste
- enhancer
- approval
- inhibitors
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Referido a compuestos inhibidores del potenciador del homologo ZESTE 2 (EZH2) de Formula (I) o una de sus sales farmaceuticamente aceptables; en donde R1 es alquilo (C1-C4) o alcoxi (C1-C4); R2 es alquilo (C1-C3) y R3 es alquilo (C1-C8), halogenoalquilo (C1-C8), hidroxialquilo (C1-C8), entre otros. Un compuesto seleccionado es: (R)-5-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)metil)-3-metil-2-(1-(1-neopentilpiperidin-4-il)etil)-5,6,7,8-tetrahidro-4H-tieno[3,2-c]azepin-4-ona. Tambien se refiere a una composicion farmaceutica que lo comprende; siendo utiles en terapia para el tratamiento del cancer
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662332131P | 2016-05-05 | 2016-05-05 | |
US201662359904P | 2016-07-08 | 2016-07-08 | |
US201762454143P | 2017-02-03 | 2017-02-03 | |
US201762482964P | 2017-04-07 | 2017-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20190106A1 true PE20190106A1 (es) | 2019-01-15 |
Family
ID=58709513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2018002174A PE20190106A1 (es) | 2016-05-05 | 2017-05-01 | Inhibidores del potenciador del homologo zeste 2 |
Country Status (21)
Country | Link |
---|---|
US (1) | US10604531B2 (es) |
EP (1) | EP3452483B1 (es) |
JP (1) | JP2019516685A (es) |
KR (1) | KR20190003699A (es) |
CN (1) | CN109328188A (es) |
AU (1) | AU2017260854B2 (es) |
BR (1) | BR112018072740A2 (es) |
CA (1) | CA3023157A1 (es) |
CL (1) | CL2018003121A1 (es) |
CO (1) | CO2018011819A2 (es) |
CR (1) | CR20180521A (es) |
DO (1) | DOP2018000238A (es) |
ES (1) | ES2801423T3 (es) |
IL (1) | IL262701A (es) |
MX (1) | MX2018013519A (es) |
PE (1) | PE20190106A1 (es) |
PH (1) | PH12018502314A1 (es) |
SG (1) | SG11201809560QA (es) |
TW (1) | TW201806955A (es) |
UY (1) | UY37225A (es) |
WO (1) | WO2017191545A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
US20210000815A1 (en) * | 2017-12-28 | 2021-01-07 | Constellation Pharmaceuticals, Inc. | Pharmacokinetic enhancement of ezh2 inhibitors through combination therapies |
CA3089639A1 (en) | 2018-01-31 | 2019-08-08 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidinyl compounds as prc2 inhibitors |
WO2020011607A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
CN111537654B (zh) * | 2020-07-07 | 2020-11-10 | 上海亚盛医药科技有限公司 | N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法 |
CN112830957B (zh) * | 2021-01-07 | 2022-07-22 | 江西师范大学 | 一种制备卡非佐米的方法 |
WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
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GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
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IL152935A0 (en) | 2000-05-19 | 2003-06-24 | Corixa Corp | Prophylactic and therapeutic treatment of infectious and other diseases with mono and dissaccharide-based compounds |
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US6525028B1 (en) | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
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ES2295639T3 (es) | 2002-06-13 | 2008-04-16 | Crucell Holland B.V. | Agonistas del receptor ox40=(=cd134) y uso terapeutico descripcion. |
DK2206517T3 (da) | 2002-07-03 | 2023-11-06 | Ono Pharmaceutical Co | Immunpotentierende sammensætninger omfattende af anti-PD-L1-antistoffer |
WO2004056875A1 (en) | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
WO2004072286A1 (ja) | 2003-01-23 | 2004-08-26 | Ono Pharmaceutical Co., Ltd. | ヒトpd−1に対し特異性を有する物質 |
CA2607147C (en) | 2005-05-09 | 2018-07-17 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
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WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
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EA030196B1 (ru) | 2013-04-30 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Ингибиторы энхансера zeste гомолога 2 |
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AU2015340614B2 (en) * | 2014-10-28 | 2018-07-19 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
TW201636344A (zh) | 2014-12-05 | 2016-10-16 | 美國禮來大藥廠 | Ezh2抑制劑 |
TW201708210A (zh) * | 2015-06-30 | 2017-03-01 | 葛蘭素史克智慧財產(第二)有限公司 | Zeste同源物2增強子之抑制劑 |
TW201718598A (zh) * | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
-
2017
- 2017-05-01 WO PCT/IB2017/052523 patent/WO2017191545A1/en unknown
- 2017-05-01 KR KR1020187034784A patent/KR20190003699A/ko not_active Application Discontinuation
- 2017-05-01 CA CA3023157A patent/CA3023157A1/en not_active Abandoned
- 2017-05-01 EP EP17723766.6A patent/EP3452483B1/en active Active
- 2017-05-01 SG SG11201809560QA patent/SG11201809560QA/en unknown
- 2017-05-01 PE PE2018002174A patent/PE20190106A1/es unknown
- 2017-05-01 ES ES17723766T patent/ES2801423T3/es active Active
- 2017-05-01 AU AU2017260854A patent/AU2017260854B2/en not_active Ceased
- 2017-05-01 MX MX2018013519A patent/MX2018013519A/es unknown
- 2017-05-01 US US16/097,322 patent/US10604531B2/en not_active Expired - Fee Related
- 2017-05-01 BR BR112018072740-7A patent/BR112018072740A2/pt not_active IP Right Cessation
- 2017-05-01 CN CN201780038943.5A patent/CN109328188A/zh active Pending
- 2017-05-01 JP JP2018557862A patent/JP2019516685A/ja active Pending
- 2017-05-01 CR CR20180521A patent/CR20180521A/es unknown
- 2017-05-03 UY UY0001037225A patent/UY37225A/es unknown
- 2017-05-03 TW TW106114574A patent/TW201806955A/zh unknown
-
2018
- 2018-10-31 IL IL262701A patent/IL262701A/en unknown
- 2018-10-31 CO CONC2018/0011819A patent/CO2018011819A2/es unknown
- 2018-10-31 CL CL2018003121A patent/CL2018003121A1/es unknown
- 2018-10-31 DO DO2018000238A patent/DOP2018000238A/es unknown
- 2018-11-05 PH PH12018502314A patent/PH12018502314A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20190003699A (ko) | 2019-01-09 |
US10604531B2 (en) | 2020-03-31 |
CN109328188A (zh) | 2019-02-12 |
EP3452483B1 (en) | 2020-04-01 |
EP3452483A1 (en) | 2019-03-13 |
UY37225A (es) | 2017-11-30 |
AU2017260854A1 (en) | 2018-11-15 |
CL2018003121A1 (es) | 2018-12-14 |
BR112018072740A2 (pt) | 2019-02-19 |
AU2017260854B2 (en) | 2020-01-30 |
CA3023157A1 (en) | 2017-11-09 |
CO2018011819A2 (es) | 2018-11-22 |
CR20180521A (es) | 2019-01-15 |
TW201806955A (zh) | 2018-03-01 |
MX2018013519A (es) | 2019-03-14 |
IL262701A (en) | 2018-12-31 |
WO2017191545A1 (en) | 2017-11-09 |
US20190092785A1 (en) | 2019-03-28 |
ES2801423T3 (es) | 2021-01-11 |
PH12018502314A1 (en) | 2019-04-15 |
JP2019516685A (ja) | 2019-06-20 |
DOP2018000238A (es) | 2019-10-31 |
SG11201809560QA (en) | 2018-11-29 |
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