PE20181053A1 - Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativas - Google Patents
Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativasInfo
- Publication number
- PE20181053A1 PE20181053A1 PE2018000386A PE2018000386A PE20181053A1 PE 20181053 A1 PE20181053 A1 PE 20181053A1 PE 2018000386 A PE2018000386 A PE 2018000386A PE 2018000386 A PE2018000386 A PE 2018000386A PE 20181053 A1 PE20181053 A1 PE 20181053A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- treatment
- pharmaceutical composition
- hydrogen
- independently selected
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
Abstract
Referido a un compuesto de Formula I, en donde X1 y X5 se seleccionan independientemente del grupo que consta de hidrogeno, halogeno, alquilo de C1-C4, haloalquilo de C1-C4, ciano, nitro, di(alquilo de C1-C4)amino, entre otros; X2, X3, X4 se seleccionan independientemente del grupo que consta de hidrogeno, cloro, alquilo de C1-C4, haloalquilo de C1-C4, alcoxi de C1-C4, entre otros; con la condicion de que al menos una de X1,X2, X3, X4, X5 no sea hidrogeno y que al menos una de X2, X3, X4 no sea alcoxi de C1-C4; L es -C(O)NH-, -NHC(O)-, -SO2NH-, -NHSO2-, o -NH-; n es 0, 1 o 2; m es 1, 2, 3, 4 o 5; R1 es H o alquilo, y R2 es arilalquilo de 5 o 6 miembros, cicloalquilalquilo de 5 o 6 miembros, en donde el radical ciclico de dicho arilalquilo o cicloalquilalquilo esta opcionalmente sustituido con uno o mas sustituyentes seleccionados independientemente entre halogeno. Tambien se refiere a una composicion farmaceutica, a un medicamento, en donde se puede utilizar en el tratamiento y/o prevencion de una enfermedad relacionada con el receptor sigma-1, siendo esta una enfermedad neurodegenerativa, entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14305919 | 2014-06-16 |
Publications (1)
Publication Number | Publication Date |
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PE20181053A1 true PE20181053A1 (es) | 2018-07-03 |
Family
ID=50982878
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016002712A PE20170518A1 (es) | 2014-06-16 | 2015-06-15 | Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativas |
PE2018000386A PE20181053A1 (es) | 2014-06-16 | 2018-03-13 | Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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PE2016002712A PE20170518A1 (es) | 2014-06-16 | 2015-06-15 | Compuestos, composicion farmaceutica y su uso en el tratamiento de enfermedades neurodegenerativas |
Country Status (29)
Country | Link |
---|---|
US (3) | US10179761B2 (es) |
EP (1) | EP3154934B1 (es) |
JP (1) | JP6704355B2 (es) |
KR (1) | KR20170041662A (es) |
CN (1) | CN106795100B (es) |
AU (1) | AU2015276256B2 (es) |
BR (1) | BR112016029571A2 (es) |
CA (1) | CA2951438C (es) |
CL (1) | CL2016003230A1 (es) |
CO (1) | CO2017000211A2 (es) |
CR (1) | CR20160581A (es) |
DO (1) | DOP2016000325A (es) |
EA (1) | EA031123B1 (es) |
EC (1) | ECSP16094286A (es) |
ES (1) | ES2880313T3 (es) |
GT (1) | GT201600255A (es) |
IL (1) | IL249440B (es) |
MA (1) | MA39533B1 (es) |
MX (1) | MX2016016769A (es) |
MY (1) | MY183757A (es) |
PE (2) | PE20170518A1 (es) |
PH (1) | PH12016502480A1 (es) |
PL (1) | PL3154934T3 (es) |
PT (1) | PT3154934T (es) |
SG (1) | SG11201610478YA (es) |
TN (1) | TN2016000550A1 (es) |
UA (1) | UA123041C2 (es) |
WO (1) | WO2015193255A1 (es) |
ZA (1) | ZA201608558B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
WO2024033399A1 (en) | 2022-08-10 | 2024-02-15 | Institut National de la Santé et de la Recherche Médicale | Sigmar1 ligand for the treatment of pancreatic cancer |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2241498A (en) * | 1940-11-25 | 1941-05-13 | Champ Items Inc | Method of manufacturing oil shields for internal combustion engines |
US2441498A (en) * | 1943-07-15 | 1948-05-11 | Astra Apotekarnes Kem Fab | Alkyl glycinanilides |
GB1307250A (en) | 1970-06-16 | 1973-02-14 | May & Baker Ltd | Benzene derivatives |
DE2438288A1 (de) * | 1974-08-09 | 1976-02-19 | Knoll Ag | Neue antiarrhythmika |
US4448776A (en) | 1981-02-12 | 1984-05-15 | Karl Bucher | Method of using certain substituted aliphatic secondary amines or their salts for easing breathing |
JPH02138162A (ja) * | 1988-11-19 | 1990-05-28 | Mitsubishi Kasei Corp | N−フェニルアルキル置換−β−アミノ酸アミド誘導体 |
WO1992022279A2 (en) * | 1991-06-06 | 1992-12-23 | G.D. Searle & Co. | N-[arylethyl]-n-alkyl-2-(1-pyrrolidinyl)ethylamine derivatives for cns disorders |
JPH07188139A (ja) * | 1993-12-24 | 1995-07-25 | Kirin Brewery Co Ltd | アミド化合物 |
FR2729146A1 (fr) * | 1995-01-06 | 1996-07-12 | Smithkline Beecham Lab | Nouveaux derives d'amine, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques |
EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
BRPI0519040A2 (pt) | 2004-12-15 | 2009-01-13 | Bayer Schering Pharma Ag | tiazolidinonas metassubstituÍdas, sua produÇço e uso como medicamentos |
CA2709186A1 (en) * | 2007-12-19 | 2009-06-25 | Wyeth Llc | 4-imidazolidinones as kv1.5 potassium channel inhibitors |
CA2839956A1 (en) * | 2011-06-20 | 2012-12-27 | Emory University | Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto |
US20130274233A1 (en) * | 2012-04-03 | 2013-10-17 | President And Fellow Of Harvard College | Modulators of hedgehog signaling pathway |
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2015
- 2015-06-15 US US15/317,742 patent/US10179761B2/en active Active
- 2015-06-15 MX MX2016016769A patent/MX2016016769A/es unknown
- 2015-06-15 MA MA39533A patent/MA39533B1/fr unknown
- 2015-06-15 MY MYPI2016002188A patent/MY183757A/en unknown
- 2015-06-15 CR CR20160581A patent/CR20160581A/es unknown
- 2015-06-15 PT PT157304619T patent/PT3154934T/pt unknown
- 2015-06-15 PE PE2016002712A patent/PE20170518A1/es not_active Application Discontinuation
- 2015-06-15 JP JP2016573483A patent/JP6704355B2/ja active Active
- 2015-06-15 AU AU2015276256A patent/AU2015276256B2/en not_active Ceased
- 2015-06-15 SG SG11201610478YA patent/SG11201610478YA/en unknown
- 2015-06-15 EA EA201790020A patent/EA031123B1/ru not_active IP Right Cessation
- 2015-06-15 WO PCT/EP2015/063370 patent/WO2015193255A1/en active Application Filing
- 2015-06-15 BR BR112016029571A patent/BR112016029571A2/pt not_active Application Discontinuation
- 2015-06-15 ES ES15730461T patent/ES2880313T3/es active Active
- 2015-06-15 CN CN201580032317.6A patent/CN106795100B/zh active Active
- 2015-06-15 KR KR1020167036029A patent/KR20170041662A/ko not_active Application Discontinuation
- 2015-06-15 EP EP15730461.9A patent/EP3154934B1/en active Active
- 2015-06-15 PL PL15730461T patent/PL3154934T3/pl unknown
- 2015-06-15 TN TN2016000550A patent/TN2016000550A1/en unknown
- 2015-06-15 UA UAA201700333A patent/UA123041C2/uk unknown
- 2015-06-15 CA CA2951438A patent/CA2951438C/en active Active
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2016
- 2016-12-07 IL IL249440A patent/IL249440B/en active IP Right Grant
- 2016-12-08 GT GT201600255A patent/GT201600255A/es unknown
- 2016-12-12 ZA ZA2016/08558A patent/ZA201608558B/en unknown
- 2016-12-12 PH PH12016502480A patent/PH12016502480A1/en unknown
- 2016-12-13 DO DO2016000325A patent/DOP2016000325A/es unknown
- 2016-12-14 EC ECIEPI201694286A patent/ECSP16094286A/es unknown
- 2016-12-15 CL CL2016003230A patent/CL2016003230A1/es unknown
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2017
- 2017-01-10 CO CONC2017/0000211A patent/CO2017000211A2/es unknown
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2018
- 2018-03-13 PE PE2018000386A patent/PE20181053A1/es unknown
- 2018-11-30 US US16/205,637 patent/US10844008B2/en active Active
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2020
- 2020-10-22 US US17/077,530 patent/US20210040034A1/en not_active Abandoned
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