PE20150644A1 - Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno - Google Patents
Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgenoInfo
- Publication number
- PE20150644A1 PE20150644A1 PE2015000095A PE2015000095A PE20150644A1 PE 20150644 A1 PE20150644 A1 PE 20150644A1 PE 2015000095 A PE2015000095 A PE 2015000095A PE 2015000095 A PE2015000095 A PE 2015000095A PE 20150644 A1 PE20150644 A1 PE 20150644A1
- Authority
- PE
- Peru
- Prior art keywords
- androgen receptor
- methods
- modified
- compositions
- receptor polypeptides
- Prior art date
Links
- 102000001307 androgen receptors Human genes 0.000 title abstract 8
- 108010080146 androgen receptors Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000000849 selective androgen receptor modulator Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Abstract
La invencion describe polipeptidos del receptor de androgeno modificado que son resistentes a la inhibicion por un inhibidor del receptor de androgeno. En la invencion se describen composiciones, combinaciones y estuches que contienen los polipeptidos del receptor de androgeno modificados y metodos de uso de los polipeptidos del receptor de androgeno modificados. En la invencion se describen, ademas, metodos de uso de los polipeptidos del receptor de androgeno modificados como agentes de analisis para la identificacion y el diseno de moduladores del receptor de androgeno de tercera generacion. En la invencion se describen, ademas, moduladores del receptor de androgeno de tercera generacion que inhiben la actividad de los polipeptidos del receptor de androgeno modificados. Se describen, ademas, composiciones farmaceuticas y medicamentos que incluyen los compuestos que se describen en la invencion, asi como tambien metodos de uso de tales moduladores del receptor de androgeno, solos y en combinacion con otros compuestos, para el tratamiento de enfermedades o condiciones, lo que incluye a los canceres, tales como los canceres de prostata resistentes a la castracion, que son mediados o dependientes de los receptores de androgeno
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261676842P | 2012-07-27 | 2012-07-27 | |
US201361783763P | 2013-03-14 | 2013-03-14 | |
US201361829123P | 2013-05-30 | 2013-05-30 |
Publications (1)
Publication Number | Publication Date |
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PE20150644A1 true PE20150644A1 (es) | 2015-05-11 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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PE2015000095A PE20150644A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
PE2019001034A PE20190845A1 (es) | 2012-07-27 | 2013-07-26 | Metodos para determinar resistencia a terapia de receptor de androgeno |
PE2019000439A PE20190574A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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PE2019001034A PE20190845A1 (es) | 2012-07-27 | 2013-07-26 | Metodos para determinar resistencia a terapia de receptor de androgeno |
PE2019000439A PE20190574A1 (es) | 2012-07-27 | 2013-07-26 | Metodos y composiciones para determinar la resistencia a la terapia con receptor de androgeno |
Country Status (34)
Country | Link |
---|---|
US (2) | US9617602B2 (es) |
EP (2) | EP3653733A1 (es) |
JP (3) | JP6297556B2 (es) |
KR (2) | KR102210183B1 (es) |
CN (3) | CN104685072A (es) |
AU (3) | AU2013295543B2 (es) |
BR (2) | BR122017017921A2 (es) |
CA (1) | CA2879926A1 (es) |
CL (1) | CL2015000194A1 (es) |
CO (1) | CO7280477A2 (es) |
CR (1) | CR20150022A (es) |
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EP2839028B1 (en) | 2012-04-20 | 2016-12-28 | Cepheid | Methods of detecting bladder cancer |
CA2889765C (en) | 2012-10-26 | 2021-06-22 | Minna D. BALBAS | Androgen receptor variants and methods for making and using |
WO2014130932A2 (en) * | 2013-02-25 | 2014-08-28 | Novartis Ag | Novel androgen receptor mutation |
CA2903104A1 (en) | 2013-03-06 | 2014-09-12 | Cepheid | Methods of detecting bladder cancer |
EP2968370A4 (en) | 2013-03-14 | 2016-09-21 | Univ Maryland | AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF |
JP2016528252A (ja) | 2013-08-12 | 2016-09-15 | トーカイ ファーマシューティカルズ, インコーポレイテッド | アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー |
EP3495355A1 (en) | 2013-10-18 | 2019-06-12 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
CN112402360A (zh) * | 2014-02-05 | 2021-02-26 | 斯洛文尼亚莱柯制药股份有限公司 | 雄激素受体拮抗剂的固体药物组合物 |
US10774387B2 (en) | 2014-05-19 | 2020-09-15 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
CA2959336A1 (en) * | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
CA3018351C (en) | 2016-03-29 | 2024-02-13 | F. Hoffmann-La Roche Ag | Method of operating a receiver for receiving analyte data, receiver and computer program product |
CN106290919B (zh) * | 2016-08-31 | 2018-03-27 | 天津市泌尿外科研究所 | 用于检测去势抵抗性前列腺癌的elisa试剂盒及使用方法 |
CN106405085B (zh) * | 2016-08-31 | 2018-03-27 | 天津市泌尿外科研究所 | 用于检测去势抵抗性前列腺癌的elisa试剂盒及使用方法 |
CN106198985B (zh) * | 2016-08-31 | 2018-03-27 | 天津市泌尿外科研究所 | 用于检测去势抵抗性前列腺癌的elisa试剂盒及使用方法 |
CN106526185B (zh) * | 2016-10-28 | 2018-03-30 | 拜尔康(天津)医药科技有限公司 | 用于检测去势抵抗性前列腺癌的elisa试剂盒及检测方法 |
ES2884064T3 (es) | 2016-12-16 | 2021-12-10 | Kangpu Biopharmaceuticals Ltd | Composición combinada que comprende un compuesto benzoheterocíclico y un modulador de la vía de los receptores androgénicos y usos de la misma |
AU2018352167B2 (en) * | 2017-10-19 | 2024-03-14 | Yale University | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
CN108018342A (zh) * | 2017-12-04 | 2018-05-11 | 合肥艾迪康临床检验所有限公司 | 检测ar基因突变的引物和方法 |
JP6993683B2 (ja) | 2017-12-15 | 2022-01-13 | 東都興業株式会社 | ビニールハウスにおけるシート押え紐の止め具 |
CN109115742A (zh) * | 2018-09-05 | 2019-01-01 | 中国农业科学院农业质量标准与检测技术研究所 | 一种抗雄激素效应的检测方法 |
CN109321569B (zh) * | 2018-10-29 | 2022-04-12 | 迈杰转化医学研究(苏州)有限公司 | 一种引物探针组合物及其应用 |
KR102473989B1 (ko) | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
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CN113533730B (zh) * | 2021-07-23 | 2022-09-06 | 南方医科大学深圳医院 | 一种血浆外泌体标志物组合及其应用 |
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CN102573472A (zh) * | 2009-10-23 | 2012-07-11 | 健康研究公司 | 治疗雄激素受体阳性癌症的方法 |
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