PE20141669A1 - Moduladores selectivos del receptor androgeno - Google Patents
Moduladores selectivos del receptor androgenoInfo
- Publication number
- PE20141669A1 PE20141669A1 PE2014000521A PE2014000521A PE20141669A1 PE 20141669 A1 PE20141669 A1 PE 20141669A1 PE 2014000521 A PE2014000521 A PE 2014000521A PE 2014000521 A PE2014000521 A PE 2014000521A PE 20141669 A1 PE20141669 A1 PE 20141669A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- selective androgen
- cyclopentil
- benzonitrile
- chloro
- Prior art date
Links
- 239000003098 androgen Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940083324 Selective androgen receptor modulator Drugs 0.000 abstract 2
- 239000000849 selective androgen receptor modulator Substances 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 102000001307 androgen receptors Human genes 0.000 abstract 1
- 108010080146 androgen receptors Proteins 0.000 abstract 1
- 201000000585 muscular atrophy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546711P | 2011-10-13 | 2011-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141669A1 true PE20141669A1 (es) | 2014-11-08 |
Family
ID=47046879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000521A PE20141669A1 (es) | 2011-10-13 | 2012-10-05 | Moduladores selectivos del receptor androgeno |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8658693B2 (enExample) |
| EP (1) | EP2766350B1 (enExample) |
| JP (1) | JP6002228B2 (enExample) |
| KR (1) | KR20140067102A (enExample) |
| CN (1) | CN103842348B (enExample) |
| AP (1) | AP2014007548A0 (enExample) |
| AR (1) | AR088082A1 (enExample) |
| AU (1) | AU2012321113B2 (enExample) |
| BR (1) | BR112014008668A2 (enExample) |
| CA (1) | CA2847889A1 (enExample) |
| CL (1) | CL2014000895A1 (enExample) |
| CO (1) | CO6910195A2 (enExample) |
| CR (1) | CR20140156A (enExample) |
| DO (1) | DOP2014000075A (enExample) |
| EA (1) | EA201490519A1 (enExample) |
| EC (1) | ECSP14013305A (enExample) |
| ES (1) | ES2626820T3 (enExample) |
| GT (1) | GT201400067A (enExample) |
| IL (1) | IL231440A0 (enExample) |
| MX (1) | MX2014004558A (enExample) |
| PE (1) | PE20141669A1 (enExample) |
| PH (1) | PH12014500808A1 (enExample) |
| PL (1) | PL2766350T3 (enExample) |
| PT (1) | PT2766350T (enExample) |
| SG (1) | SG11201401794YA (enExample) |
| TN (1) | TN2014000136A1 (enExample) |
| TW (1) | TWI449686B (enExample) |
| WO (1) | WO2013055577A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| TW201534586A (zh) * | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| US10093660B2 (en) | 2013-12-04 | 2018-10-09 | Evotec Internatonal Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| JP6479854B2 (ja) | 2014-05-07 | 2019-03-06 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＥｖｏｔｅｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ | 医薬組成物のためのスルホキシイミン置換キナゾリン |
| CN109803968A (zh) | 2016-08-15 | 2019-05-24 | 辉瑞公司 | 吡啶并嘧啶酮cdk2/4/6抑制剂 |
| PL3507289T3 (pl) | 2016-09-02 | 2021-01-25 | Suven Life Sciences Limited | Dodatnie allosteryczne modulatory receptora muskarynowego m1 |
| EP3684761A1 (en) | 2017-09-18 | 2020-07-29 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| IL297963A (en) | 2020-05-07 | 2023-01-01 | Adorx Therapeutics Ltd | Antagonists of the adenosine a2a receptor |
| JP7778095B2 (ja) * | 2020-06-24 | 2025-12-01 | セルジーン コーポレーション | セレブロン結合化合物、その組成物及びそれによる治療方法 |
| WO2025104624A1 (en) * | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594405A (en) * | 1968-05-17 | 1971-07-20 | Du Pont | Substituted pyranyl anilines as plant growth modifiers |
| DE60208630T2 (de) * | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| US8519158B2 (en) * | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| DE602006003432D1 (de) * | 2005-05-13 | 2008-12-11 | Lilly Co Eli | Latoren des androgenrezeptors |
| BRPI0619208A2 (pt) * | 2005-11-30 | 2011-09-20 | Astellas Pharma Inc | derivado de 2-aminobenzamida c07d 307/14 c07d 307/22 c07d 309/14 c07d 319/12 c07d 401/12 c07d 405/12 c07d 413/12 c07d 417/12 |
| CA2684240A1 (en) * | 2007-04-16 | 2008-10-30 | Serenex, Inc. | Tetrahydroindole and tetrahydroindazole derivatives |
| US8190467B2 (en) * | 2007-10-19 | 2012-05-29 | Michelle Letendre-Hedlund | Methods of identifying environmentally friendly businesses or individuals |
| BRPI0907844B8 (pt) * | 2008-02-22 | 2021-05-25 | Radius Health Inc | compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos |
-
2012
- 2012-09-27 AR ARP120103597A patent/AR088082A1/es unknown
- 2012-09-28 TW TW101136038A patent/TWI449686B/zh not_active IP Right Cessation
- 2012-10-05 PL PL12775406T patent/PL2766350T3/pl unknown
- 2012-10-05 CA CA2847889A patent/CA2847889A1/en not_active Abandoned
- 2012-10-05 MX MX2014004558A patent/MX2014004558A/es not_active Application Discontinuation
- 2012-10-05 AP AP2014007548A patent/AP2014007548A0/xx unknown
- 2012-10-05 KR KR1020147009338A patent/KR20140067102A/ko not_active Abandoned
- 2012-10-05 JP JP2014535757A patent/JP6002228B2/ja active Active
- 2012-10-05 PT PT127754067T patent/PT2766350T/pt unknown
- 2012-10-05 EA EA201490519A patent/EA201490519A1/ru unknown
- 2012-10-05 US US13/645,535 patent/US8658693B2/en active Active
- 2012-10-05 ES ES12775406.7T patent/ES2626820T3/es active Active
- 2012-10-05 EP EP12775406.7A patent/EP2766350B1/en active Active
- 2012-10-05 PH PH1/2014/500808A patent/PH12014500808A1/en unknown
- 2012-10-05 SG SG11201401794YA patent/SG11201401794YA/en unknown
- 2012-10-05 AU AU2012321113A patent/AU2012321113B2/en not_active Ceased
- 2012-10-05 WO PCT/US2012/058824 patent/WO2013055577A1/en not_active Ceased
- 2012-10-05 CN CN201280049445.8A patent/CN103842348B/zh active Active
- 2012-10-05 BR BR112014008668A patent/BR112014008668A2/pt not_active IP Right Cessation
- 2012-10-05 PE PE2014000521A patent/PE20141669A1/es not_active Application Discontinuation
-
2014
- 2014-03-10 IL IL231440A patent/IL231440A0/en unknown
- 2014-03-17 CO CO14057028A patent/CO6910195A2/es unknown
- 2014-03-28 TN TNP2014000136A patent/TN2014000136A1/en unknown
- 2014-04-04 CR CR20140156A patent/CR20140156A/es unknown
- 2014-04-10 CL CL2014000895A patent/CL2014000895A1/es unknown
- 2014-04-11 EC ECSP14013305 patent/ECSP14013305A/es unknown
- 2014-04-11 GT GT201400067A patent/GT201400067A/es unknown
- 2014-04-11 DO DO2014000075A patent/DOP2014000075A/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201170676A1 (ru) | Агонисты рецептора меланокортина | |
| EA201170198A1 (ru) | Фармацевтические композиции, содержащие лиганды рецептора дофамина | |
| RU2008139315A (ru) | Избирательные андрогенные рецепторные модуляторы | |
| EA201590200A1 (ru) | Модуляторы пути активации комплемента и их применение | |
| EA201001724A1 (ru) | Производные изоксазола и их применение в качестве потенциирующих средств для метаботропных глутаматных рецепторов | |
| TN2014000030A1 (en) | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as c5a receptor modulators | |
| EA201590118A1 (ru) | Производные пирролидина и их применение в качестве модуляторов пути активации комплемента | |
| CR20160212A (es) | Composiciones y métodos para modular los receptores x farnesoides | |
| CO2022010305A2 (es) | Método y aplicación de preparación de compuesto como agente de degradación de proteínas | |
| HN2012001351A (es) | Derivados de 3- hidroxi-5-arilisotiazol novedosos | |
| CL2011000835A1 (es) | Compuestos derivados de espiro-oxindol; moduladores de los canales de sodio; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento del dolor, depresion, enfermedades cardiovasculares, respiratorias, psiquiatricas, entre otras. | |
| DOP2013000181A (es) | Moduladores del receptor de glucagon | |
| EA201190021A1 (ru) | Модуляторы toll-подобных рецепторов | |
| PE20142314A1 (es) | Composiciones intranasales de dexmedetomidina y metodos de uso de ellas | |
| PE20160996A1 (es) | Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp | |
| EA201390843A1 (ru) | Применение агониста toll-подобного рецептора для лечения рака | |
| ECSP11011398A (es) | Inhibidores de beta-secretasa | |
| ECSP099552A (es) | Compuestos triciclicos, composiciones y procedimientos | |
| UY31863A (es) | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar | |
| EA201291476A1 (ru) | Комбинации, содержащие атипичные антипсихотические средства и агонисты taar1 | |
| EA201391525A1 (ru) | Гликозидные производные и их применение для лечения диабета | |
| EA201591815A1 (ru) | Бицикло [2.2.2] кислоты - модуляторы gpr120 | |
| CL2014000895A1 (es) | Compuestos derivados de {2-cloro-4-[hidroxi(cicloalquil/heterociclil)]amino]fenil}acetonitrilo, moduladores selectivos del receptor androgeno; composicion farmaceutica; composicion farmceutica que comprende una forma cristalina; y su uso en el tratamiento de la atrofia muscular | |
| AR088297A1 (es) | R(+)-n-formil-propargil-aminoindano | |
| CR11360A (es) | Benzotiazoles como moduladores del receptor de grelina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |