PE20141669A1 - Moduladores selectivos del receptor androgeno - Google Patents
Moduladores selectivos del receptor androgenoInfo
- Publication number
- PE20141669A1 PE20141669A1 PE2014000521A PE2014000521A PE20141669A1 PE 20141669 A1 PE20141669 A1 PE 20141669A1 PE 2014000521 A PE2014000521 A PE 2014000521A PE 2014000521 A PE2014000521 A PE 2014000521A PE 20141669 A1 PE20141669 A1 PE 20141669A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- selective androgen
- cyclopentil
- benzonitrile
- chloro
- Prior art date
Links
- 239000003098 androgen Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940083324 Selective androgen receptor modulator Drugs 0.000 abstract 2
- 239000000849 selective androgen receptor modulator Substances 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 102000001307 androgen receptors Human genes 0.000 abstract 1
- 108010080146 androgen receptors Proteins 0.000 abstract 1
- 201000000585 muscular atrophy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546711P | 2011-10-13 | 2011-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141669A1 true PE20141669A1 (es) | 2014-11-08 |
Family
ID=47046879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000521A PE20141669A1 (es) | 2011-10-13 | 2012-10-05 | Moduladores selectivos del receptor androgeno |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8658693B2 (enExample) |
| EP (1) | EP2766350B1 (enExample) |
| JP (1) | JP6002228B2 (enExample) |
| KR (1) | KR20140067102A (enExample) |
| CN (1) | CN103842348B (enExample) |
| AP (1) | AP2014007548A0 (enExample) |
| AR (1) | AR088082A1 (enExample) |
| AU (1) | AU2012321113B2 (enExample) |
| BR (1) | BR112014008668A2 (enExample) |
| CA (1) | CA2847889A1 (enExample) |
| CL (1) | CL2014000895A1 (enExample) |
| CO (1) | CO6910195A2 (enExample) |
| CR (1) | CR20140156A (enExample) |
| DO (1) | DOP2014000075A (enExample) |
| EA (1) | EA201490519A1 (enExample) |
| EC (1) | ECSP14013305A (enExample) |
| ES (1) | ES2626820T3 (enExample) |
| GT (1) | GT201400067A (enExample) |
| IL (1) | IL231440A0 (enExample) |
| MX (1) | MX2014004558A (enExample) |
| PE (1) | PE20141669A1 (enExample) |
| PH (1) | PH12014500808A1 (enExample) |
| PL (1) | PL2766350T3 (enExample) |
| PT (1) | PT2766350T (enExample) |
| SG (1) | SG11201401794YA (enExample) |
| TN (1) | TN2014000136A1 (enExample) |
| TW (1) | TWI449686B (enExample) |
| WO (1) | WO2013055577A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| TW201534586A (zh) * | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| AU2014359456B2 (en) | 2013-12-04 | 2019-01-24 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| CA2944103A1 (en) | 2014-05-07 | 2015-11-12 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| JP6563623B1 (ja) | 2016-08-15 | 2019-08-21 | ファイザー・インク | ピリドピリミジノンｃｄｋ２／４／６阻害剤 |
| SMT202000554T1 (it) | 2016-09-02 | 2020-11-10 | Suven Life Sciences Ltd | Modulatori allosterici positivi del recettore muscarinico m1 |
| EP3684761A1 (en) | 2017-09-18 | 2020-07-29 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| JP7778095B2 (ja) * | 2020-06-24 | 2025-12-01 | セルジーン コーポレーション | セレブロン結合化合物、その組成物及びそれによる治療方法 |
| WO2025104624A1 (en) * | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594405A (en) * | 1968-05-17 | 1971-07-20 | Du Pont | Substituted pyranyl anilines as plant growth modifiers |
| DE60208630T2 (de) * | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| AU2006247738A1 (en) * | 2005-05-13 | 2006-11-23 | Eli Lilly And Company | Substituted N-arylpyrrolidines as selective androgen receptor modulators |
| KR20080071562A (ko) * | 2005-11-30 | 2008-08-04 | 아스텔라스세이야쿠 가부시키가이샤 | ２-아미노벤즈아미드 유도체 |
| CA2684240A1 (en) * | 2007-04-16 | 2008-10-30 | Serenex, Inc. | Tetrahydroindole and tetrahydroindazole derivatives |
| WO2009052514A2 (en) * | 2007-10-19 | 2009-04-23 | Michelle Letendre-Hedlund | Methods of identifying environmentally friendly businesses or individuals |
| AU2009215843B2 (en) * | 2008-02-22 | 2011-09-08 | Ellipses Pharma Ltd | Selective androgen receptor modulators |
-
2012
- 2012-09-27 AR ARP120103597A patent/AR088082A1/es unknown
- 2012-09-28 TW TW101136038A patent/TWI449686B/zh not_active IP Right Cessation
- 2012-10-05 CA CA2847889A patent/CA2847889A1/en not_active Abandoned
- 2012-10-05 PE PE2014000521A patent/PE20141669A1/es not_active Application Discontinuation
- 2012-10-05 BR BR112014008668A patent/BR112014008668A2/pt not_active IP Right Cessation
- 2012-10-05 CN CN201280049445.8A patent/CN103842348B/zh active Active
- 2012-10-05 WO PCT/US2012/058824 patent/WO2013055577A1/en not_active Ceased
- 2012-10-05 SG SG11201401794YA patent/SG11201401794YA/en unknown
- 2012-10-05 PL PL12775406T patent/PL2766350T3/pl unknown
- 2012-10-05 EP EP12775406.7A patent/EP2766350B1/en active Active
- 2012-10-05 EA EA201490519A patent/EA201490519A1/ru unknown
- 2012-10-05 US US13/645,535 patent/US8658693B2/en active Active
- 2012-10-05 MX MX2014004558A patent/MX2014004558A/es not_active Application Discontinuation
- 2012-10-05 PT PT127754067T patent/PT2766350T/pt unknown
- 2012-10-05 AU AU2012321113A patent/AU2012321113B2/en not_active Ceased
- 2012-10-05 KR KR1020147009338A patent/KR20140067102A/ko not_active Abandoned
- 2012-10-05 AP AP2014007548A patent/AP2014007548A0/xx unknown
- 2012-10-05 PH PH1/2014/500808A patent/PH12014500808A1/en unknown
- 2012-10-05 JP JP2014535757A patent/JP6002228B2/ja active Active
- 2012-10-05 ES ES12775406.7T patent/ES2626820T3/es active Active
-
2014
- 2014-03-10 IL IL231440A patent/IL231440A0/en unknown
- 2014-03-17 CO CO14057028A patent/CO6910195A2/es unknown
- 2014-03-28 TN TNP2014000136A patent/TN2014000136A1/en unknown
- 2014-04-04 CR CR20140156A patent/CR20140156A/es unknown
- 2014-04-10 CL CL2014000895A patent/CL2014000895A1/es unknown
- 2014-04-11 DO DO2014000075A patent/DOP2014000075A/es unknown
- 2014-04-11 EC ECSP14013305 patent/ECSP14013305A/es unknown
- 2014-04-11 GT GT201400067A patent/GT201400067A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |