EA201291476A1 - Комбинации, содержащие атипичные антипсихотические средства и агонисты taar1 - Google Patents
Комбинации, содержащие атипичные антипсихотические средства и агонисты taar1Info
- Publication number
- EA201291476A1 EA201291476A1 EA201291476A EA201291476A EA201291476A1 EA 201291476 A1 EA201291476 A1 EA 201291476A1 EA 201291476 A EA201291476 A EA 201291476A EA 201291476 A EA201291476 A EA 201291476A EA 201291476 A1 EA201291476 A1 EA 201291476A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- taar1
- agonists
- atypical antipsychotic
- combinations containing
- containing atypical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Изобретение относится к фармацевтической комбинации для лечения шизофрении и острых маниакальных эпизодов, обусловленных биполярными расстройствами, включающей соединение, которое активно в отношении ассоциированного со следовыми аминами рецептора 1 (агонист TAAR1), и антипсихотическое лекарственное средство. Неожиданно обнаружено, что такая комбинация может уменьшить метаболические побочные эффекты, возникающие при применении только одного антипсихотического лекарственного средства.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10171560 | 2010-08-02 | ||
PCT/EP2011/062772 WO2012016879A1 (en) | 2010-08-02 | 2011-07-26 | Combinations comprising atypical antipsychotics and taar1 agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201291476A1 true EA201291476A1 (ru) | 2013-06-28 |
EA024703B1 EA024703B1 (ru) | 2016-10-31 |
Family
ID=44512842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201291476A EA024703B1 (ru) | 2010-08-02 | 2011-07-26 | Комбинация оланзапина и агониста taar1 |
Country Status (24)
Country | Link |
---|---|
US (2) | US9132136B2 (ru) |
EP (1) | EP2600853A1 (ru) |
JP (2) | JP5749802B2 (ru) |
KR (1) | KR101455548B1 (ru) |
CN (1) | CN103068379A (ru) |
AR (1) | AR082458A1 (ru) |
AU (1) | AU2011287701A1 (ru) |
BR (1) | BR112013002518A2 (ru) |
CA (1) | CA2802935A1 (ru) |
CL (1) | CL2013000313A1 (ru) |
CO (1) | CO6761298A2 (ru) |
CR (1) | CR20120663A (ru) |
EA (1) | EA024703B1 (ru) |
EC (1) | ECSP13012414A (ru) |
MA (1) | MA34458B1 (ru) |
MX (1) | MX340489B (ru) |
MY (1) | MY166955A (ru) |
NZ (1) | NZ604592A (ru) |
PE (1) | PE20130497A1 (ru) |
SG (1) | SG187125A1 (ru) |
TW (1) | TWI511728B (ru) |
UA (1) | UA112527C2 (ru) |
WO (1) | WO2012016879A1 (ru) |
ZA (1) | ZA201300431B (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8802673B2 (en) * | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) * | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) * | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
CN104024250B (zh) * | 2012-01-12 | 2016-01-27 | 霍夫曼-拉罗奇有限公司 | 作为痕量胺相关受体(taar)的杂环衍生物 |
ES2641376T3 (es) * | 2012-11-16 | 2017-11-08 | F. Hoffmann-La Roche Ag | Procedimiento para la preparación de ácido 2-trifluorometilisonicotínico y ésteres |
PL3080284T3 (pl) | 2013-12-11 | 2018-05-30 | F.Hoffmann-La Roche Ag | Sposób wytwarzania chiralnej 2-(4-aminofenylo)morfoliny |
WO2015165085A1 (en) * | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
WO2017192858A1 (en) * | 2016-05-04 | 2017-11-09 | Purdue Pharma L.P. | Oxazoline pseudodimers, pharmaceutical compositions and the use thereof |
EA202091945A1 (ru) | 2018-02-16 | 2021-01-18 | Суновион Фармасьютикалз Инк. | Соли, кристаллические формы и способы их получения |
EA202092490A1 (ru) | 2018-04-18 | 2020-12-23 | Констеллейшен Фармасьютикалс, Инк. | Модуляторы метилмодифицирующих ферментов, композиции и их применения |
CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP4135690A1 (en) | 2020-04-14 | 2023-02-22 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
CA3178004A1 (en) * | 2020-05-09 | 2021-11-18 | Taolei Sun | Treatment of adverse effects caused by atypical antipsychotics |
US20240190888A1 (en) * | 2021-03-29 | 2024-06-13 | Shujing Biopharma Co., Ltd | Spiro-containing derivative, and preparation method therefor and use thereof |
CN114288304A (zh) * | 2021-12-31 | 2022-04-08 | 江苏海洋大学 | 一种抗精神分裂症组合物及其应用 |
WO2024013383A1 (en) | 2022-07-15 | 2024-01-18 | F. Hoffmann-La Roche Ag | Mutant ketoreductase with increased ketoreductase activity as well as methods and uses involving the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1838716B1 (en) | 2005-01-05 | 2011-06-01 | Eli Lilly And Company | Olanzapine pamoate dihydrate |
BRPI0610780A2 (pt) * | 2005-04-22 | 2016-09-06 | Teva Pharma | formulação farmacéutica em tablete desintegrante, e, métodos para tratar um paciente em necessidade de tratamento com olanzapina, e para produzir a formulação farmacêutica em tablete |
KR20070022539A (ko) | 2005-08-22 | 2007-02-27 | 홍진표 | 지프라시돈 또는 그의 대사산물을 함유하는 항비만 조성물 |
AU2008209860A1 (en) | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | Novel 2-aminooxazolines as TAAR1 ligands for CNS disorders |
KR101222412B1 (ko) | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Taar1 리간드로서의 2-아미노옥사졸린 |
EP2182935A1 (en) | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | The use of benzamide derivatives for the treatment of cns disorders |
MX2011000464A (es) | 2008-07-24 | 2011-03-01 | Hoffmann La Roche | Derivados de 4,5-dihidro-oxazol-2-ilo. |
EP2310016B1 (en) | 2008-08-05 | 2017-10-04 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8293954B2 (en) * | 2010-03-10 | 2012-10-23 | Honeywell International Inc. | Catalyst life improvement for the vapor phase manufacture of 1-chloro-3,3,3-trifluoropropene |
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2011
- 2011-07-25 US US13/189,600 patent/US9132136B2/en not_active Expired - Fee Related
- 2011-07-26 EP EP11741429.2A patent/EP2600853A1/en not_active Withdrawn
- 2011-07-26 AU AU2011287701A patent/AU2011287701A1/en not_active Abandoned
- 2011-07-26 CN CN2011800369576A patent/CN103068379A/zh active Pending
- 2011-07-26 SG SG2013003983A patent/SG187125A1/en unknown
- 2011-07-26 MY MYPI2013000176A patent/MY166955A/en unknown
- 2011-07-26 PE PE2013000163A patent/PE20130497A1/es not_active Application Discontinuation
- 2011-07-26 MA MA35646A patent/MA34458B1/fr unknown
- 2011-07-26 KR KR1020137005202A patent/KR101455548B1/ko not_active IP Right Cessation
- 2011-07-26 NZ NZ604592A patent/NZ604592A/en not_active IP Right Cessation
- 2011-07-26 CA CA2802935A patent/CA2802935A1/en not_active Abandoned
- 2011-07-26 BR BR112013002518A patent/BR112013002518A2/pt not_active IP Right Cessation
- 2011-07-26 JP JP2013522196A patent/JP5749802B2/ja not_active Expired - Fee Related
- 2011-07-26 EA EA201291476A patent/EA024703B1/ru not_active IP Right Cessation
- 2011-07-26 WO PCT/EP2011/062772 patent/WO2012016879A1/en active Application Filing
- 2011-07-26 UA UAA201302435A patent/UA112527C2/uk unknown
- 2011-07-26 MX MX2013000745A patent/MX340489B/es active IP Right Grant
- 2011-07-29 TW TW100127153A patent/TWI511728B/zh not_active IP Right Cessation
- 2011-08-02 AR ARP110102780 patent/AR082458A1/es unknown
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2012
- 2012-12-18 CO CO12229429A patent/CO6761298A2/es unknown
- 2012-12-21 CR CR20120663A patent/CR20120663A/es unknown
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2013
- 2013-01-16 ZA ZA2013/00431A patent/ZA201300431B/en unknown
- 2013-01-31 CL CL2013000313A patent/CL2013000313A1/es unknown
- 2013-02-01 EC ECSP13012414 patent/ECSP13012414A/es unknown
- 2013-07-19 US US13/946,471 patent/US20130345201A1/en not_active Abandoned
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2015
- 2015-04-08 JP JP2015079114A patent/JP2015145408A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2015145408A (ja) | 2015-08-13 |
AU2011287701A1 (en) | 2013-01-10 |
TWI511728B (zh) | 2015-12-11 |
MA34458B1 (fr) | 2013-08-01 |
AR082458A1 (es) | 2012-12-12 |
CR20120663A (es) | 2013-04-01 |
KR20130070629A (ko) | 2013-06-27 |
BR112013002518A2 (pt) | 2016-05-31 |
US9132136B2 (en) | 2015-09-15 |
JP5749802B2 (ja) | 2015-07-15 |
NZ604592A (en) | 2015-02-27 |
WO2012016879A1 (en) | 2012-02-09 |
ECSP13012414A (es) | 2013-03-28 |
MX340489B (es) | 2016-07-11 |
TW201206912A (en) | 2012-02-16 |
KR101455548B1 (ko) | 2014-10-27 |
CA2802935A1 (en) | 2012-02-09 |
PE20130497A1 (es) | 2013-04-22 |
CO6761298A2 (es) | 2013-09-30 |
CN103068379A (zh) | 2013-04-24 |
EP2600853A1 (en) | 2013-06-12 |
JP2013536181A (ja) | 2013-09-19 |
ZA201300431B (en) | 2013-09-25 |
MY166955A (en) | 2018-07-25 |
CL2013000313A1 (es) | 2013-05-03 |
US20130345201A1 (en) | 2013-12-26 |
UA112527C2 (uk) | 2016-09-26 |
EA024703B1 (ru) | 2016-10-31 |
MX2013000745A (es) | 2013-03-05 |
SG187125A1 (en) | 2013-02-28 |
US20120028964A1 (en) | 2012-02-02 |
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