EA201490519A1 - Селективные модуляторы рецепторов андрогенов - Google Patents

Селективные модуляторы рецепторов андрогенов

Info

Publication number
EA201490519A1
EA201490519A1 EA201490519A EA201490519A EA201490519A1 EA 201490519 A1 EA201490519 A1 EA 201490519A1 EA 201490519 A EA201490519 A EA 201490519A EA 201490519 A EA201490519 A EA 201490519A EA 201490519 A1 EA201490519 A1 EA 201490519A1
Authority
EA
Eurasian Patent Office
Prior art keywords
androgen receptors
selective modulators
modulators
selective
androgen
Prior art date
Application number
EA201490519A
Other languages
English (en)
Inventor
Прабхакар Кондаджи Джадхав
Ашраф Саед
Джонатан Эдвард Грин
Венкатеш Кришнан
Дональд Пол Мэтьюс
Грегори Алан Стивенсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47046879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201490519A1 publication Critical patent/EA201490519A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Настоящее изобретение обеспечивает новые селективные модуляторы рецепторов андрогенов и их соли и содержащие их фармацевтические композиции.
EA201490519A 2011-10-13 2012-10-05 Селективные модуляторы рецепторов андрогенов EA201490519A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161546711P 2011-10-13 2011-10-13
PCT/US2012/058824 WO2013055577A1 (en) 2011-10-13 2012-10-05 Selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
EA201490519A1 true EA201490519A1 (ru) 2014-09-30

Family

ID=47046879

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490519A EA201490519A1 (ru) 2011-10-13 2012-10-05 Селективные модуляторы рецепторов андрогенов

Country Status (27)

Country Link
US (1) US8658693B2 (ru)
EP (1) EP2766350B1 (ru)
JP (1) JP6002228B2 (ru)
KR (1) KR20140067102A (ru)
CN (1) CN103842348B (ru)
AP (1) AP2014007548A0 (ru)
AR (1) AR088082A1 (ru)
AU (1) AU2012321113B2 (ru)
BR (1) BR112014008668A2 (ru)
CA (1) CA2847889A1 (ru)
CL (1) CL2014000895A1 (ru)
CO (1) CO6910195A2 (ru)
CR (1) CR20140156A (ru)
DO (1) DOP2014000075A (ru)
EA (1) EA201490519A1 (ru)
EC (1) ECSP14013305A (ru)
ES (1) ES2626820T3 (ru)
GT (1) GT201400067A (ru)
IL (1) IL231440A0 (ru)
MX (1) MX2014004558A (ru)
PE (1) PE20141669A1 (ru)
PL (1) PL2766350T3 (ru)
PT (1) PT2766350T (ru)
SG (1) SG11201401794YA (ru)
TN (1) TN2014000136A1 (ru)
TW (1) TWI449686B (ru)
WO (1) WO2013055577A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
TW201534586A (zh) * 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
AU2014359456B2 (en) 2013-12-04 2019-01-24 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
JP6479854B2 (ja) 2014-05-07 2019-03-06 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＥｖｏｔｅｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ 医薬組成物のためのスルホキシイミン置換キナゾリン
HUE055978T2 (hu) 2016-08-15 2022-01-28 Pfizer Piridopirimidinon CDK2/4/6 inhibitorok
PL3507289T3 (pl) 2016-09-02 2021-01-25 Suven Life Sciences Limited Dodatnie allosteryczne modulatory receptora muskarynowego m1
US11076596B2 (en) 2017-09-18 2021-08-03 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594405A (en) * 1968-05-17 1971-07-20 Du Pont Substituted pyranyl anilines as plant growth modifiers
ATE315555T1 (de) * 2001-05-11 2006-02-15 Pfizer Prod Inc Thiazolderivate und ihre verwendung als cdk- inhibitoren
US8519158B2 (en) * 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
PL1891038T3 (pl) * 2005-05-13 2009-04-30 Lilly Co Eli Podstawione n-arylopirolidyny jako selektywne modulatory receptora androgenowego
BRPI0619208A2 (pt) * 2005-11-30 2011-09-20 Astellas Pharma Inc derivado de 2-aminobenzamida c07d 307/14 c07d 307/22 c07d 309/14 c07d 319/12 c07d 401/12 c07d 405/12 c07d 413/12 c07d 417/12
WO2008130879A2 (en) * 2007-04-16 2008-10-30 Serenex, Inc. Tetrahydroindole and tetrahydroindazole derivatives
CN101828200A (zh) * 2007-10-19 2010-09-08 米歇尔·勒唐德尔-赫德伦 标识环境友好企业或个人的方法
WO2009105214A2 (en) * 2008-02-22 2009-08-27 Radius Health, Inc. Selective androgen receptor modulators

Also Published As

Publication number Publication date
PL2766350T3 (pl) 2017-08-31
WO2013055577A1 (en) 2013-04-18
US8658693B2 (en) 2014-02-25
TN2014000136A1 (en) 2015-07-01
BR112014008668A2 (pt) 2017-04-25
GT201400067A (es) 2015-02-27
CO6910195A2 (es) 2014-03-31
CN103842348A (zh) 2014-06-04
AU2012321113A1 (en) 2014-03-27
US20130217762A1 (en) 2013-08-22
PT2766350T (pt) 2017-05-22
DOP2014000075A (es) 2014-06-01
IL231440A0 (en) 2014-04-30
PE20141669A1 (es) 2014-11-08
CN103842348B (zh) 2015-08-19
AR088082A1 (es) 2014-05-07
CL2014000895A1 (es) 2014-08-22
TWI449686B (zh) 2014-08-21
KR20140067102A (ko) 2014-06-03
JP6002228B2 (ja) 2016-10-05
JP2014530818A (ja) 2014-11-20
TW201329026A (zh) 2013-07-16
EP2766350B1 (en) 2017-04-05
SG11201401794YA (en) 2014-09-26
EP2766350A1 (en) 2014-08-20
ES2626820T3 (es) 2017-07-26
AP2014007548A0 (en) 2014-03-31
CR20140156A (es) 2014-05-16
ECSP14013305A (es) 2014-05-31
AU2012321113B2 (en) 2015-07-09
MX2014004558A (es) 2014-08-01
CA2847889A1 (en) 2013-04-18

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